Energy Metabolism Derangement of the Hepatic Tissue Following Severe Iron Restriction to Rats and its Recovery by Iron Therapy

References

• Dallman P. R., Beutler E., Finch C. A. Annotation: effects of iron deficiency exclusive of anemia. Br. J. Haematol 1978; 40: 179
   PubMed Web of Science ®Google Scholar
• Dallman P. R. Tissue effects of iron deficiency. Iron in Biochemistry and Medicine, A. Jacobs, W. Worwood. Academic Press, New York 1974; 437–475
   Google Scholar
• Dallman P. R. Manifestations of iron deficiency. Semin. Hematol 1982; 19: 19–30
   PubMed Web of Science ®Google Scholar
• Bacon B. R., Tavill A. S. Role of the liver in normal iron metabolism, in Seminars in Liver Disease – Metals and the Liver, P. D. Berk. Thieme-Strat-ton, New York 1984; 181–192
   Google Scholar
• Finch C. A., Miller L. R., Inamdar A. R., Person R., Seiler K., Mack-Ler B. Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction. J. Clin. Invest 1976; 58: 447–453
   PubMed Web of Science ®Google Scholar
• Goodman J. R., Warshaw J. B., Dallman P. R. Cardiac hypertrophy in rats with iron and copper deficiency: quantitative contribution of mitochondrial enlargement. Pediat. Res 1970; 4: 244–256
   PubMed Web of Science ®Google Scholar
• Dallman P. R., Goodman J. R. The effect of iron deficiency on the hepatocyte: a biochemical and ultrastructural study. J. Cell Biol 1971; 48: 79–90
   PubMed Web of Science ®Google Scholar
• Salmon H. A. The cytochrome c content of the heart, kidney, liver and skeletal muscle of iron deficient rats, J. Physiol 1962; 164: 17–30
   Web of Science ®Google Scholar
• Dallman P. R., Schwartz B. C. Distribution of cytochrome c and myoglobin in rats with dietary iron deficiency. Pediatrics 1965; 35: 677–686
   PubMed Web of Science ®Google Scholar
• McKay R. H., Higuchi D. A., Winder W. W., Fell R. D., Brown E. B. Tissue effects of iron deficiency in the rat. Biochim. Biophys. Acta 1983; 757: 352–358
   PubMed Web of Science ®Google Scholar
• Maguire J. J., Davies K. J. A., Dallman P. R., Packer L. Effect of dietary iron deficiency on iron-sulfur proteins and bioenergetic functions of skeletal muscle mitochondria. Biochim. Biophys. Acta 1982; 679: 210–220
   PubMed Web of Science ®Google Scholar
• Wohlrab H., Jacobs E. E. Copper-deficient mitochondria electron transport and oxidative phosphorylation. Biochem. Biophys. Res. Commun 1967; 28: 998–1002
   PubMed Web of Science ®Google Scholar
• Bailey-Wood R., Blayney L. M., Muir J. R., Jacobs A. The effects of iron deficiency on rat liver enzymes. Br. J. Exp. Pathol 1975; 56: 193–198
   PubMed Web of Science ®Google Scholar
• Evans T. C., Mackler B. Effect of iron deficiency on energy conservation in rat liver and skeletal muscle submitochondrial particles. Biochem. Med 1985; 34: 93–99
   PubMed Web of Science ®Google Scholar
• Masini A., Ceccarelli D., Muscatello U. The effect of oligomycin on rat liver mitochondria respiring in state 4. FEBS Lett 1984; 160: 137–140
   Web of Science ®Google Scholar
• Lowry O. H., Rosebrought N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. Biol. Chem 1951; 193: 265–275
   Web of Science ®Google Scholar
• Masini A., Ceccarelli D., Trenti T., Ventura E. Transmembrane potential of liver mitochondria from hexachlorobenzene and iron treated rats. Biochim. Biophys. Acta 1984; 802: 253–258
   PubMed Web of Science ®Google Scholar
• Folch J., Lees M., Sloane-Stanley G. H. A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem 1957; 226: 497–509
   Web of Science ®Google Scholar
• Chiang S. P., Gessert C. F., Lowrly O. H. Colorimetric determination of lipids: an adaptation for micrograms amounts obtained from cerumen. Curr. List Med. Lit. Res. Rep., Air University School of Aviation Medicine, USAF, Texas 1957; 33: 56–113
   Google Scholar
• Lotscher H. R., Winterhalter K. H., Carafoli E., Richter C. The energy-state of mitochondria during the transport of Ca2+. Eur. Biochem J 1980; 110: 211–216
   PubMedGoogle Scholar
• Chance B., Williams G. R. The respiratory chain and oxidative phosphorylation. Adv. Enzymol 1956; 17: 65–69
   PubMedGoogle Scholar
• Ceccarelli D., Predieri G., Muscatello U., Masini A. A 31P-NMR study on the energy state of rat liver in an experimental model of chronic dietary iron overload. Biochem. Biophys. Res. Commun 1991; 176: 1262–1268
   PubMed Web of Science ®Google Scholar
• Rottemberg H. Uncoupling of oxidative phosphorylation in rat liver mitochondria by general anesthetics. J. Natl. Acad. Sci. USA 1983; 80: 3313
   PubMed Web of Science ®Google Scholar
• Bakker E. P., Van Den Heuveland E. J., Van Dam K. The binding of uncouplers of oxidative phosphorylation to rat-liver mitochondria, Biochim. Biophys. Acta 1974; 333: 12–21
   PubMed Web of Science ®Google Scholar
• Scherphof G. L., Scarpa A., Van Toorenenbergen A. The effect of local anesthetics on the hydrolysis of free and membrane-bound phospholipids catalyzed by various phospholypases, Biochim. Biophys. Acta 1972; 270: 226–240
   PubMed Web of Science ®Google Scholar
• Battelli D., Bellei M., Arrigoni-Martelli E., Muscatello U., Bobyleva V. Interaction of carnitine with mitochondrial cardiolipin, Biochem. Biophys. Acta 1992; 1117: 33–36
   PubMed Web of Science ®Google Scholar
• Pfeiffer D. R., Schmid P. C, Beatrice M. C, Schmid H. H. O. Intra-mitochondrial phospholipase activity and the effects of Ca2+ plus N-ethylmale-imide on mitochondrial function, J. Biol. Chem 1979; 254: 11485–11494
   Google Scholar
• Sherman A. R., Guthrie H. A., Wolinsky I., Zulak I. M. Iron-deficiency hyperlipidemia in 18-day-old rat pups. Effect of milk lipids, lipoprotein lipase and triglyceride synthesis. J. Nutr 1978; 108: 152–162
   PubMed Web of Science ®Google Scholar
• Rothenbacker H., Sherman A. R. Target organ pathology in iron-deficient suckling rats. J. Nutr 1980; 110: 1648–1654
   PubMed Web of Science ®Google Scholar
• Sherman A. R., Bartholmey S. J., Perkins E. G. Fatty acid patterns in iron deficient maternal and neonatal rats. Lipids 1982; 17: 639–643
   PubMed Web of Science ®Google Scholar
• Bartholmey S. J., Sherman A. R. Carnitine levels in iron-deficient rat pups. J. Nutr 1985; 115: 138–145
   PubMed Web of Science ®Google Scholar
• Liguori L. Iron protein succinylate in the treatment of iron deficiency. Controlled, double blind, multicenter clinical trial on over 1,000 patients. Int. J. Clin. Pharmacol. Ther. Toxicol 1993; 31: 105–123
   Google Scholar
• Cremonesi P., Caramazza I. Chemical and biological characterization of iron-protein succinylate (ITF 282). Int. J. Clin. Pharmacol. Ther. Toxicol 1993; 31: 40–51
   PubMedGoogle Scholar
• Sympson R. J., Raja K. B., Peruzzi M., Cremonesi P. Absorption of iron from iron succinyl-protein complexes by mouse small intestine. J. Pharm. Pharmacol 1991; 43: 388–391
   PubMed Web of Science ®Google Scholar
• Caramazza I., Cremonesi P., Forster R., Del Soldato P., D'Angelo L., De Ponti F., Crema A. Effects of iron compounds on the gastroenteric tract: comparison of ferrous sulfate with iron-succinyl-albumun (ITF 1096). Pharmacol. Res 1990; 22: 87
   Google Scholar
• Scrimshaw N. S. Iron deficiency. Sci. Am 1991; 10: 24–30
   Google Scholar
• Bartholmey S. J., Sherman A. R. Impaired ketogenesis in iron-deficient rat pups. J. Nutr 1986; 116: 2180–2189
   PubMed Web of Science ®Google Scholar
• Gyulai L., Roth Z., Leigh J. S., Chance B. Bioenergetic studies of mitochondrial oxidative phosphorylation using 31-phosphorus NMR. J. Biol. Chem 1985; 260: 3947–3954
   PubMed Web of Science ®Google Scholar
• Weisenberg E., Halbreich A., Mager J. Biochemical lesions in copper-deficient rats caused by secondary iron deficiency. Biochem. J 1980; 188: 633–641
   PubMed Web of Science ®Google Scholar