Detection of pepsin in mouth swab: correlation with clinical gastroesophageal reflux in preterm infants

References

• Newell SJ, Booth IW, Morgan ME, et al. Gastro-oesophageal reflux in preterm infants. Arch Dis Child 1989;64:780–6
   PubMed Web of Science ®Google Scholar
• Ewer AK, Durbin GM, Morgan ME, Booth IW. Gastric emptying and gastro-oesophageal reflux in preterm infants. Arch Dis Child Fetal Neonatal Ed 1996;75:F117–21
   PubMed Web of Science ®Google Scholar
• Omari TI, Barnett C, Snel A, et al. Mechanisms of gastroesophageal reflux in healthy premature infants. J Pediatr 1998;133:650–4
   PubMed Web of Science ®Google Scholar
• Omari TI, Barnett CP, Benninga MA, et al. Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease. Gut 2002;51:475–9
   PubMed Web of Science ®Google Scholar
• Omari TI, Rommel N, Staunton E, et al. Paradoxical impact of body positioning on gastroesophageal reflux and gastric emptying in the premature neonate. J Pediatr 2004;145:194–200
   PubMed Web of Science ®Google Scholar
• Siegel M. Gastric emptying time in premature and compromised infants. J Pediatr Gastroenterol Nutr 1983;2:S136–40
   PubMed Web of Science ®Google Scholar
• Herbst JJ, Minton SD, Book LS. Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr 1979;95:763–8
   PubMed Web of Science ®Google Scholar
• Jolley SG, Lorenz ML, Hendrickson M, Kurlinski JP. Esophageal pH monitoring abnormalities and gastroesophageal reflux disease in infants with intestinal malrotation. Arch Surg 1999;134:747–52; discussion 752–3
   PubMedGoogle Scholar
• Sheikh S, Stephen TC, Sisson B. Prevalence of gastroesophageal reflux in infants with recurrent brief apneic episodes. Can Respir J 1999;6:401–4
   PubMedGoogle Scholar
• Fuloria M, Hiatt D, Dillard RG, O’Shea TM. Gastroesophageal reflux in very low birth weight infants: association with chronic lung disease and outcomes through 1 year of age. J Perinatol 2000;20:235–9
   PubMedGoogle Scholar
• Radford PJ, Stillwell PC, Blue B, Hertel G. Aspiration complicating bronchopulmonary dysplasia. Chest 1995;107:185–8
   PubMed Web of Science ®Google Scholar
• Grant L, Cochran D. Can pH monitoring reliably detect gastro-oesophageal reflux in preterm infants? Arch Dis Child Fetal Neonatal Ed 2001;85:F155–7; discussion F157–8
   PubMed Web of Science ®Google Scholar
• Mitchell DJ, McClure BG, Tubman TR. Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants. Arch Dis Child 2001;84:273–6
   PubMed Web of Science ®Google Scholar
• Lopez Alonso M, Moya MJ, Cabo JA, et al. Acid and non-acid gastro-esophageal reflux in newborns. Preliminar results using intraluminal impedance. Cir Pediatr 2005;18:121–6
   PubMedGoogle Scholar
• Lopez-Alonso M, Moya MJ, Cabo JA, et al. Twenty-four-hour esophageal impedance-pH monitoring in healthy preterm neonates: rate and characteristics of acid, weakly acidic, and weakly alkaline gastroesophageal reflux. Pediatrics 2006;118:e299–308
   PubMed Web of Science ®Google Scholar
• Vandenplas Y, Salvatore S, Vieira MC, Hauser B. Will esophageal impedance replace pH monitoring? Pediatrics 2007;119:118–22
   PubMed Web of Science ®Google Scholar
• Metheny NA, Chang YH, Ye JS, et al. Pepsin as a marker for pulmonary aspiration. Am J Crit Care 2002;11:150–4
   PubMed Web of Science ®Google Scholar
• Krishnan U, Mitchell JD, Messina I, et al. Assay of tracheal pepsin as a marker of reflux aspiration. J Pediatr Gastroenterol Nutr 2002;35:303–8
   PubMed Web of Science ®Google Scholar
• Meert KL, Daphtary KM, Metheny NA. Detection of pepsin and glucose in tracheal secretions as indicators of aspiration in mechanically ventilated children. Pediatr Crit Care Med 2002;3:19–22
   PubMedGoogle Scholar
• Aghai ZH, Kumar S, Farhath S, et al. Dexamethasone suppresses expression of Nuclear Factor-kappaB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress. Pediatr Res 2006;59:811–15
   PubMed Web of Science ®Google Scholar
• Farhath S, He Z, Nakhla T, et al. Pepsin, a marker of gastric contents, is increased in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatrics 2008;121:e253–9
   PubMed Web of Science ®Google Scholar
• He Z, O’Reilly RC, Bolling L, et al. Detection of gastric pepsin in middle ear fluid of children with otitis media. Otolaryngol Head Neck Surg 2007;137:59–64
   PubMed Web of Science ®Google Scholar
• Kageyama T, Takahashi K. Pepsinogen C and pepsin C from gastric mucosa of Japanese monkey. Purification and characterization. J Biochem 1976;80:983–92
   PubMed Web of Science ®Google Scholar
• Roberts NB, Taylor WH. Comparative pepstatin inhibition studies on individual human pepsins and pepsinogens 1,3 and 5(gastricsin) and pig pepsin A. J Enzyme Inhib Med Chem 2003;18:209–17
   PubMed Web of Science ®Google Scholar
• Foster C, Aktar A, Kopf D, et al. Pepsinogen C: a type 2 cell-specific protease. Am J Physiol Lung Cell Mol Physiol 2004;286:L382–7
   PubMed Web of Science ®Google Scholar
• Truan N, Vizoso F, Fresno MF, et al. Expression and clinical significance of pepsinogen C in resectable pancreatic cancer. Int J Biol Markers 2001;16:31–6
   PubMed Web of Science ®Google Scholar
• Samuels TL, Johnston N. Pepsin as a marker of extraesophageal reflux. Ann Otol Rhinol Laryngol 2010;119:203–8
   PubMed Web of Science ®Google Scholar
• Starosta V, Kitz R, Hartl D, et al. Bronchoalveolar pepsin, bile acids, oxidation, and inflammation in children with gastroesophageal reflux disease. Chest 2007;132:1557–64
   PubMed Web of Science ®Google Scholar
• Ufberg JW, Bushra JS, Patel D, et al. A new pepsin assay to detect pulmonary aspiration of gastric contents among newly intubated patients. Am J Emerg Med 2004;22:612–14
   PubMed Web of Science ®Google Scholar
• Abd El-Fattah AM, Abdul Maksoud GA, Ramadan AS, et al. Pepsin assay: a marker for reflux in pediatric glue ear. Otolaryngol Head Neck Surg 2007;136:464–70
   PubMed Web of Science ®Google Scholar
• He Z, O’Reilly RC, Mehta D. Gastric pepsin in middle ear fluid of children with otitis media: clinical implications. Curr Allergy Asthma Rep 2008;8:513–18
   PubMed Web of Science ®Google Scholar
• Potluri S, Friedenberg F, Parkman HP, et al. Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung. Dig Dis Sci 2003;48:1813–17
   PubMed Web of Science ®Google Scholar
• Knight J, Lively MO, Johnston N, et al. Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope 2005;115:1473–8
   PubMed Web of Science ®Google Scholar
• Kim TH, Lee KJ, Yeo M, et al. Pepsin detection in the sputum/saliva for the diagnosis of gastroesophageal reflux disease in patients with clinically suspected atypical gastroesophageal reflux disease symptoms. Digestion 2008;77:201–6
   PubMed Web of Science ®Google Scholar
• Ervine E, McMaster C, McCallion W, Shields MD. Pepsin measured in induced sputum – a test for pulmonary aspiration in children? J Pediatr Surg 2009;44:1938–41
   PubMed Web of Science ®Google Scholar
• Metheny NA, Dahms TE, Chang YH, et al. Detection of pepsin in tracheal secretions after forced small-volume aspirations of gastric juice. J Parenter Enteral Nutr 2004;28:79–84
   PubMed Web of Science ®Google Scholar