Meta-analyses on the association of MTR A2756G and MTRR A66G polymorphisms with neural tube defect risks in Caucasian children

References

• van der Put NM, Eskes TK, Blom HJ. Is the common 677C–>T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis QJM 1997;90:111–5
   Google Scholar
• Amorim MR, Lima MA, Castilla EE, Orioli IM. Non-Latin European descent could be a requirement for association of NTDs and MTHFR variant 677C >T: a meta-analysis. Am J Med Genet A 2007;143A:1726–32
   PubMedGoogle Scholar
• Wang XW, Luo YL, Wang W, et al. Association between MTHFR A1298C polymorphism and neural tube defect susceptibility: a metaanalysis. Am J Obstet Gynecol 2012;206:251. e1–7
   PubMedGoogle Scholar
• Doudney K, Grinham J, Whittaker J, et al. Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects. Am J Med Genet A 2009;149A:1585–9
   PubMed Web of Science ®Google Scholar
• Brouns R, Ursem N, Lindemans J, et al. Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects. Prenat Diagn 2008;28:485–93
   PubMedGoogle Scholar
• O'Leary VB, Mills JL, Pangilinan F, et al. Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association. Mol Genet Metab 2005;85:220–7
   PubMedGoogle Scholar
• Gos M, Sliwerska E, Szpecht-Potocka A. Mutation incidence in folate metabolism genes and regulatory genes in Polish families with neural tube defects. J Appl Genet 2004; 45:363–8
   PubMedGoogle Scholar
• Gueant-Rodriguez RM, Rendeli C, Namour B, et al. Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Neurosci Lett 2003;344:189–92
   PubMed Web of Science ®Google Scholar
• Zhu H, Wicker NJ, Shaw GM, et al. Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Mol Genet Metab 2003;78:216–21
   PubMed Web of Science ®Google Scholar
• De Marco P, Calevo MG, Moroni A, et al. Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population. J Hum Genet 2002;47:319–24
   PubMed Web of Science ®Google Scholar
• Johanning GL, Tamura T, Johnston KE, Wenstrom KD. Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects. J Med Genet 2000;37:949–51
   PubMedGoogle Scholar
• Shaw GM, Todoroff K, Finnell RH, et al. Infant methionine synthase variants and risk for spina bifida. J Med Genet 1999;36:86–7
   PubMedGoogle Scholar
• Christensen B, Arbour L, Tran P, et al. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. Am J Med Genet 1999;84:151–7
   PubMed Web of Science ®Google Scholar
• Morrison K, Papapetrou C, Hol FA, et al. Susceptibility to spina bifida; an association study of five candidate genes. Ann Hum Genet 1998;62:379–96
   PubMed Web of Science ®Google Scholar
• van der Put NM, van der Molen EF, Kluijtmans LA, et al. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease. QJM 1997;90:511–7
   PubMedGoogle Scholar
• Pietrzyk JJ, Bik-Multanowski M, Sanak M, Twardowska M. Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida. J Appl Genet 2003;44:111–3
   PubMedGoogle Scholar
• Wilson A, Platt R, Wu Q, et al. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab 1999;67:317–23
   PubMed Web of Science ®Google Scholar
• Relton CL, Wilding CS, Pearce MS, et al. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. J Med Genet 2004;41:256–60
   PubMed Web of Science ®Google Scholar
• van der Linden IJ, den Heijer M, Afman LA, et al. The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida. J Mol Med (Berl) 2006;84:1047–54
   PubMed Web of Science ®Google Scholar
• DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177–88
   PubMed Web of Science ®Google Scholar
• Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719–48
   PubMed Web of Science ®Google Scholar
• Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629–34
   PubMed Web of Science ®Google Scholar
• Brody LC, Baker PJ, Chines PS, et al. Methionine synthase: high-resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects. Mol Genet Metab 1999;67:324–33
   PubMedGoogle Scholar
• Doolin MT, Barbaux S, McDonnell M, et al. Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Am J Hum Genet 2002;71:1222–6
   PubMed Web of Science ®Google Scholar
• Boyles AL, Billups AV, Deak KL, et al. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect 2006;114:1547–52
   PubMedGoogle Scholar
• Shaw GM, Lu W, Zhu H, et al. 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. BMC Med Genet 2009;10:49 . doi: 10.1186/1471-2350-10-49
   PubMed Web of Science ®Google Scholar
• Morrison K, Edwards YH, Lynch SA, et al. Methionine synthase and neural tube defects. J Med Genet 1997;34:958--960
   PubMed Web of Science ®Google Scholar
• Relton CL, Wilding CS, Laffling AJ, et al. Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy. Mol Genet Metab 2004;81:273–81
   PubMedGoogle Scholar
• HY Al Farra. Methionine synthase polymorphisms frequencies distribution in the Jordanian population. J Pediatr Neurol 2011;9:35–40
   Google Scholar
• Lucock M, Daskalakis I, Briggs D, et al. Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c –> t methylenetetrahydrofolate reductase and 2756a –> g methionine synthase genotypes. Mol Genet Metab 2000;70:27–44
   PubMed Web of Science ®Google Scholar
• Al FH. Methionine synthase polymorphisms (MTR 2756 A>G and MTR 2758 C>G) frequencies and distribution in the Jordanian population and their correlation with neural tube defects in the population of the northern part of Jordan. Indian J Hum Genet 2010;16:138–43
   PubMedGoogle Scholar
• Naushad SM, Devi AR. Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India. J Perinat Med 2010;38:63–9
   PubMed Web of Science ®Google Scholar
• Candito M, Rivet R, Herbeth B, et al. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. Am J Med Genet A 2008;146A:1128–33
   PubMed Web of Science ®Google Scholar
• Relton CL, Wilding CS, Laffling AJ, et al. Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy. Mol Genet Metab 2004;81:273–81
   PubMedGoogle Scholar
• Doolin MT, Barbaux S, McDonnell M, et al. Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Am J Hum Genet 2002;71:1222–6
   PubMed Web of Science ®Google Scholar