681
Views
1
CrossRef citations to date
0
Altmetric
PERSPECTIVE

Unique Intracellular Trafficking Processes Associated With Neural Cell Adhesion Molecule and Its Intracellular Signaling

&
Pages 69-74 | Received 13 Oct 2010, Accepted 16 Dec 2010, Published online: 19 Jan 2011

REFERENCES

  • Arribas J, Borroto A (2002). Protein ectodomain shedding. Chem Rev. 102:4627–4638.
  • Beggs HE, Baragona SC, Hemperly JJ, Maness PF (1997). NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn). J Biol Chem. 272:8310–8319.
  • Berezin V (2009). Structure and Function of the Neural Cell Adhesion Molecule (NCAM). Advances in Experimental Medicineand Biology, Vol. 663. Springer Verlag, Berlin.
  • Bodrikov V, Leshchyns'ka I, Sytnyk V, Overvoorde J, den Hertog J, Schachner M (2005). RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation. J Cell Biol. 168:127–139.
  • Bodrikov V, Sytnyk V, Leshchyns'ka I, den Hertog J, Schachner M (2008). NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth. J Cell Biol. 182:1185–1200.
  • Castillo-Gómez E, Gómez-Climent MA, Varea E, Guirado R, Blasco-Ibáñez JM, Crespo C, Martínez-Guijarro FJ, Nácher J (2008). Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats. Exp Neurol. 214:97–111.
  • Caswell PT, Chan M, Lindsay AJ, McCaffrey MW, Boettiger D, Norman JC (2008). Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J Cell Biol. 183:143–155.
  • Cavallaro U, Niedermeyer J, Fuxa M, Christofori G (2001). N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nat Cell Biol. 3: 650–657.
  • de Diesbach MT, Cominelli A, N'Kuli F, Tyteca D, Courtoy PJ (2010). Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes. Exp Cell Res. 316:3239–3253.
  • Diestel S, Schaefer D, Cremer H, Schmitz B (2007). NCAM is ubiquitylated, endocytosed and recycled in neurons. J Cell Sci. 120:4035–4049.
  • Dikic I, Giordano S (2003). Negative receptor signalling. Curr Opin Cell Biol. 15:128–135.
  • Ditlevsen DK, Berezin V, Bock E (2007). Signalling pathways underlying neural cell adhesion molecule-mediated survival of dopaminergic neurons. Eur J Neurosci. 25:1678–1684.
  • Ditlevsen DK, Køhler LB, Pedersen MV, Risell M, Kolkova K, Meyer M, Berezin V, Bock E (2003). The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neuronal differentiation and survival. J Neurochem. 84:546–556.
  • Ditlevsen DK, Povlsen GK, Berezin V, Bock E (2008). NCAM-induced intracellular signaling revisited. J Neurosci Res. 86: 727–743.
  • Eswarakumar VP, Lax I, Schlessinger J (2005). Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16:139–149.
  • Eva R, Dassie E, Caswell PT, Dick G, ffrench-Constant C, Norman JC, Fawcett JW (2010). Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells. J Neurosci. 30:11654–11669.
  • Francavilla C, Cattaneo P, Berezin V, Bock E, Ami D, de Marco A, Christofori G, Cavallaro U (2009). The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking. J Cell Biol. 187:1101–1116.
  • Francavilla C, Loeffler S, Piccini D, Kren A, Christofori G, Cavallaro U (2007). Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor. J Cell Sci. 120:4388–4394.
  • Hansen RK, Christensen C, Korshunova I, Kriebel M, Burkarth N, Kiselyov VV, Olsen M, Ostergaard S, Holm A, Volkmer H, Walmod PS, Berezin V, Bock E (2007). Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway. J Neurochem. 103:1396–1407.
  • Hansen SMM, Køhler LB, Li S, Kiselyov V, Christensen C, Owczarek S, Bock E, Berezin V (2008). NCAM-derived peptides function as agonists for the fibroblast growth factor receptor. J Neurochem. 106:2030–2041.
  • Hildebrandt H, Mühlenhoff M, Gerardy-Schahn R (2010). Polysialylation of NCAM. Adv Exp Med Biol. 663:95–109.
  • Huovila APJ, Turner AJ, Pelto-Huikko M, Kärkkäinen I, Ortiz RM (2005). Shedding light on ADAM metalloproteinases. Trends Biochem Sci. 30:413–422.
  • Johannes L, Popoff V (2008). Tracing the retrograde route in protein trafficking. Cell. 135:1175–1187.
  • Kalus I, Bormann U, Mzoughi M, Schachner M, Kleene R (2006). Proteolytic cleavage of the neural cell adhesion molecule by ADAM17/TACE is involved in neurite outgrowth. J Neurochem. 98:78–88.
  • Kiryushko D, Kofoed T, Skladchikova G, Holm A, Berezin V, Bock E (2003). A synthetic peptide ligand of neural cell adhesion molecule (NCAM), C3d, promotes neuritogenesis and synaptogenesis and modulates presynaptic function in primary cultures of rat hippocampal neurons. J Biol Chem. 278:12325–12334.
  • Kiselyov VV, Skladchikova G, Hinsby AM, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Poulsen FM, Berezin V, Bock E (2003). Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure. 11:691–701.
  • Kleene R, Mzoughi M, Joshi G, Kalus I, Bormann U, Schulze C, Xiao MF, Dityatev A, Schachner M (2010). NCAM-induced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments. J Neurosci. 30:10784–10798.
  • Kolkova K, Novitskaya V, Pedersen N, Berezin V, Bock E (2000). Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. J Neurosci. 20:2238–2246.
  • Kos FJ, Chin CS (2002). Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56. Immunol Cell Biol. 80:364–369.
  • Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC (2001). Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol. 3:802–808.
  • Little EB, Edelman GM, Cunningham BA (1998). Palmitoylation of the cytoplasmic domain of the neural cell adhesion molecule N-CAM serves as an anchor to cellular membranes. Cell Adhes Commun. 6:415–430.
  • Lo HW, Ali-Seyed M, Wu Y, Bartholomeusz G, Hsu SC, Hung MC (2006). Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. J Cell Biochem. 98:1570–1583.
  • Maher PA (1996). Nuclear translocation of fibroblast growth factor (FGF) receptors in response to FGF-2. J Cell Biol. 134: 529–536.
  • Maness PF, Schachner M (2007). Neural recognition molecules of the immunoglobulin superfamily: Signaling transducers of axon guidance and neuronal migration. Nat Neurosci. 10: 19–26.
  • Medina M, Dotti CG (2003). RIPped out by presenilin-dependent gamma-secretase. Cell Signal. 15:829–841.
  • Mosesson Y, Mills GB, Yarden Y (2008). Derailed endocytosis: An emerging feature of cancer. Nat Rev Cancer. 8:835–850.
  • Muller PAJ, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH (2009). Mutant p53 drives invasion by promoting integrin recycling. Cell. 139:1327–1341.
  • Planque N (2006). Nuclear trafficking of secreted factors and cell-surface receptors: New pathways to regulate cell proliferation and differentiation, and involvement in cancers. Cell Commun Signal. 4:7.
  • Reilly JF, Maher PA (2001). Importin beta-mediated nuclear import of fibroblast growth factor receptor: Role in cell proliferation. J Cell Biol. 152:1307–1312.
  • Roepstorff K, Grandal MV, Henriksen L, Knudsen SLJ, Lerdrup M, Grøvdal L, Willumsen BM, van Deurs B (2009). Differential effects of EGFR ligands on endocytic sorting of the receptor. Traffic. 10:1115–1127.
  • Rønn LC, Doherty P, Holm A, Berezin V, Bock E (2000). Neurite outgrowth induced by a synthetic peptide ligand of neural cell adhesion molecule requires fibroblast growth factor receptor activation. J Neurochem. 75:665–671.
  • Sanchez-Heras E, Howell FV, Williams G, Doherty P (2006). The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule. J Biol Chem. 281:35208–35216.
  • Schmid RS, Maness PF (2008). L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth. Curr Opin Neurobiol. 18:245–250.
  • Stewart A, Ham C, Zachary I (2002). The focal adhesion kinase amino-terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-terminal domain. Biochem Biophys Res Commun. 299:62–73.
  • Tang BL, Ng EL (2009). Rabs and cancer cell motility. Cell Motil Cytoskeleton. 66:365–370.
  • Wang YN, Yamaguchi H, Hsu JM, Hung MC (2010). Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene. 29:3997–4006.
  • Williams EJ, Furness J, Walsh FS, Doherty P (1994). Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron. 13:583–594.
  • Williams EJ, Walsh FS, Doherty P (1994). The production of arachidonic acid can account for calcium channel activation in the second messenger pathway underlying neurite outgrowth stimulated by NCAM, N-cadherin, and L1. J Neurochem. 62:1231–1234.
  • Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A (2002). FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci U S A. 99:6684–6689.
  • Xia W, Wolfe MS (2003). Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci. 116:2839–2844.
  • Xiao MF, Xu JC, Tereshchenko Y, Novak D, Schachner M, Kleene R (2009). Neural cell adhesion molecule modulates dopaminergic signaling and behavior by regulating dopamine D2 receptor internalization. J Neurosci. 29:14752–14763.
  • Yap CCC, Lasiecka ZM, Caplan S, Winckler B (2010). Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting. J Neurosci. 30:6646–6657.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.