Localization of Urokinase Type Plasminogen Activator to Focal Adhesions Requires Ligation of Vitronectin Integrin Receptors

References

• Andreasen P., Kjoller L., Christensen L., Duffy M.J. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int. J. Cancer 1997; 72: 1–22
   PubMed Web of Science ®Google Scholar
• Brooks P.C., Stromblad S., Sanders L.C., Von Schalscha T.L., Aimes R.T., Stetler-Stevenson W.H., Quigley J.P., Cheresh D.A. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin avb3. Cell 1996; 85: 683–693
   PubMed Web of Science ®Google Scholar
• Bugge T.H., Lund L.R., Kobrinck K.K., Nielsen B.S., Holmback K., Drew A.F., Flick M.J., Witte D.P., Dano K., Degen J.L. Reduced metastasis of polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice. Oncogene 1998; 16: 3097–3104
   PubMed Web of Science ®Google Scholar
• Busso N., Masur S.K., Lazega D., Waxman S., Ossowski L. Induction of cell migration by prourokinase binding to its receptor: Possible mechanism for signal transduction in human epithelial cells. J. Cell Biol. 1994; 126: 259–270
   PubMed Web of Science ®Google Scholar
• Carmeliet P., Moons L., Lijnen R., Janssens S., Lupu F., Collen D., Gerard R.D. Inhibitory role of plasminogen activator inhibitor-I in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. Circulation 1997; 96: 3180–3191
   PubMed Web of Science ®Google Scholar
• Chakravortty D., Kumar K.S. Interaction of lipopolysaccharide with human small intestinal lamina propria fibroblasts favors neutrophil migration and peripheral blood mononuclear cell adhesion by the production of pro-inflammatory mediators and adhesion molecules. Biochim. Biophys. Acta 1999; 1453: 261–272
   PubMed Web of Science ®Google Scholar
• Cherny R.C., Honan M.A., Thiagarajan P. Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion. J. Bid. Chem. 1993; 268: 9725–9729
   PubMed Web of Science ®Google Scholar
• Ciambrone G.J., McKeown-Longo P.J. Vitronectin regulates the synthesis and localization of urokinase-type plasminogen activator in HT-1080 cells. J. Biol. Chem. 1992; 267: 13617–13622
   PubMed Web of Science ®Google Scholar
• Crossen R., Gruenwald S. Baculovirus Expression Vector System Manual. PharMingen, San Diego, CA
   Google Scholar
• Delannet M., Martin F., Bossy B., Cheresh D.A., Reichardt L.F., Duband J.L. Specific roles of the αvβ1, αvβ3 and αvβ5 integrins in avian neural crest cell adhesion and migration on vitronectin. Development 1994; 120: 2687–2702
   PubMed Web of Science ®Google Scholar
• Deng G., Curriden S.A., Wang S., Rosenberg S., Loskutoff D.J. Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?. J. Cell Bid. 1996; 134: 1563–1571
   PubMed Web of Science ®Google Scholar
• Deng G., Royle G., Seiffert D., Loskutoff D.J. The PAI-1 vitronectin interaction: Two cats in a bag?. Thromb. Haemost. 1995; 11: 66–10
   Google Scholar
• Deryugina E.I., Bourdon M.A., Luo G.X., Reisfeld R.A., Strongin A. Matrix metalloproteinase-2 activation modulates glioma cell migration. J. Cell Sci. 1997; 110: 2473–2482
   Web of Science ®Google Scholar
• Drake C.J., Cheresh D.A., Little C.D. An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization. J. Cell Sci. 1995; 108: 2655–2661
   PubMed Web of Science ®Google Scholar
• Frelinger A.L., III, Lam S.C., Plow E.F., Smith M.A., Loftus J.C., Ginsberg M.H. Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. J. Biol. Chem. 1988; 263: 12397–12402
   PubMed Web of Science ®Google Scholar
• Gladson C.L., Cheresh D.A. Glioblastoma expression of vitronectin and the αvβ3 integrin adhesion mechanism for transformed cells. J. Clin. Invest. 1991; 88: 1924–1932
   PubMed Web of Science ®Google Scholar
• Gladson C.L., Wilcox J.N., Sanders L., Gillespie G.Y., Cheresh D.A. Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J. Cell Sci. 1995; 108: 947–956
   PubMed Web of Science ®Google Scholar
• Goxe B., Flechon J.E., Delasalle S., Salesse R. RGD-mediated adhesion of porcine granulosa cells modulate their differentiation response to FSH. in vitro. Bid. Cell 1995; 83: 169–177
   Web of Science ®Google Scholar
• Hawley-Nelson P., Ciccarone V., Gebeyehu G., Jessee J. LipofectAMINE reagent: A new, higher efficiency polycationic liposome transfection reagent. Focus 1993; 15: 73–79
   Google Scholar
• Hocking D.C., Smith R.K., McKeown-Longo P.J. A novel role for the integrin-binding III-10 module in fibro-nectin matrix assembly. J. Cell Bid. 1996; 133: 431–444
   PubMed Web of Science ®Google Scholar
• Hocking D.C., Sottile J., Reho T., Fassler R., McKeown-Longo P.J. Inhibition of fibronectin matrix assembly by the heparin-binding domain of vitronectin. J. Bid. Chem. 1999; 274: 27257–27264
   PubMed Web of Science ®Google Scholar
• Johnsen M., Lund L.R., Romer J., Almholt K., Dano K. Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation. Curr. Opin. Cell Biol. 1998; 10: 667–671
   PubMed Web of Science ®Google Scholar
• Kanse S.M., Kost C., Wilhelm O.G., Andreasen P.A., Preissner K.T. The urokinase receptor is a major vitronectin-binding protein on endothelial cells. Exp. Cell Res. 1996; 224: 344–353
   PubMed Web of Science ®Google Scholar
• Konakova M., Hucho F., Schleuning W.D. Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction. Eur. J. Biochem. 1998; 253: 421–429
   PubMedGoogle Scholar
• Koshelnick Y., Ehart M., Hufnag P., Heinrich P.C., Binder B.R. Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598. J. Biol. Chem. 1997; 272
   PubMed Web of Science ®Google Scholar
• Lewis J.M., Cheresh D.A., Schwartz M.A. Protein kinase C regulates αvβ5 dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol. 1996; 134: 1323–1332
   PubMed Web of Science ®Google Scholar
• Mazzieri R., Masiero L., Zanetta L., Monea S., Onisto M., Garbisa S., Mignatti P. Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants. EMBO J. 1997; 16: 2319–2322
   PubMed Web of Science ®Google Scholar
• McKeown-Longo P.J., Mosher D.F. Interaction of the 70 kilodalton amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts. J. Cell Biol. 1985; 100: 364–374
   PubMed Web of Science ®Google Scholar
• McKeown-Longo P.J., Panetti T.S. Receptor mediated endocytosis of vitronectin by fibroblast monolayers. Biology of Vitronectins and their Receptors, K.T. Preissner, S. Rosenblatt, C. Kost, J. Wegerhoff, D.F. Mosher. Elsevier Science Publishers, B.V. 1993; 111–118
   Google Scholar
• Memmo L.M., McKeown-Longo P. The αvβ5 integrin functions as an endocytic receptor for vitronectin. J. Cell Sci. 1998; 111: 425–433
   PubMed Web of Science ®Google Scholar
• Moser T.L., Enghild J.J., Pizzo S.V., Stack M.S. Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells. Biochem. J. 1995; 307: 867–873
   PubMed Web of Science ®Google Scholar
• Mueller S.C., Ghersi G., Akiyama S.K., Sang Q.-X.A., Howard L., Pineiro-Sanchez M., Nakahara H., Yeh Y., Chen W.-T. A novel protease-docking function of integrin at invadopodia. J. Biol. Chem. 1999; 274: 24947–24952
   PubMed Web of Science ®Google Scholar
• Newham P., Craig S.E., Clark K., Mould A.P., Humphries M.J. Analysis of ligand-induced and ligand attenuated epitopes on the leukocyte integrin α4β1 VCAM-1, rnucosal addressin cell adhesion molecule-I, and fibronectin induce distinct conformational changes. J. Immunol. 1998; 160: 4508–4517
   PubMed Web of Science ®Google Scholar
• Nguyen D.H., Hussaini I.M., Gonias S.L. Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinases 1 and 2 which is required for increased cellular motility. J. Biol. Chem. 1998; 273: 8502–8507
   PubMed Web of Science ®Google Scholar
• Nguyen D.H.D., Catling A.D., Webb D.J., Sankovic M., Walker L.A., Somlyo A.V., Weber M.J., Gonias S.L. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J. Cell Biol. 1999; 146: 149–164
   PubMed Web of Science ®Google Scholar
• Oliver N., Newby R.F., Furcht L.T., Bourgeois S. Regulation of fibronectin biosynthesis by glucocorticoids in human fibrosarcoma cells and normal flbroblasts. Cell 1983; 33: 287–296
   PubMed Web of Science ®Google Scholar
• Panetti T.S., McKeown-Longo P.J. The αvβ5 integrin receptor regulates receptor-mediated endocytosis of vitronectin. J. Biol. Chem. 1993; 268: 11492–11495
   PubMed Web of Science ®Google Scholar
• Planus E., Barlovatz-Meimon G., Rogers R.A., Bonavaud S., Ingber D.E., Wang N. Binding of urokinase to plasminogen activator inhibitor type-1 mediates cell adhesion and spreading. J. Cell Sci. 1997; 110: 1091–1098
   PubMed Web of Science ®Google Scholar
• Plough M., Ronne E., Behrendt N., Jensen A.L., Blasi F., Dano K. Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J. Biol. Chem. 1991; 266: 1926–1933
   PubMed Web of Science ®Google Scholar
• Pollanen J., Saksela O., Salonen E.-M., Andreasen P., Nielsen L., Dano K., Vaheri A. Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells. J. Cell Biol. 1987; 104: 1085–1096
   PubMed Web of Science ®Google Scholar
• Preissner K.T., Potzsch B. Vessel wall-dependent metabolic pathways of the adhesive proteins, von-Willebrand-factor and vitronectin. Histol. Histopathol. 1995; 10: 239–251
   PubMed Web of Science ®Google Scholar
• Seiffert D., Ciambrone G., Wagner N.V., Binder B.R., Loskutoff D.J. The somatomedin B domain of vitronectin. J. Biol. Chem. 1994; 269: 2659–2666
   PubMed Web of Science ®Google Scholar
• Seiffert D., Geisterfer M., Gauldie J., Young E., Podor T.J. IL-6 stimulates vitronectin gene expression. in vivo. J. Immunol. 1995; 155: 3180–3185
   PubMed Web of Science ®Google Scholar
• Seiffert D., Iruela-Arispe M.L., Sage E.H., Loskutoff D.J. Distribution of vitronectin mRNA during murine development. Develop Dynamics 1995; 203: 71–79
   PubMed Web of Science ®Google Scholar
• Seiffert D., Loskutoff D.J. Type I plasminogen activator inhibitor induces multimerization of plasma vitronectin. J. Biol. Chem. 1996; 271
   Web of Science ®Google Scholar
• Seiffert D., Wagner N.N., Loskutoff D.J. Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor. J. Cell Biol. 1990; 111: 1283–1291
   PubMed Web of Science ®Google Scholar
• Simon D.I., Rao N.K., Xu H., Wei Y., Majdic O., Ronne E., Kobzik L., Chapman H.A. Mac-I (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 1996; 88: 3185–3194
   PubMed Web of Science ®Google Scholar
• Stetler-Stevenson W.G., Liotta L.A., Kleiner D.E. Extracellular matrix 6: role of matrix metalloproteinase in tumor invasion and metastasis. FASEB J. 1993; 7: 1434–1441
   PubMed Web of Science ®Google Scholar
• Stromblad S., Becker J.C., Yebra M., Brooks P.C., Cheresh D.A. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis. J. Clin. Invest. 1996; 98: 426–433
   PubMed Web of Science ®Google Scholar
• Tang H., Kerins D.M., Hao Q., Inagami T., Vaughan D.E. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J. Biol. Chem. 1998; 273: 18268–18272
   PubMed Web of Science ®Google Scholar
• Tomasini-Johansson N.R., Sundberg C., Lindmark G., Gailit J.O., Rubin K. Vitronectin in colorectal adenocarcinoma - synthesis by stromal cells in culture. Exp. Cell Res. 1994; 214: 303–312
   PubMed Web of Science ®Google Scholar
• Vogel B.E., Lee S.-J., Hildebrand A., Craig W., Pierschbacher M.D., Wong-Staal F., Ruoslahti E. A novel integrin specificity exemplified by binding of the a & integrin to the basic domain of the HIV Tat protein and vitronectin. J. Cell Biol. 1993; 121: 461–468
   PubMed Web of Science ®Google Scholar
• Waltz D.A., Chapman H.A. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J. Biol. Chem. 1994; 269
   Web of Science ®Google Scholar
• Waltz D.A., Natkin L.R., Fujita R.M., Wei Y., Chapman H.A. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J. Clin. Invest. 1997; 100: 58–67
   PubMed Web of Science ®Google Scholar
• Wei Y., Lukashev M., Simon D.I., Bodary S.C., Rosenberg S., Doyle M.V., Chapman H.A. Regulation of integrin function by the urokinase receptor. Science 1996; 273: 1551–1555
   PubMed Web of Science ®Google Scholar
• Wei Y., Waltz D.A., Rao N., Drummond R.J., Rosenberg S., Chapman H.A. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. Biol. Chem. 1994; 269: 32380–32388
   PubMed Web of Science ®Google Scholar
• Wei Y., Yang X., Liu Q., Wilkins J.A., Chapman H.A. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J. Cell Biol. 1999; 144: 1285–1294
   PubMed Web of Science ®Google Scholar
• Wilcox S.A., Reho T., Higgins P.J., Tominna-Sebald E., McKeown-Longo P.J. Localization of urokinase to focal adhesions by human fibrosarcoma cells synthesizing recombinant vitronectin. Biochem. Cell Biol. 1996; 74: 899–910
   PubMed Web of Science ®Google Scholar
• Xue W., Kindzelskii A.L., Todd R.F.I., Petty H.R. Physical association of complement receptor type 3 and urokinase type plasminogen activator receptor in neutrophil membranes. J. Immunol. 1994; 152: 4630–4640
   PubMed Web of Science ®Google Scholar
• Xue W., Mizukami I, Todd R.F., Petty H.R. Urokinase-type plasminogen activator receptors associate with β1 and β3 integrins of fibrosarcoma cells: dependence on extracellular matrix components. Cancer Res 1997; 57: 1682–1689
   PubMed Web of Science ®Google Scholar
• Yatohgo T., Izumi M., Kashiwagi H., Hayashi M. Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct. Funct. 1988; 13: 281–292
   PubMed Web of Science ®Google Scholar
• Yebra M., Filardo E.J., Bayna E.M., Kawahara E., Becker J.C., Cheresh D.A. Induction of carcinoma cell migration on vitronectin by NF-kB-dependent gene expression. Molec. Biol. Cell 1995; 6: 841–850
   PubMed Web of Science ®Google Scholar