112
Views
9
CrossRef citations to date
0
Altmetric
Original Article

The essential role of protein kinase Cδ in diabetes-induced neural tube defects

, , &
Pages 2020-2024 | Received 21 Oct 2011, Accepted 16 Mar 2012, Published online: 21 Apr 2012

References

  • Correa A, Gilboa SM, Besser LM, Botto LD, Moore CA, Hobbs CA, Cleves MA, et al. Diabetes mellitus and birth defects. Am J Obstet Gynecol 2008;199:237.e1–237.e9.
  • Mills JL. Malformations in infants of diabetic mothers. Teratology 1982;25:385–394.
  • Reece EA. Obesity, diabetes, and links to congenital defects: a review of the evidence and recommendations for intervention. J Matern Fetal Neonatal Med 2008;21:173–180.
  • Chappell JH Jr, Wang XD, Loeken MR. Diabetes and apoptosis: neural crest cells and neural tube. Apoptosis 2009;14:1472–1483.
  • Zhao Z, Reece EA. Experimental mechanisms of diabetic embryopathy and strategies for developing therapeutic interventions. J Soc Gynecol Investig 2005;12:549–557.
  • Hiramatsu Y, Sekiguchi N, Hayashi M, Isshiki K, Yokota T, King GL, Loeken MR. Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes 2002;51:2804–2810.
  • Wentzel P, Wentzel CR, Gäreskog MB, Eriksson UJ. Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity. Teratology 2001;63:193–201.
  • Gäreskog M, Wentzel P. Altered protein kinase C activation associated with rat embryonic dysmorphogenesis. Pediatr Res 2004;56:849–857.
  • Gäreskog M, Wentzel P. N-Acetylcysteine and α-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-δ and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. J Endocrinol 2007;192:207–214.
  • Zhao Z, Wu YK, Reece EA. Demonstration of the essential role of protein kinase C isoforms in hyperglycemia-induced embryonic malformations. Reprod Sci 2008;15:349–356.
  • Cao Y, Zhao Z, Eckert RL, Reece EA. Protein kinase Cβ2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway. Am J Obstet Gynecol 2011;204:226.e1–226.e5.
  • Villalba M. A possible role for PKC δ in cerebellar granule cells apoptosis. Neuroreport 1998;9:2381–2385.
  • Li L, Lorenzo PS, Bogi K, Blumberg PM, Yuspa SH. Protein kinase Cδ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol 1999;19:8547–8558.
  • Shukla A, Stern M, Lounsbury KM, Flanders T, Mossman BT. Asbestos-induced apoptosis is protein kinase C δ-dependent. Am J Respir Cell Mol Biol 2003;29:198–205.
  • Pongracz J, Webb P, Wang K, Deacon E, Lunn OJ, Lord JM. Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-δ. J Biol Chem 1999;274:37329–37334.
  • Zrachia A, Dobroslav M, Blass M, Kazimirsky G, Kronfeld I, Blumberg PM, Kobiler D, et al. Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C δ. Implications for Sindbis virus-induced apoptosis. J Biol Chem 2002;277:23693–23701.
  • Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase C δ. Apoptosis 2003;8:19–27.
  • Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE, Vlassara H. AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-δ: implications for vascular disease. Am J Physiol, Cell Physiol 2010;298:C624–C634.
  • Kato K, Yamanouchi D, Esbona K, Kamiya K, Zhang F, Kent KC, Liu B. Caspase-mediated protein kinase C-δ cleavage is necessary for apoptosis of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2009;297:H2253–H2261.
  • Thamilselvan V, Menon M, Thamilselvan S. Oxalate-induced activation of PKC-α and -δ regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells. Am J Physiol Renal Physiol 2009;297:F1399–F1410.
  • Loeken MR. Free radicals and birth defects. J Matern Fetal Neonatal Med 2004;15:6–14.
  • Chang TI, Horal M, Jain SK, Wang F, Patel R, Loeken MR. Oxidant regulation of gene expression and neural tube development: insights gained from diabetic pregnancy on molecular causes of neural tube defects. Diabetologia 2003;46:538–545.
  • Yang P, Zhao Z, Reece EA. Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy. Am J Obstet Gynecol 2008;198:130, 131–137.
  • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010;140:900–917.
  • Minamino T, Kitakaze M. ER stress in cardiovascular disease. J Mol Cell Cardiol 2010;48:1105–1110.
  • Sokka AL, Putkonen N, Mudo G, Pryazhnikov E, Reijonen S, Khiroug L, Belluardo N, et al. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. J Neurosci 2007;27:901–908.
  • Qi X, Mochly-Rosen D. The PKCδ -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis. J Cell Sci 2008;121:804–813.
  • Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene 2008;27:6245–6251.
  • Reece EA, Ma XD, Wu YK, Dhanasekaran D. Aberrant patterns of cellular communication in diabetes-induced embryopathy. I. Membrane signalling. J Matern Fetal Neonatal Med 2002;11:249–253.
  • Yang P, Zhao Z, Reece EA. Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy. Biochem Biophys Res Commun 2007;357:749–754.
  • Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, Tsukiyama T, et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. Nature 2002;416:865–869.
  • Reece EA, Homko CJ. Prepregnancy care and the prevention of fetal malformations in the pregnancy complicated by diabetes. Clin Obstet Gynecol 2007;50:990–997.
  • Zhao Z, Yang P, Eckert RL, Reece EA. Caspase-8: a key role in the pathogenesis of diabetic embryopathy. Birth Defects Res B Dev Reprod Toxicol 2009;86:72–77.
  • Derubertis FR, Craven PA. Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 1994;43:1–8.
  • Craven PA, Studer RK, Negrete H, DeRubertis FR. Protein kinase C in diabetic nephropathy. J Diabetes Complicat 1995;9:241–245.
  • Craven PA, DeRubertis FR. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose. J Clin Invest 1989;83:1667–1675.
  • Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, et al. Exacerbated vein graft arteriosclerosis in protein kinase C δ-null mice. J Clin Invest 2001;108:1505–1512.
  • Cantley J, Boslem E, Laybutt DR, Cordery DV, Pearson G, Carpenter L, Leitges M, Biden TJ. Deletion of protein kinase Cd in mice modulates stability of inflammatory genes and protects against cytokine-stimulated β cell death in vitro and in vivo. Diabetologia 2011;54:380–389.
  • Gopalakrishna R, Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med 2000;28:1349–1361.
  • Reyland ME, Anderson SM, Matassa AA, Barzen KA, Quissell DO. Protein kinase C δ is essential for etoposide-induced apoptosis in salivary gland acinar cells. J Biol Chem 1999;274:19115–19123.
  • Santiago-Walker AE, Fikaris AJ, Kao GD, Brown EJ, Kazanietz MG, Meinkoth JL. Protein kinase C δ stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J Biol Chem 2005;280:32107–32114.
  • Csala M, Margittai E, Bánhegyi G. Redox control of endoplasmic reticulum function. Antioxid Redox Signal 2010;13:77–108.
  • Shen HM, Liu ZG. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 2006;40:928–939.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.