References
- de Boer, M. L., Mordvinov, V. A., Thomas, M. A., and Sanderson, C. J. 1999. Role of nuclear factor of activated T-cells (NFAT) in the expression of IL-5 and other cytokines involved in the regulation of hemopoetic cells. Int. J. Biochem. Cell. Biol. 31:1221–1236
- Feske, S. 2007. Calcium signalling in lymphocyte activation and disease. Nat. Rev. Immunol. 7:690–702
- Feske, S. 2009. ORAI1 and STIM1 deficiency in human and mice: Roles of store-operated Ca2+ entry in the immune system and beyond. Immunol. Rev. 231:189–209
- Feske, S. 2011. Immunodeficiency due to defects in store-operated calcium entry. Ann. NY Acad. Sci. 1238:74–90
- Feske, S., Giltnane, J., Dolmetsch, R., et al. 2001. Gene regulation mediated by calcium signals in T-lymphocytes. Nat. Immunol. 2:316–324
- Feske, S., Gwack, Y., Prakriya, M., et al. 2006. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441:179–185
- Feske, S., Okamura, H., Hogan, P. G., and Rao, A. 2003. Ca2+/calcineurin signaling in cells of the immune system. Biochem. Biophys. Res. Commun. 311:1117–1132
- Feske, S., Picard, C., and Fischer, A. 2010. Immunodeficiency due to mutations in ORAI1 and STIM1. Clin. Immunol. 135:169–182
- Feske, S., Prakriya, M., Rao, A., and Lewis, R. S. 2005. A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T-cells from immunodeficient patients. J. Exp. Med. 202:651–662
- Gregory, C. R., Kyles, A. E., Bernsteen, L., et al. 2004. Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a non-human primate model. Transplantation 78:681–685
- Jin, S., Chin, J., Kitson, C., et al. 2013. Natural regulatory T-cells are resistant to calcium release-activated calcium (CRAC/ORAI) channel inhibition. Int. Immunol. 25:497–506
- Lebrec, H., Cowan, L., Lagrou, M., et al. 2011. An inter-laboratory retrospective analysis of immunotoxicological endpoints in non-human primates: T-cell-dependent antibody responses. J. Immunotoxicol. 8:238–250
- Lewis, R. S. 2001. Calcium signaling mechanisms in T-lymphocytes. Annu. Rev. Immunol. 19:497–521
- Lin, F. F., Elliott, R., Colombero, A., et al. 2013. Generation and characterization of fully human monoclonal antibodies against human Orai1 for autoimmune disease. J. Pharmacol. Exp. Ther. 345:225–238
- Liou, J., Kim, M. L., Do Heo, W., et al. 2005. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ Influx. Curr. Biol. 15:1235–1241
- Lissner, D., and Siegmund, B. 2013. Ulcerative colitis: Current and future treatment strategies. Digest. Dis. 31:91–94
- Liu, X. K., Lin, X., and Gaffen, S. L. 2004. Crucial role for nuclear factor of activated T-cells in T-cell receptor-mediated regulation of human IL-17. J. Biol. Chem. 279:52762–52771
- McCarl, C. A., Picard, C., Khalil, S., et al. 2009. ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. J. Allergy Clin. Immunol. 124:1311–1318
- Naesens, M., Kuypers, D. R., and Sarwal, M. 2009. Calcineurin inhibitor nephrotoxicity. Clin. J. Am. Soc. Nephrol. 4:481–508
- National Research Council. 2011. Guide for the Care and Use of Laboratory Animals: 8th Edition. Washington, D.C.: National Academies Press
- Oh-Hora, M. 2009. Calcium signaling in the development and function of T-lineage cells. Immunol. Rev. 231:210–214
- Oh-Hora, M., Komatsu, N., Pishyareh, M., et al. 2013. Agonist-selected T-cell development requires strong T-cell receptor signaling and store-operated calcium entry. Immunity 38:881–895
- Oh-Hora, M., and Rao, A. 2008. Calcium signaling in lymphocytes. Curr. Opin. Immunol. 20:250–258
- Oh-Hora, M., and Rao, A. 2009. The calcium/NFAT pathway: Role in development and function of regulatory T-cells. Microbes Infect. 11:612–619
- Parekh, A. B., and Putney, J. W. 2005. Store-operated calcium channels. Physiol. Rev. 85:757–810
- Picard, C., McCarl, C. A., Papolos, A., et al. 2009. STIM1 Mutation associated with a syndrome of immunodeficiency and autoimmunity. New Engl. J. Med. 360:1971–1980
- Piccotti, J. R., Alvey, J. D., Reindel, J. F., and Guzman, R. E. 2005. T-Cell-dependent antibody response: Assay development in cynomolgus monkeys. J. Immunotoxicol. 2:191–196
- Prakriya, M., Feske, S., Gwack, Y., et al. 2006. Orai1 is an essential pore subunit of the CRAC channel. Nature 443:230–233
- Putney, J. J. 1986. A model for receptor-regulated calcium entry. Cell Calcium 7:1–12
- Roos, J., Digregorio, P. J., Yeromin, A. V., et al. 2005. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J. Cell Biol. 169:435–445
- Schuurman, H. J., Slingerland, W., Mennninger, K., et al. 2001. Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: Relation to efficacy in kidney allografting. Transplant. Intl. 14:320–328
- Shaw, P. J., and Feske, S. 2012. Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity. J. Physiol. 590:4157–4167
- Smith, H. W., Winstead, C. J., Stank, K. K., et al. 2003. A predictive F344 rat immunotoxicology model: Cellular parameters combined with humoral response to NP-CγG and KLH. Toxicology 194:129–145
- Srinivas, N. R., Weiner, R. S., Warner, G., et al. 1996. Pharmacokinetics and pharmaco-dynamics of CTLA4lg (BMS-188667), a novel immunosuppressive agent, in monkeys following multiple doses. J. Pharm. Sci. 85:1–4
- Vercauteren, S. B., Bosmans, J. L., Elseviers, M. M., et al. 1998. A meta-analysis and morphological review of cyclosporine-induced nephrotoxicity in auto-immune diseases. Kidney Int. 54:536–545
- Vig, M., Beck, A., Billingsley, J. M., et al. 2006. CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr. Biol. 16:2073–2079
- Yeromin, A. V., Zhang, S. L., Jiang, W., et al. 2006. Molecular identification of CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443:226–229
- Zhang, S. L., Yu, Y., Roos, J., et al. 2005. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 437:902–905