Tumour suppressor PTEN enhanced enzyme activity of GPx, SOD and catalase by suppression of PI3K/AKT pathway in non-small cell lung cancer cell lines

References

• Svensk AM, Soini Y, Pääkkö P, Hiravikoski P, Kinnula VL. Differential expression of superoxide dismutases in lung cancer. Am J Clin Pathol 2004;122:395–404.
   PubMed Web of Science ®Google Scholar
• Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med 2003;167:1600–1619.
   PubMed Web of Science ®Google Scholar
• Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 1997;57:4183–4186.
   PubMed Web of Science ®Google Scholar
• Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 1997;57:3660–3663.
   PubMed Web of Science ®Google Scholar
• Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG et al. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 1997;57:4997–5000.
   PubMed Web of Science ®Google Scholar
• Rhei E, Kang L, Bogomolniy F, Federici MG, Borgen PI, Boyd J. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res 1997;57:3657–3659.
   PubMed Web of Science ®Google Scholar
• Kohno T, Takahashi M, Manda R, Yokota J. Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers. Genes Chromosomes Cancer 1998;22:152–156.
   PubMed Web of Science ®Google Scholar
• Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 1997;57:3935–3940.
   PubMed Web of Science ®Google Scholar
• Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumour suppression. Nat Genet 1998;19:348–355.
   PubMed Web of Science ®Google Scholar
• Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 1998;8:1169–1178.
   PubMed Web of Science ®Google Scholar
• Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943–1947.
   PubMed Web of Science ®Google Scholar
• Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997;15:356–362.
   PubMed Web of Science ®Google Scholar
• Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 1997;57:2124–2129.
   PubMed Web of Science ®Google Scholar
• Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:13375–13378.
   PubMed Web of Science ®Google Scholar
• Wang T, Zhang X, Li JJ. The role of NF-κB in the regulation of cell stress responses. Int Immunopharmacol 2002;2:1509–1520.
   PubMed Web of Science ®Google Scholar
• Baichwal VR, Baeuerle PA. Activate NF-κB or die? Curr Biol 1997;7:R94–R96.
   PubMed Web of Science ®Google Scholar
• Henkel T, Machleidt T, Alkalay I, Krönke M, Ben-Neriah Y, Baeuerle PA. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 1993;365:182–185.
   PubMed Web of Science ®Google Scholar
• Hoffmann A, Levchenko A, Scott ML, Baltimore D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 2002;298:1241–1245.
   PubMed Web of Science ®Google Scholar
• D’Angio CT, Finkelstein JN. Oxygen regulation of gene expression: a study in opposites. Mol Genet Metab 2000;71:371–380.
   PubMedGoogle Scholar
• Li N, Karin M. Is NF-κB the sensor of oxidative stress? FASEB J 1999;13:1137–1143.
   PubMed Web of Science ®Google Scholar
• Choi C, Cho H, Park J, Cho C, Song Y. Suppressive effects of genistein on oxidative stress and NFκB activation in RAW 264.7 macrophages. Biosci Biotechnol Biochem 2003;67:1916–1922.
   PubMed Web of Science ®Google Scholar
• Akca H, Demiray A, Tokgun O, Yokota J. Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in lung cancer cells. Lung Cancer 2011;73:302–309.
   PubMed Web of Science ®Google Scholar
• Akinci O, Mihci E, Tacoy S, Kardelen F, Keser I, Aslan M. Neutrophil oxidative metabolism in Down syndrome patients with congenital heart defects. Environ Mol Mutagen 2010;51:57–63.
   PubMedGoogle Scholar
• Akca H, Tani M, Hishida T, Matsumoto S, Yokota J. Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells. Lung Cancer 2006;54:25–33.
   PubMedGoogle Scholar
• Venkatesan B, Mahimainathan L, Das F, Ghosh-Choudhury N, Ghosh Choudhury G. Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells. J Cell Physiol 2007;211:457–467.
   PubMed Web of Science ®Google Scholar
• Leung HW, Kuo CL, Yang WH, Lin CH, Lee HZ. Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol 2006;534:12–18.
   PubMed Web of Science ®Google Scholar