720
Views
34
CrossRef citations to date
0
Altmetric
Research Articles (Regular)

Synthesis and biological evaluation of some novel 6-aryl-2-(p-sulfamylphenyl)-4,5-dihydropyridazin-3(2H)-ones as anti-cancer, antimicrobial, and anti-inflammatory agents

, , , &
Pages 266-271 | Received 25 Nov 2008, Accepted 19 Jun 2009, Published online: 29 Dec 2009

References

  • Coates WJ. In: Katritzky AR, Rees CW, Scriven EFV, eds. Comprehensive Heterocyclic Chemistry (Vol. 2): Pyridazines and their benzo derivatives, Exeter, UK: Elsevier, 1996:1–91.
  • Tisler M, Stanovnik B, eds. Advances in Heterocyclic Chemistry, Vol. 49. London, Academic Press, 1990:385–472.
  • Kuroda S, Akahane A, Itani H, Nishimura S, Durkin K, Kinoshita T, et al. Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist. Bioorg Med Chem Lett 1999;9:1979–84.
  • Costantino L, Rastelli G, Cignarella G, Barlocco D. Synthesis and aldose reductase inhibitory activity of a new series of benz[h]cinnolinone derivatives. Farmaco 2000;55:544–52.
  • Kwon SK, Moon A. Synthesis of 3-alkylthio-6-allylthiopyridazine derivatives and their antihepatocarcinoma activity. Arch Pharm Res 2005;28:391–4.
  • Sönmez M, Berber İ, Akbaş E. Synthesis, antibacterial and antifungal activity of some new pyridazinone metal complexes. Eur J Med Chem 2006;41:101–5.
  • Harris RR, Black L, Surapaneni S, Kolasa T, Majest S, Namovic MT, et al. ABT-963 [2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy) 5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], a highly potent and selective disubstituted pyridazinone cyclooxgenase-2 inhibitor. J Pharmacol Exp Ther 2004;311:904–12.
  • Krungkrai J, Supuran CT. The alpha-carbonic anhydrase from the malaria parasite and its inhibition. Curr Pharm Des 2008;14:631–40.
  • Scozzafava A, Briganti F, Ilies MA, Supuran CT. Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes. J Med Chem 2000;43:292–300.
  • Chohan ZH, Shaikh AU, Rauf A, Supuran CT. Antibacterial, antifungal and cytotoxic properties of novel N-substituted sulfonamides from 4-hydroxycoumarin. J Enzyme Inhib Med Chem 2006;21:741–8.
  • Chohan ZH, Metal-based sulfonamides: their preparation, characterization,and in-vitro antibacterial, antifungalcytotoxic properties. X-ray structure of 4-[(2-hydroxybenzylidene) amino]benzenesulfonamide. J Enzyme Inhib Med Chem 2008;3:120–30.
  • Kim SJ, Jeong HJ, Choi IY, Lee KM, Park RK, Hong SH, et al. Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l]benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells. J Pharmacol Exp Ther 2005;314:27–34.
  • Khanna IK, Weier RM, Yu Y, Collins PW, Miyashiro JM, Koboldt CM, et al. 1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2. J Med Chem 1997;40:1619–33.
  • Khan MSY, Siddiqui AA. Syntheses and anti-inflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-pyridazinones. Ind J Chem 2000;39B:614–19.
  • Khan MSY, Hussain A, Sharma S. Studies on butenolides: 2-arylidene-4-(substituted aryl)but-3-en-4-olides—synthesis, reactions and biological activity. Indian J Chem 2002;41B:2160–71.
  • Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 1991;83:757–66.
  • Boyd MR, Paull KD. Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Dev Res 1995;34:91–109.
  • Boyd MR. In: Teicher BA, ed. Cancer Drug Discovery and Development: Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval. Totowa, NJ: Humana Press, 1997:23–43.
  • Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med 1962;111:544–7.
  • Rathish IG, Kalim Javed, Ahmad S, Bano S, Alam MS, Pillai KK, et al. Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide. Bioorg Med Chem Lett 2009;19:255–8.
  • Bisen PS, Verma K, eds. Handbook of Microbiology. Shahdara, Delhi, India: CBS Publishers and Distributors, 1994.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.