Umbilical cord prostaglandins in term and preterm parturition

References

• Maddipati KR, Romero R, Chaiworapongsa T, et al. Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor. FASEB J 2014;28:4835–46
   PubMed Web of Science ®Google Scholar
• Karim SM. The role of prostaglandins in human parturition. Proc Royal Soc Med 1971;64:10–12
   PubMedGoogle Scholar
• Mitchell MD. Prostaglandins during pregnancy and the perinatal period. J Reprod Fertil 1981;62:305–15
   PubMedGoogle Scholar
• Romero R, Emamian M, Wan M, et al. Prostaglandin concentrations in amniotic fluid of women with intra-amniotic infection and preterm labor. Am J Obstet Gynecol 1987;157:1461–7
   PubMed Web of Science ®Google Scholar
• Romero R, Wu YK, Mazor M, et al. Amniotic fluid prostaglandin E2 in preterm labor. Prostaglandins Leukot Essent Fatty Acids 1988;34:141–5
   PubMed Web of Science ®Google Scholar
• Romero R, Wu YK, Sintori M, et al. Amniotic fluid concentrations of prostaglandin F2 alpha, 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) and 11-deoxy-13,14-dihydro-15-keto-11, 16-cyclo-prostaglandin E2 (PGEM-LL) in preterm labor. Prostaglandins 1989;37:149–61
   PubMed Web of Science ®Google Scholar
• Romero R, Baumann P, Gomez R, et al. The relationship between spontaneous rupture of membranes, labor, and microbial invasion of the amniotic cavity and amniotic fluid concentrations of prostaglandins and thromboxane B2 in term pregnancy. Am J Obstet Gynecol 1993;168:1654–64; discussion 1664–8
   PubMed Web of Science ®Google Scholar
• Romero R, Baumann P, Gonzalez R, et al. Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term. Am J Obstet Gynecol 1994;171:1613–20
   PubMed Web of Science ®Google Scholar
• Romero R, Gonzalez R, Baumann P, et al. Topographic differences in amniotic fluid concentrations of prostanoids in women in spontaneous labor at term. Prostaglandins Leukot Essent Fatty Acids 1994;50:97–104
   PubMed Web of Science ®Google Scholar
• Mitchell MD, Romero RJ, Edwin SS, et al. Prostaglandins and parturition. Reprod Fertil Dev 1995;7:623–32
   PubMed Web of Science ®Google Scholar
• Romero R, Munoz H, Gomez R, et al. Increase in prostaglandin bioavailability precedes the onset of human parturition. Prostaglandins Leukot Essent Fatty Acids 1996;54:187–91
   PubMed Web of Science ®Google Scholar
• Gibb W. The role of prostaglandins in human parturition. Ann Med 1998;30:235–41
   PubMed Web of Science ®Google Scholar
• Challis JR, Sloboda DM, Alfaidy N, et al. Prostaglandins and mechanisms of preterm birth. Reproduction 2002;124:1–17
   PubMed Web of Science ®Google Scholar
• Olson DM. The role of prostaglandins in the initiation of parturition. Best Pract Res Clin Obstet Gynaecol 2003;17:717–30
   PubMed Web of Science ®Google Scholar
• Challis JR, Bloomfield FH, Bocking AD, et al. Fetal signals and parturition. J Obstet Gynaecol Res 2005;31:492–9
   PubMed Web of Science ®Google Scholar
• Lee SE, Romero R, Park IS, et al. Amniotic fluid prostaglandin concentrations increase before the onset of spontaneous labor at term. J Matern Fetal Neonatal Med 2008;21:89–94
   PubMed Web of Science ®Google Scholar
• Mitchell MD, Chang MC, Chaiworapongsa T, et al. Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues. J Clin Endocrinol Metab 2005;90:4244–8
   PubMed Web of Science ®Google Scholar
• Vidaeff AC, Ramin SM. Potential biochemical events associated with initiation of labor. Curr Med Chem 2008;15:614–19
   PubMed Web of Science ®Google Scholar
• Sykes L, MacIntyre DA, Teoh TG, et al. Anti-inflammatory prostaglandins for the prevention of preterm labour. Reproduction 2014;148:R29–40
   PubMed Web of Science ®Google Scholar
• Kirton KT, Wyngarden LJ, Bergstrom KK. Prostaglandins and myometrial contractility. Adv Biosci 1973;9:651–5
   PubMedGoogle Scholar
• Novy MJ, Thomas CL, Lees MH. Uterine contractility and regional blood flow responses to oxytocin and prostaglandin E2 in pregnant rhesus monkeys. Am J Obstet Gynecol 1975;122:419–33
   PubMed Web of Science ®Google Scholar
• Wikland M, Lindblom B, Wilhelmsson L, et al. Oxytocin, prostaglandins, and contractility of the human uterus at term pregnancy. Acta Obstet Gynecol Scand 1982;61:467–72
   PubMed Web of Science ®Google Scholar
• Rydnert J, Joelsson I. Effect of the naturally occurring prostaglandins E2 and F2 alpha on the human myometrium in vivo during pregnancy. Acta Obstet Gynecol Scand 1985;64:577–82
   PubMed Web of Science ®Google Scholar
• Wiqvist N, Bryman I, Lindblom B, et al. The role of prostaglandins for the coordination of myometrial forces during labour. Acta Physiol Hung 1985;65:313–22
   PubMed Web of Science ®Google Scholar
• Asboth G, Phaneuf S, Lopez Bernal AL. Prostaglandin E receptors in myometrial cells. Acta Physiol Hung 1997;85:39–50
   PubMedGoogle Scholar
• Astle S, Thornton S, Slater DM. Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancy. Mol Hum Reprod 2005;11:279–87
   PubMed Web of Science ®Google Scholar
• Woodcock NA, Taylor CW, Thornton S. Prostaglandin F2alpha increases the sensitivity of the contractile proteins to Ca2+ in human myometrium. Am J Obstet Gynecol 2006;195:1404–6
   PubMed Web of Science ®Google Scholar
• Olson DM, Ammann C. Role of the prostaglandins in labour and prostaglandin receptor inhibitors in the prevention of preterm labour. Front Biosci 2007;12:1329–43
   PubMed Web of Science ®Google Scholar
• Hurd WW, Gibbs SG, Rudinsky KA. Differential regulation of myometrial prostaglandin production by changes in length. Am J Obstet Gynecol 2008;198:225 e221–4
   Web of Science ®Google Scholar
• Durn JH, Marshall KM, Farrar D, et al. Lipidomic analysis reveals prostanoid profiles in human term pregnant myometrium. Prostaglandins Leukot Essent Fatty Acids 2010;82:21–6
   PubMed Web of Science ®Google Scholar
• Mittal P, Romero R, Tarca AL, et al. A molecular signature of an arrest of descent in human parturition. Am J Obstet Gynecol 2011;204:177 e115–33
   Web of Science ®Google Scholar
• Chiossi G, Costantine MM, Bytautiene E, et al. The effects of prostaglandin E1 and prostaglandin E2 on in vitro myometrial contractility and uterine structure. Am J Perinatol 2012;29:615–22
   PubMed Web of Science ®Google Scholar
• Arulkumaran S, Kandola MK, Hoffman B, et al. The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility. J Clin Endocrinol Metab 2012;97:489–98
   PubMed Web of Science ®Google Scholar
• Conde-Agudelo A, Nieto A, Rosas-Bermudez A, et al. Misoprostol to reduce intraoperative and postoperative hemorrhage during cesarean delivery: a systematic review and metaanalysis. Am J Obstet Gynecol 2013;209:40. e1–40. e17
   PubMed Web of Science ®Google Scholar
• Keirse MJ, Thiery M, Parewijck W, et al. Chronic stimulation of uterine prostaglandin synthesis during cervical ripening before the onset of labor. Prostaglandins 1983;25:671–82
   PubMed Web of Science ®Google Scholar
• Norman M, Ekman G, Malmstrom A. Prostaglandin E2-induced ripening of the human cervix involves changes in proteoglycan metabolism. Obstet Gynecol 1993;82:1013–20
   PubMed Web of Science ®Google Scholar
• Voss DH, Cumminsky KC, Cook VD, et al. Effect of three concentrations of intracervical prostaglandin E2 gel for cervical ripening. J Matern Fetal Med 1996;5:186–93
   PubMedGoogle Scholar
• Denison FC, Calder AA, Kelly RW. The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor. Am J Obstet Gynecol 1999;180:614–20
   PubMed Web of Science ®Google Scholar
• Wing DA, Ham D, Paul RH. A comparison of orally administered misoprostol with vaginally administered misoprostol for cervical ripening and labor induction. Am J Obstet Gynecol 1999;180:1155–60
   PubMed Web of Science ®Google Scholar
• Fujimoto T, Savani RC, Watari M, et al. Induction of the hyaluronic acid-binding protein, tumor necrosis factor-stimulated gene-6, in cervical smooth muscle cells by tumor necrosis factor-alpha and prostaglandin E(2). Am J Pathol 2002;160:1495–502
   PubMed Web of Science ®Google Scholar
• Ben-Aroya Z, Hallak M, Segal D, et al. Ripening of the uterine cervix in a post-cesarean parturient: prostaglandin E2 versus Foley catheter. J Matern Fetal Neonatal Med 2002;12:42–5
   PubMedGoogle Scholar
• Larmon JE, Magann EF, Dickerson GA, et al. Outpatient cervical ripening with prostaglandin E2 and estradiol. J Matern Fetal Neonatal Med 2002;11:113–17
   PubMedGoogle Scholar
• D'Aniello G, Bocchi C, Florio P, et al. Cervical ripening and induction of labor by prostaglandin E2: a comparison between intracervical gel and vaginal pessary. J Matern Fetal Neonatal Med 2003;14:158–62
   PubMedGoogle Scholar
• Chien EK, Macgregor C. Expression and regulation of the rat prostaglandin E2 receptor type 4 (EP4) in pregnant cervical tissue. Am J Obstet Gynecol 2003;189:1501–10
   PubMed Web of Science ®Google Scholar
• Yogev Y, Ben-Haroush A, Gilboa Y, et al. Induction of labor with vaginal prostaglandin E2. J Matern Fetal Neonatal Med 2003;14:30–4
   PubMedGoogle Scholar
• Garry D, Figueroa R, Kalish RB, et al. Randomized controlled trial of vaginal misoprostol versus dinoprostone vaginal insert for labor induction. J Matern Fetal Neonatal Med 2003;13:254–9
   PubMedGoogle Scholar
• Hertelendy F, Zakar T. Prostaglandins and the myometrium and cervix. Prostaglandins Leukot Essent Fatty Acids 2004;70:207–22
   PubMed Web of Science ®Google Scholar
• Crane JM, Delaney T, Butt KD, et al. Predictors of successful labor induction with oral or vaginal misoprostol. J Matern Fetal Neonatal Med 2004;15:319–23
   PubMedGoogle Scholar
• Tornblom SA, Patel FA, Bystrom B, et al. 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor. J Clin Endocrinol Metab 2004;89:2909–15
   PubMed Web of Science ®Google Scholar
• Word RA, Li XH, Hnat M, et al. Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts. Semin Reprod Med 2007;25:69–79
   PubMed Web of Science ®Google Scholar
• Ji H, Dailey TL, Long V, et al. Prostaglandin E2-regulated cervical ripening: analysis of proteoglycan expression in the rat cervix. Am J Obstet Gynecol 2008;198:536 e531–7
   Web of Science ®Google Scholar
• Timmons B, Akins M, Mahendroo M. Cervical remodeling during pregnancy and parturition. Trends Endocrinol Metab 2010;21:353–61
   PubMed Web of Science ®Google Scholar
• Mahendroo M. Cervical remodeling in term and preterm birth: insights from an animal model. Reproduction 2012;143:429–38
   PubMed Web of Science ®Google Scholar
• Favilli A, Acanfora MM, Bini V, et al. Single indication of labor induction with prostaglandins: is advanced maternal age a risk factor for cesarean section? A matched retrospective cohort study. J Matern Fetal Neonatal Med 2013;26:665–8
   PubMed Web of Science ®Google Scholar
• Haas J, Barzilay E, Chayen B, et al. Safety of labor induction with prostaglandin E2 in grandmultiparous women. J Matern Fetal Neonatal Med 2013;26:49–51
   PubMed Web of Science ®Google Scholar
• Melamed N, Yariv O, Hiersch L, et al. Labor induction with prostaglandin E2: characteristics of response and prediction of failure. J Matern Fetal Neonatal Med 2013;26:132–6
   PubMed Web of Science ®Google Scholar
• Timmons BC, Reese J, Socrate S, et al. Prostaglandins are essential for cervical ripening in LPS-mediated preterm birth but not term or antiprogestin-driven preterm ripening. Endocrinology 2014;155:287–98
   PubMed Web of Science ®Google Scholar
• Kishore AH, Owens D, Word RA. Prostaglandin E2 regulates its own inactivating enzyme, 15-PGDH, by EP2 receptor-mediated cervical cell-specific mechanisms. J Clin Endocrinol Metab 2014;99:1006–18
   PubMed Web of Science ®Google Scholar
• McLaren J, Taylor DJ, Bell SC. Prostaglandin E(2)-dependent production of latent matrix metalloproteinase-9 in cultures of human fetal membranes. Mol Hum Reprod 2000;6:1033–40
   PubMed Web of Science ®Google Scholar
• Ulug U, Goldman S, Ben-Shlomo I, et al. Matrix metalloproteinase (MMP)-2 and MMP-9 and their inhibitor, TIMP-1, in human term decidua and fetal membranes: the effect of prostaglandin F(2alpha) and indomethacin. Mol Hum Reprod 2001;7:1187–93
   PubMed Web of Science ®Google Scholar
• Menon R, Fortunato SJ. The role of matrix degrading enzymes and apoptosis in rupture of membranes. J Soc Gynecol Investig 2004;11:427–37
   PubMedGoogle Scholar
• Moore RM, Mansour JM, Redline RW, et al. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta 2006;27:1037–51
   PubMed Web of Science ®Google Scholar
• Oger S, Mehats C, Dallot E, et al. Evidence for a role of phosphodiesterase 4 in lipopolysaccharide-stimulated prostaglandin E2 production and matrix metalloproteinase-9 activity in human amniochorionic membranes. J Immunol 2005;174:8082–9
   PubMed Web of Science ®Google Scholar
• Makino S, Zaragoza DB, Mitchell BF, et al. Prostaglandin F2alpha and its receptor as activators of human decidua. Semin Reprod Med 2007;25:60–8
   PubMed Web of Science ®Google Scholar
• Lee SE, Park IS, Romero R, et al. Amniotic fluid prostaglandin F2 increases even in sterile amniotic fluid and is an independent predictor of impending delivery in preterm premature rupture of membranes. J Matern-Fetal Neonat Med 2009;22:880–6
   PubMed Web of Science ®Google Scholar
• Lee DC, Romero R, Kim JS, et al. Evidence for a spatial and temporal regulation of prostaglandin-endoperoxide synthase 2 expression in human amnion in term and preterm parturition. J Clin Endocrinol Metab 2010;95:E86–91
   PubMed Web of Science ®Google Scholar
• Rossi D, Pianta S, Magatti M, et al. Characterization of the conditioned medium from amniotic membrane cells: prostaglandins as key effectors of its immunomodulatory activity. PLoS One 2012;7:e46956
   PubMed Web of Science ®Google Scholar
• Alzamil HA, Pawade J, Fortier MA, et al. Expression of the prostaglandin F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm labor. Front Physiol 2014;5:272
   PubMed Web of Science ®Google Scholar
• Phillips RJ, Fortier MA, Lopez Bernal A. Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation. BMC Pregn Childbirth 2014;14:241
   PubMed Web of Science ®Google Scholar
• Menon R, Fortunato SJ, Yu J, et al. Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes. Placenta 2011;32:317–22
   PubMed Web of Science ®Google Scholar
• Dray F, Frydman R. Primary prostaglandins in amniotic fluid in pregnancy and spontaneous labor. Am J Obstet Gynecol 1976;126:13–19
   PubMed Web of Science ®Google Scholar
• Nieder J, Augustin W. Increase of prostaglandin E and F equivalents in amniotic fluid during late pregnancy and rapid PG F elevation after cervical dilatation. Prostagland Leukotr Med 1983;12:289–97
   PubMedGoogle Scholar
• Mazor M, Wiznitzer A, Maymon E, et al. Changes in amniotic fluid concentrations of prostaglandins E2 and F2 alpha in women with preterm labor. Isr J Med Sci 1990;26:425–8
   PubMedGoogle Scholar
• Romero R, Emamian M, Quintero R, et al. Amniotic fluid prostaglandin levels and intra-amniotic infections. Lancet 1986;1:1380
   PubMed Web of Science ®Google Scholar
• Lopez Bernal A, Hansell DJ, Canete Soler R, et al. Prostaglandins, chorioamnionitis and preterm labour. Br J Obstet Gynaecol 1987;94:1156–8
   PubMedGoogle Scholar
• Bry K, Hallman M. Prostaglandins, inflammation, and preterm labor. J Perinatol 1989;9:60–5
   PubMedGoogle Scholar
• Romero R, Wu YK, Mazor M, et al. Amniotic fluid arachidonate lipoxygenase metabolites in preterm labor. Prostaglandins Leukot Essent Fatty Acids 1989;36:69–75
   PubMed Web of Science ®Google Scholar
• Lamont RF, Anthony F, Myatt L, et al. Production of prostaglandin E2 by human amnion in vitro in response to addition of media conditioned by microorganisms associated with chorioamnionitis and preterm labor. Am J Obstet Gynecol 1990;162:819–25
   PubMed Web of Science ®Google Scholar
• Mitchell MD, Romero RJ, Avila C, et al. Prostaglandin production by amnion and decidual cells in response to bacterial products. Prostaglandins Leukot Essent Fatty Acids 1991;42:167–9
   PubMed Web of Science ®Google Scholar
• van Meir CA, Matthews SG, Keirse MJ, et al. 15-hydroxyprostaglandin dehydrogenase: implications in preterm labor with and without ascending infection. J Clin Endocrinol Metab 1997;82:969–76
   PubMed Web of Science ®Google Scholar
• Hsu CD, Meaddough E, Aversa K, et al. Dual roles of amniotic fluid nitric oxide and prostaglandin E2 in preterm labor with intra-amniotic infection. Am J Perinatol 1998;15:683–7
   PubMed Web of Science ®Google Scholar
• Romero R, Espinoza J, Goncalves LF, et al. Inflammation in preterm and term labour and delivery. Semin Fetal Neonatal Med 2006;11:317–26
   PubMed Web of Science ®Google Scholar
• Leaver HA, MacPherson HD, Hutchon DJ. Amniotic fluid prostaglandins F2 alpha and E2, measured at artificial rupture of the membranes, predict the subsequent progress of labour. Prostagland Leukotr Med 1987;28:237–42
   PubMedGoogle Scholar
• Menon R, Fortunato SJ, Milne GL, et al. Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. Obstet Gynecol 2011;118:121–34
   PubMed Web of Science ®Google Scholar
• Olson DM, Skinner K, Challis JR. Prostaglandin output in relation to parturition by cells dispersed from human intrauterine tissues. J Clin Endocrinol Metab 1983;57:694–9
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Anceschi MM, Bleasdale JE. Beta-adrenergic stimulation of prostaglandin production by human amnion tissue. Prostaglandins 1984;27:37–49
   PubMed Web of Science ®Google Scholar
• Teixeira FJ, Zakar T, Hirst JJ, et al. Prostaglandin endoperoxide-H synthase (PGHS) activity and immunoreactive PGHS-1 and PGHS-2 levels in human amnion throughout gestation, at term, and during labor. J Clin Endocrinol Metab 1994;78:1396–402
   PubMed Web of Science ®Google Scholar
• Hirst JJ, Teixeira FJ, Zakar T, et al. Prostaglandin H synthase-2 expression increases in human gestational tissues with spontaneous labour onset. Reprod Fertil Dev 1995;7:633–7
   PubMed Web of Science ®Google Scholar
• Gibb W, Sun M. Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua. J Endocrinol 1996;150:497–503
   PubMed Web of Science ®Google Scholar
• Fuentes A, Spaziani EP, O'Brien WF. The expression of cyclooxygenase-2 (COX-2) in amnion and decidua following spontaneous labor. Prostaglandins 1996;52:261–7
   PubMed Web of Science ®Google Scholar
• Brennand JE, Leask R, Kelly RW, et al. Mechanisms involved in the stimulatory effect of amniotic fluid on prostaglandin production by human fetal membranes. Prostaglandins Leukot Essent Fatty Acids 1998;58:369–75
   PubMed Web of Science ®Google Scholar
• Furuta I, Yamada H, Sagawa T, et al. Effects of inflammatory cytokines on prostaglandin E(2) production from human amnion cells cultured in serum-free condition. Gynecol Obstetr Investig 2000;49:93–7
   PubMed Web of Science ®Google Scholar
• Challis JRG, Matthews SG, Gibb W, et al. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 2000;21:514–50
   PubMed Web of Science ®Google Scholar
• Harirah H, Thota C, Wentz MJ, et al. Elevated expression of catechol-O-methyltransferase is associated with labor and increased prostaglandin E(2) production by human fetal membranes. Am J Obstet Gynecol 2009;201:496 e491–7
   Web of Science ®Google Scholar
• McCoshen JA, Tulloch HV, Johnson KA. Umbilical cord is the major source of prostaglandin E2 in the gestational sac during term labor. Am J Obstet Gynecol 1989;160:973–8
   PubMed Web of Science ®Google Scholar
• Benirschke K, Kaufmann P, Baergen R. Pathology of the human placenta. New York: Springer; 2006
   Google Scholar
• Han YM, Romero R, Kim JS, et al. Region-specific gene expression profiling: novel evidence for biological heterogeneity of the human amnion. Biol Reprod 2008;79:954–61
   PubMed Web of Science ®Google Scholar
• Marvin KW, Keelan JA, Eykholt RL, et al. Expression of angiogenic and neurotrophic factors in the human amnion and choriodecidua. Am J Obstet Gynecol 2002;187:728–34
   PubMed Web of Science ®Google Scholar
• Erez O, Romero R, Tarca AL, et al. Differential expression pattern of genes encoding for anti-microbial peptides in the fetal membranes of patients with spontaneous preterm labor and intact membranes and those with preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med 2009;22:1103–15
   PubMed Web of Science ®Google Scholar
• Kim SY, Romero R, Tarca AL, et al. miR-143 regulation of prostaglandin-endoperoxidase synthase 2 in the amnion: implications for human parturition at term. PLoS One 2011;6:e24131
   PubMed Web of Science ®Google Scholar
• Willman EA, Collins WP. The concentrations of prostaglandin E2 and prostaglandin F2alpha in tissues within the fetoplacental unit after spontaneous or induced labour. Br J Obstet Gynaecol 1976;83:786–9
   PubMedGoogle Scholar
• Willman EA, Collins WP. Distribution of prostaglandins E2 and F2 alpha within the foetoplacental unit throughout human pregnancy. J Endocrinol 1976;69:413–19
   PubMed Web of Science ®Google Scholar
• Siegel RJ, Villa LC, Fishbein MC. Immunohistochemical localization of 6-keto-prostaglandin F1 alpha and prostaglandin E2 in the human umbilical cord before and after labor. Lab Invest 1987;56:550–3
   PubMed Web of Science ®Google Scholar
• Pacora P, Chaiworapongsa T, Maymon E, et al. Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 2002;11:18–25
   PubMedGoogle Scholar
• Redline RW, Faye-Petersen O, Heller D, et al. Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 2003;6:435–48
   PubMed Web of Science ®Google Scholar
• Redline RW. Inflammatory responses in the placenta and umbilical cord. Semin Fetal Neonatal Med 2006;11:296–301
   PubMed Web of Science ®Google Scholar
• Mi Lee S, Romero R, Lee KA, et al. The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. J Matern Fetal Neonatal Med 2011;24:37–42
   PubMed Web of Science ®Google Scholar
• Kim SM, Romero R, Park JW, et al. The relationship between the intensity of intra-amniotic inflammation and the presence and severity of acute histologic chorioamnionitis in preterm gestation. J Matern Fetal Neonatal Med 2014. [Epub ahead of print]
   Web of Science ®Google Scholar
• Kim YM, Chaemsaithong P, Romero R, et al. Placental lesions associated with acute atherosis. J Matern Fetal Neonatal Med 2014. [Epub ahead of print]
   Web of Science ®Google Scholar
• Sibai BM, Ewell M, Levine RJ, et al. Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group. Am J Obstet Gynecol 1997;177:1003–10
   PubMed Web of Science ®Google Scholar
• Slater D, Berger L, Newton R, et al. The relative abundance of type 1 to type 2 cyclo-oxygenase mRNA in human amnion at term. Biochem Biophys Res Commun 1994;198:304–8
   PubMed Web of Science ®Google Scholar
• Slater DM, Berger LC, Newton R, et al. Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term. Am J Obstet Gynecol 1995;172:77–82
   PubMed Web of Science ®Google Scholar
• Hirst JJ, Teixeira FJ, Zakar T, et al. Prostaglandin endoperoxide-H synthase-1 and -2 messenger ribonucleic acid levels in human amnion with spontaneous labor onset. J Clin Endocrinol Metab 1995;80:517–23
   PubMed Web of Science ®Google Scholar
• Slater D, Dennes W, Sawdy R, et al. Expression of cyclo-oxygenase types-1 and -2 in human fetal membranes throughout pregnancy. J Mol Endocrinol 1999;22:125–30
   PubMed Web of Science ®Google Scholar
• Hillier SL, Martius J, Krohn M, et al. A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity. N Engl J Med 1988;319:972–8
   PubMed Web of Science ®Google Scholar
• Mueller-Heubach E, Rubinstein DN, Schwarz SS. Histologic chorioamnionitis and preterm delivery in different patient populations. Obstet Gynecol 1990;75:622–6
   PubMed Web of Science ®Google Scholar
• Romero R, Salafia CM, Athanassiadis AP, et al. The relationship between acute inflammatory lesions of the preterm placenta and amniotic fluid microbiology. Am J Obstet Gynecol 1992;166:1382–8
   PubMed Web of Science ®Google Scholar
• Hillier SL, Witkin SS, Krohn MA, et al. The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection. Obstet Gynecol 1993;81:941–8
   PubMed Web of Science ®Google Scholar
• Greig PC, Ernest JM, Teot L, et al. Amniotic fluid interleukin-6 levels correlate with histologic chorioamnionitis and amniotic fluid cultures in patients in premature labor with intact membranes. Am J Obstet Gynecol 1993;169:1035–44
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol 1998;179:1254–60
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Park JS, et al. The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 2000;183:1124–9
   PubMed Web of Science ®Google Scholar
• Williams MC, O'Brien WF, Nelson RN, et al. Histologic chorioamnionitis is associated with fetal growth restriction in term and preterm infants. Am J Obstet Gynecol 2000;183:1094–9
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Moon JB, et al. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2001;185:1130–6
   PubMed Web of Science ®Google Scholar
• Ustun C, Kocak I, Baris S, et al. Subclinical chorioamnionitis as an etiologic factor in preterm deliveries. Int J Gynaecol Obstet 2001;72:109–15
   PubMed Web of Science ®Google Scholar
• Romero R, Espinoza J, Chaiworapongsa T, et al. Infection and prematurity and the role of preventive strategies. Semin Neonatol 2002;7:259–74
   PubMedGoogle Scholar
• Goncalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002;8:3–13
   PubMedGoogle Scholar
• Shim SS, Romero R, Hong JS, et al. Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 2004;191:1339–45
   PubMed Web of Science ®Google Scholar
• Kim YM, Romero R, Chaiworapongsa T, et al. Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis. Am J Obstet Gynecol 2004;191:1346–55
   PubMed Web of Science ®Google Scholar
• De Paepe ME, Friedman RM, Gundogan F, et al. The histologic fetoplacental inflammatory response in fatal perinatal group B-streptococcus infection. J Perinatol 2004;24:441–5
   PubMedGoogle Scholar
• Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. BJOG 2006;113:17–42
   PubMed Web of Science ®Google Scholar
• Lee SE, Romero R, Kim CJ, et al. Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation. J Matern-Fetal Neonat Med 2006;19:693–7
   PubMed Web of Science ®Google Scholar
• Romero R, Gotsch F, Pineles B, et al. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr Rev 2007;65:S194–202
   PubMed Web of Science ®Google Scholar
• Romero R, Espinoza J, Goncalves LF, et al. The role of inflammation and infection in preterm birth. Semin Reprod Med 2007;25:21–39
   PubMed Web of Science ®Google Scholar
• Holzman C, Lin X, Senagore P, et al. Histologic chorioamnionitis and preterm delivery. Am J Epidemiol 2007;166:786–94
   PubMed Web of Science ®Google Scholar
• Seong HS, Lee SE, Kang JH, et al. The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor. Am J Obstet Gynecol 2008;199:375 e371–5
   Web of Science ®Google Scholar
• Romero R, Lockwood CJ. Pathogenesis of spontaneous preterm labor. In: Creasy RK, Resnik R, Iams JD, editors. Creasy and Resnik's maternal-fetal medicine: principles and practice. Philadelphia: Elsevierl 2009:521–43
   Google Scholar
• Kim MJ, Romero R, Gervasi MT, et al. Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection. Lab Invest 2009;89:924–36
   PubMed Web of Science ®Google Scholar
• DiGiulio DB, Romero R, Kusanovic JP, et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010;64:38–57
   PubMed Web of Science ®Google Scholar
• Park HS, Romero R, Lee SM, et al. Histologic chorioamnionitis is more common after spontaneous labor than after induced labor at term. Placenta 2010;31:792–5
   PubMed Web of Science ®Google Scholar
• Menon R, Taylor RN, Fortunato SJ. Chorioamnionitis–a complex pathophysiologic syndrome. Placenta 2010;31:113–20
   PubMed Web of Science ®Google Scholar
• Lee SM, Lee KA, Kim SM, et al. The risk of intra-amniotic infection, inflammation and histologic chorioamnionitis in term pregnant women with intact membranes and labor. Placenta 2011;32:516–21
   PubMed Web of Science ®Google Scholar
• Bersani I, Thomas W, Speer CP. Chorioamnionitis–the good or the evil for neonatal outcome? J Matern Fetal Neonatal Med 2012;25:12–16
   PubMed Web of Science ®Google Scholar
• Martinelli P, Sarno L, Maruotti GM, et al. Chorioamnionitis and prematurity: a critical review. J Matern Fetal Neonatal Med 2012;25:29–31
   PubMed Web of Science ®Google Scholar
• Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science 2014;345:760–5
   PubMed Web of Science ®Google Scholar
• Vajrychova M, Kacerovsky M, Tambor V, et al. Microbial invasion and histological chorioamnionitis upregulate neutrophil-gelatinase associated lipocalin in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2014. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Combs CA, Gravett M, Garite TJ, et al. Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes. Am J Obstet Gynecol 2014;210:125 e121–25 e115
   Web of Science ®Google Scholar
• Kacerovsky M, Musilova I, Andrys C, et al. Prelabor rupture of membranes between 34 and 37 weeks: the intraamniotic inflammatory response and neonatal outcomes. Am J Obstet Gynecol 2014;210:325 e321–25 e310
   Web of Science ®Google Scholar
• Kacerovsky M, Musilova I, Hornychova H, et al. Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes. Am J Obstet Gynecol 2014;211:385 e381–9
   Web of Science ®Google Scholar
• Gomez R, Romero R, Ghezzi F, et al. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194–202
   PubMed Web of Science ®Google Scholar
• Romero R, Gomez R, Ghezzi F, et al. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol 1998;179:186–93
   PubMed Web of Science ®Google Scholar
• Gotsch F, Romero R, Kusanovic JP, et al. The fetal inflammatory response syndrome. Clin Obstet Gynecol 2007;50:652–83
   PubMed Web of Science ®Google Scholar
• Madsen-Bouterse SA, Romero R, Tarca AL, et al. The transcriptome of the fetal inflammatory response syndrome. Am J Reprod Immunol 2010;63:73–92
   PubMed Web of Science ®Google Scholar
• Romero R, Savasan ZA, Chaiworapongsa T, et al. Hematologic profile of the fetus with systemic inflammatory response syndrome. J Perinat Med 2011;40:19–32
   PubMed Web of Science ®Google Scholar
• Chaiworapongsa T, Romero R, Berry SM, et al. The role of granulocyte colony-stimulating factor in the neutrophilia observed in the fetal inflammatory response syndrome. J Perinat Med 2011;39:653–66
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Cobo T, Andrys C, et al. The fetal inflammatory response in subgroups of women with preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med 2013;26:795–801
   PubMed Web of Science ®Google Scholar
• Hofer N, Kothari R, Morris N, et al. The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates. Am J Obstet Gynecol 2013;209:542 e541–42 e511
   Web of Science ®Google Scholar
• Baracos V, Rodemann HP, Dinarello CA, et al. Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever. N Engl J Med 1983;308:553–8
   PubMed Web of Science ®Google Scholar
• Huribal M, Cunningham ME, D'Aiuto ML, et al. Endothelin-1 and prostaglandin E2 levels increase in patients with burns. J Am Coll Surg 1995;180:318–22
   PubMed Web of Science ®Google Scholar
• Haupt W, Fritzsche H, Hohenberger W, et al. Selective cytokine release induced by serum and separated plasma from septic patients. Eur J Surg 1996;162:769–76
   PubMedGoogle Scholar
• Hahn EL, Clancy KD, Tai HH, et al. Prostaglandin E2 alterations during sepsis are partially mediated by endotoxin-induced inhibition of prostaglandin 15-hydroxydehydrogenase. J Trauma 1998;44:777–81; discussion 781–2
   PubMedGoogle Scholar
• Brogliato AR, Antunes CA, Carvalho RS, et al. Ketoprofen impairs immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2. Shock 2012;38:620–9
   PubMed Web of Science ®Google Scholar
• Kwiatkoski M, Soriano RN, Araujo RM, et al. Hydrogen sulfide inhibits preoptic prostaglandin E2 production during endotoxemia. Exp Neurol 2013;240:88–95
   PubMed Web of Science ®Google Scholar
• Kawano M, Mori N. Prostacyclin producing activity of human umbilical, placental and uterine vessels. Prostaglandins 1983;26:645–62
   PubMed Web of Science ®Google Scholar
• Monuszko E, Halevy S, Freese KJ, et al. Umbilical vessels endothelium and vascular reactivity. Microcirc Endothelium Lymphatics 1990;6:183–208
   PubMedGoogle Scholar
• Scalera F. Intracellular glutathione and lipid peroxide availability and the secretion of vasoactive substances by human umbilical vein endothelial cells after incubation with TNF-alpha. Eur J Clin Investig 2003;33:176–82
   PubMed Web of Science ®Google Scholar
• Daray FM, Minvielle AI, Puppo S, et al. Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein. Eur J Pharmacol 2004;499:189–95
   PubMed Web of Science ®Google Scholar
• Errasti AE, del-Rey G, Cesio CE, et al. Expression and functional evidence of the prostaglandin F2alpha receptor mediating contraction in human umbilical vein. Euro J Pharmacol 2009;610:68–74
   PubMed Web of Science ®Google Scholar
• Topal G, Foudi N, Uydes-Dogan BS, et al. Involvement of prostaglandin F2alpha in preeclamptic human umbilical vein vasospasm: a role of prostaglandin F and thromboxane A2 receptors. J Hypertens 2010;28:2438–45
   PubMed Web of Science ®Google Scholar
• Kim SR, Bae SK, Park HJ, et al. Thromboxane A(2) increases endothelial permeability through upregulation of interleukin-8. Biochem Biophys Res Commun 2010;397:413–19
   PubMed Web of Science ®Google Scholar