Possible adverse effect of high δ-alpha-tocopherol intake on hepatic iron overload: Enhanced production of vitamin C and the genotoxin, 8-hydroxy-2′- deoxyguanosine

References

• Aebi H. 1984. Catalase in vitro. Methods Enzymol 105:121–126.
   PubMed Web of Science ®Google Scholar
• Asare GA, Kew MC, Mossanda KS, Paterson AC, Siziba K, Kahler-Venter PC. 2009. Effect of exogenous antioxidants on dietary iron overload. J Clin Biochem Nutr 44:85–94.
   PubMed Web of Science ®Google Scholar
• Asare GA, Mossanda KSA, Kew MC, Paterson AC, Kahler-Venter CP, Siziba K. 2006b. Hepatocellular carcinoma caused by iron overload: a possible mechanism of direct hepatocarcinogenicity. Toxicology 219:41–52.
   PubMed Web of Science ®Google Scholar
• Asare GA, Paterson AC, Kew MC, Khan S, Mossanda KSA. 2006a. Iron-free neoplastic nodules and hepatocellular carcinoma without cirrhosis in Wistar rats fed a diet high in iron. J Pathol 208:82–90.
   PubMed Web of Science ®Google Scholar
• ABTS. 1994. The alpha-tocopherol, beta carotene cancer prevention study group. The effect of vitamin E and beta carotene on the incidence of lung cancers in male smokers. N Engl J Med 330:1029–1035.
   PubMed Web of Science ®Google Scholar
• Bacon BR, Britton RS, Neill R. 1989. Effects of vitamin E deficiency on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload. Hepatology 9:398–404.
   Google Scholar
• Bacon BR, Tavill AS, Brittenham GM, Park CH, Recknagel RO. 1983. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 71:429–439.
   PubMed Web of Science ®Google Scholar
• Banudevi S, Krishnamoorthy G, Venkataraman P, Vignesh C, Aruldhas MM, Arunakaran J. 2006. Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food Chem Toxicol 44:2040–2046.
   PubMed Web of Science ®Google Scholar
• Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. 2007. Motality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297:842–857.
   PubMed Web of Science ®Google Scholar
• Bothwell TH, Seftel H, Jacobs P, Torrance JD, Baumslag N. 1964. Iron overload in Bantu subjects: studies on the availability of iron in Bantu beer. Am J Clin Nutr 14:47–51.
   PubMed Web of Science ®Google Scholar
• Britton RS, O’Neill R, Bacon BR. 1990. Hepatic mitochondrial malondialdehyde metabolism in rats with chronic iron overload. Hepatology 11:93–97.
   PubMed Web of Science ®Google Scholar
• Brown KE, Poulos JE, Li L, Soweid AM, Ramm GA, O’Neill R, Britton RS, Bacon BR. 1997. Effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload. Am J Physiol 272:G116–G123.
   PubMed Web of Science ®Google Scholar
• Cao G, Prior RL. 1999. Measurement of oxygen radical absorbance capacity in biological samples. Methods Enzymol 299:50–62.
   PubMed Web of Science ®Google Scholar
• Cheng WH, Valentine BA, Lei XG. 1999. High levels of dietary vitamin E do not replace cellular glutathione peroxidase (GPX1) in protecting mice from acute oxidative stress. J Nutr 129:1951–1957.
   PubMed Web of Science ®Google Scholar
• Damljanović I, Vukićević M, Radulović N, Palić R, Ellmerer E, Ratković Z, Joksović MD, Vukićević RD. 2009. Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit. Bioorg Med Chem Lett 19:1093–1096.
   PubMed Web of Science ®Google Scholar
• de Cabo R, Burgess JR, Navas P. 2006. Adaptations to oxidative stress induced by vitamin E deficiency in rat liver. J Bioenerg Biomembr 38:309–317.
   PubMed Web of Science ®Google Scholar
• Dey SK, Nayak P, Roy S. 2003. Alpha-tocopherol supplementation on chromium toxicity: a study on rat liver and kidney cell membrane. J Environ Sci (China) 15:356–359.
   PubMed Web of Science ®Google Scholar
• Dillard CJ, Downey JE, Tappel AL. 1984. Effect of antioxidants on lipid peroxidation in iron-loaded rats. Lipids 19:127–133.
   PubMed Web of Science ®Google Scholar
• Dresow B, Albert C, Zimmermann I, Nielsen P. 1995. Ethane exhalation and vitamin E/ubiquinol status as markers of lipid peroxidation in ferrocene iron-loaded rats. Hepatology 21:1099–1105.
   PubMed Web of Science ®Google Scholar
• Duarte TL, Jones GD. 2007. Vitamin C modulation of H2O2-induced damage and iron homeostasis in human cells. Free Radic BiolMed. 43:1165–1175.
   PubMed Web of Science ®Google Scholar
• Ertekin A, Deger Y, Mert H, Mert N, Yur F, Dede S, Demir H. 2007. Investigation of the effects of alpha-tocopherol on the levels of Fe, Cu, Zn, Mn, and carbonic anhydrase in rats with bleomycin-induced pulmonary fibrosis. Biol Trace Elem Res 116:289–300.
   PubMed Web of Science ®Google Scholar
• Flader D, Brandsch C, Hirche F, Eder K. 2003. Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. Int J Vit Nutr Res 73:275–283.
   PubMed Web of Science ®Google Scholar
• Galleano M, Puntarulo S. 1997. Dietary alpha-tocopherol supplementation on antioxidant defenses after in vivo iron overload in rats. Toxicology 124:73–81.
   PubMed Web of Science ®Google Scholar
• Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Sesso HD, Buring JE. 2009. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA 301:52–62.
   PubMed Web of Science ®Google Scholar
• Gordeuk VR. 2002. African iron overload. Semin Hematol 39:263–269.
   PubMed Web of Science ®Google Scholar
• Greenberg ER, Baron JA, Tosteson TD, Freeman DH Jr, Beck GJ, Bond JH, Colacchio TA, Coller JA, Frankl HD, Haile RW, Mandel JS, Nierenberg DW, Rothstein R, Snover DC, Stevens MM, Summers RW, van Stolk RU. 1994. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group. N Engl J Med 331:141–147.
   PubMed Web of Science ®Google Scholar
• Gumpricht E, Devereaux MW, Traber M, Sokol RJ. 2004. Enrichment of rat hepatic organelles by vitamin E administered subcutaneously. Free Radic Biol Med 37:1712–1717.
   PubMed Web of Science ®Google Scholar
• Hamilton IM, Gilmore WS, Benzie IF, Mulholland CW, Strain JJ. 2000. Interactions between vitamin C and E in human subjects. Br J Nutr 84:261–267.
   PubMed Web of Science ®Google Scholar
• Handelman GJ. 1997. High-dose vitamin supplements for cigarette smokers: caution is indicated. Nutr Rev 55:369–370.
   PubMed Web of Science ®Google Scholar
• Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, Jialal I, Johnston CS, Kelly FJ, Kraemer K, Packer L, Parthasarathy S, Sies H, Traber MG. 2005. Vitamins E and C are safe across a broad range of intakes. Am J Clin Nutr 81:736–745.
   PubMed Web of Science ®Google Scholar
• Hussain SP, Raja K, Amstad PA, Sawyer M, Trudel LJ, Wogan GN, Hofseth LJ, Shields PG, Billiar TR, Trautwein C, Hohler T, Galle PR, Phillips DH, Markin R, Marrogi AJ, Harris CC. 2000. Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer prone chronic inflammatory disease. Proc Natl Acad Sci USA 97:12770–12775.
   PubMed Web of Science ®Google Scholar
• Ibrahim W, Lee U-S, Yeh C-C, Szabo J, Bruckner G, Chow CK. 1997. Oxidative stress and antioxidant status in mouse liver: effects of dietary lipid, vitamin E and iron. J Nutr 127:1401–1406.
   PubMed Web of Science ®Google Scholar
• Ichiba M, Maeta Y, Mukoyama T, Saeki T, Yasui S, Kanbe T, Okano J, Tanabe Y, Hirooka Y, Yamada S, Kurimasa A, Murawaki Y, Shiota G. 2003. Expression of 8-hydroxy-2′- deoxyguanosine in chronic liver disease and hepatocellular carcinoma. Liver Int 23:338–345.
   PubMed Web of Science ®Google Scholar
• Inan C, Kilinç K, Kotiloğlu E, Akman HO, Kiliç I, Michl J. 1998. Antioxidant therapy of cobalt and vitamin E in hemosiderosis. J Lab Clin Med 132:157–165.
   PubMed Web of Science ®Google Scholar
• Kadirvel R, Sundaram K, Mani S, Samuel S, Elango N, Panneerselvam C. 2007. Supplementation of ascorbic acid and alpha-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats. Hum Exp Toxicol 26:939–946.
   PubMed Web of Science ®Google Scholar
• Kalender Y, Yel M, Kalender S. 2005. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats, the effects of vitamin E and Catechin. Toxicology 209:39–45.
   PubMed Web of Science ®Google Scholar
• Kew MC. 2009. Hepatic iron overload and hepatocellular carcinoma. Cancer Lett 286:38–43.
   PubMed Web of Science ®Google Scholar
• Kew MC, Asare GA. 2007. Dietary iron overload in the African and hepatocellular carcinoma. Liv Int 27:735–741.
   PubMed Web of Science ®Google Scholar
• Kovjazin R, Eldar T, Patya M, Vanichkin A, Lander HM, Novogrodsky A. 2003. Ferrocene-induced lymphocyte activation and anti-tumor activity is mediated by redox-sensitive signaling. FASEB J 17:467–469.
   PubMed Web of Science ®Google Scholar
• Lankin VZ, Ivanova MV, Konovalova GG, Tikhaze AK, Kaminnyi AI, Kukharchuk VV. 2007. Effect of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors and antioxidant vitamins on free radical lipid oxidation in rat liver. Bull Exp Biol Med 143:414–417.
   PubMed Web of Science ®Google Scholar
• Leppala JM, Virtamo J, Fogelholm R, Huttunen JK, Albanes D, Taylor PR, Heinonen OP. 2000. Controlled trial of alpha-tocopherol and beta-carotene supplements on stroke incidence and mortality in male smokers. Arterioscler Thromb Vasc Biol 20:230–235.
   PubMed Web of Science ®Google Scholar
• Long Y, Sun C, Wang C. 2003. Influences of iron overload on lipid peroxidation in rats and inhibiting effects of antioxidant vitamins. Wei Sheng Yan Jiu 32:209–211.
   PubMedGoogle Scholar
• Lonn E, Bosch J, Yusuf S, Sheridan P, Poque J, Arnold JM, Ross C, Arnold A, Sleight P, Probstfield J, Dagenais GR, HOPE and HOPE-TOO Trial Investigators. 2005. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 293:1338–1347.
   PubMed Web of Science ®Google Scholar
• Madinaveitia JL. 1965. Ferrocene as haematinics. Br J Pharmacol 24:352–359.
   Web of Science ®Google Scholar
• Mallory MA, Sthapanachai C, Kowdley KV. 2003. Iron overload related to excessive vitamin C intake. Ann Intern Med 139:532–533.
   PubMed Web of Science ®Google Scholar
• Mathew TC, Abdeen S, Dashti H, Mathew E, Al-Bader A. 2007. Effect of alpha-interferon and alpha-tocopherol in reversing hepatic cirrhosis in rats. Anat Histol Embryol 36:88–93.
   PubMed Web of Science ®Google Scholar
• Miller ER III, Pastor-Barrius R, Dalal D, Riemersma RA, Appel LJ, Guallar E. 2005. Mata-analysis: high-dosage vitamin E supplementation may increase all-cause of mortality. Ann Intern Med 142:37–46.
   PubMed Web of Science ®Google Scholar
• Nemmiche S, Chabane-Sari D, Guiraud P. 2007. Role of alpha-tocopherol in cadmium-induced oxidative stress in Wistar rat’s blood, liver and brain. Chem Biol Interact 170:221–230.
   PubMed Web of Science ®Google Scholar
• Niederau C, Fischer R, Sonnenberg A, Stremmel W, Trampisch, HAJ, Strohmeyer G. 1985. Survival and causes of death in cirrhotic and non-cirrhotic patients with primary hemochromatosis. N Engl J Med 313:1256–1262.
   PubMed Web of Science ®Google Scholar
• Nourooz-Zadeh J, Tajaddini-Sarmadi J, Wolff SP. 1994. Measurement of plasma hydroperoxide concentrations by ferrous oxidation-xylenol orange assay in conjunction with triphenyphosphine. Anal Biochem 220:403–409.
   PubMed Web of Science ®Google Scholar
• Omaye ST, Turnbull JD, Sauberlich HE. 1979. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol 62:3–11.
   PubMedGoogle Scholar
• Packer L. 1992. New horizons in vitamin E research-the vitamin E cycle, biochemistry and clinical applications. In: Ong ASH, Parker L, editors. Lipid-soluble antioxidants: Biochemistry and clinical applications. Molecular and cell biology updates. Basel, Switzerland: Birkhauser Verlag. pp 1–12.
   Google Scholar
• Parkin DM, Bray FI, Devesa SS. 2001. Cancer burden in the year 2000. The global picture. Eur J Cancer 37(Suppl 8):S4–S66.
   PubMed Web of Science ®Google Scholar
• Pietrangelo A, Rocchi E, Schiaffonati L, Ventura E, Cairo G. 1990. Liver gene expression during chronic dietary iron overload in rats. Hepatology 11:798–804.
   PubMed Web of Science ®Google Scholar
• Reeves PG, Nielsen FH, Fahey GC Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939–1951.
   PubMed Web of Science ®Google Scholar
• Ryter SW, Tyrrell RM. 2000. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med 28:289–309.
   PubMed Web of Science ®Google Scholar
• Salganik RI. 2001. The benefits and hazards of antioxidants: controlling apoptosis and other protective mechanisms in cancer patients and the human population. J Am Coll Nutr 5(Suppl):464S–475S.
   Google Scholar
• Salganik RI, Albright CD, Rodgers J, Kim J, Zeisel SH, Sivashinsky MS, Van Dyke TA. 2000. Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice. Carcinogenesis 21:909–914.
   PubMed Web of Science ®Google Scholar
• Tafazoli S, Spehar DD, O’Brien PJ. 2005. Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab Rev 37:311–325.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Fujitta N, Sugimoto R, Urawa N, Horiike S, Kobayashi R, Iwasa M, Ma N, Kawanishi S, Watanabe S, Kaito M, Takei Y. 2008. Hepatic oxidative DNA damage in association with increased risk for hepatocellular carcinoma in chronic hepatitis C. Br J Cancer 98:580–586.
   PubMed Web of Science ®Google Scholar
• Tector AJ, Olynyk JK, Britton RS, Janney CG, O’Neill R, Bacon BR. 1995. Hepatic mitochondrial oxidative metabolism and lipid peroxidation in iron-loaded rats fed ethanol. J Lab Clin Med 126:597–602.
   PubMed Web of Science ®Google Scholar
• Toyokuni S, Okamoto K, Yodoi J, Hiai H. 1995. Persistent oxidation stress in cancer. FEBS Lett 358:1–3.
   PubMed Web of Science ®Google Scholar
• Valerio LG Jr. 2007. Mammalian iron metabolism. Toxicol Mech Methods 17:497–517.
   PubMed Web of Science ®Google Scholar
• Valerio LG, Petersen DR. 2000. Characterization of hepatic iron overload following dietary administration of dicyclopentadienyl iron (ferrocene) to mice: cellular, biochemical and molecular aspects. Exp Mol Pathol 68:1–12.
   PubMed Web of Science ®Google Scholar
• Valls-Belles V, Torres MC, Boix L, Muñiz P, Gonzalez-Sanjose ML, Codoñer-Franch P. 2008. Alpha-tocopherol, MDA-HNE and 8-OHdG levels in liver and heart mitochondria of adriamycin-treated rats fed with alcohol-free beer. Toxicology 249:97–101.
   PubMed Web of Science ®Google Scholar
• Vatassery GT, Bauer T, Dysken M. 1999. High doses of vitamin E in the treatment of disorders of the central nervous system in the aged. Am J Clin Nutr 70:793–801.
   PubMed Web of Science ®Google Scholar
• Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. 2003. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomized trials. Lancet 361:2017–2023.
   PubMed Web of Science ®Google Scholar
• Williams R. 2006. Global challenges in liver disease. Hepatology 44:521–526.
   PubMed Web of Science ®Google Scholar
• Wong MC, Portmann B, Sherwood R, Niemela O, Koivisto H, Parkkila S, Trick K, L’abbe MR, Wilson J, Dash PR, Srirajaskanthan R, Preedy VR, Wiseman H. 2007. The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver. Metabolism 56:865–875.
   PubMed Web of Science ®Google Scholar
• Zaidi SM, Al-Qirim TM, Banu N. 2005. Effects of antioxidant vitamins on glutathione depletion peroxidation induced by restraint stress in the rat liver on. Drugs RD 6:157–165.
   PubMedGoogle Scholar