1,163
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Tunisian radish (Raphanus sativus) extract prevents cadmium-induced immunotoxic and biochemical alterations in rats

, , &
Pages 40-47 | Received 30 Sep 2013, Accepted 02 Jan 2014, Published online: 14 Feb 2014

References

  • Abbès, S., Ben Salah-Abbès, J., Nahdi, K., et al. (2007). Inactivation of cadmium-induced immune-toxicological alterations in rats by Tunisian montmorillonite clay. Int. Immunopharmacol. 7:750–760
  • Banerjee, S., and Flores-Rozas, H. (2005). Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex. Nucl. Acids Res. 33:1410–1419
  • Ben Salah-Abbès, J., Abbès, S., Abdel-Wahhab, M. A., and Oueslati, R. (2009a). Raphanus sativus extract protects against zearalenone-induced reproductive toxicity, oxidative stress and mutagenic alterations in male Balb/c mice. Toxicon 53:525–533
  • Ben Salah-Abbès, J., Abbès, S., Haous, Z., et al. (2008b). Zearalenone induces immunotoxicity in mice: Possible protective effects of radish extract (Raphanus sativus). J. Pharm. Pharmacol. 60:761–770
  • Ben Salah-Abbès, J., Abbès, S., Haous, Z., and Oueslati, R. (2009b). Raphanus sativus extract prevents and ameliorates zearalenone-induced peroxidative hepatic damage in Balb/c mice. J. Pharm. Pharmacol. 61:1545–1554
  • Ben Salah-Abbès, J., Abbès, S., Ouanes, Z., et al. (2008a). Investigation of Tunisian radish extract (Raphanus sativus) as anti-oxidants and radical scavenging properties against Zeralenone toxicity in Balb/c mice. J. Appl. Toxicol. 28:6–14
  • Beyersmann, D., and Hechtenberg, S. (1997). Cadmium, gene regulation, and cellular signaling in mammalian cells. Toxicol. Appl. Pharmacol. 144:247–261
  • Blakley, B. R. (1985). The effect of CdCl2 on immune response in mice. Can. J. Comp. Med. 49:104–108
  • Boujelben, M., Ghorbel, F., Vincent, C., et al. (2006). Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: Interactions of magnesium supplementation. Exp. Toxicol. Pathol. 57:437–443
  • Boyum, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation of Ig. Scand. J. Clin. Lab. Invest. 21:98–100
  • Cai, Y., Aoshima, K., Katoh, T., et al. (2001). Renal tubular dysfunction in male inhabitants of a cadmium-polluted area in Toyama, Japan - an eleven-year follow-up study. J. Epidemiol. 11:180–189
  • Cifone, M. G., Alesse, E., di Eugenio, R., et al. (1989). In vivo Cd treatment alters natural killer activity and large granular lymphocyte number in the rat. Immunopharmacology 18:149–156
  • Congiu, L., Chicca, M., Pilastro, A., et al. (2000). Effects of chronic dietary cadmium on hepatic glutathione levels and glutathione peroxidase activity in starlings (Sturnus vulgaris). Arch. Environ. Contam. Toxicol. 38:357–361
  • Cuénod, A. (1954). Flore de la Tunisie: cryptogames vasculaires, gymnospermes et monocotylé-dones (Efarabi, Ed.). Tunis: Office de l’expérimentation de la vulgarisation agricoles de Tunisie, pp. 126
  • Dan, G., Lall, S. B., and Rao, D. N. (2000). Humoral and cell-mediated immune response to cadmium in mice. Drug Chem. Toxicol. 23:349–360
  • Descotes, J. (1992). Immunotoxicology of cadmium. IARC Sci. Publ. 118:385–390
  • Dong, S. Y., Shen, H. M., and Ong, C. N. (2001). Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes. Mol. Cell. Biochem. 222:11–20
  • Esaki, H., and Onozaki, H. (1982). Antimicrobial action of pungent principles in radish root. Eiyo To Shokuryo. 35:207–211
  • Exon, J. H., South, E. H., and Hendrix, K. (1996). Effects of metals on the humoral immune response. In: Toxicology of Metals (Chang, L. W., Ed.). Boca Raton, FL: CRC Lewis, pp. 798–801
  • Fang, Y. Z., Yang, S., and Wu, G. (2002). Free radicals, anti-oxidants and nutrition. Nutrition 18:872–877
  • FAO/WHO. (2003). Summary and Conclusions of the 61st Meeting on Food Additives and Contaminants. Rome, 10-19 June (2003). Available online at: fttp://ftp.fao.org/es/esn/jecfa/jecfa61sc.pdf
  • Gill, C. I., Haldar, S., Porter, S., et al. (2004). The effect of cruciferous and leguminous sprouts on genotoxicity, in vitro and in vivo. Cancer Epidemiol. Biomarkers Prev. 13:1199–1205
  • Gupta Sen, R., Gupta Sen, E., Dhakal, B. K., et al. (2004b). Vitamin C and vitamin E protect rat testes from Cd-induced reactive oxygen species. Mol. Cells 17:132–137
  • Gupta Sen, R., Kim, J., Gomes, C., et al. (2004a). Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Mol. Cell. Endocrinol. 221:57–65
  • Hashem, F. A., and Saleh, M. M. (1999). Anti-microbial components of some Cruciferae plants. Phytother. Res. 13:329–332
  • Hashimoto, T., Ueda, Y., Oi, N., et al. (2006). Effect of combined administration of quercetin, rutin, and extract of White Radish sprout rich in campherol glucosides on the metabolism in rats. Biosci. Adv. Biochem. Eng. Biotechnol. 70:279–281
  • Hecht, S. S. (1999). Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J. Nutr. 129:768S–774S
  • Holladay, S. D., Lindstrom, P., Blaylock, B. L., et al. (1991). Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 44:385–392
  • Horiguchi, H., Harada, A., Oguma, E., et al. (2000). Cadmium-induced acute hepatic injury is exacerbated in human IL-8 transgenic mice. Toxicol. Appl. Pharmacol. 163:231–239
  • Hovland, J., Cantor, R. M., Lee, G. S., et al. (2000). Identification of a murine locus conveying susceptibility to cadmium-induced forelimb malformations. Genomics 63:193–201
  • Jeffery, E. H., and Jarrell, V. (2001). Cruciferous vegetables and cancer prevention. In: Handbook of Nutraceuticals and Functional Foods, (Wildman, R. E., Ed.). Boca Raton, FL: CRC Press, pp. 169–192
  • Kapoor. L. D. (Ed.). (1990). Handbook of Ayurvedic Medicinal Plants. Boca Raton, FL: CRC Press
  • Kara, H., Karatas, F., Canatan, H., and Servi, K. (2005). Effects of exogenous metallothionein on acute cadmium toxicity in rats. Biol Trace. Elem. Res. 104:223–232
  • Katsuzaki, H., Miyahara, Y., Ota, M., et al. (2004). Chemistry and anti-oxidative activity of hot water extract of Japanese radish (daikon). Biofactors 21:211–214
  • Kishimoto, H., Surh, C.D., and Sprent J. (1995). Upregulation of surface markers on dying thymocytes. J. Exp. Med. 181:649–655
  • Klaassen, C. D., Liu, S., and Choudhuti, S. (1999). Metallothionein: An intracellular protein to protect against cadmium toxicity. Ann. Rev. Pharmacol. Toxicol. 39:267–294
  • Koller, L. D. (1998). Cadmium. In: Immunotoxicology of Environmental and Occupational Metals (Zelikoff, J. T., and Thomas, P. T., Eds.). London: Taylor & Francis, pp. 41–61
  • Lai, Z. W., Fiore, N. C., Gasiewicz, T. A., and Silverstone, A. E. (1998). 2,3,7,8-Tetrachloro-dibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture. Toxicol. Appl. Pharmacol. 149:167–177
  • Lei, L. J., Jin, T. Y., and Zhou, Y. F. (2005). Effects of cadmium on levels of insulin in rats. Wei Sheng Yan Jiu. 34:394–396
  • Liaudet, L., Mabley, J. G., Soriano, F. G., et al. (2001). Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture. Am. J. Respir. Crit. Care Med. 164:1213–1220
  • Lugasi, A., Dwoeschak, E., Blazovics, A., and Kery, A. (2001). Antioxidant and free radical scavenging properties of squeezed juice from black radish (Raphanus sativus L. var niger) root. Phytother Res. 12:502–506
  • Marth, E., Barth, S., and Jelavcan, S. (2000). Influence of Cd on the immune system description of stimulating reactions. Cent. Eur. Public Health 8:40–44
  • Marth, E., Jelovcan, S., Kleinhappl, B., et al. (2001). The effect of heavy metal on the immune system at low concentrations. Int. J. Occup. Med. Environ. Health 14:375–386
  • Nadkarni, K. M. (1976). Indian materia medica. Bombay: Popular Prakashan, pp. 35–49
  • Nasr, Y. A., Hemdan, F. E., and Ulrich, S., et al. (2006). The in vitro immune modulation by cadmium depends on the way of cell activation. Toxicology 222:37–45
  • Navarro, C. M., Montilla, P. M., Martin, A., et al. (1993). Free radicals scavenger and anti-hepatotoxic activity of Rosmarinus. Plant Med. 59:312–314
  • Nishimura, Y., Yamaguchi, J. Y., Kanada, A., et al. (2005). Increase in intracellular Cd2+ concentration of rat cerebellar granule neurons incubated with cadmium chloride: Cadmium cytotoxicity under external Ca-free condition. Toxicol. In Vitro 20:211–216
  • Othumpangat, S., Kashon, M., and Joseph, P. (2005). Eukaryotic translation initiation factor 4E is a cellular target for toxicity and death due to exposure to cadmium chloride. J. Biol. Chem. 280:25162–25169
  • Payette, Y., Lachapelle, M., Daniel, C., et al. (1995). Decreased IL-2 receptor and cell cycle changes in murine lymphocytes exposed in vitro to low doses of cadmium chloride. Int. J. Immunopharmacol. 17:235–246
  • Prestera, T., Zhang, Y., Spencer, S. R., et al. (1993). Electrophile counterattack response: Protection against neoplasia and toxicity. Adv. Enzyme Regul. 33:281–296
  • Rana, S. V., Rekha, S., and Seema, V. (1996). Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury. Indian J. Exp. Biol. 34:177–179
  • Satarug, S., Baker, J. R., Urbenjapol, S., et al. (2003). A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett. 137:65–83
  • Satoh, M., Kaji, T., and Tohyama C. (2003). Low dose exposure to cadmium and its health effects. Part 3. Toxicity in laboratory animals and cultured cells. Nippon Eiseigaku Zasshi 57:615–623
  • Schulte, S., Mengel, K., Gatke, U., and Friedberg, K. D. (1994). No influence of cadmium on the production of specific antibodies in mice. Toxicology 93:263–268
  • Shapiro, T. A., Fahey, J. W., Wade, K. L., et al. (2001). Chemo-protective glucosinolates and isothiocyanates of broccoli sprouts metabolism and excretion in humans. Cancer Epidemiol. Biomarkers Prev. 10:501–508
  • Sipos, P., Hagymasi, K., Lugasi, A., et al. (2002). Effects of black radish root (Raphanus sativus L. var niger) on the colon mucosa in rats fed a fat rich diet. Phytother. Res. 16:677–679
  • Stoeppler, M. (1991). Cadmium. In: Metals and Their Compounds in the Environment, (Merian, E., Ed.). New York: VCH, pp. 803–851
  • Stohs, S. J., Bagchi, D., Hassoun, E., and Bagchi, M. (2001). Oxidative mechanisms in toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 20:77–83
  • Suh, S. J., Moon, S. K., and Kim, C. H. (2006). Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G1 cell cycle. Int. Immunopharmacol. 68:854–861
  • Suzuki, C., Ohnishi-Kameyama, M., Sasaki, K., et al. (2006). Behavior of glucosinolates in pickling cruciferous vegetables J. Agric. Food Chem. 54:9430–9436
  • Takaya, Y., Kondo, Y., Furukawa, T., and Niwa, M. (2003). Anti-oxidant constituents of radish sprout (Kaiware-daikon), Raphanus sativus L. J. Agric. Food Chem. 51:8061–8066
  • USAF (United States Air Force). (1990). Cadmium. In: Installation Restoration Program Toxicology Guide, Vol. 5. Wright Patterson AFB, OH: Harry G. Armstrong Aerospace Medical Research Laboratory
  • Waalkes, M. P., Anver, M. R., and Diwan, B. A. (1999). Chronic toxic and carcinogenic effects of oral cadmium in the Noble (NBL/Cr) rat: Induction of neoplastic and proliferative lesions of adrenal, kidney, prostate, and testes. J. Toxicol. Environ. Health 58:199–214
  • Wang, L., Burhenne, K., Kristensen, B. K., and Rasmussen, S. K. (2004). Purification and cloning of a Chinese red radish peroxidase that metabolize pelargonidin and forms a gene family in Brassicaceae. Gene 343:323–335
  • Yiin, S. J., Chern, C. L., Sheu, J. Y., and Lin, T. H. (1999). Cadmium-induced lipid peroxidation in rat testes and protection by selenium. Biometals 12:353–357
  • Yoshiro, S., Yasukazu, Y., Takashi, A., et al. (2003). Cell death caused by selenium deficiency and protective effect of anti-oxidants. J. Biol. Chem. 278:39428–39433
  • Zelikoff, J. T., Bowser, D., Squibb, K. S., and Frenkel, K. (1995). Immunotoxicity of low level Cd exposure in fish: An alternative animal model for immunotoxicological studies. J. Toxicol. Environ. Health 45:235–248
  • Zhou, T., Jia, X., Chapin, R. E., et al. (2004). Cadmium at a non-toxic dose alters gene expression in mouse testes. Toxicol. Lett. 154:191–200

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.