Chimeras of the Integrin β Subunit Mid-Region Reveal Regions Required for Heterodimer Formation and for Activation

References

• Al-Shamkhani A., Law S. K.A. Expression of the HS2 epitope on the β2 subunit is dependent on its interaction with the α subunits of the leukocyte integrins LFA-1, Mac-1 and p150,95 and the presence of Ca2+. European Journal of Immunology 1998; 28: 3291–3300
   PubMed Web of Science ®Google Scholar
• Anderson D. C., Kishimoto T. K., Smith C. W. Leukocyte adhesion deficiency and other disorders of leukocyte adherence and motility. The Metabolic Basis of Inherited Diseases7th Edition, C.R. Shriver, A. L. Beaudet, W. S. SlyValle. McGraw-Hill, New York 1994; 3955–3994
   Google Scholar
• Andrew D., Shock A., Ball E., Ortlepp S., Bell J., Robinson M. KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD 18 and promotes both LFA-1- and CR3-dependent adhesion. The European Journal of Immunology 1993; 23: 2217–2222
   PubMed Web of Science ®Google Scholar
• Bajt M. L., Goodman T., McGuire S. L. β2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (αL/32. CD11a/CD18) and MAC-1 (αMβ2, CD11b/CD 18). The Journal of Biological Chemistry 1995; 270: 94–98
   PubMed Web of Science ®Google Scholar
• Bilsland C. A.G., Diamond M. S., Springer T. A. The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. The Journal of Immunology 1994; 152: 4582–4589
   PubMed Web of Science ®Google Scholar
• Bork P., Doerks T., Springer T. A., Snel B. Domains in plexins: Links to integrins and transcription factors. Trends in Biochemical Sciences 1999; 24: 261–263
   PubMed Web of Science ®Google Scholar
• Cai T. Q., Law S. K., Zhao H. R., Wright S. D. Reversible inactivation of purified leukocyte integrin CR3 (CD11b/CD18, αMβ2) by removal of divalent cations from a cryptic site. Cell Adhesion and Communication 1995; 3: 399–406
   PubMed Web of Science ®Google Scholar
• Douglass W. A., Hyland R. H., Buckley C. D., Al-Shamkhani A., Shaw J. M., Scarth S. L., Simmons D. L., Law S. K.A. The role of the cysteine-rich region of the β2 integrin subunit in the leukocyte function-associated antigen-1 (LFA-I, αLβ2, CD11a/CD18) heterodimer formation and ligand binding. FEBS Letters 1998; 440: 414–418
   PubMed Web of Science ®Google Scholar
• Dransfield I., Cabanas C., Craig A., Hogg N. Divalent cation regulation of the function of the leukocyte integrin LFA-1. The Journal of Cell Biology 1992; 116: 219–226
   PubMed Web of Science ®Google Scholar
• Dransfield I., Hogg N. Regulated expression of Mg2+binding epitope on leukocyte integrin α subunits. European Molecular Biology Organisation Journal 1989; 8: 3759–3765
   PubMed Web of Science ®Google Scholar
• Emsley J., King S. L., Bergelson J. M., Liddington R. C. Crystal structure of the I domain from integrin α2β1. The Journal of Biological Chemistry 1997; 272: 28512–28517
   PubMed Web of Science ®Google Scholar
• Goodman T. G., Bajt M. L. Identifying the putative metal ion-dependent adhesion site in the β2 (CD 18) sub-unit required for αLβ2 and αMβ2 ligand interactions. The Journal of Biological Chemistry 1996; 271: 23729–23736
   PubMed Web of Science ®Google Scholar
• Hogg N. CD11a workshop panel report. Leucocyte typing VI: White cell differentiation antigens, T.H. Kishimoto, A. von Kikutani, S. M. von dem Borne, D. Goyert Mason, M. Miyasaka, L. Moretta, K.S. Okumura, T. A. Shaw, K. Springer Sugamura, H. Zola, Garland, New York 1997; 355–357
   Google Scholar
• Huang C., Zang Q., Takagi J., Springer T. K. Structural and functional studies with antibodies to the integrin β2 subunit. A model for the I-Iike domain. The Journal of Biological Chemistry 2000; 275: 21514–21524
   PubMed Web of Science ®Google Scholar
• Humphries M. J. Integrin Structure. Biochemical Society Transactions 2000; 28: 311–340
   PubMed Web of Science ®Google Scholar
• Hynes R. O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992; 69: 11–25
   PubMed Web of Science ®Google Scholar
• Lee J. O., Bankston L. A., Arnaout M. A., Liddington R. C. Two conformations of the integrin A-domain (I-domain): a pathway for activation?. Structure 1995a; 3: 1333–1340
   PubMed Web of Science ®Google Scholar
• Lee J. O., Rieu P., Arnaout M. A., Liddington R. Crystal structure of the A domain from the α subunit of integrin CR3 (CD11b/CD18). Cell 1995b; 80: 631–638
   PubMed Web of Science ®Google Scholar
• Marlin S. D., Springer T. A. Purified intercellular adhesion molecule-1 (ICAM-I) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 1987; 51: 813–819
   PubMed Web of Science ®Google Scholar
• Mathew E. C., Shaw J. M., Bonilla F. A., Law S. K.A., Wright D. A. A novel point mutation in CD 18 causing expression of dysfunctional CD11/CD18 leucocyte integrins in a patient with leucocyte adhesion deficiency (LAD). Clinical and Experimental Immunology 2000; 121: 133–138
   PubMed Web of Science ®Google Scholar
• Michishita M., Videm V., Arnaout M. A. A novel divalent cation-binding site in the A domain of the β2 integrin CR3 (CD11b/CD 18) is essential for ligand binding. Cell 1993; 72: 857–867
   PubMed Web of Science ®Google Scholar
• Qu A., Leahy D. J. Crystal structure of the I-domain from the CD11a/CD18 (LFA-I, αLβ2) integrin. Proceedings of the National Academy of Science (USA 1995; 92: 10277–10281
   PubMed Web of Science ®Google Scholar
• Randi A. M., Hogg N. I domain of β2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1. Journal of Biological Chemistry 1994; 269: 12395–12398
   PubMed Web of Science ®Google Scholar
• Simmons D. L. Cloning cell surface molecules by transient expression in mammalian cells. Cellular Interactions in Development, D. Hartley. Oxford University Press, Oxford 1993; 93–128
   Google Scholar
• Springer T. A. Adhesion receptors of the immune system. Nature 1990; 346: 425–434
   PubMed Web of Science ®Google Scholar
• Springer T. A. Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain. Proceedings of the National Academy of Science (USA 1997; 94: 65–72
   PubMed Web of Science ®Google Scholar
• Stephens P., Romer J. T., Spitali M., Shock A., Ortlepp S., Figdor C. G., Robinson M. K. KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats. Cell Adhesion and Communication 1995; 3: 375–384
   PubMed Web of Science ®Google Scholar
• Tan S. M., Hyland R. H., Al-Shamkhani A., Douglass W. A., Shaw J. M., Law S. K.A. Effect of integrin β2 subunit truncations of LFA- (CD11a/CD18) and Mac-1 (CD11b/CD18) assembly, surface expression and function. The Journal of Immunology 2000; 165: 2574–2581
   PubMed Web of Science ®Google Scholar
• Tozer E. C., Liddington R. C., Sutcliffe M. J., Smeeton A. H., Loftus J. C. Ligand binding to integrin αIIbβ3 is dependent on a MIDAS-like domain in the β3 subunit. The Journal of Biological Chemistry 1996; 271: 1978–1984
   Google Scholar
• Tuckwell D. S., Humphries M. J. A structure prediction for the ligand-binding region of the integrin β subunit: Evidence for the presence of a von Willebrand factor A domain. FEBS Letters 1996; 400: 297–303
   Web of Science ®Google Scholar
• Tuckwell D. S., Reid K. B., Barnes M. J., Humphries M. J. The A-domain of integrin α2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif. European Journal of Biochemistry 1996; 241: 732–739
   PubMedGoogle Scholar
• Zang Q., Springer T. A. Amino acid residues in the PSI domain and cysteine-rich repeats of the β2 subunit that restrain activation of the integrin αXβ2. The Journal of Biological Chemistry 2001; 276: 6922–6929
   PubMed Web of Science ®Google Scholar
• Zang Q., Lu C., Huang C., Takagi J., Springer T. A. The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 β subunit contacts the a subunit β-propeller domain near β-sheet 3. The Journal of Biological Chemistry 2000; 275: 22202–22212
   PubMed Web of Science ®Google Scholar
• Zhou L., Lee D. H., Plescia J., Lau C. Y., Altieri D. C. Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain. The Journal of Biological Chemistry 1994; 269: 17075–17079
   PubMed Web of Science ®Google Scholar