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Research Article

Hepatic effects of aminoglutethimide: A model aromatic amine

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Pages 24-32 | Received 29 Aug 2013, Accepted 18 Nov 2013, Published online: 19 Dec 2013

References

  • Bowen, D. G., Mccaughan, G. W., and Bertolino, P. 2005. Intrahepatic immunity: A tale of two sites? Trends Immunol. 26:512–517
  • Cocconi, G. 1994. First generation aromatase inhibitors-aminoglutethimide and testololactone. Breast Cancer Res.Treat. 30:57–80
  • Crispe, I. N., Dao, T., Klugewitz, K., et al. 2000. The liver as a site of T-cell apoptosis: Graveyard or killing field? Immunol. Rev. 174:47–62
  • Dissanayake, D., Hall, H., Berg-Brown, N., Elford, A. R., et al. 2011. Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T-cells. Nat. Med. 17:1663–1667
  • Dutta, J., Fan, Y., Gupta, N., Fan, G., and Gelinas, C. 2006. Current insights into the regulation of programmed cell death by NF-κB. Oncogene 25:6800–6816
  • Elsheikh, A., Lavergne, S. N., Castrejon, J. L., et al. 2010. Drug antigenicity, immunogenicity, and costimulatory signaling: Evidence for formation of a functional antigen through immune cell metabolism. J. Immunol. 185:6448–6460
  • Eweiss, N., Nicholls, P. J., and Askam, V. 1983. Absorption and elimination of aminoglute-thimide in the rat and guinea pig. IRCS Med. Sci. Biochem. 11:843–844
  • Goldkind, L., and Laine, L. 2006. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: Lessons learned from the bromfenac experience. Pharmacoepidemiol. Drug Safety 15:213–220
  • Goss, P. E., Jarman, M., and Griggs, L. J. 1985. Metabolism of aminoglutethimide in humans: Quantification and clinical relevance of induced metabolism. Br. J. Cancer 51:259–262
  • Hayden, M. S., West, A. P., and Ghosh, S. 2006. NF-κB and the immune response. Oncogene. 25:6758–6780
  • Jaeschke, H., Williams, C. D., Ramachandran, A., and Bajit, M. L. 2012. Acetaminophen hepatotoxicity and repair: The role of sterile inflammation and innate immunity. Liver Int. 32:8–20
  • Kono, H., and Rock, K. L. 2008. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8:279–289
  • Lu, W., Li, X., and Uetrecht, J. P. 2008. Changes in gene expression induced by carbamazepine and phenytoin: Testing the Danger Hypothesis. J. Immunotoxicol. 5:107–113
  • Metushi, I. G., Nakagawa, T., and Uetrecht, J. 2012. Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: Humans are more like mice than rats. Chem. Res. Toxicol. 25:2567–2576
  • Murray, F. T., Santner, S., Samojlik, E., and Santen, R. J. 1979. Serum aminoglutethimide levels: Studies of serum half-life, clearance, and patient compliance. J. Clin. Pharmacol. 19:704–711
  • Murray, M., Cantrill, E., and Farrell, G. C. 1993. Induction of cytochrome P450 2B1 in rat liver by the aromatase inhibitor aminoglutethimide. J. Pharmacol. Exp. Ther. 265:477–481
  • Nagel, G. A., Wander, H. E., and Blossey, H. C. 1982. Phase II study of aminoglutethimide and medroxyprogesterone acetate in the treatment of patients with advanced breast cancer. Cancer Res. (Suppl.) 42:3442s–3444s
  • Ng, W., and Uetrecht, J. 2013a. Changes in gene expression induced by aromatic amine drugs: Testing the danger hypothesis. J. Immunotox. 10:178–191
  • Ng, W., and Uetrecht, J. 2013b. Effect of aminoglutethimide on neutrophils in rats - implications for idiosyncratic drug-induced blood dyscrasias. Chem. Res. Toxicol. 26:1271–1281
  • Ng, W., Lobach, A. R. M., Zhu, X., et al. 2012. Animal models of idiosyncratic drug reactions. Adv. Pharmacol. 63:81–135
  • Pacitto, S. R., Uetrecht, J. P., Boutros, P. C., and Popovic, M. 2007. Changes in gene expression induced by tienilic acid and sulfamethoxazole: Testing the danger hypothesis. J. Immunotoxicol. 4:253–266
  • Seguin, B., Boutros, P. C., Li, X., et al. 2005. Gene expression profiling in a model of D-penicillamine-induced autoimmunity in the Brown Norway rat: Predictive value of early signs of danger. Chem. Res. Toxicol. 18:1193–1202
  • Uetrecht, J. 2002. N-Oxidation of drugs associated with idiosyncratic drug reactions. Drug Metab. Rev. 34:651–665
  • Uetrecht, J., and Naisbitt, D. J. 2013. Idiosyncratic adverse drug reactions: Current concepts. Pharmacol. Rev. 65:779–808
  • Waring, J. F., Ciurlionis, R., Jolly, R. A., et al. 2001. Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol. Lett. 120:359–368

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