Elevated vaginal pH in the absence of current vaginal infection, still a challenging obstetrical problem

References

• Linhares IM, Summers PR, Larsen B, et al. Contemporary perspectives on vaginal pH and lactobacilli. Am J Obstet Gynecol 2011;204:120 e1–5
   Google Scholar
• Bahram A, Hamid B, Zohre T. Prevalence of bacterial vaginosis and impact of genital hygiene practices in non-pregnant women in zanjan, iran. Oman Med J 2009;24:288–93
   PubMedGoogle Scholar
• Azargoon A, Darvishzadeh S. Association of bacterial vaginosis, trichomonas vaginalis, and vaginal acidity with outcome of pregnancy. Arch Iranian Med 2006;9:213–17
   Google Scholar
• Saling E. Prevention of prematurity. A review of our activities during the last 25 years. J Perinatal Med 1997;25:406–17
   PubMed Web of Science ®Google Scholar
• Hauth JC, Macpherson C, Carey JC, et al. Early pregnancy threshold vaginal pH and Gram stain scores predictive of subsequent preterm birth in asymptomatic women. Am J Obstet Gynecol 2003;188:831–5
   PubMed Web of Science ®Google Scholar
• Cauci S, McGregor J, Thorsen P, et al. Combination of vaginal pH with vaginal sialidase and prolidase activities for prediction of low birth weight and preterm birth. Am J Obstet Gynecol 2005;192:489–96
   PubMed Web of Science ®Google Scholar
• Simhan HN, Caritis SN, Krohn MA, Hillier SL. Elevated vaginal pH and neutrophils are associated strongly with early spontaneous preterm birth. Am J Obstet Gynecol 2003;189:1150–4
   PubMed Web of Science ®Google Scholar
• Hemalatha R, Ramalaxmi BA, KrishnaSwetha G, et al. Cervicovaginal inflammatory cytokines and sphingomyelinase in women with and without bacterial vaginosis. Am J Med Sci 2012;344:35–9
   Google Scholar
• Gravitt PE, Hildesheim A, Herrero R, et al. Correlates of IL-10 and IL-12 concentrations in cervical secretions. Journal of clinical immunology. 2003;23:175–83
   PubMed Web of Science ®Google Scholar
• Genc MR, Karasahin E, Onderdonk AB, et al. Association between vaginal 70-kd heat shock protein, interleukin-1 receptor antagonist, and microbial flora in mid trimester pregnant women. Am J Obstet Gynecol 2005;192:916–21
   PubMed Web of Science ®Google Scholar
• Brown D Jr. Clinical variability of bacterial vaginosis and trichomoniasis. J Reproduct Med 2004;49:781–6
   Google Scholar
• Howman RA, Charles AK, Jacques A, et al. Inflammatory and haematological markers in the maternal, umbilical cord and infant circulation in histological chorioamnionitis. PloS One 2012;7:e51836
   PubMed Web of Science ®Google Scholar
• Faber R, Stepan H, Springer C, Viehweg B. Multivariate analysis of the significance of vaginal bacterial colonization in the occurrence of a preterm birth with various risk parameters. Zentralblatt Gynakol 1997;119:28–32
   Google Scholar
• Saling E, Brandt-Niebelschutz S, Schmitz C. Prevention of late abortion and high risk premature labor–measures suited for routine practice. Zeitsch Geburtshilfe Perinatol. 1991;195:209–21
   PubMedGoogle Scholar
• Ruggiero C, Cherubini A, Ble A, et al. Uric acid and inflammatory markers. Eur Heart J 2006;27:1174–81
   PubMed Web of Science ®Google Scholar
• Figueroa D, Mancuso MS, Szychowski JM, et al. Does midtrimester Nugent score or high vaginal pH predict gestational age at delivery in women at risk for recurrent preterm birth? Am J Obstet Gynecol 2011;204:46e1–4
   Google Scholar
• Matijevic R, Grgic O, Knezevic M. Vaginal pH versus cervical length in the mid-trimester as screening predictors of preterm labor in a low-risk population. Int J Gynaecol Obstet 2010;111:41–4
   PubMed Web of Science ®Google Scholar
• Simhan HN, Bodnar LM, Krohn MA. Paternal race and bacterial vaginosis during the first trimester of pregnancy. Am J Obstet Gynecol 2008;198:196e1–4
   Google Scholar
• Salgado SS, Salgado MKR. Structural changes in pre-eclamptic and eclamptic placentas – an ultrastructural study. JCPSP 2011;21:482–6
   Google Scholar
• Gorodeski GI, Hopfer U, Liu CC, Margles E. Estrogen acidifies vaginal pH by up-regulation of proton secretion via the apical membrane of vaginal-ectocervical epithelial cells. Endocrinology 2005;146:816–24
   PubMed Web of Science ®Google Scholar
• Vambergue A, Fajardy I. Consequences of gestational and pregestational diabetes on placental function and birth weight. World J Diab 2011;2:196–203
   PubMedGoogle Scholar
• Chiesa C, Signore F, Assumma M, et al. Serial measurements of C-reactive protein and interleukin-6 in the immediate postnatal period: reference intervals and analysis of maternal and perinatal confounders. Clin Chem 2001;47:1016–22
   PubMed Web of Science ®Google Scholar
• Guaschino S, De Seta F, Piccoli M, et al. Aetiology of preterm labour: bacterial vaginosis. BJOG Int J Obstet Gynaecol 2006;113:46–51
   PubMed Web of Science ®Google Scholar
• Ugwumadu A, Manyonda I, Reid F, Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial. Lancet 2003;361:983–8
   PubMed Web of Science ®Google Scholar
• Jazayeri A, Arnold H, Jazayeri MK, Spellacy WN. A prospective study of vaginal pH as a predictor of preterm delivery. J Maternal-fetal Neonat Med 2002;11:30–3
   Google Scholar
• Sendag F, Kazandi M, Akercan F, et al. Vaginal fluid pH, cervicovaginitis and cervical length in pregnancy. Clin Exp Obstet Gynecol 2010;37:127–30
   PubMed Web of Science ®Google Scholar
• Svare JA, Schmidt H, Hansen BB, Lose G. Bacterial vaginosis in a cohort of Danish pregnant women: prevalence and relationship with preterm delivery, low birthweight and perinatal infections. BJOG Int J Obstet Gynaecol 2006;113:1419–25
   PubMed Web of Science ®Google Scholar
• Schneeweis C, Grafe M, Bungenstock A, et al. Chronic CRP-exposure inhibits VEGF-induced endothelial cell migration. J Atherosc Thromb 2010;17:203–12
   PubMed Web of Science ®Google Scholar
• Sundgren NC, Zhu W, Yuhanna IS, et al. Coupling of Fcgamma receptor I to Fcgamma receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function. Circulat Res 2011;109:1132–40
   Google Scholar
• Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005;16:3553–62
   PubMed Web of Science ®Google Scholar