Oxidative stress and persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide and different oxygen concentrations

References

• Walsh-Sukys MC, Tyson JE, Wright LL, Bauer CR, Korones SB, Stevenson DK, Verter J, et al. Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes. Pediatrics 2000;105:14–20.
   PubMed Web of Science ®Google Scholar
• Rossi GP, Seccia TM, Nussdorfer GG. Reciprocal regulation of endothelin-1 and nitric oxide: relevance in the physiology and pathology of the cardiovascular system. Int Rev Cytol 2001;209:241–272.
   PubMedGoogle Scholar
• Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995;333:214–221.
   PubMed Web of Science ®Google Scholar
• Brennan LA, Steinhorn RH, Wedgwood S, Mata-Greenwood E, Roark EA, Russell JA, Black SM. Increased superoxide generation isassociated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res 2003;92:683–691.
   PubMed Web of Science ®Google Scholar
• Wedgwood S, Steinhorn RH, Bunderson M, Wilham J, Lakshminrusimha S, Brennan LA, Black SM. Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 2005;289:L660–L666.
   PubMed Web of Science ®Google Scholar
• Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340:819–820.
   PubMed Web of Science ®Google Scholar
• Kinsella JP, Truog WE, Walsh WF, Goldberg RN, Bancalari E, Mayock DE, Redding GJ, et al. Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr 1997;131:55–62.
   PubMed Web of Science ®Google Scholar
• Roberts JD Jr, Fineman JR, Morin FC 3rd, Shaul PW, Rimar S, Schreiber MD, Polin RA, et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med 1997;336:605–610.
   PubMed Web of Science ®Google Scholar
• Wessel DL, Adatia I, Van Marter LJ, Thompson JE, Kane JW, Stark AR, Kourembanas S. Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics 1997;100:E7.
   PubMed Web of Science ®Google Scholar
• Davidson D, Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, Rhines J, Chang CT. Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group. Pediatrics 1998;101:325–334.
   PubMed Web of Science ®Google Scholar
• Foubert L, Fleming B, Latimer R, Jonas M, Oduro A, Borland C, Higenbottam T. Safety guidelines for use of nitric oxide. Lancet 1992;339:1615–1616.
   PubMed Web of Science ®Google Scholar
• Thomassen MJ, Buhrow LT, Connors MJ, Kaneko FT, Erzurum SC, Kavuru MS. Nitric oxide inhibits inflammatory cytokine production by human alveolar macrophages. Am J Respir Cell Mol Biol 1997;17:279–283.
   PubMed Web of Science ®Google Scholar
• Sinclair SE, Altemeier WA, Matute-Bello G, Chi EY. Augmented lung injury due to interaction between hyperoxia and mechanical ventilation. Crit Care Med 2004;32:2496–2501.
   PubMed Web of Science ®Google Scholar
• Walsh-Sukys Mc, Tyson JE, Wright LL, Bauer CR, Korones SB, Stevenson DK, Verter Jet al. Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes. Pediatrics 2000;105:14–20.
   PubMed Web of Science ®Google Scholar
• Lakshminrusimha S, Russell JA, Wedgwood S, Gugino SF, Kazzaz JA, Davis JM, Steinhorn RH. Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension. Am J Respir Crit Care Med 2006;174:1370–1377.
   PubMed Web of Science ®Google Scholar
• Burón E, Garrote JA, Arranz E, Oyágüez P, Fernández Calvo JL, Blanco Quirós A. Markers of pulmonary inflammation in tracheobronchial fluid of premature infants with respiratory distress syndrome. Allergol Immunopathol (Madr) 1999;27:11–17.
   PubMedGoogle Scholar
• Esteban J, Morcillo JE, Cortjo J. Oxidative stress and pulmonary inflammation: pharmacological intervention with antioxidants. Pharmacol Res 1999;40:393–404.
   PubMed Web of Science ®Google Scholar
• Wedgwood S, Steinhorn RH, Bunderson M, Wilham J, Lakshminrusimha S, Brennan LA, et al. Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 2005;289:L660–L666.
   PubMed Web of Science ®Google Scholar
• Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620–1624.
   PubMed Web of Science ®Google Scholar
• Chollet-Martin S, Gatecel C, Kermarrec N, Gougerot-Pocidalo MA, Payen DM. Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation. Am J Respir Crit Care Med 1996;153:985–990.
   PubMed Web of Science ®Google Scholar
• Raghuram N, Fortenberry JD, Owens ML, Brown LA. Effects of exogenous nitric oxide and hyperoxia on lung fibroblast viability and DNA fragmentation. Biochem Biophys Res Commun 1999;262:685–691.
   PubMed Web of Science ®Google Scholar
• Lakshminrusimha S, Russell JA, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Wynn KA, et al. Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen. Pediatr Res 2007;62:313–318.
   PubMed Web of Science ®Google Scholar
• Kinsella JP, Parker TA, Galan H, Sheridan BC, Halbower AC, Abman SH. Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 1997;41:457–463.
   PubMed Web of Science ®Google Scholar
• Truog WE, Ballard PL, Norberg M, Golombek S, Savani RC, Merrill JD, Parton LA, et al.; Nitric Oxide (to Prevent) Chronic Lung Disease Study Investigators. Inflammatory markers and mediators in tracheal fluid of premature infants treated with inhaled nitric oxide. Pediatrics 2007;119:670–678.
   PubMed Web of Science ®Google Scholar
• Ballard PL, Truog WE, Merrill JD, Gow A, Posencheg M, Golombek SG, Parton LA, et al. Plasma biomarkers of oxidative stress: relationship to lung disease and inhaled nitric oxide therapy in premature infants. Pediatrics 2008;121:555–561.
   PubMed Web of Science ®Google Scholar