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Review Article

The use of intravenous and inhaled magnesium sulphate in management of children with bronchial asthma

Pages 1809-1815 | Received 07 Nov 2012, Accepted 15 Dec 2013, Published online: 30 Jan 2014

References

  • Everhart RS, Koinis-Mitchell D, McQuaid EL, et al. Ethnic differences in caregiver quality of life in pediatric asthma. J Dev Behav Pediatr 2012;33:599–607
  • Lugogo NL, MacIntyre NR. Life-threatening asthma: pathophysiology and management. Respir Care 2008;53:726–35
  • Davies G, Paton JY, Beaton SJ, et al. Children admitted with acute wheeze/asthma during November 1998–2005: a national UK audit. Arch Dis Child 2008;93:952–8
  • Ozcan C, Toyran M, Civelek E, et al. Evaluation of respiratory viral pathogens in acute asthma exacerbations during childhood. J Asthma 2011;48:888–93
  • Martinez FD. Managing childhood asthma: challenge of preventing exacerbations. Pediatrics 2009;123:S146–50
  • Frieri M. New concepts in asthma pathophysiology. Curr Allergy Asthma Rep 2005;5:339–40
  • Pilotto LS, Smith BJ, Nitschke M, et al. Industry, air quality, cigarette smoke and rates of respiratory illness in Port Adelaide. Aust N Z J Public Health 1999;23:657–60
  • Anderson SD. Single-dose agents in the prevention of exercise-induced asthma: a descriptive review. Treat Respir Med 2004;3:365–79
  • Jenkins C, Costello J, Hodge L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. BMJ 2004;328:434–40
  • Rodrigo GJ, Neffen H, Colodenco FD, Castro-Rodriguez JA. Formoterol for acute asthma in the emergency department: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 2010;104:247–52
  • Saulnier F, Préau S, Onimus T, et al. Management of acute asthma management. Rev Mal Respir 2012;29:612–25
  • Reinhart R. Magnesium metabolism. Arch Intern Med 1988;148:2415–20
  • Saris NEL, Mervaala E, Karppanen H, et al. Magnesium: an update on physiological, clinical and analytical aspects. Clin Chim Acta 2000;294:1–26
  • Romani AM. Cellular magnesium homeostasis. Arch Biochem Biophys 2011;512:1–23
  • Altura BM, Altura BT, Carella A. Magnesium deficiency induced spasms of umbilical vessels: relation to preeclampsia, hypertension, growth retardation. Science 1983;221:376–8
  • Rowe BH, Camargo CA Jr. The role of magnesium sulfate in the acute and chronic management of asthma. Curr Opin Pulm Med 2008;14:70–6
  • Trendelenburg P. Physiologische and pharmakologische untersuchungen an der isolierten bronchial muskulatur. Archiv Experim Pathol Pharmakol 1912;69:79–107
  • Rosello HJ, Pla JC. Sulfato de magnesio en la crisis de asma. Prensa Med Argentina 1936;29:1677–80
  • Spivey WH, Skobeloff EM, Levin RM. Effect of magnesium chloride on rabbit bronchial smooth muscle. Ann Emerg Med 1990;19:1107–12
  • Gurkan F, Haspolat K, Bosnak M, et al. Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy. Eur J Emerg Med 1999;6:201–5
  • Zervas E, Papatheodorou G, Psathakis K, et al. Reduced intracellular Mg concentrations in patients with acute asthma. Chest 2003;123:113–18
  • Gontijo-Amaral C, Ribeiro MA, Gontijo LS, et al. Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial. Eur J Clin Nutr 2007;61:54–60
  • De Valk HM, Kok PTM, Sruyvenberg A, et al. Extracellular and intracellular magnesium concentrations in asthmatics patients. Eur Respir J 1993;6:1122–5
  • Haury VG. Blood serum magnesium in bronchial asthma and its treatment by the administration of magnesium sulphate. J Labor Clin Med 1940;26:340–4
  • Sinert R, Spektor M, Gorlin A, et al. Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium. Scand J Clin Lab Invest 2005;65:659–70
  • Getal HV. Blood serum magnesium in bronchial asthma and its treatment by administration of magnesium sulphate. J Lab Clin Med 1940;26:340–6
  • Skobeloff EM, Spivey WH, McNamara RM, Greenspon L. Intravenous magnesium sulphate for the treatment of acute asthma in the emergency department. JAMA 1989;262:1210–13
  • Nicklas RA. National and international guidelines for the diagnosis and treatment of asthma. Curr Opin Pulmonary Med 1997;3:51–5
  • Porter RS, Nester, Braitman LE, Geary U, Dalsey WC. Intravenous magnesium is ineffective in adult asthma, a randomized trial. Eur J Emerg Med 2001;8:9–15
  • Lougheed MD, Lemière C, Dell SD, et al. Canadian Thoracic Society Asthma Management Continuum – 2010 consensus summary for children six years of age and over, and adults. Can Respir J 2010;17:15–24
  • Alter HJ, Koepsell TD, Hilty WM. Intravenous magnesium as an adjuvant in acute bronchospasm: a meta-analysis. Ann Emerg Med 2000;36:191–7
  • Noppen M, Vanmaele L, Impens N, Schandevyl W. Bronchodilating effect of intravenous magnesium sulfate in acute severe bronchial asthma. Chest 1990;97:373–6
  • Silverman RA, Osborn H, Runge J, et al. IV magnesium sulfate in the treatment of acute severe asthma: a multicenter randomized controlled trial. Chest 2002;122:489–97
  • Singh AK, Gaur S, Kumar R. A randomized controlled trial of intravenous magnesium sulphate as an adjunct to standard therapy in acute severe asthma. Iran J Allergy Asthma Immunol 2008;7:221–9
  • Kowal A, Panaszek B, Barg W, Obojski A. The use of magnesium in bronchial asthma: a new approach to an old problem. Arch Immunol Ther Exp 2007;55:35–9
  • Schuh S, Zemek R, Plint A, et al. Magnesium use in asthma pharmacotherapy: a Pediatric Emergency Research Canada study. Pediatrics 2012;129:852–9
  • Bloch H, Silverman R, Mancherje N, et al. Intravenous magnesium sulfate as an adjunct in the treatment of acute asthma. Chest 1995;107:1576–81
  • Ciarallo L, Sauer AH, Shannon MW. Intravenous magnesium therapy for moderate to severe pediatric asthma: results of randomized, placebo-controlled trial. J Pediatrics 1996;129:809–14
  • Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous magnesium sulfate treatment for acute asthma in the emergency department: a systematic review of the literature. Ann Emerg Med 2000;36:181–90
  • Santana JC, Baretto SSM, Piva JP, Garcia PCR. Controlled study on intravenous magnesium sulfate or salbutamol in early treatment of severe acute asthma attack in children. J Pediatr (Rio J) 2001;77:279–87
  • Cheuk DK, Chau TC, Lee SL. A meta-analysis on intravenous magnesium sulphate for treating acute asthma. Arch Dis Child 2005;90:74–7
  • Torresa S, Sticcoa N, Boscha JJ, et al. Effectiveness of magnesium sulfate as initial treatment of acute severe asthma in children, conducted in a tertiary-level university hospital. A randomized, controlled trial. Arch Argent Pediatr 2012;110:291–6
  • Øymar K, Halvorsen T. Emergency presentation and management of acute severe asthma in children. Scand J Trauma. Res Emerg Med 2009;17:40–4
  • Jones LA, Goodacre S. Magnesium sulphate in the treatment of acute asthma: evaluation of current practice in adult emergency departments. Emerg Med J 2009;26:783–5
  • Li J. Sufficient dosing of intravenous magnesium for severe asthma. Ann Emerg Med 2001;37:552–3
  • Chande VT, Skoner DP. A trial of nebulized magnesium sulfate to reverse bronchospasm in asthmatic patients. Ann Emerg Med 1992;21:1111–15
  • Nannini LJJ, Pendino JC, Corna RA, et al. Magnesium sulfate as a vehicle for nebulized salbutamol in acute asthma. Am J Med 2000;108:193–7
  • Mangat HS, D'Souza GA, Jacob MS. Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma: a clinical trial. Eur Respir J 1998;12:341–4
  • Meral A, Coker M, Tanac R. Inhalation therapy with magnesium sulfate and salbutamol sulfate in bronchial asthma. Turk J Pediatr 1996;38:169–75
  • Mahajan P, Haritos D, Rosenberg N, Thomas R. Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma. J Emerg Med 2004;27:21–5
  • Coates AL, Leung K, Vecellio L, Schuh S. Testing of nebulizers for delivering magnesium sulfate to pediatric asthma patients in the emergency department. Respir Care 2011;56:314–18
  • Cairns CB, Kraft M. Magnesium attenuates the neutrophil respiratory burst in adult asthmatic patients. Acad Emerg Med 1996;3:1093–7
  • Mahajan P, Haritos D, Rosenberg N, Thomas R. Comparison of nebulized magnesium sulfate plus albuterol to nebulized albuterol plus saline in children with acute exacerbations of mild to moderate asthma. J Emerg Med 2004;27:21–5
  • Hughes R, Goldkorn A, Masoli M, et al. Use of isotonic nebulised magnesium sulfate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomised placebo-controlled trial. Lancet 2003;361:2114–17
  • Blitz M, Blitz S, Hughes R, et al. Aerosolized magnesium sulfate for acute asthma. A systematic review. Chest 2005;128:337–44
  • Wang XF, Hong JG. Management of severe asthma exacerbation in children. World J Pediatr 2011;7:293–301
  • Bessmertny O, DiGregorio RV, Cohen H, et al. A randomized clinical trial of nebulized magnesium sulfate in addition to albuterol in the treatment of acute mild-to-moderate asthma exacerbations in adults. Ann Emerg Med 2002;39:585–91
  • Aggarwal P, Sharad S, Handa R, et al. Comparison of nebulised magnesium sulphate and salbutamol combined with salbutamol alone in the treatment of acute bronchial asthma: a randomised study. Emerg Med J 2006;23:358–62
  • Zandsteeg AM, Hirmann P, Pasma HR, et al. Effect of MgSO4 on FEV1 in stable severe asthma patients with chronic airflow limitation. Magnes Res 2009;22:256–61
  • Villeneuve EJ, Zed PJ. Nebulized magnesium sulfate in the management of acute exacerbations of asthma. Ann Pharmacother 2006;40:1118–24
  • Mohammed S, Goodacre S. Intravenous and nebulised magnesium sulphate for acute asthma: systematic review and meta-analysis. Emerg Med J 2007;24:823–30
  • Green SM, Rothrock SG. Intravenous magnesium for acute asthma: failure to decrease emergency treatment duration or need for hospitalisation. Ann Emerg Med 1992;21:260–5
  • Hill JM, Britton J. Effect of intravenous magnesium sulphate on airway calibre and airway reactivity to histamine in asthmatic subjects. Br J Clin Pharmacol 1996;42:629–31
  • Rodrigo G, Rodrigo C. Early prediction of poor response of MgSO4 in acute asthma patients in the emergency department. Chest 1998;114:1016–21
  • Bernstein WK, Khastgir T, Khastgir A, et al. Lack of effectiveness of magnesium in chronic stable asthma. A prospective, randomized, double-blind, placebocontrolled, crossover trial in normal subjects and in patients with chronic stable asthma. Arch Intern Med 1995;155:271–6
  • Scarfone RJ, Loiselle JM, Joffe MD, et al. A randomized trial of magnesium in the emergency department treatment of children with asthma. Ann Emerg Med 2000;36:572–8
  • Schuh S, Macias C, Freedman S, et al. North American practice patterns of i.v. magnesium therapy in severe acute asthma in children. Acad Emerg Med 2010;17:1189–96
  • Boonyavorakul C, Thakkinstian A, Charoenpan P. Intravenous magnesium sulfate in acute severe asthma. Respiratory 2000;5:221–5
  • Aggarwal P, Sharad S, Handa R, et al. Comparison of nebulised magnesium sulphate and salbutamol combined with salbutamol alone in the treatment of acute bronchial asthma: a randomised study. Emerg Med J 2006;23:358--62
  • Kuitert LM, Kletchko SL. Intravenous magnesium sulfate in acute, life threatening asthma. Ann Emerg Med 1991;20:1243–5
  • Skorodin MS, Tenholder MF, Yetter B, et al. Magnesium sulfate in exacerbations of chronic obstructive pulmonary disease. Arch Intern Med 1995;155:496–500
  • Tiffany BR, Berk WA, Todd IK, et al. Magnesium bolus or infusion fails to improve expiratory flow in acute asthma exacerbations. Chest 1993;104:831–4
  • Greenberg S. Effect of prostacyclin and 9a, 11a-epoxymethanoprostaglandin H2 on calcium and magnesium fluxes and tension development in canine intralobar pulmonary arteries and veins. J Pharmacol Exp Ther 1981;219:326–37
  • Ransnas LA, Jasper JR, Leiber D, Insel PA. Beta adrenergic receptor-mediated dissociation and membrane release of the Gs protein in S49 lymphoma-cell membranes: dependence on Mg 2+ and GTP. Biochem J 1992;283:519–24
  • Dominguez LJ, Barbagallo M, Di-Lorenzo G, et al. Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma. Clin Sci 1998;95:137–42
  • Bois P. Effect of magnesium deficiency on mast cells and urinary histamine in rats. Br J Exp Pathol 1963;44:151–5
  • Wei W, Franz KB. A synergism of antigen challenge and severe magnesium deficiency on blood and urinary histamine levels in rats. J Am Coll Nutr 1990;9:616–22
  • Corbridge TC, Hall JB. The assessment and management of adults with status asthmaticus. Am J Respir Crit Care Med 1995;151:1296–316
  • Iseri LT, French JH. Magnesium: nature’s physiologic calcium blocker. Am Heart J 1984;108:188–93
  • Villeneuve EJ, Zed PJ. Nebulized magnesium sulfate in the management of acute exacerbations of asthma. Ann Pharmacother 2006;40:1118–24

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