273
Views
6
CrossRef citations to date
0
Altmetric
Original Article

The levels of Pdx1/insulin, Cacna1c and Cacna1d, and β-cell mass in a rat model of intrauterine undernutrition

, &
Pages 437-443 | Received 13 Mar 2010, Accepted 27 May 2010, Published online: 27 Sep 2010

References

  • Valcamonico A, Accorsi P, Sanzeni C, Martelli P, La Boria P, Cavazza A, Frusca T. Mid- and long-term outcome of extremely low birth weight (ELBW) infants: an analysis of prognostic factors. J Matern Fetal Neonatal Med 2007;20:465–471.
  • Abe Y, Kikuchi T, Nagasaki K, Hiura M, Tanaka Y, Ogawa Y, Uchiyama M. Lower birth weight associated with current overweight status is related with the metabolic syndrome in obese Japanese children. Hypertens Res 2007;30:627–634.
  • Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993;36:62–67.
  • Bazaes RA, Alegria A, Pittaluga E, Avila A, Iniguez G, Mericq V. Determinants of insulin sensitivity and secretion in very-low-birth-weight children. J Clin Endocrinol Metabol 2004;89:1267–1272.
  • Limesand SW, Rozance PJ, Zerbe GO, Hutton JC, Hay WW Jr. Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Endocrinology 2006;147:1488–1497.
  • Gatford KL, Mohammad SN, Harland ML, De Blasio MJ, Fowden AL, Robinson JS, Owens JA. Impaired β-cell function and inadequate compensatory increases in β-cell mass after intrauterine growth restriction in sheep. Endocrinology 2008;149:5118–5127.
  • Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir S. Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 1997;138:1736–1741.
  • Bruin JE, Gerstein HC, Morrison KM, Holloway AC. Increased pancreatic β-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria. Toxicol Sci 2008;103:362–370.
  • Ackermann AM, Gannon M. Molecular regulation of pancreatic β-cell mass development, maintenance, and expansion. J Mol Endocrinol 2007;38:193–206.
  • Feanny MA, Fagan SP, Ballian N, Liu SH, Li Z, Wang X, Fisher W, Brunicardi FC, Belaguli NS. PDX-1 expression is associated with islet proliferation in vitro and in vivo. J Surg Res 2008;144:8–16.
  • Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Develop Biol 2008;314:406–417.
  • Yang SN, Berggren PO. β-cell CaV channel regulation in physiology and pathophysiology. Am J Physiol 2005;288:E16–E28.
  • Yang SN, Berggren PO. CaV2.3 channel and PKCλ: new players in insulin secretion. J Clin Investig 2005;115:16–20.
  • Bence-Hanulec KK, Marshall J, Blair LA. Potentiation of neuronal L calcium channels by IGF-1 requires phosphorylation of the α1 subunit on a specific tyrosine residue. Neuron 2000;27:121–131.
  • Blair LA, Bence-Hanulec KK, Mehta S, Franke T, Kaplan D, Marshall J. Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival. J Neurosci 1999;19:1940–1951.
  • Gao L, Blair LA, Salinas GD, Needleman LA, Marshall J. Insulin-like growth factor-1 modulation of CaV1.3 calcium channels depends on Ca2+ release from IP3-sensitive stores and calcium/calmodulin kinase II phosphorylation of the α1 subunit EF hand. J Neurosci 2006;26:6259–6268.
  • Nitert MD, Nagorny CL, Wendt A, Eliasson L, Mulder H. CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells. J Mol Endocrinol 2008;41:1–11.
  • Wang X, Liang L, Du L. The effects of intrauterine undernutrition on pancreas ghrelin and insulin expression in neonate rats. J Endocrinol 2007;194:121–129.
  • Bruder ED, Lee JJ, Widmaier EP, Raff H. Microarray and real-time PCR analysis of adrenal gland gene expression in the 7-day-old rat: effects of hypoxia from birth. Physiol Genom 2007;29:193–200.
  • Maiorana A, Del Bianco C, Cianfarani S. Adipose tissue: a metabolic regulator. Potential implications for the metabolic outcome of subjects born small for gestational age (SGA). Rev Diabet Stud 2007 Fall;4:134–146.
  • Iniguez G, Ong K, Bazaes R, Avila A, Salazar T, Dunger D, Mericq V. Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-for-gestational-age children. J Clin Endocrinol Metab 2006;91:4645–4649.
  • Dunger DB, Ong KK, Sandhu MS. Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes. Hormone Res 2003;60(suppl 3):131–135.
  • Chiesa C, Osborn JF, Haass C, Natale F, Spinelli M, Scapillati E, Spinelli A, Pacifico L. Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry? Clin Chem 2008;54:550–558.
  • Stoffers DA, Desai BM, DeLeon DD, Simmons RA. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes 2003;52:734–740.
  • Park JH, Stoffers DA, Nicholls RD, Simmons RA. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Investig 2008;118:2316–2324.
  • Brissova M, Blaha M, Spear C, Nicholson W, Radhika A, Shiota M, Charron MJ, Wright CV, Powers AC. Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am J Physiol 2005;288:E707–E714.
  • Holland AM, Gonez LJ, Naselli G, Macdonald RJ, Harrison LC. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of β-cells in the adult pancreas. Diabetes 2005;54:2586–2595.
  • Larsen MO, Rolin B, Wilken M, Carr RD, Gotfredsen CF. Measurements of insulin secretory capacity and glucose tolerance to predict pancreatic β-cell mass in vivo in the nicotinamide/streptozotocin Gottingen minipig, a model of moderate insulin deficiency and diabetes. Diabetes 2003;52:118–123.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.