Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway

References

• Aimola P, Carmignani M, Volpe AR, et al. (2012). Cadmium induces p53-dependent apoptosis in human prostate epithelial cells. PLoS one 7:e33647
   PubMedGoogle Scholar
• Akbaş Y, Pata YS, Görür K, et al. (2003). The effect of l-carnitine on the prevention of experimentally induced myringosclerosis in rats. Hear Res 184:107–12
   PubMedGoogle Scholar
• Brama M, Politi L, Santini P, et al. (2012). Cadmium-induced apoptosis and necrosis in human osteoblasts: role of caspases and mitogen-activated protein kinases pathways. J Endocrinol Invest 35:198–208
   PubMed Web of Science ®Google Scholar
• Cannino G, Ferruggia E, Luparello C, Rinaldi AM. (2008). Effects of cadmium chloride on some mitochondria-related activity and gene expression of human MDA-MB231 breast tumor cells. J Inorg Biochem 102:1668–76
   Web of Science ®Google Scholar
• Chargui A, Zekri S, Jacquillet G, et al. (2011). Cadmium-induced autophagy in rat kidney: an early biomarker of subtoxic exposure. Toxicol Sci 121:31–42
   PubMed Web of Science ®Google Scholar
• Chiarelli R, Agnello M, Bosco L, Roccheri MC. (2014). Sea urchin embryos exposed to cadmium as an experimental model for studying the relationship between autophagy and apoptosis. Mar Environ Res 93:47–55
   PubMed Web of Science ®Google Scholar
• Dagda RK, Cherra SJ, Kulich SM, et al. (2009). Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 284:13843–55
   PubMed Web of Science ®Google Scholar
• Dong Z, Wang L, Xu J, et al. (2009). Promotion of autophagy and inhibition of apoptosis by low concentrations of cadmium in vascular endothelial cells. Toxicol In Vitro 23:105–10
   PubMed Web of Science ®Google Scholar
• Elmore SP, Qian T, Grissom SF, Lemasters JJ. (2001). The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J 15:2286–87
   PubMed Web of Science ®Google Scholar
• Ferraresi R, Troiano L, Roat E, et al. (2006). Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett 580:6612–16
   PubMedGoogle Scholar
• Frank M, Duvezin-Caubet S, Koob S, et al. (2012). Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. BBA-Mol Cell Res 1823:2297–310
   PubMed Web of Science ®Google Scholar
• Gobe G, Crane D. (2010). Mitochondria, reactive oxygen species and cadmium toxicity in the kidney. Toxicol Lett 198:49–55
   PubMed Web of Science ®Google Scholar
• Hawley TS, Hawley RG. (2004). Flow cytometry protocols. Totowa (NJ): Humana Press
   Google Scholar
• Joselin AP, Hewitt SJ, Callaghan SM, et al. (2012). ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Hum Mol Genet 21:4888–903
   PubMed Web of Science ®Google Scholar
• Karalija A, Novikova LN, Kingham PJ, et al. (2012). Neuroprotective effects of N-acetyl-cysteine and acetyl-l-carnitine after spinal cord injury in adult rats. PLoS One 7:e41086
   PubMed Web of Science ®Google Scholar
• Kim I, Rodriguez-Enriquez S, Lemasters JJ. (2007). Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 462:245–53
   PubMed Web of Science ®Google Scholar
• Kim Y, Park J, Kim S, et al. (2008). PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res 377:975–80
   PubMed Web of Science ®Google Scholar
• Lemasters JJ. (2005). Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuv Res 8:3–5
   PubMed Web of Science ®Google Scholar
• Luo YH, Wu SB, Wei YH, et al. (2013). Cadmium-based quantum dot induced autophagy formation for cell survival via oxidative stress. Chem Res Toxicol 26:662–73
   PubMed Web of Science ®Google Scholar
• Marianna H, Ming W, Tanmay SC, et al. (2013). ROS inhibitor N-acetyl-l-cysteine antagonizes the activity of proteasome inhibitors. Biochem J 454:201–8
   PubMedGoogle Scholar
• Matsuda N, Sato S, Shiba K, et al. (2010). PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189:211–21
   PubMed Web of Science ®Google Scholar
• Narendra DP, Jin SM, Tanaka A, et al. (2010). PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8:e1000298
   PubMed Web of Science ®Google Scholar
• Okamoto K, Kondo-Okamoto N, Ohsumi Y. (2009). Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell 17:87–97
   PubMed Web of Science ®Google Scholar
• Park SJ, Shin JH, Kim ES, et al. (2012). Mitochondrial fragmentation caused by phenanthroline promotes mitophagy. FEBS Lett 586:4303–10
   Google Scholar
• Pi H, Xu S, Zhang L, et al. (2013). Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium. Autophagy 9:1–21
   Google Scholar
• Qu K, Shen NY, Xu XS, et al. (2013). Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction. Acta Pharmacol Sin 34:1217–28
   PubMed Web of Science ®Google Scholar
• Rodriguez-Enriquez S, Kim I, Currin RT, Lemasters JJ. (2006). Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2:39–46
   PubMed Web of Science ®Google Scholar
• Sansanwal P, Yen B, Gahl WA, et al. (2010). Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis. J Am Soc Nephrol 21:272–83
   PubMed Web of Science ®Google Scholar
• Shih YL, Lin CJ, Hsu SW, et al. (2005). Cadmium toxicity toward caspase-independent apoptosis through the mitochondria-calcium pathway in mtDNA-depleted cells. Ann NY Acad Sci 1042:497–505
   PubMed Web of Science ®Google Scholar
• Son YO, Wang X, Hitron JA, et al. (2011). Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells. Toxicol Appl Pharmacol 255:287–96
   PubMedGoogle Scholar
• Waisberg M, Joseph P, Hale B, Beyersmann D. (2003). Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95–117
   PubMed Web of Science ®Google Scholar
• Wang SH, Shih YL, Ko WC, et al. (2008). Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway. Cell Mol Life Sci 65:3640–52
   PubMed Web of Science ®Google Scholar
• Wang X, Su B, Liu W, et al. (2011). DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson’s disease. Aging Cell 10:807–23
   PubMed Web of Science ®Google Scholar
• Wang Y, Nartiss Y, Steipe B, et al. (2012). ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy 8:1462–76
   PubMed Web of Science ®Google Scholar
• Yang LY, Wu KH, Chiu WT, et al. (2009). The cadmium-induced death of mesangial cells results in nephrotoxicity. Autophagy 5:571–72
   PubMed Web of Science ®Google Scholar