Adding folate to the contraceptive pill: a new concept for the prevention of neural tube defects

References

• Sohn CH, Tercanli S, Holzgreve W. Ultraschall in Gynäkologie und Geburtshilfe. Heidelberg: Springer; 2003.
   Google Scholar
• Available at: www.who.int/en/
   Google Scholar
• Czeizel AE. Specified critical period of different congenital abnormalities: a new approach for human teratological studies. Congenit Anom (Kyoto) 2008;48:103–109.
   PubMedGoogle Scholar
• Warkany J. Congenital malformations. Notes and comments. Chicago, IL: Year Book Medical Publishers; 1971.
   Google Scholar
• Field B. Anencephalus, encephalocele and spinal meningomyelocele. Med J Aust 1974;1:889–890.
   PubMed Web of Science ®Google Scholar
• Bower C, D’Antoine H, Stanley FJ. Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification. Birth Defects Res Part A Clin Mol Teratol 2009;85:269–273.
   PubMedGoogle Scholar
• Czeizel AE. Schisis association. Am J Med Genet 1981;10:25–35.
   PubMed Web of Science ®Google Scholar
• Czeizel AE, Medveczky E. Periconceptional multivitamin supplementation and multimalformed offspring. Obstet Gynecol 2003;102:1255–1261.
   PubMed Web of Science ®Google Scholar
• Czeizel AE, Puhó EH, Bánhidy F. No association between periconceptional multivitamin supplementation and risk of multiple congenital abnormalities: a population-based case-control study. Am J Med Genet A 2006;140:2469–2477.
   PubMedGoogle Scholar
• Stevenson AC, Johnston HA, Stewart MI, Golding DR. Congenital malformations. A report of a study of series of consecutive births in 24 centres. Bull World Health Organ 1966;34 Suppl:9–127.
   PubMedGoogle Scholar
• Ren A, Zhang L, Li Z, Hao L, Tian Y, Li Z. Awareness and use of folic acid, and blood folate concentrations among pregnant women in northern China – an area with a high prevalence of neural tube defects. Reprod Toxicol 2006;22:431–436.
   PubMed Web of Science ®Google Scholar
• Czeizel A, Révész C. Major malformations of the central nervous system in Hungary. Br J Prev Soc Med 1970;24:205–222.
   PubMedGoogle Scholar
• Czeizel A, Sankaranarayanan K. The load of genetic and partially genetic disorders in man. I. Congenital anomalies: estimates of detriment in terms of years of life lost and years of impaired life. Mutat Res 1984;128:73–103.
   PubMedGoogle Scholar
• Bentley TG, Weinstein MC, Willett WC, Kuntz KM. A cost-effectiveness analysis of folic acid fortification policy in the United States. Public Health Nutr 2009;12:455–467.
   PubMed Web of Science ®Google Scholar
• Pietrzik K, Bailey L, Shane B. Folic acid and l-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet 2010;49:535–548.
   PubMed Web of Science ®Google Scholar
• Perry J, Chanarin I. Intestinal absorption of reduced folate compounds in man. Br J Haematol 1970;18:329–339.
   PubMed Web of Science ®Google Scholar
• Fohr IP, Prinz-Langenohl R, Brönstrup A, Bohlmann AM, Nau H, Berthold HK, Pietrzik K. 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women. Am J Clin Nutr 2002;75:275–282.
   PubMed Web of Science ®Google Scholar
• Smithells RW, Sheppard S, Schorah CJ. Vitamin dificiencies and neural tube defects. Arch Dis Child 1976;51:944–950.
   PubMed Web of Science ®Google Scholar
• Smithells RW, Sheppard S, Schorah CJ, Seller MJ, Nevin NC, Harris R, Read AP, Fielding DW. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 1980;1:339–340.
   PubMed Web of Science ®Google Scholar
• MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131–137.
   PubMed Web of Science ®Google Scholar
• Czeizel AE. Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am J Med Genet 1996;62:179–183.
   PubMed Web of Science ®Google Scholar
• Laurence KM, James N, Miller MH, Tennant GB, Campbell H. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J (Clin Res Ed) 1981;282:1509–1511.
   PubMed Web of Science ®Google Scholar
• Mulinare J, Cordero JF, Erickson JD, Berry RJ. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988;260:3141–3145.
   PubMed Web of Science ®Google Scholar
• Bower C, Stanley FJ. Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med J Aust 1989;150:613–619.
   PubMed Web of Science ®Google Scholar
• Simpson JL, Mills JL, Rhoads GG, Cunningham GC, Hoffman HJ, Conley MR. Vitamins, folic acid and neural tube defects: comments on investigations in the United States. Prenat Diagn 1991;11:641–648.
   PubMed Web of Science ®Google Scholar
• Milunsky A, Jick H, Jick SS, Bruell CL, MacLaughlin DS, Rothman KJ, Willett W. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 1989;262:2847–2852.
   PubMed Web of Science ®Google Scholar
• Vergel RG, Sanchez LR, Heredero BL, Rodriguez PL, Martinez AJ. Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat Diagn 1990;10:149–152.
   PubMed Web of Science ®Google Scholar
• Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832–1835.
   PubMed Web of Science ®Google Scholar
• Shaw GM, Schaffer D, Velie EM, Morland K, Harris JA. Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects. Epidemiology 1995;6:219–226.
   PubMed Web of Science ®Google Scholar
• Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, Mulinare J, et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999;341:1485–1490.
   PubMed Web of Science ®Google Scholar
• Goh YI, Bollano E, Einarson TR, Koren G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can 2006;28:680–689.
   PubMedGoogle Scholar
• Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM. Folate levels and neural tube defects. Implications for prevention. JAMA 1995;274:1698–1702.
   PubMed Web of Science ®Google Scholar
• Daly S, Mills JL, Molloy AM, Conley M, Lee YJ, Kirke PN, Weir DG, Scott JM. Minimum effective dose of folic acid for food fortification to prevent neural-tube defects. Lancet 1997;350:1666–1669.
   PubMed Web of Science ®Google Scholar
• Busby A, Abramsky L, Dolk H, Armstrong B, Addor MC, Anneren G, Armstrong N, et al. Preventing neural tube defects in Europe: a missed opportunity. Reprod Toxicol 2005;20:393–402.
   PubMed Web of Science ®Google Scholar
• Spina bifida and anencephaly before and after folic acid mandate-United States, 1995-1996 and 1999-2000. MMWR Morb Mortal Wkly Rep 2004;53:362–365.
   PubMedGoogle Scholar
• EUROCAT Special Report. (May 2003). Available at: http://www.eurocat.ulster.ac.uk/pdf/Part%20I.pdf
   Google Scholar
• Achterbergh R, Lakeman P, Stemerding D, Moors EH, Cornel MC. Implementation of preconceptional carrier screening for cystic fibrosis and haemoglobinopathies: a sociotechnical analysis. Health Policy 2007;83:277–286.
   PubMed Web of Science ®Google Scholar
• de Jong-van den Berg LTW, van der Zee AH, Schaafsma E, et al. Counselling women about periconceptional use of folic acid: the role of the community pharmacist can be improved. Int J Pharmaceut Pract 1999;7:138–142.
   Google Scholar
• Meijer WM, de Smit DJ, Jurgens RA, de Jong-van den Berg LTW. Improved periconceptional use of folic acid after patient education in pharmacies: promising results of a pilot study in the Netherlands. Int J Pharmaceut Pract 2005;13:47–51.
   Google Scholar
• de Walle HE, de Jong-van den Berg LT. Ten years after the Dutch public health campaign on folic acid: the continuing challenge. Eur J Clin Pharmacol 2008;64:539–543.
   PubMed Web of Science ®Google Scholar
• Cornel MC, de Smit DJ, de Jong-van den Berg LT. Folic acid–the scientific debate as a base for public health policy. Reprod Toxicol 2005;20:411–415.
   PubMed Web of Science ®Google Scholar
• Health Council of the Netherlands. Towards an optimal use of folic acid. Publication no. 2008/02E. The Hague: Health Council of the Netherlands, 2008. Available at: http://www.gezondheidsraad.nl/sites/default/files/200802E_0.pdf. Accessed on 28 May 2010.
   Google Scholar
• Dinger JC, Heinemann LAJ, Westhoff C, Cronin M, Schellschmidt. Contraceptive efficacy of oral contraceptives in real world clinical practice: The impact of age, weight, BMI, dose, and duration of use. ACOG 2007, Poster Presentation.
   Google Scholar
• IMS MIDAS, Worldbank Population 2010 EU29.
   Google Scholar
• Bakker DJ, de Jong-van den Berg LT, Fokkema MR. Controlled study on folate status following folic acid supplementation and discontinuation in women of child-bearing age. Ann Clin Biochem 2009;46:231–234.
   PubMed Web of Science ®Google Scholar
• van Eijsden M, Smits LJ, van der Wal MF, Bonsel GJ. Association between short interpregnancy intervals and term birth weight: the role of folate depletion. Am J Clin Nutr 2008;88:147–153.
   PubMed Web of Science ®Google Scholar
• Barnhart KT, Schreiber CA. Return to fertility following discontinuation of oral contraceptives. Fertil Steril 2009;91:659–663.
   PubMed Web of Science ®Google Scholar
• Cronin M, Schellschmidt I, Dinger J. Rate of pregnancy after using drospirenone and other progestin-containing oral contraceptives. Obstet Gynecol 2009;114:616–622.
   PubMed Web of Science ®Google Scholar
• Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005;353:487–497.
   PubMed Web of Science ®Google Scholar
• Oakley D, Sereika S, Bogue EL. Oral contraceptive pill use after an initial visit to a family planning clinic. Fam Plann Perspect 1991;23:150–154.
   PubMedGoogle Scholar
• Smith JD, Oakley D. Why do women miss oral contraceptive pills? An analysis of women’s self-described reasons for missed pills. J Midwifery Womens Health 2005;50:380–385.
   PubMed Web of Science ®Google Scholar
• Center for Disease Control and Prevention. Use of dietary supplements containing folic acid among women of childbearing age – United States, 2005. MMWR Morb Mortal Wkly Rep 2005;54:955–8. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5438a4.htm. Accessed on 28 February 2010.
   PubMedGoogle Scholar
• Inskip HM, Crozier SR, Godfrey KM, Borland SE, Cooper C, Robinson SM; Southampton Women’s Survey Study Group. Women’s compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study. BMJ 2009;338:b481.
   PubMed Web of Science ®Google Scholar
• Pashley S, O’Donoghue MF. The safety of anti-epileptic drug regimens: a qualitative study of factors determining the success of counselling women before conception. J Fam Plann Reprod Health Care 2009;35:153–156.
   PubMedGoogle Scholar
• Osterhues A, Holzgreve W, Michels KB. Shall we put the world on folate? Lancet 2009;374:959–961.
   PubMed Web of Science ®Google Scholar
• US Food and Drug Administration, Center for Drug Evaluation and Research. Advisory Committee for Reproductive Health drugs meeting. Summary minutes, 15 December 2003. Available at: http://www.fda.gov/ohrms/dockets/ac/03/minutes/4002M1_Final.htm. Accessed on 28 February 2010.
   Google Scholar