925
Views
12
CrossRef citations to date
0
Altmetric
KIEV MEETING: Poster Presentations

The cannabinoid R(+)methanandamide induces IL-6 secretion by prostate cancer PC3 cells

, , &
Pages 249-256 | Received 22 Jun 2009, Accepted 06 Aug 2009, Published online: 12 Nov 2009

References

  • Bartke, N., and Hannun, Y.A. 2009. Bioactive sphingolipids: Metabolism and function. J. Lipid Res. 50:S91–S96.
  • Basso, A.S., Cheroutre, H., and Mucida, D. 2009. More stories on Th17 cells. Cell Res. 19:399–411.
  • Bielawska, A., Perry, D.K., and Hannun, Y.A. 2001. Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal. Biochem. 298:141–150.
  • Bifulco, M., and Di Marzo, V. 2002. Targeting the endocannabinoid system in cancer therapy: A call for further research. Nat Med. 8:547–550.
  • Blazquez, C., Salazar, M., Carracedo, A., Lorente, M., Egia, A., Gonzalez-Feria, L., Haro, A., Velasco, G., and Guzman, M. 2008. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68:1945–1952.
  • Bligh, E.G., and Dyer, W.J. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911–917.
  • Cabral, G.A., and Griffin-Thomas, L. 2009. Emerging role of the cannabinoid receptor CB2 in immune regulation: Therapeutic prospects for neuroinflammation. Expert Rev. Mol. Med. 11:e3.
  • Carracedo, A., Gironella, M., Lorente, M., Garcia, S., Guzman, M., Velasco, G., and Iovanna, J.L. 2006. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res. 66:6748–6755.
  • Cianchi, F., Papucci, L., Schiavone, N., Lulli, M., Magnelli, L., Vinci, M.C., Messerini, L., Manera, C., Ronconi, E., Romagnani, P., Donnini, M., Perigli, G., Trallori, G., Tanganelli, E., Capaccioli, S., and Masini, E. 2008. Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells. Clin. Cancer Res. 14:7691–7700.
  • Crawford, E.D. 2009. Understanding the epidemiology, natural history, and key pathways involved in prostate cancer. Urology 73:S4–S10.
  • Croxford, J.L., and Yamamura, T. 2005. Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases? J. Neuroimmunol. 166:3–18.
  • Di Marzo, V., Melck, D., De Petrocellis, L., and Bisogno, T. 2000. Cannabimimetic fatty acid derivatives in cancer and inflammation. Prostaglandins Lipid Med. 61:43–61.
  • Di Marzo, V., De Petrocellis, L., and Bisogno, T. 2005. The biosynthesis, fate, and pharmacological properties of endocannabinoids. In: Cannabinoids [Handbook Exp. Pharmacol., Vol. 168 (Pertwee, R., Ed.), Berlin: Springer-Verlag, pp. 147–185.
  • Diaz-Laviada, I., and Ruiz-Llorente, L. 2005. Signal transduction activated by cannabinoid receptors. Mini Rev. Med. Chem. 5:619–630.
  • Eichele, K., Ramer, R., and Hinz, B. 2009. R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. Pharm. Res. 26:346–355.
  • Germano, G., Allavena, P., and Mantovani, A. 2008. Cytokines as a key component of cancer-related inflammation. Cytokine 43:374–379.
  • Herrera, B., Carracedo, A., Diez-Zaera, M., Gomez del Pulgar, T., Guzman, M., and Velasco, G. 2006. The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway. Exp. Cell Res. 312:2121–2131.
  • Hosking, R.D., and Zajicek, J.P. 2008. Therapeutic potential of cannabis in pain medicine. Br. J. Anesth. 101:59–68.
  • Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Murray, T., and Thun, M.J. 2008. Cancer statistics, 2008. CA Cancer J. Clin. 58(2):71–96.
  • Lamour, N.F., and Chalfant, C.E. 2005. Ceramide-1-phosphate: The “missing” link in eicosanoid biosynthesis and inflammation. Mol. Interv. 5:358–367.
  • Leggett, T. 2006. A review of the world cannabis situation. Bull. Narc. 58:1–155.
  • Mahdy, A.E., Cheng, J.C., Li, J., Elojeimy, S., Meacham, W.D., Turner, L.S., Bai, A., Gault, C.R., McPherson, A.S., Garcia, N., Beckham, T.H., Saad, A., Bielawska, A., Bielawski, J., Hannun, Y.A., Keane, T.E., Taha, M.I., Hammouda, H.M., Norris, J.S., and Liu, X. 2009. Acid ceramidase up-regulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol. Ther. 17:430–438.
  • Malagarie-Cazenave, S., Olea-Herrero, N., Vara, D., and Diaz-Laviada, I. 2009. Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells. FEBS Lett. 583:141–147.
  • McLoughlin, R.M., Hurst, S.M., Nowell, M.A., Harris, D.A., Horiuchi, S., Morgan, L.W., Wilkinson, T.S., Yamamoto, N., Topley, N., and Jones, S.A. 2004. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. J. Immunol. 172:5676–5683.
  • Mechergui, Y.B., Ben Jemaa, A., Mezigh, C., Fraile, B., Ben Rais, N., Paniagua, R., Royuela, M., and Oueslati, R. 2009. The profile of prostate epithelial cytokines and its impact on sera prostate-specific antigen levels. Inflammation 32:202–210.
  • Morales, A., Lee, H., Goni, F.M., Kolesnick, R., and Fernandez-Checa, J.C. 2007. Sphingolipids and cell death. Apoptosis 12:923–939.
  • Oukka, M. 2008. Th17 cells in immunity and autoimmunity. Ann. Rheum. Dis. 67(S3):26–29.
  • Pchejetski, D., Doumerc, N., Golzio, M., Naymark, M., Teissie, J., Kohama, T., Waxman, J., Malavaud, B., and Cuvillier, O. 2008. Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. Mol. Cancer Ther. 7:1836–1845.
  • Pertwee, R.G. 2005. Pharmacological actions of cannabinoids. In: Cannabinoids [Handbook Exp. Pharmacol., Vol. 168 (Pertwee, R., Ed.), Berlin: Springer-Verlag, pp. 1–51.
  • Pertwee, R.G. 2006. The pharmacology of cannabinoid receptors and their ligands: An overview. Int. J. Obesity (London) 30(Suppl. 1):S13–S18.
  • Pertwee, R.G. 2009. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br. J. Pharmacol. 156:397–411.
  • Pisanti, S., Malfitano, A.M., Grimaldi, C., Santoro, A., Gazzerro, P., Laezza, C., and Bifulco, M. 2009. Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents. Best Pract. Res. Clin. Endocrinol. Metab. 23:117–131.
  • Ruiz-Llorente, L., Sanchez, M.G., Carmena, M.J., Prieto, J.C., Sanchez-Chapado, M., Izquierdo, A., and Diaz-Laviada, I. 2003. Expression of functionally-active cannabinoid receptor CB1 in the human prostate gland. Prostate 54:95–102.
  • Saddoughi, S.A., Song, P., and Ogretmen, B. 2008. Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell. Biochem. 49:413–440.
  • Sanchez, M.G., Ruiz-Llorente, L., Sanchez, A.M., and Diaz-Laviada, I. 2003. Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal 15:851–869.
  • Sanchez, M.G., Sanchez, A.M., Collado, B., Malagarie-Cazenave, S., Olea, N., Carmena, M.J., Prieto, J.C., and Diaz-Laviada, I.I. 2005. Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue. Eur. J. Pharmacol. 515:20–27.
  • Sanchez, A.M., Malagarie-Cazenave, S., Olea, N., Vara, D., Chiloeches, A., and Diaz-Laviada, I. 2007. Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis 12:2013–2024.
  • Sanchez, A.M., Martinez-Botas, J., Malagarie-Cazenave, S., Olea, N., Vara, D., Lasuncion, M.A., and Diaz-Laviada, I. 2008. Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: A microarray study. Biochem. Biophys. Res. Commun. 372:785–791.
  • Sander, L.E., Obermeier, F., Dierssen, U., Kroy, D.C., Singh, A.K., Seidler, U., Streetz, K.L., Lutz, H.H., Muller, W., Tacke, F., and Trautwein, C. 2008. Gp130 signalling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation. J. Immunol. 181:3586–3594.
  • Sarfaraz, S., Afaq, F., Adhami, V.M., and Mukhtar, H. 2005. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res. 65:1635–1641.
  • Saxena, S., Banerjee, M., Shirumalla, R.K., and Ray, A. 2008. Ceramide kinase: A potential anti-inflammatory target? Curr. Opin. Invest. Drugs 9:455–462.
  • Schenck, M., Carpinteiro, A., Grassme, H., Lang, F., and Gulbins, E. 2007. Ceramide: Physiological and pathophysiological aspects. Arch. Biochem. Biophys. 462:171–175.
  • Simmons, M.N., and Klein, E.A. 2009. Combined androgen blockade revisited: Emerging options for the treatment of castration-resistant prostate cancer. Urology 73:697–705.
  • Spolski, R., and Leonard, W.J. 2008a. Interleukin-21: Basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26:57–79.
  • Spolski, R., and Leonard, W.J. 2008b. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr. Opin. Immunol. 20:295–301.
  • Sun, Y., and Bennett, A. 2007. Cannabinoids: A new group of agonists of PPARs. PPAR Res. 23513 [Epub ahead of print]..
  • Tokanovic, S., Malone, D.T., and Ventura, S. 2007. Stimulation of epithelial CB1 receptors inhibits contractions of the rat prostate gland. Br. J. Pharmacol. 150:227–234.
  • Velasco, G., Galve-Roperh, I., Sanchez, C., Blazquez, C., Haro, A., and Guzman, M. 2005. Cannabinoids and ceramide: Two lipids acting hand-by-hand. Life Sci. 77:1723–1731.
  • Wang, G., Reed, E., and Li, Q.Q. 2004. Apoptosis in prostate cancer: Progressive and therapeutic implications. Int. J. Mol. Med. 14:23–34.
  • Yuan, X., and Balk, S.P. 2009. Mechanisms mediating androgen receptor reactivation after castration. Urol. Oncol. 27:36–41.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.