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Research Articles

Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract

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Pages 150-158 | Received 22 Dec 2010, Accepted 25 Jan 2011, Published online: 14 Mar 2011

References

  • Alam, J., Stewart, D., Touchard, C., Boinapally, S., Choi, A. M. and Cook, J. L. 1999. Nrf2, a Cap’n’Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem. 274:26071–26078.
  • Barnes, P. J. 2008. Emerging pharmacotherapies for COPD. Chest. 134:1278–1286.
  • Barnes, P. J. 2005. Emerging targets for COPD therapy. Curr Drug Targets Inflamm Allergy. 4:675–683.
  • Barnes, P. J. 2009. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 41:631–638.
  • Barnes, P. J. and Hansel, T. T. 2004. Prospects for new drugs for chronic obstructive pulmonary disease. Lancet. 364:985–996.
  • Blake, D. J., Singh, A., Kombairaju, P., Malhotra, D., Mariani, T. J., Tuder, R. M., Gabrielson, E. and Biswal, S. 2009. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am J Respir Cell Mol Biol. 42:524–536.
  • Capelli, A., Di Stefano, A., Gnemmi, I. and Donner, C. F. 2005. CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis. Eur Respir J. 25:701–707.
  • Cho, H. Y., Imani, F., Miller-DeGraff, L., Walters, D., Melendi, G. A., Yamamoto, M., Polack, F. P. and Kleeberger, S. R. 2009. Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med. 179:138–150.
  • Chung, K. F. 2006. Cytokines as targets in chronic obstructive pulmonary disease. Curr Drug Targets. 7:675–681.
  • Clarke, J. D., Dashwood, R. H. and Ho, E. 2008. Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 269:291–304.
  • de Boer, W. I., Sont, J. K., van Schadewijk, A., Stolk, J., van Krieken, J. H. and Hiemstra, P. S. 2000. Monocyte chemoattractant protein-1, interleukin 8, and chronic airways inflammation in COPD. J Pathol. 190:619–626.
  • Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M. and Talalay, P. 2002. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of Phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA. 99:11908–11913.
  • Fahey, J. W. and Talalay, P. 1999. Antioxidant functions of sulforaphane: A potent inducer of Phase II detoxication enzymes. Food Chem Toxicol. 37:973–979.
  • Goven, D., Boutten, A., Leçon-Malas, V., Marchal-Sommé, J., Amara, N., Crestani, B., Fournier, M., Lesèche, G., Soler, P., Boczkowski, J. and Bonay, M. 2008. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax. 63:916–924.
  • Hogg, J. C., Chu, F., Utokaparch, S., Woods, R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O. and Paré, P. D. 2004. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 350:2645–2653.
  • Iizuka, T., Ishii, Y., Itoh, K., Kiwamoto, T., Kimura, T., Matsuno, Y., Morishima, Y., Hegab, A. E., Homma, S., Nomura, A., Sakamoto, T., Shimura, M., Yoshida, A., Yamamoto, M. and Sekizawa, K. 2005. Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells. 10:1113–1125.
  • Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D. and Yamamoto, M. 1999. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13:76–86.
  • Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O’Connor, T. and Yamamoto, M. 2003. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells. 8:379–391.
  • Keatings, V. M., Collins, P. D., Scott, D. M. and Barnes, P. J. 1996. Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med. 153:530–534.
  • Kensler, T. W., Wakabayashi, N. and Biswal, S. 2007. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 47:89–116.
  • Kobayashi, A., Kang, M. I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K. and Yamamoto, M. 2004. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol. 24:7130–7139.
  • Kobayashi, A., Kang, M. I., Watai, Y., Tong, K. I., Shibata, T., Uchida, K. and Yamamoto, M. 2006. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol. 26:221–229.
  • Laan, M., Bozinovski, S. and Anderson, G. P. 2004. Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells. J Immunol. 173:4164–4170.
  • Lin, W., Wu, R. T., Wu, T., Khor, T. O., Wang, H. and Kong, A. N. 2008. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2-dependent pathway. Biochem Pharmacol. 76:967–973.
  • Malhotra, D., Thimmulappa, R., Navas-Acien, A., Sandford, A., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J., Pare, P., Tuder, R. M. and Biswal, S. 2008. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med. 178:592–604.
  • Martin, T., Cardarelli, P. M., Parry, G. C., Felts, K. A. and Cobb, R. R. 1997. Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-κ B and AP-1. Eur J Immunol. 27:1091–1097.
  • Pryor, W. A., Prier, D. G. and Church, D. F. 1983. Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ Health Perspect. 47:345–355.
  • Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C. and Zielinski, J.; Global Initiative for Chronic Obstructive Lung Disease. 2007. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 176:532–555.
  • Rahman, I. and Kilty, I. 2006. Antioxidant therapeutic targets in COPD. Curr Drug Targets. 7:707–720.
  • Rangasamy, T., Cho, C. Y., Thimmulappa, R. K., Zhen, L., Srisuma, S. S., Kensler, T. W., Yamamoto, M., Petrache, I., Tuder, R. M. and Biswal, S. 2004. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest. 114:1248–1259.
  • Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N. and Biswal, S. 2005. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med. 202:47–59.
  • Ritz, S. A., Wan, J. and Diaz-Sanchez, D. 2007. Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract. Am J Physiol Lung Cell Mol Physiol. 292:L33–L39.
  • Sacerdoti, D., Colombrita, C., Ghattas, M. H., Ismaeil, E. F., Scapagnini, G., Bolognesi, M., Li Volti, G. and Abraham, N. G. 2005. Heme oxygenase-1 transduction in endothelial cells causes downregulation of monocyte chemoattractant protein-1 and of genes involved in inflammation and growth. Cell Mol Biol (Noisy-le-grand). 51:363–370.
  • Shokawa, T., Yoshizumi, M., Yamamoto, H., Omura, S., Toyofuku, M., Shimizu, Y., Imazu, M. and Kohno, N. 2006. Induction of heme oxygenase-1 inhibits monocyte chemoattractant protein-1 mRNA expression in U937 cells. J Pharmacol Sci. 100:162–166.
  • Stockley, R. A. 2009. Progression of chronic obstructive pulmonary disease: Impact of inflammation, comorbidities and therapeutic intervention. Curr Med Res Opin. 25:1235–1245.
  • Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., Sporn, M. B., Gabrielson, K. L., Champion, H. C., Tuder, R. M., Kensler, T. W. and Biswal, S. 2009. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci USA. 106:250–255.
  • Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Nasuhara, Y., Kaga, K., Kondo, S. and Nishimura, M. 2008. Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 39:673–682.
  • Thimmulappa, R. K., Lee, H., Rangasamy, T., Reddy, S. P., Yamamoto, M., Kensler, T. W. and Biswal, S. 2006a. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest. 116:984–995.
  • Thimmulappa, R. K., Mai, K. H., Srisuma, S., Kensler, T. W., Yamamoto, M. and Biswal, S. 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62:5196–5203.
  • Thimmulappa, R. K., Scollick, C., Traore, K., Yates, M., Trush, M. A., Liby, K. T., Sporn, M. B., Yamamoto, M., Kensler, T. W. and Biswal, S. 2006b. Nrf2-dependent protection from LPS-induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun. 351:883–889.
  • Traves, S. L., Culpitt, S. V., Russell, R. E., Barnes, P. J. and Donnelly, L. E. 2002. Increased levels of the chemokines GROα and MCP-1 in sputum samples from patients with COPD. Thorax. 57:590–595.
  • Ueda, A., Ishigatsubo, Y., Okubo, T. and Yoshimura, T. 1997. Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-κB sites and NF-κB/Rel subunit specificity. J Biol Chem. 272:31092–31099.
  • Venugopal, R. and Jaiswal, A. K. 1996. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc Natl Acad Sci USA. 93:14960–14965.
  • Viegi, G., Pistelli, F., Sherrill, D. L., Maio, S., Baldacci, S. and Carrozzi, L. 2007. Definition, epidemiology, and natural history of COPD. Eur Respir J. 30:993–1013.
  • Wakabayashi, N., Slocum, S. L., Skoko, J. J., Shin, S. and Kensler, T. W. 2010. When NRF2 talks, who’s listening? Antioxid Redox Signal. 13:1649–1663.
  • Yamamoto, C., Yoneda, T., Yoshikawa, M., Fu, A., Tokuyama, T., Tsukaguchi, K. and Narita, N. 1997. Airway inflammation in COPD assessed by sputum levels of interleukin-8. Chest. 112:505–510.
  • Zakkar, M., Van der Heiden, K., Luong, l. e. A., Chaudhury, H., Cuhlmann, S., Hamdulay, S. S., Krams, R., Edirisinghe, I., Rahman, I., Carlsen, H., Haskard, D. O., Mason, J. C. and Evans, P. C. 2009. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 29:1851–1857.
  • Zhou, L., Tan, A., Iasvovskaia, S., Li, J., Lin, A. and Hershenson, M. B. 2003. Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-κB-mediated gene expression in airway epithelial cells. Am J Respir Cell Mol Biol. 28:762–769.

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