Sodium tungstate (Na₂WO₄) exposure increases apoptosis in human peripheral blood lymphocytes

References

• Alves, R.J., Jotz, G.P., do Amaral, V.S., Montes, T.M., Menezes, H.S. and de Andrade, H.H. 2008. The evaluation of maté (Ilex paraguariensis) genetic toxicity in human lymphocytes by the cytokinesis-block in the micronucleus assay. Toxicol. In Vitro 22:695–698.
   PubMed Web of Science ®Google Scholar
• ATSDR (Agency for Toxic Substances and Disease Registry). 2005. Toxicological Profile for Tungsten. Atlanta: US-DHHS.
   Google Scholar
• Ballester, J., Domínguez, J., Muñoz, M.C., Sensat, M., Rigau, T., Guinovart, J.J. and Rodríguez-Gil, J.E. 2005. Tungstate treatment improves Leydig cell function in streptozotocin-diabetic rats. J. Androl. 26:706–715.
   PubMed Web of Science ®Google Scholar
• Berek, L., Petri, I.B., Mesterházy, A., Téren, J. and Molnár, J. 2001. Effects of mycotoxins on human immune functions in vitro. Toxicol. In Vitro 15:25–30.
   PubMed Web of Science ®Google Scholar
• Bree, R.T., Neary, C., Samali, A. and Lowndes, N.F. 2004. The switch from survival responses to apoptosis after chromosomal breaks. DNA Repair (Amst.) 3:989–995.
   PubMed Web of Science ®Google Scholar
• Carmona, M.C., Amigó, M., Barceló-Batllori, S., Julià, M., Esteban, Y., Moreno, S. and Gomis, R. 2009. Dual effects of sodium tungstate on adipocyte biology: inhibition of adipogenesis and stimulation of cellular oxygen consumption. Int. J. Obes. (Lond). 33:534–540.
   PubMed Web of Science ®Google Scholar
• CDC (Centers for Disease Control). 2003. Cross-sectional Exposure Assessment of Environmental Contaminants in Churchill County. Nevada, Atlanta: CDC.
   Google Scholar
• Chinnaiyan, A.M., Huber-Lang, M., Kumar-Sinha, C., Barrette, T.R., Shankar-Sinha, S., Sarma, V.J., Padgaonkar, V.A. and Ward, P.A. 2001. Molecular signatures of sepsis: multiorgan gene expression profiles of systemic inflammation. Am. J. Pathol. 159:1199–1209.
   PubMed Web of Science ®Google Scholar
• Deitch, E.A., Kemper, A.C., Specian, R.D. and Berg, R.D. 1992. A study of the relationship among survival, gut-origin sepsis, and bacterial translocation in a model of systemic inflammation. J. Trauma 32:141–147.
   PubMedGoogle Scholar
• Domínguez, J.E., Muñoz, M.C., Zafra, D., Sanchez-Perez, I., Baqué, S., Caron, M., Mercurio, C., Barberà, A., Perona, R., Gomis, R. and Guinovart, J.J. 2003. The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway. J. Biol. Chem. 278:42785–42794.
   PubMed Web of Science ®Google Scholar
• Eke, D. and Celik, A. 2008. Genotoxicity of thimerosal in cultured human lymphocytes with and without metabolic activation sister chromatid exchange analysis proliferation index and mitotic index. Toxicol. In Vitro 22:927–934.
   PubMed Web of Science ®Google Scholar
• Fastje, C.D., Kim, L., Sun, N.N., Wong, S.S., Sheppard, P.R. and Witte, M.L. 2009. Prenatal exposure of mice to tungstate is associated with decreased transcriptome-expression of the putative tumor suppressor gene, DMBT1: Implications for childhood leukemia. Land Contam. Reclam. 17:169–178.
   Google Scholar
• Ferreira, V., Sidénius, N., Tarantino, N., Hubert, P., Chatenoud, L., Blasi, F. and Körner, M. 1999. In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. J. Immunol. 162:6442–6450.
   PubMed Web of Science ®Google Scholar
• Foster, J.D., Young, S.E., Brandt, T.D. and Nordlie, R.C. 1998. Tungstate: A potent inhibitor of multifunctional glucose-6-phosphatase. Arch. Biochem. Biophys. 354:125–132.
   PubMed Web of Science ®Google Scholar
• Gómez-Ramos, A., Domínguez, J., Zafra, D., Corominola, H., Gomis, R., Guinovart, J.J. and Avila, J. 2006. Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. J. Neurosci. Res. 83:264–273.
   PubMed Web of Science ®Google Scholar
• Haneke, K. 2003. Tungsten and Selected Tungsten Compounds. Edited by NIOEH Sciences.
   Google Scholar
• Happel, N. and Doenecke, D. 2009. Histone H1 and its isoforms: Contribution to chromatin structure and function. Gene 431:1–12.
   PubMedGoogle Scholar
• Haque, S.J., Flati, V., Deb, A. and Williams, B.R. 1995. Roles of protein-tyrosine phosphatases in Stat1 a-mediated cell signaling. J. Biol. Chem. 270:25709–25714.
   PubMed Web of Science ®Google Scholar
• Heidari, Z., Harati, M., Mahmoudzadeh-Sagheb, H.R. and Moudi, B. 2008. Beta cell protective effects of sodium tungstate in streptozotocin-induced diabetic rats: glycemic control, blockage of oxidative stress and beta cell histochemistry. Iran. Biomed. J. 12:143–152.
   PubMedGoogle Scholar
• Holder, I.A., Frede, E.A., Neely, A.N. and Babcock, G.F. 2000. Reduction of neutrophil apoptosis with Pseudomonas aeruginosa immune serum. In: 5th World Congress on Trauma, Shock, Inflammation and Sepsis (Faist, E., Ed.), Bologna, Italy: Monduzzi Editore.
   Google Scholar
• Johnson, J.L., Rajagopalan, K.V. and Cohen, H.J. 1974. Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. J. Biol. Chem. 249:859–866.
   PubMed Web of Science ®Google Scholar
• Kahl, S. and Elsasser, T.H. 2004. Endotoxin challenge increases xanthine oxidase activity in cattle: Effect of growth hormone and Vitamin E treatment. Domest. Anim. Endocrinol. 26:315–328.
   PubMed Web of Science ®Google Scholar
• Kalinich, J.F., Emond, C.A., Dalton, T.K., Mog, S.R., Coleman, G.D., Kordell, J.E., Miller, A.C. and McClain, D.E. 2005. Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environ. Health Perspect. 113:729–734.
   PubMed Web of Science ®Google Scholar
• Kane, M.A., Kasper, C.E. and Kalinich, J.F. 2009. The use of established skeletal muscle cell lines to assess potential toxicity from embedded metal fragments. Toxicol. In Vitro 23:356–359.
   PubMed Web of Science ®Google Scholar
• Knauf, J.A., Ouyang, B., Knudsen, E.S., Fukasawa, K., Babcock, G. and Fagin, J.A. 2006. Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints. J. Biol. Chem. 281:3800–3809.
   PubMedGoogle Scholar
• Konishi, A., Shimizu, S., Hirota, J., Takao, T., Fan, Y., Matsuoka, Y., Zhang, L., Yoneda, Y., Fujii, Y., Skoultchi, A.I. and Tsujimoto, Y. 2003. Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell. 114:673–688.
   PubMed Web of Science ®Google Scholar
• Koutsospyros, A., Braida, W., Christodoulatos, C., Dermatas, D. and Strigul, N. 2006. A review of tungsten: From environmental obscurity to scrutiny. J. Hazard. Mater. 136:1–19.
   PubMed Web of Science ®Google Scholar
• Kratzmeier, M., Albig, W., Meergans, T. and Doenecke, D. 1999. Changes in the protein pattern of H1 histones associated with apoptotic DNA fragmentation. Biochem. J. 337(Pt 2):319–327.
   PubMed Web of Science ®Google Scholar
• Leggett, R.W. 1997. A model of the distribution and retention of tungsten in the human body. Sci. Total Environ. 206:147–165.
   PubMed Web of Science ®Google Scholar
• Maemura, K., Zheng, Q., Wada, T., Ozaki, M., Takao, S., Aikou, T., Bulkley, G.B., Klein, A.S. and Sun, Z. 2005. Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells. Immunol. Cell Biol. 83:336–343.
   PubMed Web of Science ®Google Scholar
• McInturf, S.M., Bekkedal, M.Y., Wilfong, E., Arfsten, D., Gunasekar, P.G. and Chapman, G.D. 2008. Neurobehavioral effects of sodium tungstate exposure on rats and their progeny. Neurotoxicol. Teratol. 30:455–461.
   PubMed Web of Science ®Google Scholar
• Muñoz, M.C., Barberà, A., Domínguez, J., Fernàndez-Alvarez, J., Gomis, R. and Guinovart, J.J. 2001. Effects of tungstate, a new potential oral anti-diabetic agent, in Zucker diabetic fatty rats. Diabetes 50:131–138.
   PubMed Web of Science ®Google Scholar
• Okamura, H., Yoshida, K., Amorim, B.R. and Haneji, T. 2008. Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells. J. Cell. Biochem. 103:1488–1496.
   PubMed Web of Science ®Google Scholar
• Piquer, S., Barceló-Batllori, S., Julià, M., Marzo, N., Nadal, B., Guinovart, J.J. and Gomis, R. 2007. Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6b cells. Biochem. Biophys. Res. Commun. 358:385–391.
   PubMed Web of Science ®Google Scholar
• Rose, F.R., Bailey, K., Keyte, J.W., Chan, W.C., Greenwood, D. and Mahida, Y.R. 1998. Potential role of epithelial cell-derived histone H1 proteins in innate antimicrobial defense in the human gastrointestinal tract. Infect. Immun. 66:3255–3263.
   PubMed Web of Science ®Google Scholar
• Stankiewicz, P.J. and Gresser, M.J. 1988. Inhibition of phosphatase and sulfatase by transition-state analogues. Biochemistry. 27:206–212.
   PubMed Web of Science ®Google Scholar
• Steinberg, K.K., Relling, M.V., Gallagher, M.L., Greene, C.N., Rubin, C.S., French, D., Holmes, A.K., Carroll, W.L., Koontz, D.A., Sampson, E.J. and Satten, G.A. 2007. Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada. Environ. Health Perspect. 115:158–164.
   PubMed Web of Science ®Google Scholar
• Victorino, G.P., Ramirez, R.M., Chong, T.J., Curran, B. and Sadjadi, J. 2008. Ischemia-reperfusion injury in rats affects hydraulic conductivity in two phases that are temporally and mechanistically separate. Am. J. Physiol. Heart Circ. Physiol. 295:H2164–H2171.
   Web of Science ®Google Scholar
• Vorbach, C., Harrison, R. and Capecchi, M.R. 2003. Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Trends Immunol. 24:512–517.
   PubMed Web of Science ®Google Scholar
• Yan, S. R., Fumagalli, L., Dusi, S. and Berton, G. 1995. Tumor necrosis factor triggers redistribution to a Triton X-100-insoluble, cytoskeletal fraction of beta 2 integrins, NADPH oxidase components, tyrosine phosphorylated proteins, and the protein tyrosine kinase p58fgr in human neutrophils adherent to fibrinogen. J Leukoc Biol. 58 (5):596–606.
   Web of Science ®Google Scholar
• Zlatanova, J.S., Srebreva, L.N., Banchev, T.B., Tasheva, B.T. and Tsanev, R.G. 1990. Cytoplasmic pool of histone H1 in mammalian cells. J. Cell. Sci. 96 (Pt 3):461–468.
   PubMed Web of Science ®Google Scholar