Proteomic analysis of midtrimester amniotic fluid to identify novel biomarkers for preterm delivery

References

• Mathews TJ, Menacker F, MacDorman MF. Infant mortality statistics from the 2002 period: linked birth/infant death data set. Natl Vital Stat Rep 2004;53:1–29.
   PubMedGoogle Scholar
• Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Munson ML. Births: final data for 2003. Natl Vital Stat Rep 2005;54:1–116.
   PubMedGoogle Scholar
• Oh KJ, Lee SE, Jung H, Kim G, Romero R, Yoon BH. Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency. J Perinat Med 2010;38:261–268.
   PubMed Web of Science ®Google Scholar
• Vaisbuch E, Romero R, Gomez R, Kusanovic JP, Mazaki-Tovi S, Chaiworapongsa T, Hassan SS. An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 2011;24:391–396.
   PubMed Web of Science ®Google Scholar
• Lee SE, Romero R, Park CW, Jun JK, Yoon BH. The frequency and significance of intraamniotic inflammation in patients with cervical insufficiency. Am J Obstet Gynecol 2008;198:633.e1–633.e8.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaiworapongsa T, Savasan ZA, Hussein Y, Dong Z, Kusanovic JP, Kim CJ, Hassan SS. Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE. J Matern Fetal Neonatal Med 2012;25:558–567.
   PubMed Web of Science ®Google Scholar
• Romero R, Quintero R, Oyarzun E, Wu YK, Sabo V, Mazor M, Hobbins JC. Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. Am J Obstet Gynecol 1988;159:661–666.
   PubMed Web of Science ®Google Scholar
• Gómez R, Romero R, Nien JK, Medina L, Carstens M, Kim YM, Chaiworapongsa T, et al. Idiopathic vaginal bleeding during pregnancy as the only clinical manifestation of intrauterine infection. J Matern Fetal Neonatal Med 2005;18:31–37.
   PubMed Web of Science ®Google Scholar
• Gomez R, Romero R, Nien JK, Chaiworapongsa T, Medina L, Kim YM, Yoon BH, et al. A short cervix in women with preterm labor and intact membranes: a risk factor for microbial invasion of the amniotic cavity. Am J Obstet Gynecol 2005;192:678–689.
   PubMed Web of Science ®Google Scholar
• Hassan S, Romero R, Hendler I, Gomez R, Khalek N, Espinoza J, Nien JK, et al. A sonographic short cervix as the only clinical manifestation of intra-amniotic infection. J Perinat Med 2006;34:13–19.
   PubMed Web of Science ®Google Scholar
• Kim SM, Romero R, Lee J, Mi Lee S, Park CW, Shin Park J, Yoon BH. The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: do the diagnostic criteria for preterm labor need to be changed? J Matern Fetal Neonatal Med 2012.
   Web of Science ®Google Scholar
• Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M. The preterm parturition syndrome. BJOG 2006;113 Suppl 3:17–42.
   PubMed Web of Science ®Google Scholar
• Greci LS, Gilson GJ, Nevils B, Izquierdo LA, Qualls CR, Curet LB. Is amniotic fluid analysis the key to preterm labor? A model using interleukin-6 for predicting rapid delivery. Am J Obstet Gynecol 1998;179:172–178.
   PubMed Web of Science ®Google Scholar
• Heikkinen J, Möttönen M, Pulkki K, Lassila O, Alanen A. Cytokine levels in midtrimester amniotic fluid in normal pregnancy and in the prediction of pre-eclampsia. Scand J Immunol 2001;53:310–314.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Oh SY, Romero R, Shim SS, Han SY, Park JS, Jun JK. An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery. Am J Obstet Gynecol 2001;185:1162–1167.
   PubMed Web of Science ®Google Scholar
• Cho CK, Shan SJ, Winsor EJ, Diamandis EP. Proteomics analysis of human amniotic fluid. Mol Cell Proteomics 2007;6:1406–1415.
   PubMed Web of Science ®Google Scholar
• Ghezzi F, Franchi M, Raio L, Di Naro E, Bossi G, D’Eril GV, Bolis P. Elevated amniotic fluid C-reactive protein at the time of genetic amniocentesis is a marker for preterm delivery. Am J Obstet Gynecol 2002;186:268–273.
   PubMed Web of Science ®Google Scholar
• Ghidini A, Jenkins CB, Spong CY, Pezzullo JC, Salafia CM, Eglinton GS. Elevated amniotic fluid interleukin-6 levels during the early second trimester are associated with greater risk of subsequent preterm delivery. Am J Reprod Immunol 1997;37:227–231.
   PubMed Web of Science ®Google Scholar
• Nien JK, Yoon BH, Espinoza J, Kusanovic JP, Erez O, Soto E, Richani K, et al. A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery. Am J Obstet Gynecol 2006;195:1025–1030.
   PubMed Web of Science ®Google Scholar
• Wenstrom KD, Andrews WW, Tamura T, DuBard MB, Johnston KE, Hemstreet GP. Elevated amniotic fluid interleukin-6 levels at genetic amniocentesis predict subsequent pregnancy loss. Am J Obstet Gynecol 1996;175:830–833.
   PubMed Web of Science ®Google Scholar
• Chaiworapongsa T, Romero R, Tolosa JE, Yoshimatsu J, Espinoza J, Kim YM, Kim JC, et al. Elevated monocyte chemotactic protein-1 in amniotic fluid is a risk factor for pregnancy loss. J Matern Fetal Neonatal Med 2002;12:159–164.
   PubMedGoogle Scholar
• Michaels JE, Dasari S, Pereira L, Reddy AP, Lapidus JA, Lu X, Jacob T, et al. Comprehensive proteomic analysis of the human amniotic fluid proteome: gestational age-dependent changes. J Proteome Res 2007;6:1277–1285.
   PubMed Web of Science ®Google Scholar
• Queloz PA, Crettaz D, Thadikkaran L, Sapin V, Gallot D, Jani J, Deprest J, et al. Proteomic analyses of amniotic fluid: potential applications in health and diseases. J Chromatogr B Analyt Technol Biomed Life Sci 2007;850:336–342.
   PubMed Web of Science ®Google Scholar
• Romero R, Espinoza J, Rogers WT, Moser A, Nien JK, Kusanovic JP, Gotsch F, et al. Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: the use of a novel computational method to analyze mass spectrometric profiling. J Matern Fetal Neonatal Med 2008;21:367–388.
   PubMed Web of Science ®Google Scholar
• Romero R, Kusanovic JP, Gotsch F, Erez O, Vaisbuch E, Mazaki-Tovi S, Moser A, et al. Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:261–280.
   PubMed Web of Science ®Google Scholar
• Tsangaris GT, Kolialexi A, Karamessinis PM, Anagnostopoulos AK, Antsaklis A, Fountoulakis M, Mavrou A. The normal human amniotic fluid supernatant proteome. In Vivo 2006;20:479–490.
   PubMed Web of Science ®Google Scholar
• Gravett MG, Novy MJ, Rosenfeld RG, Reddy AP, Jacob T, Turner M, McCormack A, et al. Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers. JAMA 2004;292:462–469.
   PubMed Web of Science ®Google Scholar
• Buhimschi IA, Christner R, Buhimschi CS. Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation. BJOG 2005;112:173–181.
   PubMed Web of Science ®Google Scholar
• Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, et al. Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis. PLoS Med 2007;4:e18.
   PubMed Web of Science ®Google Scholar
• Bujold E, Romero R, Kusanovic JP, Erez O, Gotsch F, Chaiworapongsa T, Gomez R, et al. Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry. J Matern Fetal Neonatal Med 2008;21:697–713.
   PubMed Web of Science ®Google Scholar
• Rüetschi U, Rosén A, Karlsson G, Zetterberg H, Rymo L, Hagberg H, Jacobsson B. Proteomic analysis using protein chips to detect biomarkers in cervical and amniotic fluid in women with intra-amniotic inflammation. J Proteome Res 2005;4:2236–2242.
   PubMed Web of Science ®Google Scholar
• Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci USA 1990;87:210–214.
   PubMed Web of Science ®Google Scholar
• Hitti J, Lapidus JA, Lu X, Reddy AP, Jacob T, Dasari S, Eschenbach DA, et al. Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid. Am J Obstet Gynecol 2010;203:32.e1–32.e8.
   PubMed Web of Science ®Google Scholar
• Lee SE, Han BD, Park IS, Romero R, Yoon BH. Evidence supporting proteolytic cleavage of insulin-like growth factor binding protein-1 (IGFBP-1) protein in amniotic fluid. J Perinat Med 2008;36:316–323.
   PubMed Web of Science ®Google Scholar
• Lee J, Lee SM, Oh KJ, Park CW, Jun JK, Yoon BH. Fragmented forms of insulin-like growth factor binding protein-1 in amniotic fluid of patients with preterm labor and intact membranes. Reprod Sci 2011;18:842–849.
   PubMed Web of Science ®Google Scholar
• Tsangaris G, Weitzdörfer R, Pollak D, Lubec G, Fountoulakis M. The amniotic fluid cell proteome. Electrophoresis 2005;26:1168–1173.
   PubMed Web of Science ®Google Scholar
• Buhimschi CS, Weiner CP, Buhimschi IA. Proteomics, part II: the emerging role of proteomics over genomics in spontaneous preterm labor/birth. Obstet Gynecol Surv 2006;61:543–553.
   PubMed Web of Science ®Google Scholar
• Wenstrom KD, Andrews WW, Hauth JC, Goldenberg RL, DuBard MB, Cliver SP. Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery. Am J Obstet Gynecol 1998;178:546–550.
   PubMed Web of Science ®Google Scholar
• Gomez R, Galasso M, Romero R, Mazor M, Sorokin Y, Gonçalves L, Treadwell M. Ultrasonographic examination of the uterine cervix is better than cervical digital examination as a predictor of the likelihood of premature delivery in patients with preterm labor and intact membranes. Am J Obstet Gynecol 1994;171:956–964.
   PubMed Web of Science ®Google Scholar
• Goepfert AR, Goldenberg RL, Mercer B, Iams J, Meis P, Moawad A, Thom E, et al. The preterm prediction study: quantitative fetal fibronectin values and the prediction of spontaneous preterm birth. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol 2000;183:1480–1483.
   PubMed Web of Science ®Google Scholar
• Gonçalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002;8:3–13.
   PubMedGoogle Scholar
• Dammann O, Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr 2000;12:99–104.
   PubMed Web of Science ®Google Scholar
• Davis NM, Ford GW, Anderson PJ, Doyle LW; Victorian Infant Collaborative Study Group. Developmental coordination disorder at 8 years of age in a regional cohort of extremely-low-birthweight or very preterm infants. Dev Med Child Neurol 2007;49:325–330.
   PubMed Web of Science ®Google Scholar
• Maalouf EF, Duggan PJ, Rutherford MA, Counsell SJ, Fletcher AM, Battin M, Cowan F, Edwards AD. Magnetic resonance imaging of the brain in a cohort of extremely preterm infants. J Pediatr 1999;135:351–357.
   PubMed Web of Science ®Google Scholar
• Gomez R, Ghezzi F, Romero R, Yoon BH, Mazor M, Berry SM. Two thirds of human fetuses with microbial invasion of the amnion cavity have a detectable systematic cytokine response before birth. Am J Obstet Gynecol 1997;176:514.
   Google Scholar
• Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194–202.
   PubMed Web of Science ®Google Scholar
• Bamberg C, Fotopoulou C, Linder M, Roehr CC, Dudenhausen JW, Henrich W, Kalache K. Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-a, and lipopolysaccharide binding protein in normal pregnancies: a prospective evaluation according to parity, gestational age, and fetal gender. J Perinat Med 2011;39:403–409.
   PubMed Web of Science ®Google Scholar
• Bamberg C, Fotopoulou C, Thiem D, Roehr CC, Dudenhausen JW, Kalache KD. Correlation of midtrimester amniotic fluid cytokine concentrations with adverse pregnancy outcome in terms of spontaneous abortion, preterm birth, and preeclampsia. J Matern Fetal Neonatal Med 2012;25:812–817.
   PubMed Web of Science ®Google Scholar
• Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M, Vijayaraghavan J, et al.; PREGNANT Trial. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2011;38:18–31.
   PubMed Web of Science ®Google Scholar
• Romero R, Nicolaides K, Conde-Agudelo A, Tabor A, O’Brien JM, Cetingoz E, Da Fonseca E, et al. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol 2012;206:124.e1–124.19.
   PubMed Web of Science ®Google Scholar
• Wang B, Navath RS, Romero R, Kannan S, Kannan R. Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells. Int J Pharm 2009;377:159–168.
   PubMedGoogle Scholar
• Wang X, Svedin P, Nie C, Lapatto R, Zhu C, Gustavsson M, Sandberg M, et al. N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Ann Neurol 2007;61:263–271.
   PubMed Web of Science ®Google Scholar
• Kannan S, Dai H, Navath RS, Balakrishnan B, Jyoti A, Janisse J, Romero R, Kannan RM. Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model. Sci Transl Med 2012;4:130ra46.
   PubMed Web of Science ®Google Scholar