191
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Methemoglobin levels in umbilical cord blood of women with intrauterine growth restriction and preeclampsia

, , , , &
Pages 789-794 | Received 13 Mar 2013, Accepted 26 Aug 2013, Published online: 02 Oct 2013

References

  • Toledo Jr JC, Augusto O. Connecting the chemical and biological properties of nitric oxide. Chem Res Toxicol 2012;25:975–89
  • Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J 2012;33:829–37, 837a–d
  • Moncada S, Higgs EA. Endogenous nitric oxide: physiology, pathology and clinical relevance. Eur J Clin Invest 1991;21:361–74
  • Rapoport R, Murad F. Agonist-induced endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 1989;65:1–21
  • Krause BJ, Hanson MA, Casanello P. Role of nitric oxide in placental vascular development and function. Placenta 2011;32:797–805
  • Lyall F. Development of the utero-placental circulation: the role of carbon monoxide and nitric oxide in trophoblast invasion and spiral artery transformation. Microsc Res Tech 2003;60:402–11
  • Lyall F, Bulmer JN, Kelly H, et al. Human trophoblast invasion and spiral artery transformation: the role of nitric oxide. Am J Pathol 1999;154:1105–14
  • Sladek SM, Magness RR, Conrad KP. Nitric oxide and pregnancy. Am J Physiol 1997;272:R441–63
  • Poston L. The control of blood flow to the placenta. Exp Physiol 1997;82:377–87
  • Kon V, Harris RC, Ichikawa I. A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. J Clin Invest 1990;85:1728–33
  • von Dadelszen P, Magee L. What matters in preeclampsia are the associated adverse outcomes: the view from Canada. Curr Opin Obstet Gynecol 2008;20:110–15
  • Kinzler WL, Vintzileos AM. Fetal growth restriction: a modern approach. Curr Opin Obstet Gynecol 2008;20:125–31
  • Wadsack C, Desoye G, Hiden U. The feto-placental endothelium in pregnancy pathologies. Wien Med Wochenschr 2012;162:220–4
  • Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol 2006;195:40–9
  • Ahmed A, Cudmore MJ. Can the biology of VEGF and haem oxygenases help solve pre-eclampsia? Biochem Soc Trans 2009;37:1237–42
  • Ahmed A. New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications. Thromb Res 2011;127:S72–5
  • Huppertz B. Placental pathology in pregnancy complications. Thromb Res 2011;127:S96–9
  • Sibley CP, Pardi G, Cetin I, et al. Pathogenesis of intrauterine growth restriction (IUGR) – conclusions derived from a European Union Biomed 2 Concerted Action project “Importance of Oxygen Supply in Intrauterine Growth Restricted Pregnancies” – a workshop report. Placenta 2002;23:S75–9
  • Archer S. Measurement of nitric-oxide in biological models. FASEB J 1993;7:349–60
  • Salter M, Knowles RG. Assay of NOS activity by the measurement of conversion of oxyhemoglobin to methemoglobin by NO. Methods Mol Biol 1998;100:61–5
  • Speakman ED, Boyd JC, Bruns DE. Measurement of methemoglobin in neonatal samples containing fetal hemoglobin. Clin Chem 1995;41:458–61
  • Noris M, Perico N, Remuzzi G. Mechanisms of disease: pre-eclampsia. Nat Clin Pract Nephrol 2005;1:98–114
  • Ballard JL, Khoury JC, Wedig K, et al. New Ballard Score, expanded to include extremely premature infants. J Pediatr 1991;119:417–23
  • Kramer MS, Platt RW, Wen SW, et al; Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System. A new and improved population-based Canadian reference for birth weight for gestational age. Pediatrics 2001;108:E35
  • Reiter CD, Wang X, Tanus-Santos JE, et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002;8:1383–9
  • Benedetto C, Marozio L, Tancredi A, et al. Biochemistry of HELLP syndrome. Adv Clin Chem 2011;53:85–104
  • Ariza AC, Bobadilla N, Diaz L, et al. Placental gene expression of calcitonin gene-related peptide and nitric oxide synthases in preeclampsia: effects of magnesium sulfate. Magnes Res 2009;22:44–9
  • Chen XN, Xu J, Feng Z, et al. Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation. Acta Pharmacol Sin 2010;31:813–20
  • Bakris GL. Pharmacological augmentation of endothelium-derived nitric oxide synthesis. J Manag Care Pharm 2007;13:S9–12
  • Guay J. Methemoglobinemia related to local anesthetics: a summary of 242 episodes. Anesth Analg 2009;108:837–45
  • Rutherford RA, McCarthy A, Sullivan MH, et al. Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth-retarded and pre-eclamptic pregnancies. Br J Pharmacol 1995;116:3099–109
  • Parra MC, Lees C, Mann GE, et al. Vasoactive mediator release by fetal endothelial cells in intrauterine growth restriction and preeclampsia. Am J Obstet Gynecol 2001;184:497–502
  • Hata T, Hashimoto M, Manabe A, et al. Maternal and fetal nitric oxide synthesis is decreased in pregnancies with small for gestational age infants. Hum Reprod 1998;13:1070–3
  • Casanello P, Krause B, Torres E, et al. Reduced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia. Placenta 2009;30:625–33
  • Casanello P, Sobrevia L. Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y+/hCAT-1 and y+/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells. Circ Res 2002;91:127–34
  • Li Y, Zheng J, Bird IM, Magness RR. Mechanisms of shear stress-induced endothelial nitric-oxide synthase phosphorylation and expression in ovine fetoplacental artery endothelial cells. Biol Reprod 2004;70:785–96
  • Balligand JL, Feron O, Dessy C. eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol Rev 2009;89:481–534
  • Rafikov R, Fonseca FV, Kumar S, et al. eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol 2011;210:271–84
  • Krause BJ, Carrasco-Wong I, Caniuguir A, et al. Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels. Placenta 2013;34:20–8
  • Lyall F, Greer IA, Young A, Myatt L. Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction. Placenta 1996;17:165–8
  • Hracsko Z, Hermesz E, Ferencz A, et al. Endothelial nitric oxide synthase is up-regulated in the umbilical cord in pregnancies complicated with intrauterine growth retardation. In Vivo 2009;23:727–32
  • Andersen MR, Walker LR, Stender S. Reduced endothelial nitric oxide synthase activity and concentration in fetal umbilical veins from maternal cigarette smokers. Am J Obstet Gynecol 2004;191:346–51
  • Andersen MR, Simonsen U, Uldbjerg N, et al. Smoking cessation early in pregnancy and birth weight, length, head circumference, and endothelial nitric oxide synthase activity in umbilical and chorionic vessels: an observational study of healthy singleton pregnancies. Circulation 2009;119:857–64
  • Pisaneschi S, Strigini FA, Sanchez AM, et al. Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction. PLoS ONE 2012;7:e45294
  • Conrad KP, Kerchner LJ, Mosher MD. Plasma and 24-h NOx and cGMP during normal pregnancy and preeclampsia in women on a reduced NOx diet. Am J Physiol-Renal Physiol 1999;277:F48–57
  • Baylis C, Vallance P. Measurement of nitrite and nitrate levels in plasma and urine – what does this measure tell us about the activity of the endogenous nitric oxide system? Curr Opin Nephrol Hypertens 1998;7:59–62
  • Gladwin MT, Schechter AN. NO contest: nitrite versus S-nitroso-hemoglobin. Circ Res 2004;94:851–5
  • Izumi H, Yallampalli C, Garfield RE. Gestational changes in L-arginine-induced relaxation of pregnant rat and human myometrial smooth muscle. Am J Obstet Gynecol 1993;169:1327–37
  • Lees C, Jauniaux E, Jurkovic D, Campbell S. Placental nitric oxide production and umbilical artery vascular impedance in early pregnancy. Obstet Gynecol 1998;91:761–5
  • Lopez-Jaramillo P, Arenas WD, Garcia RG, et al. The role of the L-arginine-nitric oxide pathway in preeclampsia. Ther Adv Cardiovasc Dis 2008;2:261–75
  • Poniedzialek-Czajkowska E, Marciniak B, Kimber-Trojnar Z, et al. Nitric oxide in normal and preeclamptic pregnancy. Curr Pharm Biotechnol 2011;12:743–9
  • Morris NH, Sooranna SR, Learmont JG, et al. Nitric oxide synthase activities in placental tissue from normotensive, pre-eclamptic and growth retarded pregnancies. Br J Obstet Gynaecol 1995;102:711–14
  • Orpana AK, Avela K, Ranta V, et al. The calcium-dependent nitric oxide production of human vascular endothelial cells in preeclampsia. Am J Obstet Gynecol 1996;174:1056–60
  • Di Iorio R, Marinoni E, Emiliani S, et al. Nitric oxide in preeclampsia: lack of evidence for decreased production. Eur J Obstet Gynecol Reprod Biol 1998;76:65–70
  • Braekke K, Ueland PM, Harsem NK, Staff AC. Asymmetric dimethylarginine in the maternal and fetal circulation in preeclampsia. Pediatr Res 2009;66:411–15
  • Lyall F, Young A, Greer IA. Nitric oxide concentrations are increased in the fetoplacental circulation in preeclampsia. Am J Obstet Gynecol 1995;173:714–18
  • Chedraui P, Solis EJ, Bocci G, et al. Feto-placental nitric oxide, asymmetric dimethylarginine and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in severe preeclampsia. J Matern Fetal Neonatal Med 2013;26:226–32
  • Shaamash AH, Elsnosy ED, Makhlouf AM, et al. Maternal and fetal serum nitric oxide (NO) concentrations in normal pregnancy, pre-eclampsia and eclampsia. Int J Gynaecol Obstet 2000;68:207–14
  • Kanter M, Gurbuz H, Okman TK. Endothelial nitric oxide synthase immunreactivity and the ultrastructure of endothelial cells of umbilical artery in normal and preeclamptic pregnancies. Clin Exp Hypertens 2010;32:458–63
  • Salama RH, Fathalla MM, Mekki AR, Elsadek Bel K. Implication of umbilical cord in preeclampsia. Med Princ Pract 2011;20:124–8
  • Giannubilo SR, Menegazzi M, Tedeschi E, et al. Doppler analysis and placental nitric oxide synthase expression during fetal growth restriction. J Matern Fetal Neonatal Med 2008;21:617–22
  • Rossmanith WG, Hoffmeister U, Wolfahrt S, et al. Expression and functional analysis of endothelial nitric oxide synthase (eNOS) in human placenta. Mol Hum Reprod 1999;5:487–94
  • Vedmedovska N, Rezeberga D, Teibe U, et al. Microscopic lesions of placenta and Doppler velocimetry related to fetal growth restriction. Arch Gynecol Obstet 2011;284:1087–93
  • Spinillo A, Gardella B, Bariselli S, et al. Placental histopathological correlates of umbilical artery Doppler velocimetry in pregnancies complicated by fetal growth restriction. Prenat Diagn 2012;32:1263–72
  • Beinder E, Mohaupt MG, Schlembach D, et al. Nitric oxide synthase activity and Doppler parameters in the fetoplacental and uteroplacental circulation in preeclampsia. Hypertens Pregnancy 1999;18:115–27
  • Tranquilli AL, Giannubilo SR, Tedeschi E, et al. Placental expression of nitric oxide synthase during HELLP syndrome: the correlation with maternal-fetal Doppler velocimetry. Acta Obstet Gynecol Scand 2005;84:849–53
  • Grunewald C, Kublickas M, Carlstrom K, et al. Effects of nitroglycerin on the uterine and umbilical circulation in severe preeclampsia. Obstet Gynecol 1995;86:600–4
  • Cacciatore B, Halmesmaki E, Kaaja R, et al. Effects of transdermal nitroglycerin on impedance to flow in the uterine, umbilical, and fetal middle cerebral arteries in pregnancies complicated by preeclampsia and intrauterine growth retardation. Am J Obstet Gynecol 1998;179:140–5
  • Lees C, Valensise H, Black R, et al. The efficacy and fetal-maternal cardiovascular effects of transdermal glyceryl trinitrate in the prophylaxis of pre-eclampsia and its complications: a randomized double-blind placebo-controlled trial. Ultrasound Obstet Gynecol 1998;12:334–8
  • Shesely EG, Gilbert C, Granderson G, et al. Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy. Am J Obstet Gynecol 2001;185:1198–203
  • Kusinski LC, Stanley JL, Dilworth MR, et al. eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype. Am J Physiol Regul Integr Comp Physiol 2012;303:R86–93
  • Xiao XM, Li LP. L-Arginine treatment for asymmetric fetal growth restriction. Int J Gynaecol Obstet 2005;88:15–18
  • Vosatka RJ, Hassoun PM, Harvey-Wilkes KB. Dietary L-arginine prevents fetal growth restriction in rats. Am J Obstet Gynecol 1998;178:242–6
  • Helmbrecht GD, Farhat GS. L-arginine reverses the adverse pregnancy changes induced by nitricoxide synthase inhibition in the rat. Am J Obstet Gynecol 1996;175:800–5
  • Kiechle FL, Malinski T. Nitric oxide. Biochemistry, pathophysiology, and detection. Am J Clin Pathol 1993;100:567–75
  • Kelm M, Feelisch M, Spahr R, et al. Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells. Biochem Biophys Res Commun 1988;154:236–44
  • Hamon I, Gauthier-Moulinier H, Grelet-Dessioux E, et al. Methaemoglobinaemia risk factors with inhaled nitric oxide therapy in newborn infants. Acta Paediatr 2010;99:1467–73

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.