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Research Article

Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine

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Pages 463-467 | Received 09 Nov 2011, Accepted 13 Dec 2011, Published online: 03 Feb 2012

References

  • Seiler N. Catabolism of polyamines. Amino Acids 2004;26:217–233.
  • Wallace HM, Fraser AV, Hughes A. A perspective of polyamine metabolism. Biochem J 2003;376:1–14.
  • Casero RA Jr, Pegg AE. Spermidine/spermine N1-acetyltransferase–the turning point in polyamine metabolism. FASEB J 1993;7:653–661.
  • Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA Jr Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Res 2001;61:5370–5373.
  • Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J 2002;367:665–675.
  • Wu T, Yankovskaya V, McIntire WS. Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. J Biol Chem 2003;278: 20514–20525.
  • Agostinelli E, Arancia G, Vedova LD, Belli F, Marra M, Salvi M et al. The biological functions of polyamine oxidation products by amine oxidases: perspectives of clinical applications. Amino Acids 2004;27:347–358.
  • Casero RA Jr, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov 2007;6:373–390.
  • Amendola R, Cervelli M, Fratini E, Polticelli F, Sallustio DE, Mariottini P. Spermine metabolism and anticancer therapy. Curr Cancer Drug Targets 2009;9:118–130.
  • Casero RA, Pegg AE. Polyamine catabolism and disease. Biochem J 2009;421:323–338.
  • Cervelli M, Polticelli F, Federico R, Mariottini P. Heterologous expression and characterization of mouse spermine oxidase. J Biol Chem 2003;278:5271–5276.
  • Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem J 2003;370:19–28.
  • Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM et al. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Biochem Biophys Res Commun 2003;304:605–611.
  • Bellelli A, Cavallo S, Nicolini L, Cervelli M, Bianchi M, Mariottini P et al. Mouse spermine oxidase: a model of the catalytic cycle and its inhibition by N,N1-bis(2,3-butadienyl)-1,4-butanediamine. Biochem Biophys Res Commun 2004;322:1–8.
  • Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV et al. Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity. Cancer Chemother Pharmacol 2005;56:83–90.
  • Wu T, Ling KQ, Sayre LM, McIntire WS. Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527. Biochem Biophys Res Commun 2005;326:483–490.
  • Binda C, Coda A, Angelini R, Federico R, Ascenzi P, Mattevi A. A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase. Structure 1999;7:265–276.
  • Binda C, Angelini R, Federico R, Ascenzi P, Mattevi A. Structural bases for inhibitor binding and catalysis in polyamine oxidase. Biochemistry 2001;40:2766–2776.
  • Huang Q, Liu Q, Hao Q. Crystal structures of Fms1 and its complex with spermine reveal substrate specificity. J Mol Biol 2005;348:951–959.
  • Bianchi M, Polticelli F, Ascenzi P, Botta M, Federico R, Mariottini P et al. Inhibition of polyamine and spermine oxidases by polyamine analogues. FEBS J 2006;273:1115–1123.
  • Tavladoraki P, Cervelli M, Antonangeli F, Minervini G, Stano P, Federico R et al. Probing mammalian spermine oxidase enzyme-substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization. Amino Acids 2011;40:1115–1126.
  • Bey P, Bolkenius FN, Seiler N, Casara P. N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J Med Chem 1985;28:1–2.
  • Gendron R, Grenier D, Sorsa T, Mayrand D. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol 1999;6:437–439.
  • Cronan CA, Potempa J, Travis J, Mayo JA. Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II). Oral Microbiol Immunol 2006;21:212–217.
  • Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 2010;31:455–461.

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