238
Views
4
CrossRef citations to date
0
Altmetric
Review Article

Maternal factor V Leiden and adverse pregnancy outcome: deciding whether or not to test

&
Pages 889-894 | Received 15 May 2010, Accepted 26 Jul 2011, Published online: 25 Apr 2012

References

  • De Stefano V, Chiusolo P, Paciaroni K, Leone G. Epidemiology of factor V Leiden: Clinical implications. Semin Thromb Hemost 1998;24:367–379.
  • Pabinger I. Thrombophilia and its impact on pregnancy. Thromb Res 2009;123 Suppl 3:S16–S21.
  • Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: A meta-analysis. Lancet 2003;361:901–908.
  • Dudding TE, Attia J. The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: A meta-analysis. Thromb Haemost 2004;91:700–711.
  • Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: A meta-analysis. Arch Intern Med 2004;164:558–563.
  • Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, Walker ID et al.: Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study: Thrombophilia in pregnancy: A systematic review. Br J Haematol 2006;132:171–196.
  • Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J, Seligsohn U, et al. The association of factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: A systematic review and meta-analysis of prospective cohort studies. PLoS Med 2010;7:e1000292.
  • Wang X, Chen C, Wang L, Chen D, Guang W, French J. Conception, early pregnancy loss, and time to clinical pregnancy: A population-based prospective study. Fertil Steril 2003;79:577–584.
  • Kosmas IP, Tatsioni A, Ioannidis JP. Association of Leiden mutation in factor V gene with hypertension in pregnancy and pre-eclampsia: A meta-analysis. J Hypertens 2003;21:1221–1228.
  • Lin J, August P. Genetic thrombophilias and preeclampsia: A meta-analysis. Obstet Gynecol 2005;105:182–192.
  • Dudding T, Heron J, Thakkinstian A, Nurk E, Golding J, Pembrey M, Ring SM, et al. Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: A genetic association study and meta-analysis. J Thromb Haemost 2008;6:1869–1875.
  • Howley HE, Walker M, Rodger MA. A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. Am J Obstet Gynecol 2005;192:694–708.
  • Facco F, You W, Grobman W. Genetic thrombophilias and intrauterine growth restriction: A meta-analysis. Obstet Gynecol 2009;113:1206–1216.
  • Lindqvist PG, Svensson PJ, Marsaál K, Grennert L, Luterkort M, Dahlbäck B. Activated protein C resistance (FV:Q506) and pregnancy. Thromb Haemost 1999;81:532–537.
  • Grandone E, Colaizzo D, Tiscia G, Vergura P, Cappucci F, Greco L, Margaglione M, Martinelli P; Prenacel Study Group. Impact of common thrombophilias and JAK2 V617F on pregnancy outcomes in unselected Italian women. J Thromb Haemost 2011;9:496–501.
  • Sedano-Balbás S, Lyons M, Cleary B, Murray M, Gaffney G, Maher M. APCR, factor V gene known and novel SNPs and adverse pregnancy outcomes in an Irish cohort of pregnant women. BMC Pregnancy Childbirth 2010;10:11.
  • Said JM, Higgins JR, Moses EK, Walker SP, Borg AJ, Monagle PT, Brennecke SP. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. Obstet Gynecol 2010;115:5–13.
  • Kahn SR, Platt R, McNamara H, Rozen R, Chen MF, Genest J Jr, Goulet L, et al. Inherited thrombophilia and preeclampsia within a multicenter cohort: The Montreal Preeclampsia Study. Am J Obstet Gynecol 2009;200:151.e1–9; discussion e1.
  • Clark P, Wu O. ABO(H) blood groups and pre-eclampsia. A systematic review and meta-analysis. Thromb Haemost 2008;100:469–474.
  • Lindqvist PG, Svensson P, Dahlbäck B. Activated protein C resistance – in the absence of factor V Leiden – and pregnancy. J Thromb Haemost 2006;4:361–366.
  • Kocher O, Cirovic C, Malynn E, Rowland CM, Bare LA, Young BA, Henslee JG, et al. Obstetric complications in patients with hereditary thrombophilia identified using the LCx microparticle enzyme immunoassay: A controlled study of 5,000 patients. Am J Clin Pathol 2007;127:68–75.
  • Dizon-Townson D, Miller C, Sibai B, Spong CY, Thom E, Wendel G Jr, Wenstrom K, et al.; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet Gynecol 2005;106:517–524.
  • Nurk E, Tell GS, Refsum H, Ueland PM, Vollset SE. Factor V Leiden, pregnancy complications and adverse outcomes: The Hordaland Homocysteine Study. QJM 2006;99:289–298.
  • Ganzevoort W, Rep A, De Vries JI, Bonsel GJ, Wolf H. Relationship between thrombophilic disorders and type of severe early-onset hypertensive disorder of pregnancy. Hypertens Pregnancy 2007;26:433–45.
  • Murphy RP, Donoghue C, Nallen RJ, D’Mello M, Regan C, Whitehead AS, Fitzgerald DJ. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy. Arterioscler Thromb Vasc Biol 2000;20:266–270.
  • Lund M, Nielsen HS, Hviid TV, Steffensen R, Nyboe Andersen A, Christiansen OB. Hereditary thrombophilia and recurrent pregnancy loss: A retrospective cohort study of pregnancy outcome and obstetric complications. Hum Reprod 2010;25:2978–2984.
  • Hiltunen LM, Laivuori H, Rautanen A, Kaaja R, Kere J, Krusius T, Paunio M, Rasi V. Factor V Leiden as risk factor for unexplained stillbirth – a population-based nested case-control study. Thromb Res 2010;125:505–510.
  • Simchen MJ, Ofir K, Moran O, Kedem A, Sivan E, Schiff E. Thrombophilic risk factors for placental stillbirth. Eur J Obstet Gynecol Reprod Biol 2010;153:160–164.
  • Foka ZJ, Lambropoulos AF, Saravelos H, Karas GB, Karavida A, Agorastos T, Zournatzi V, et al. Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Hum Reprod 2000;15:458–462.
  • Hernández-Díaz S, Toh S, Cnattingius S. Risk of pre-eclampsia in first and subsequent pregnancies: Prospective cohort study. BMJ 2009;338:b2255.
  • Lykke JA, Paidas MJ, Langhoff-Roos J. Recurring complications in second pregnancy. Obstet Gynecol 2009;113:1217–1224.
  • Mostello D, Kallogjeri D, Tungsiripat R, Leet T. Recurrence of preeclampsia: Effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births. Am J Obstet Gynecol 2008;199:55.e1–55.e7.
  • Brown MA, Mackenzie C, Dunsmuir W, Roberts L, Ikin K, Matthews J, Mangos G, Davis G. Can we predict recurrence of pre-eclampsia or gestational hypertension? BJOG 2007;114:984–993.
  • Trogstad L, Skrondal A, Stoltenberg C, Magnus P, Nesheim BI, Eskild A. Recurrence risk of preeclampsia in twin and singleton pregnancies. Am J Med Genet A 2004;126A:41–45.
  • Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, Irgens LM. Fetal and maternal contributions to risk of pre-eclampsia: Population based study. BMJ 1998;316:1343–1347.
  • Makkonen N, Heinonen S, Kirkinen P. Obstetric prognosis in second pregnancy after preeclampsia in first pregnancy. Hypertens Pregnancy 2000;19:173–181.
  • Sibai BM, Mercer B, Sarinoglu C. Severe preeclampsia in the second trimester: Recurrence risk and long-term prognosis. Am J Obstet Gynecol 1991;165:1408–1412.
  • McDonald SD, Best C, Lam K. The recurrence risk of severe de novo pre-eclampsia in singleton pregnancies: A population-based cohort. BJOG 2009;116:1578–1584.
  • Bhattacharya S, Townend J, Bhattacharya S. Recurrent miscarriage: Are three miscarriages one too many? Analysis of a Scottish population-based database of 151,021 pregnancies. Eur J Obstet Gynecol Reprod Biol 2010;150:24–27.
  • Brigham SA, Conlon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum Reprod 1999;14:2868–2871.
  • Clifford K, Rai R, Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod 1997;12:387–389.
  • Bhattacharya S, Prescott GJ, Black M, Shetty A. Recurrence risk of stillbirth in a second pregnancy. BJOG 2010;117:1243–1247.
  • Sharma PP, Salihu HM, Kirby RS. Stillbirth recurrence in a population of relatively low-risk mothers. Paediatr Perinat Epidemiol 2007;21 Suppl 1:24–30.
  • Brenner B, Hoffman R, Blumenfeld Z, Weiner Z, Younis JS. Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. Thromb Haemost 2000;83:693–697.
  • Brenner B, Hoffman R, Carp H, Dulitsky M, Younis J; Live-Enox Investigators. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: The Live-Enox study. J Thromb Haemost 2005;3:227–229.
  • Kupferminc MJ, Fait G, Many A, Lessing JB, Yair D, Bar-Am A, Eldor A. Low-molecular-weight heparin for the prevention of obstetric complications in women with thrombophilias. Hypertens Pregnancy 2001;20:35–44.
  • Gris JC, Mercier E, Quéré I, Lavigne-Lissalde G, Cochery-Nouvellon E, Hoffet M, Ripart-Neveu S, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004;103:3695–3699.
  • Carp H, Dolitzky M, Inbal A. Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia. J Thromb Haemost 2003;1:433–438.
  • Sanson BJ, Lensing AW, Prins MH, Ginsberg JS, Barkagan ZS, Lavenne-Pardonge E, Brenner B, et al. Safety of low-molecular-weight heparin in pregnancy: A systematic review. Thromb Haemost 1999;81:668–672.
  • Kupferminc MJ, Rimon E, Many A, Sharon M, Lessing JB, Gamzu R. Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications. J Matern Fetal Neonatal Med 2011;24:1042–1045.
  • Clark P, Walker ID, Langhorne P, Crichton L, Thomson A, Greaves M, Whyte S, Greer IA; Scottish Pregnancy Intervention Study (SPIN) collaborators. SPIN (Scottish Pregnancy Intervention) study: A multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. Blood 2010;115:4162–4167.
  • Kaandorp SP, Goddijn M, van der Post JA, Hutten BA, Verhoeve HR, Hamulyák K, Mol BW, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010;362:1586–1596.
  • Sarig G, Vidergor G, Brenner B. Assessment and management of high-risk pregnancies in women with thrombophilia. Blood Rev 2009;23:143–147.
  • Kist WJ, Janssen NG, Kalk JJ, Hague WM, Dekker GA, de Vries JI. Thrombophilias and adverse pregnancy outcome – A confounded problem! Thromb Haemost 2008;99:77–85.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.