4,603
Views
17
CrossRef citations to date
0
Altmetric
Review Article

Use of a rat basophil leukemia (RBL) cell-based immunological assay for allergen identification, clinical diagnosis of allergy, and identification of anti-allergy agents for use in immunotherapy

, , , &
Pages 199-205 | Received 29 Jan 2014, Accepted 28 Apr 2014, Published online: 12 Jun 2014

References

  • Ballmer-Weber, B. K., Hoffmann, A., Wuthrich, B., et al. 2002. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy 57:228–235
  • Blanc, F., Adel-Patient, K., Drumare, M. F., et al. 2009. Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors. Clin. Exp. Allergy 39:1277–1285
  • Blanc, F., Vissers, Y. M., Adel-Patient, K., et al. 2011. Boiling peanut Ara h 1 results in the formation of aggregates with reduced allergenicity. Mol. Nutr. Food Res. 55:1887–1894
  • Blanco, C., Carrillo, T., Ortega, N., et al. 1998. Comparison of skin-prick test and specific serum IgE determination for the diagnosis of latex allergy. Clin. Exp. Allergy. 28:971–976
  • Buhring, H. J., Streble, A., and Valent, P. 2004. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int. Arch. Allergy Immunol. 133:317–329
  • Chen, B. H., Hung, M. H., Chen, J. Y., et al. 2012. Anti-allergic activity of grapeseed extract (GSE) on RBL-2H3 mast cells. Food Chem. 132:968–974
  • Chung, M. J., Sohng, J. K., Choi, D. J., and Park, Y. I. 2013. Inhibitory effect of phloretin and biochanin A on IgE-mediated allergic responses in rat basophilic leukemia RBL-2H3 cells. Life Sci. 93:401–408
  • Church, M. K., Shute, J. K., and Sampson, A. P. 2003. Mast cell-derived mediators. In: Adkinson N. F., Busse W. W., Bochner B. S., Holgate S. T., Simons F. E. R., and Lemanske R. F., eds. Middleton’s Allergy: Principles and Practice. Philadelphia, PA: Elsevier, pp. 186–209
  • Cianferoni, A. 2014. Food allergy. Curr. Pharm. Design 20:931–945
  • Codex Alimentarius Commission. Alinorm 03/34: Joint FAO/WHO Food Standard Programme, Codex Alimentarius Commission, Twenty-Fifth Session, Rome, June 30–July 5, 2003. Appendix III, Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants and Appendix IV, Annex on the assessment of possible allergenicity, pp. 4–60
  • Coutts, S. M., Nehring R. E. Jr, and Jariwala, N. U. 1980. Purification of rat peritoneal mast cells: Occupation of IgE-receptors by IgE prevents loss of the receptors. J. Immunol. 124:2309–2315
  • Crockard, A. D., and Ennis, M. 2001. Basophil histamine release tests in the diagnosis of allergy and asthma. Clin. Exp. Allergy 31:345–350
  • Dibbern, D. A. Jr., Palmer, G. W., Williams, P. B., et al. 2003. RBL cells expressing human FcɛRI are a sensitive tool for exploring functional IgE allergen inter-actions: Studies with sera from peanut-sensitive patients. J. Immunol. Meth. 274:37–45
  • Dupont, C. 2011. Food allergy: Recent advances in pathophysiology and diagnosis. Ann. Nutr. Metab. 59:8–18
  • Ebo, D. G., Bridts, C. H., Hagendorens, M. M., et al. 2008. Basophil activation test by flow cytometry: Present and future applications in allergology. Cytometry Clin. Cytometry 74B:201–210
  • Ebo, D. G., Sainte-Laudy, J., Bridts, C. H., et al. 2006. Flow-assisted allergy diagnosis: Current applications and future perspectives. Allergy 61:1028–1039
  • Ehn, B. M., Allmere, T., Telemo, E., et al. 2005. Modification of IgE binding to beta-lactoglobulin by fermentation and proteolysis of cow’s milk. J. Agric. Food Chem. 53:3743–3748
  • Ehrlich, P. 1877. Contributions to the understanding of analine dyes and their use in microscopic techniques. Arch. Mikr. Anat. 13:263–277
  • Eigenmann, P. A., and Sampson, H. A. 1998. Interpreting skin prick tests in the evaluation of food allergy in children. Pediatr. Allergy Immunol. 9:186–191
  • FAO/WHO. 2001. Evaluation of allergenicity of genetically modified foods. Report of a joint FAO/WHO expert consultation on allergenicity of foods derived from biotechnology. Rome: Food and Agriculture Organization of the United Nations (FAO)
  • Gibbs, B. F., Amon, U., and Pearce, F. L. 1997. Spontaneous histamine release from mast cells and basophils is controlled by the cellular environment. Inflamm. Res. 46:S25–S26
  • Gilfillan, A. M., and Tkaczyk, C. 2006. Integrated signaling pathways for mast-cell activation. Nat. Rev. Immunol. 6:218–230
  • Gilfillan, A. M., Kado-Fong, H., Wiggan, G. A., et al. 1992. Conservation of signal transduction mechanisms via the human FcɛRIα after transfection into a rat mast cell-line, RBL-2H3. J. Immunol. 149:2445–2451
  • Goodman, R. E., Vieths, S., Sampson, H. A., et al. 2008. Allergenicity assessment of genetically modified crop–what makes sense? Nat. Biotechnol. 26:73–81
  • Guo, Y. C., Li, Z. X., Lin, H., et al. 2009. Studies on the specific degranulation of mast cell sensitized by several allergens in vitro. Cell. Mol. Immunol. 6:149–153
  • Han, E. H., Hwang, Y. P., Kim, H. G., et al. 2011. Ethyl acetate extract of Psidium guajava inhibits IgE-mediated allergic responses by blocking FcɛRI signaling. Food Chem. Toxicol. 49:100–108
  • Hauswirth, A. W., Natter, S., Ghannadan, M., et al. 2002. Recombinant allergens promote expression of CD203c on basophils in sensitized individuals. J. Allergy Clin. Immunol. 110:102–109
  • Hazebrouck, S., Ah-Leung, S., Bidat, E., et al. 2014. Goat’s milk allergy without cow’s milk allergy: Suppression of non-cross-reactive epitopes on caprine β-casein. Clin. Exp. Allergy 44:602–610
  • Hoffmann, A., Jamin, A., Foetisch, K., et al. 1999. Determination of the allergenic activity of birch pollen and apple prick test solutions by measurement of β-hexosaminidase release from RBL-2H3 cells. Allergy 54:446–454
  • Hoffmann, A., Vieths, S., and Haustein, D. 1997. Biologic allergen assay for in vivo test allergens with an in vitro model of the murine Type I reaction. J. Allergy Clin. lmmunol. 99:227–232
  • Horigome, K., Bullock, E. D., and Johnson, E. M. Jr. 1994. Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction. J. Biol. Chem. 269:2695–2702
  • Ishida, M., Nishi, K., Watanabe, H., and Sugahara, T. 2013. Inhibitory effect of aqueous spinach extract on degranulation of RBL-2H3 cells. Food Chem. 136:322–327
  • Jarvinen, K. M., Geller, L., Bencharitiwong, R., and Sampson, H. A. 2011. Presence of functional autoreactive human milk-specific IgE in infants with cow milk allergy. Clin. Exp. Allergy 42:238–247
  • Jimenez-Saiz, R., Belloque, J., Molina, E., and Lopez-Fandino, R. 2011. Human immunoglobulin E (IgE) binding to heated and glycated ovalbumin and ovomucoid before and after in vitro digestion. J. Agric. Food Chem. 59:10044–10051
  • Kadooka, Y., Idota, T., Gunji, H., et al. 2000. A method for measuring specific IgE in sera by direct ELISA without interference by IgG competition or IgG autoantibodies to IgE. Int. Arch. Allergy Immunol. 122:264–269
  • Kahlert, H., Cromwell, O., and Fiebig, H. 2003. Measurement of basophil-activating capacity of grass pollen allergens, allergoids and hypoallergenic recombinant derivatives by flow cyto- metry using anti-CD203c. Clin. Exp. Allergy 33:1266–1272
  • Kaul, S., Luttkopf, D., Kastner, B., et al. 2007. Mediator release assays based on human or murine immunoglobulin E in allergen standardization. Clin. Exp. Allergy 37:141–150
  • Knight, A. K., Shreffler, W. G., Sampson, H. A., et al. 2006. Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in children. J. Allergy Clin. Immunol. 117:842–847
  • Knippels, L. M. J., van der Kleij, H. P. M., Koppelman, S. J., et al. 2000. Comparison of antibody responses to hen's egg and cow's milk proteins in orally sensitized rats and food-allergic patients. Allergy 55:251–258
  • Kobayashi, S., and Tanabe, S. 2006. Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen. Int. J. Mol. Med. 17:511–515
  • Kuba-Miyara, M., Agarie, K., Sakima, R., et al. 2012. Inhibitory effects of an ellagic acid glucoside, okica- melliaside, on antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. Int. Immunopharmacol. 12:675–681
  • Ladics, G. S., van Bilsen, J. H., Brouwer, H. M., et al. 2008. Assessment of three human FcɛRI-transfected RBL cell-lines for identifying IgE-induced degranulation utilizing peanut-allergic patient sera and peanut protein extract. Regul. Toxicol. Pharm. 51:288–294
  • Marchand, F., Mecheri, S., Guilloux, L., et al. 2003. Human serum IgE-mediated mast cell degranulation shows poor correlation to allergen-specific IgE content. Allergy 58:1037–1043
  • Mayorga, C., Sanz, M. L., Gamboa, P. M., and García B. E. 2010. In vitro diagnosis of immediate allergic reactions to drugs: An update. J. Invest. Allergol. Clin. Immunol. 20:103–109
  • Mills, E. N., Sancho, A. I., Rigby, N. M., et al. 2009. Impact of food processing on the structural and allergenic properties of food allergens. Mol. Nutr. Food Res. 53:963–969
  • Mittag, D., Akkerdaas, J., Ballmer-Weber, B. K., et al. 2004. Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy. J. Allergy Clin. Immunol. 114:1410–1417
  • Nowak-Wegrzyn, A. H., Bencharitiwong, R., Schwarz, J., et al. 2009. Mediator release assay for assessment of biological potency of German cockroach allergen extracts. J. Allergy Clin. Immunol. 123:949–955
  • Ocmant, A., Mulierw, S., Hanssensw, L., et al. 2009. Basophil activation tests for the diagnosis of food allergy in children. Clin. Exp. Allergy 39:1234–1245
  • Palmera, G. W., Dibbern, D. A. Jr., Burks, A. W., et al. 2005. Comparative potency of Ara h 1 and Ara h 2 in immunochemical and functional assays of allergenicity. Clin. Immunol. 115:302–312
  • Passante, E., and Frankish, N. 2009. The RBL-2H3 cell line: Its provenance and suitability as a model for the mast cell. Inflamm. Res. 58:737–745
  • Passante, E., Ehrhardt, C., Sheridan, H., and Frankish, N. 2009. RBL-2H3 cells are an imprecise model for mast cell mediator release. Inflamm. Res. 58:611–618
  • Rancé, F., Abbal, M., and Lauwers-Cancès, V. 2002. Improved screening for peanut allergy by combined use of skin prick tests and specific IgE assays. J. Allergy Clin. Immunol. 109:1027–1033
  • Rashid, A., Sadroddiny, E., Ye, H. T., et al. 2012. Review: Diagnostic and therapeutic applications of rat basophilic leukemia cells. Mol. Immunol. 52:224–228
  • Sabbah, A., Drouet, M., Sainte-Laudry, J., et al. 1997. Contribution of flow cytometry to allergologic diagnosis. Allerg. Immunol. 29:15–21
  • Sabbah, A., Plassais, R., Grenapin, S., et al. 1998. Testing basophil activation by flow cytometry in the diagnosis of allergy to hyme-nopteran venom. Allerg. Immunol. 30:44–48
  • Sainte-Laudy, J., Vallon, C., and Guerin, J. C. 1994. Analysis of membrane expression of the CD63 human basophil activation marker. Applications to allergologic diagnosis. Allergy Immunol. 26:211–214
  • Sainte-Laudy, J., Vallon, C., and Guerin, J. C. 1996. Diagnosis of latex allergy: Comparison of histamine release and flow cytometric analysis of basophil activation. Inflamm. Res. 45:S35–S36
  • Sancho, A. I., Rigby, N. M., Zuidmeer, L., et al. 2005. The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple. Mal d 3. Allergy 60:1262–1268
  • Sathe, S. K., Teuber, S. S., and Roux, K. H. 2005. Effects of food processing on the stability of food allergens. Biotechnol. Adv. 23:423–429
  • Scheurer, S., Son, D. Y., Boehm, M., et al. 1999. Cross-reactivity and epitope analysis of Pru a 1, the major cherry allergen. Mol. Immunol. 36:155–167
  • Schuurman, H. J., Cheng, J., and Lam, T. 2003. Pathology of xenograft rejection: A commentary. Xenotransplantation 10:293–299
  • Serup, J., and Staberg, B. 1985. Quantification of wheal reactions with laser doppler flow cytometry. Allergy 40:233–237
  • Sharnan, J., Kumar, L., and Singh, S. 2001. Comparison of results of skin prick tests, enzyme-linked immunosorbent assays and food challenges in children with respiratory allergy. J. Trop. Pediatr. 47:376–378
  • Siraganian, R. P., McGivney, A., Barsumian, E. L., et al. 1982. Variants of the rat basophilic leukemia cell line for the study of histamine release. Fed. Proc. 41:30–34
  • Sordet, C., Culerrier, R., Granier, C., et al. 2009. Expression of Jug r 1, the 2S albumin allergen from walnut (Juglans regia), as a correctly folded and functional recombinant protein. Peptides 30:1213–1221
  • Sun, N., Zhou, C., Pu, Q., et al. 2013. Allergic reactions compared between BN and Wistar rats after oral exposure to ovalbumin. J. Immunotoxicol. 10:67–74
  • Sussmang, L., Harveyr, P., and Schocketal, L. 1982. Evaluation of skin test response using two techniques of measurement. Ann. Allergy 48:75–77
  • Takagi, K., Nakamura, R., Teshima, R., and Sawada, J. 2003. Application of human FcɛRIα-chain-transfected RBL-2H3 cells for estimation of active serum IgE. Biol. Pharm. Bull. 26:252–255
  • Taudou, G., Varin-Blank, N., Jouin, H., et al. 1993. Expression of the α-chain of human FcɛRI in transfected rat basophilic leukemia cells functional activation after sensitization with human mite-specific IgE. Int. Arch. Allergy Immunol. 100:344–350
  • Toda, M., Reese, G., Gadermaier, G., et al. 2011. Protein unfolding strongly modulates the allergenicity and immune- genicity of Pru p 3, the major peach allergen. J. Allergy Clin. Immunol. 128:1022–1030
  • Tregoat, V. S., and Garssen, J. 2011. Method for determining an allergic response. Patent #US 7977063 B2
  • Trivedi, B., Valerio, C., and Slater, J. E. 2003. Endotoxin content of standardized allergen vaccines. J. Allergy Clin. Immunol. 111:777–783
  • Untersmayr, E., Poulsen, L. K., Platzer, M. H., et al. 2005. The effects of gastric digestion on codfish allergenicity. J. Allergy Clin. Immunol. 115:377–382
  • van Escha, B. C., Knipping, K., Jeurink, P., et al. 2011. In vivo and in vitro evaluation of the residual allergenicity of partially hydrolyzed infant formulas. Toxicol. Lett. 201:264–269
  • van der Veen, M. J., van Ree, R., Aalberse, R. C., et al. 1997. Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J. Allergy Clin. Immunol. 100:327–334
  • van Ree, R., and Aalberse, R. C. 1999. Specific IgE without clinical allergy. J. Allergy Clin. Immunol. 103:1000–1001
  • Vissers, Y. M., Iwan, M., Adel-Patient, K., et al. 2011. Effect of roasting on the allergenicity of major peanut allergens Ara h 1 and Ara h 2/6: The necessity of degranulation assays. Clin. Exp. Allergy 41:1631–1642
  • Vogel, L. Holzhauser, T., and Vieths, S. 2006. Development of a biological assay to determine the allergenic potential of foods. J. Verbr. Lebensm. 1:317–324
  • Vogel, L., Luttkopf, D., Hatahet, L., et al. 2005. Development of a functional in vitro assay as a novel tool for the standardization of allergen extracts in the human system. Allergy 60:1021–1028
  • Wang, J., and Sampson, H. A. 2009. Food allergy: Recent advances in pathophysiology and treatment. Allergy Asthma Immunol. Res. 1:19–29
  • Zhang, T., Yang, C., Rupa, P., et al. 2012. Inhibitory effects of Quillaja saponin on IgE-mediated degranulation of rat basophilic leukemia RBL–2H3 Cells. J. Funct. Foods 4:864–871

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.