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Research Article

Pyrimidine-fused heterocycle derivatives as a novel class of inhibitors for α-glucosidase

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Pages 1228-1235 | Received 23 May 2012, Accepted 03 Sep 2012, Published online: 08 Oct 2012

References

  • Tripathi BK, Srivastava AK. Diabetes mellitus: complications and therapeutics. Med Sci Monit 2006;12:RA130–RA147.
  • Venn-Watson S, Carlin K, Ridgway S. Dolphins as animal models for type 2 diabetes: sustained, post-prandial hyperglycemia and hyperinsulinemia. Gen Comp Endocrinol 2011;170:193–199.
  • Grillo MA, Colombatto S. Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases. Amino Acids 2008;35:29–36.
  • Krasikov VV, Karelov DV, Firsov LM. alpha-Glucosidases. Biochemistry Mosc 2001;66:267–281.
  • Zhang L, Hogan S, Li J, Sun S, Canning C, Zheng SJ, Zhou K. Grape skin extract inhibits mammalian intestinal α-glucosidase activity and suppresses postprandial glycemic response in streptozocin-treated mice. Food Chem 2011;126:466–471.
  • Hakamata W, Muroi M, Nishio T, Oku T, Takatsuki A, Osada H, Fukuhara K, Okuda H, Kurihara M. N-linked oligosaccharide processing enzymes as molecular targets for drug discovery. J Appl Glycosci 2006;53:149.
  • Durantel D. Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection. Curr Opin Investig Drugs 2009;10:860–870.
  • Okada K, Yanagawa T, Warabi E, Yamastu K, Uwayama J, Takeda KUtsunomiya H, Yoshida H, Shoda J, Ishii TThe alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice. Hepatol Res 2009;39:490–500.
  • Asano N. Sugar-mimicking glycosidase inhibitors: bioactivity and application. Cell Mol Life Sci 2009;66:1479–1492.
  • van de Laar FA, Lucassen PL, Akkermans RP, van de Lisdonk EH, Rutten GE, van Weel C. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diabetes Care 2005;28:154–163.
  • Banday AH, Mir BP, Lone IH, Suri KA, Kumar HM. Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents. Steroids 2010;75:805–809.
  • Shamroukh AH, Zaki ME, Morsy EM, Abdel-Motti FM, Abdel-Megeid FM. Synthesis of pyrazolo[4’,3’:5,6]pyrano[2,3-d]pyrimidine derivatives for antiviral evaluation. Arch Pharm (Weinheim) 2007;340:236–243.
  • Singh B, Maheshwari A, Dak G, Sharma K, Talesara GL. Studies of Antimicrobial Activities of some 4-Thiazolidinone Fused Pyrimidines, [1,5]-Benzodiazepines and their Oxygen Substituted Hydroxylamine Derivatives. Indian J Pharm Sci 2010;72:607–612.
  • Bahashwan SA. Pharmacological studies of some pyrimidino derivatives. Afr J Pharm Pharmacol 2011;5:527–531.
  • Lossow WJ, Migiorini RH, Brot N, Chaikoff IL. effect of total exclusion of the exocrine pancreas in the rat upon in vitro esterification of C14-labeled cholesterol by the intestine and upon lymphatic absorption of C14-labeled cholesterol. J Lipid Res 1964;5:198–202.
  • Saijyo J, Suzuki Y, Okuno Y, Yamaki H, Suzuki T, Miyazawa M. Alpha-glucosidase inhibitor from Bergenia ligulata. J Oleo Sci 2008;57:431–435.
  • Gowri PM, Tiwari AK, Ali AZ, Rao JM. Inhibition of alpha-glucosidase and amylase by bartogenic acid isolated from Barringtonia racemosa Roxb. seeds. Phytother Res 2007;21:796–799.
  • Liu M, Zhang W, Qiu L, Lin X. Synthesis of butyl-isobutyl-phthalate and its interaction with a-glucosidase in vitro. J Biochem 2011;149:27–33.
  • Bourassa P, Dubeau S, Maharvi GM, Fauq AH, Thomas TJ, Tajmir-Riahi HA. Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin. Biochimie 2011;93:1089–1101.
  • Rashad AE, Shamroukh AH, Abdel-Megeid RE, Sayed HH, Abdel-Wahed NM. Studies on the reactivity of (9-Methyl-5,6-dihydronaphtho[1â,2â:4,5]-thieno[2,3-d]pyrimidin-11-yl)hydrazine towards some reagents for biological evaluation. Sci Pharm 2010;78:1–12.

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