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Original Article

Adoptive transfer of mesenchymal stromal cells accelerates intestinal epithelium recovery of irradiated mice in an interleukin-6-dependent manner

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Pages 1164-1170 | Received 07 Jan 2012, Accepted 04 Apr 2012, Published online: 10 May 2012

References

  • Chao NJ. Accidental or intentional exposure to ionizing radiation: biodosimetry and treatment options. Exp Hematol. 2007;35(Suppl 1):24–7.
  • Dainiak N, Sorba S. Early identification of radiation accident victims for therapy of bone marrow failure. Stem Cells. 1997; 15(Suppl 2):275–85.
  • Hecht G. Innate mechanisms of epithelial host defense: spotlight on intestine. Am J Physiol. 1999;277:C351–8.
  • Brooke G, Cook M, Blair C, Han R, Heazlewood C, Jones B, . Therapeutic applications of mesenchymal stromal cells. Semin Cell Dev Biol. 2007;18:846–58.
  • Jones BJ, McTaggart SJ. Immunosuppression by mesenchymal stromal cells: from culture to clinic. Exp Hematol. 2008; 36:733–41.
  • Nasef A, Mathieu N, Chapel A, Frick J, Francois S, Mazurier C, . Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation. 2007;84: 231–7.
  • Hu KX, Sun QY, Guo M, Ai HS. The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury. Br J Radiol. 2010;83:52–8.
  • Kudo K, Liu Y, Takahashi K, Tarusawa K, Osanai M, Hu DL, . Transplantation of mesenchymal stem cells to prevent radiation-induced intestinal injury in mice. J Radiat Res (Tokyo). 2010;51:73–9.
  • Semont A, Mouiseddine M, Francois A, Demarquay C, Mathieu N, Chapel A, . Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis. Cell Death Differ. 2010;17:952–61.
  • Semont A, Francois S, Mouiseddine M, Francois A, Sache A, Frick J, . Mesenchymal stem cells increase self- renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Adv Exp Med Biol. 2006;585:19–30.
  • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, . Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7.
  • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, . IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009;15:103–13.
  • Jin X, Zimmers TA, Zhang Z, Pierce RH, Koniaris LG. Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut. 2010;59:186–96.
  • Romieu-Mourez R, Francois M, Boivin MN, Bouchentouf M, Spaner DE, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol. 2009;182:7963–73.
  • Benderitter M, Gourmelon P, Bey E, Chapel A, Clairand I, Prat M, . New emerging concepts in the medical management of local radiation injury. Health Phys. 2010;98:851–7.
  • Yan L, Cai C, Li J, Xu S, Chang Q, Li Y, . Present status and perspectives of stem cell-based therapies for gastrointestinal diseases. Stem Cell Rev. 2009;5:278–82.
  • Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, . Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet. 2004;363:1439–41.
  • Le Blanc K, Samuelsson H, Gustafsson B, Remberger M, Sundberg B, Arvidson J, . Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia. 2007;21:1733–8.
  • Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum. 2005;48: 1416–23.
  • Koc ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, . Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol. 2000;18:307–16.
  • Francois S, Bensidhoum M, Mouiseddine M, Mazurier C, Allenet B, Semont A, . Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage. Stem Cells. 2006;24:1020–9.
  • Saha S, Bhanja P, Kabarriti R, Liu L, Alfieri AA, Guha C. Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice. PLoS One.2011; 6(9):e24072.
  • Jin X, Zimmers TA, Zhang Z, Pierce RH, Koniaris LG. Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut. 2010;59:186–96.

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