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Research Article

Predicting anti-cancer activity of quinoline derivatives: CoMFA and CoMSIA approach

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Pages 854-861 | Received 24 Oct 2010, Accepted 25 Feb 2011, Published online: 08 Apr 2011

References

  • Ryckebusch A, Garcin D, Lansiaux A, Goossens JF, Baldeyrou B, Houssin R et al. Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives. J Med Chem 2008;51:3617–3629.
  • Ferlin MG, Chiarelotto G, Gasparotto V, Dalla Via L, Pezzi V, Barzon L et al. Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones. J Med Chem 2005;48:3417–3427.
  • Gasparotto V, Castagliuolo I, Chiarelotto G, Pezzi V, Montanaro D, Brun P et al. Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: A new class of antimitotic agents devoid of aromatase activity. J Med Chem 2006;49:1910–1915.
  • Pommier Y. DNA topoisomerase I and II in cancer chemotherapy: Update and perspectives. Cancer Chemother Pharmacol 1993;32:103–108.
  • Bhargava R, Lal P, Chen B. HER-2/neu and topoisomerase IIa gene amplification and protein expression in invasive breast carcinomas: Chromogenic in situ hybridization and immunohistochemical analyses. Am J Clin Pathol 2005;123:889–895.
  • Schmidt F, Knobbe CB, Frank B, Wolburg H, Weller M. The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. Oncol Rep 2008;19:1061–1066.
  • Lucio VBD, Marina VM, Rodriguez RB. The molecular biology of topoisomerase IIα and its importance in the acquisition of multidrug resistance in cancer Clin. Transl Onco 2002;4:170–178.
  • Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L. The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci USA 2002;99:15387–15392.
  • Duguet M. When helicase and topoisomerase meet! J Cell Sci 1997;110 (Pt 12):1345–1350.
  • Ravichandran V, Jain PK, Mourya VK, Agrawal RK. QSAR study on some arylsulfonamides as anti-HIV agents. Med Chem Res 2007;16:342–351.
  • Ravichandran V, Mourya VK, Agrawal RK. QSAR Study of novel 1,1,3− trioxo [1,2,4] - thiadiazine (TTDs) analogues as potent anti-HIV agents. ARKIVOC 2007;14:204–212.
  • Ravichandran V, Mourya VK, Agrawal RK. QSAR Modeling of HIV-1 Reverse transcriptase inhibitory activity with PETT derivatives. Dig J Nanomat Biostr 2008;3:9–17.
  • Ravichandran V, Mourya VK, Agrawal RK. QSAR Analysis of 6-aryl-2,4-dioxo-5-hexenoic acids as HIV–1 integrase inhibitors. Ind J Phar Edu Res 2008;42:40–47.
  • Ravichandran V, Agrawal RK. Predicting anti-HIV activity of PETT derivatives: CoMFA approach. Bioorg Med Chem Lett 2007;17:2197–2202.
  • Ravichandran V, Sankar S, Agrawal RK. Comparative molecular similarity indices analysis for predicting anti-HIV activity of phenyl ethyl thiourea (PET) derivatives. Med Chem Res 2008;17:1–11.
  • Prashantha Kumar BR, Sankar G, Nasir Baig RB, Chandrashekaran S. Novel Biginelli dihydropyrimidines with potential anticancer activity: A parallel synthesis and CoMSIA study. Eur J Med Chem 2009;44:4192–4198.
  • Prashanthakumar BR, Nanjan MJ. Comparative molecular similarity indices analysis for predicting the antihyperglycemic activity of thioglitazones. Med Chem Res 2010;19:1000–1010.
  • Chen YL, Chen IL, Wang TC, Han CH, Tzeng CC. Synthesis and anticancer evaluation of certain 4-anilinofuro[2,3-b]quinoline and 4-anilinofuro[3,2-c]quinoline derivatives. Eur J Med Chem 2005;40:928–934.
  • Lee BD, Li Z, French KJ, Zhuang Y, Xia Z, Smith CD. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem 2004;47:1413–1422.
  • Chen YL, Huang CJ, Huang ZY, Tseng CH, Chang FS, Yang SH et al. Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives. Bioorg Med Chem 2006;14:3098–3105.
  • SYBYL [computer program], version 6.7. St. Louis (MO): Tripose Associates, USA.

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