Donor lymphocyte infusions to leukemic bone lesions are therapeutically effective in a Ph+ ALL patient with post-HSCT relapse

References

• Baccarani, M., Cortes, J., Pane, F., et al; European LeukemiaNet. 2009. Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet. J. Clin. Oncol. 27:6041–6051
   PubMed Web of Science ®Google Scholar
• Blair, A., Goulden, N. J., Libri, N. A., et al. 2005. Immunotherapeutic strategies in acute lymphoblastic leukemia relapsing after stem cell transplantation. Blood Rev. 19:289–300
   PubMed Web of Science ®Google Scholar
• Dlubek, D., Drabczak-Skrzypek, D., and Lange, A. 2006. Low CXCR4 membrane expression on CD34+ cells characterizes cells mobilized to blood. Bone Marrow Transplant. 37:19–23
   PubMed Web of Science ®Google Scholar
• Eefting, M., Halkes, C. J., de Wreede, L. C., et al. 2014. Myeloablative T-cell-depleted alloSCT with early sequential prophylactic donor lymphocyte infusion is an efficient and safe post-remission treatment for adult ALL. Bone Marrow Transplant. 49:287–291
   PubMed Web of Science ®Google Scholar
• Fukui, J., Inaba, M., Ueda, Y., et al. 2007. Prevention of graft-versus-host disease by intra-bone marrow injection of donor T-cells. Stem Cells 25:1595–1601
   PubMed Web of Science ®Google Scholar
• Guilhot, J., Baccarani, M., Clark, R. E., et al. 2012. Definitions, methodological, and statistical issues for Phase 3 clinical trials in chronic myeloid leukemia: A proposal by the European Leukemia Net. Blood 119:5963–5971
   PubMed Web of Science ®Google Scholar
• Ikehara, S. 2007. Innovative BMT methods for intractable diseases. Immunol. Res. 38:251–260
   PubMed Web of Science ®Google Scholar
• Kamimura, T., Miyamoto, T., Kawano, N., et al. 2012. Successful treatment by donor lymphocyte infusion of adult T-cell leukemia/lymphoma relapse following allogeneic hematopoietic stem cell transplantation. Int. J. Hematol. 95:725–730
   PubMed Web of Science ®Google Scholar
• Kircher, B., Stevanovic, S., Urbanek, M., et al. 2002. Induction of HA-1-specific cytotoxic T-cell clones parallels the therapeutic effect of donor lymphocyte infusion. Br. J. Hematol. 117:935–939
   PubMed Web of Science ®Google Scholar
• Klimczak, A., and Lange, A. 2000. Apoptosis of keratinocytes is associated with infiltration of CD8+ lymphocytes and accumulation of Ki67 antigen. Bone Marrow Transplant. 26:1077–1082
   PubMed Web of Science ®Google Scholar
• Kolb, H. J., Schattenberg, A., Goldman, J. M., et al; European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. 1995. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow-grafted patients 1995. Blood 86:2041–2050
   PubMed Web of Science ®Google Scholar
• Kurzrock, R., Kantarjian, H. M., Druker, B. J., and Talpaz, M. 2003. Philadelphia chromosome-positive leukemias: From basic mechanisms to molecular therapeutics. Ann. Intern. Med. 138:819–830
   PubMed Web of Science ®Google Scholar
• Maldonado, L., Teague, J. E., Morrow, M. P., et al. 2014. Intramuscular therapeutic vaccination targeting HPV16 induces T-cell responses that localize in mucosal lesions. Sci. Transl. Med. 29:6:221ra13
   Google Scholar
• Miyake, T., Hosaka, N., Cui, W., et al. 2009. Adult thymus transplantation with allogeneic intra-bone marrow-bone marrow transplantation from same donor induces high thymopoiesis, mild graft-versus-host reaction, and strong graft-versus-tumor effects. Immunology 126:552–564
   PubMed Web of Science ®Google Scholar
• Mustjoki, S., Auvinen, K., Kreutzman, A., et al. 2013. Rapid mobilization of cytotoxic lymphocytes induced by dasatinib therapy. Leukemia 27:914–924
   PubMed Web of Science ®Google Scholar
• Schmid, C., Labopin, M., Nagler, A., et al; EBMT Acute Leukemia Working Party. 2007. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: A retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J. Clin. Oncol. 25:4938–4945
   PubMed Web of Science ®Google Scholar
• Suzuki, Y., Adachi, Y., Minamino, K., et al. 2005. A new strategy for treatment of malignant tumor: Intra-bone marrow-bone marrow transplantation plus CD4- donor lymphocyte infusion. Stem Cells 23:365–370
   PubMed Web of Science ®Google Scholar
• Terwey, T. H., Le Duc, T. M., Hemmati, P. G., et al. 2013. NIH-defined graft-versus-host disease and evidence for a potent graft-versus-leukemia effect in patients with acute lymphoblastic leukemia. Ann. Oncol. 24:1363–1370
   PubMed Web of Science ®Google Scholar
• van der Voort, R., Volman, T. J., Verweij, V., et al. 2013. Homing characteristics of donor T-cells after experimental allogeneic bone marrow transplantation and post-transplantation therapy for multiple myeloma. Biol. Blood Marrow Transplant. 19:378–386
   PubMed Web of Science ®Google Scholar
• van der Zouwen, B., Kruisselbrink, A. B., Jordanova, E. S., et al. 2012. Alloreactive effector T-cells require the local formation of a pro-inflammatory environment to allow crosstalk and high avidity interaction with non-hematopoietic tissues to induce GVHD reactivity. Biol. Blood Marrow Transplant. 18:1353–1367
   PubMedGoogle Scholar
• van Rhee, F., and Kolb, H. J. 1995. Donor leukocyte transfusions for leukemic relapse. Curr. Opin. Hematol. 2:423–430
   PubMedGoogle Scholar
• Warren, E. H., and Deeg, H. J. 2013. Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategies. Tissue Antigens 81:183–193
   PubMedGoogle Scholar
• Yan, C. H., Wang, J. Z., Liu, D. H., et al. 2013. Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion: Superior outcomes compared with chemotherapy alone and an analysis of prognostic factors. Eur. J. Hematol. 91:304–314
   PubMed Web of Science ®Google Scholar