561
Views
29
CrossRef citations to date
0
Altmetric
Original Article

Low maternal vitamin B12 is a risk factor for neural tube defects: a meta-analysis

, &
Pages 389-394 | Received 30 Nov 2010, Accepted 11 Apr 2011, Published online: 01 Jun 2011

References

  • Boulet SL, Yang Q, Mai C, Kirby RS, Collins JS, Robbins JM, Meyer R, Canfield MA, Mulinare J. Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. Birth Defects Res A: Clin Mol Teratol 2008;82:527–532.
  • Gu X, Lin LM, Zheng XY, Zhang T, Song XM, Wang JF, Li XH, Li PZ, Chen G, Wu JL, et al. High prevalence of NTDs in Shanxi province: a combined epidemiological approach. Birth Defects Res A Clin Mol Teratol 2007;79:702–707.
  • Pitkin RM. Folate and neural tube defects. Am J Clin Nutr 2007;85:285–288.
  • Heseker HB, Mason JB, Selhub J, Rosenberg IH, Jacques PF. Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr 2009;102:173–180.
  • Bell KN, Oakley GP, Jr. Tracking the prevention of folic acid-preventable spina bifida and anencephaly. Defects Res A Clin Mol Teratol 2006;76:654–657.
  • Oakley GP, Jr., Bell KN, Weber MB. Recommendations for accelerating global action to prevent folic acid-preventable birth defects and other folate-deficiency diseases: meeting of experts on preventing folic acid-preventable neural tube defects. Birth Defects Res A Clin Mol Teratol 2004;70:835–837.
  • Bell KN, Oakley GP, Jr. Update on prevention of folic acid-preventable spina bifida and anencephaly. Birth Defects Res A Clin Mol Teratol 2009;85:102–107.
  • Molloy AM, Kirke PN, Troendle JF, Burke H, Sutton M, Brody LC, Scott JM, Mills JL. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatrics 2009;123:917–923.
  • Blom HJ, Shaw GM, den Heijer M, Finnell RH. Neural tube defects and folate: case far from closed. Nat Rev Neurosci 2006;7:724–731.
  • Manios Y, Kourlaba G, Grammatikaki E, Androutsos O, Moschonis G, Roma-Giannikou E. Development of a diet-lifestyle quality index for young children and its relation to obesity: the preschoolers diet-lifestyle index. PublicHealth Nutr 2010;13:2000–2009.
  • Li F, Watkins D, Rosenblatt DS. Vitamin B12 and birth defects. Mol Genet Metab 2009;98:166–172.
  • Luo X, Zhang L, Wei H, Liu W, Wang M, Ning Q. Methylmalonic acid in amniotic fluid and maternal urine as a marker for neural tube defects. J Huazhong Univ Sci Technolog Med Sci 2004;24:166–169.
  • Thompson MD, Cole DE, Ray JG. Vitamin B12 and neural tube defects: the Canadian experience. Am J Clin Nutr 2009;89:697–701.
  • Gaber KR, Farag MK, Soliman SE, El-Bassyouni HT, El-Kamah G. Maternal vitamin B12 and the risk of fetal neural tube defects in Egyptian patients. Clin Lab 2007;53:69–75.
  • Ray JG, Wyatt PR, Thompson MD, Vermeulen MJ, Meier C, Wong PY, Farrell SA, Cole DE. Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. Epidemiology 2007;18:362–366.
  • Song YZ, Li BX, Hao H, Xin RL, Zhang T, Zhang CH, Kobayashi K, Wang ZN, Zheng XY. Selective screening for inborn errors of metabolism and secondary methylmalonic aciduria in pregnancy at high risk district of neural tube defects: a human metabolome study by GC-MS in China. Clin Biochem 2008;41:616–620.
  • Zhang T, Xin R, Gu X, Wang F, Pei L, Lin L, Chen G, Wu J, Zheng X. Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr 2009;12:680–686.
  • Ceyhan ST, Beyan C, Atay V, Yaman H, Alanbay I, Kaptan K, Baser I. Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect. Gynecol Endocrinol 2010;26:578–581.
  • Selhub J, Jacques PF, Dallal G, Choumenkovitch S, Rogers G. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food Nutr Bull 2008;29:S67–S73.
  • Molloy AM, Kirke P, Hillary I, Weir DG, Scott JM. Maternal serum folate and vitamin B12 concentrations in pregnancies associated with neural tube defects. Arch Dis Child 1985;60:660–665.
  • Adams MJ, Jr., Khoury MJ, Scanlon KS, Stevenson RE, Knight GJ, Haddow JE, Sylvester GC, Cheek JE, Henry JP, Stabler SP, et al. Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects. Teratology 1995;51:311–317.
  • Suarez L, Hendricks K, Felkner M, Gunter E. Maternal serum B12 levels and risk for neural tube defects in a Texas–Mexico border population. Ann Epidemiol 2003;13:81–88.
  • Groenen PM, van Rooij IA, Peer PG, Gooskens RH, Zielhuis GA, Steegers-Theunissen RP. Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida. Am J Obstet Gynecol 2004;191:11–17.
  • Cech I, Burau KD. Serological differences in folate/vitamin B12 in pregnancies affected by neural tube defects. South Med J 2010;103:419–424.
  • Egger M, Smith GD. Meta-analysis: potentials and promise. BMJ 1997;315:1371–1374.
  • Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to meta-analysis. John Wiley & Sons, Ltd, Chichester; 2009.
  • Ray JG, Blom HJ. Vitamin B12 insufficiency and the risk of fetal neural tube defects. QJM 2003;96:289–295.
  • Grewal J, Carmichael SL, Song J, Shaw GM. Neural tube defects: an analysis of neighbourhood- and individual-level socio-economic characteristics. Paediatr Perinat Epidemiol 2009;23:116–124.
  • Schulpis K, Spiropoulos A, Gavrili S, Karikas G, Grigori C, Vlachos G, Papassotiriou I. Maternal–neonatal folate and vitamin B12 serum concentrations in Greeks and in Albanian immigrants. J Hum Nutr Diet 2004;17:443–448.
  • Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193–200.
  • Zhu JH, Hu DJ, Hao L, Zhang BL, Cogswell ME, Bailey LB, Li Z, Berry RJ. Iron, folate, and B(12) deficiencies and their associations with anemia among women of child-bearing age in a rural area in Northern China. Int J Vitam Nutr Res 2010;80:144–154.
  • Yajnik CS, Deshpande SS, Jackson AA, Refsum H, Rao S, Fisher DJ, Bhat DS, Naik SS, Coyaji KJ, Joglekar CV, et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia 2008;51:29–38.
  • DeMaeyer E, Adiels-Tegman M. The prevalence of anaemia in the world. World Health Stat Q 1985;38:302–316.
  • Allen L; Vitamin B12 Working Group. Vitamin B12 fortification. Background Paper for the workshop, Stone Mountain, GA, 30 March–3 April 2008. The Flour Fortifcation Initiative. 2008 ( http://www.sph.emory.edu/wheatflour/atlanta08/papers. html).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.