Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood

References

• Baken, K. A., Pennings, J. L., de Vries, A., et al. 2006. Gene expression profiling of bis(tri-n-butyltin)oxide (TBTO)-induced immunotoxicity in mice and rats. J. Immunotoxicol. 3:227–244
   PubMedGoogle Scholar
• Baken, K. A., Pennings, J. L., Jonker, M. J., et al. 2008. Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening. Toxicol. Appl. Pharmacol. 226:46–59
   PubMed Web of Science ®Google Scholar
• Begley, L. A., Kasina, S., MacDonald, J., and Macoska, J. A. 2008. The inflammatory micro-environment of the aging prostate facilitates cellular proliferation and hypertrophy. Cytokine 43:194–199
   PubMed Web of Science ®Google Scholar
• Bosmann, M., and Ward, P. A. 2013. Modulation of inflammation by IL-27. J. Leukocyte Biol. 94:1159–1165
   PubMed Web of Science ®Google Scholar
• Buck, R. C., Franklin, J., Berger, U., et al. 2011. Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins. Integr. Environ. Assess. Manag. 7:513–541
   PubMedGoogle Scholar
• Caminschi, I., Vandenabeele, S., Sofi, M., et al. 2006. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. DNA Seq. 17:8–14
   PubMed Web of Science ®Google Scholar
• Chao, C., Joyce-Shaikh, B., Grein, J., et al. 2011. C17 prevents inflammatory arthritis and associated joint destruction in mice. PLoS One 6:e22256
   Web of Science ®Google Scholar
• Corsini, E., Luebke, R. W., Germolec, D. R., and DeWitt, J. C. 2014. Perfluorinated compounds: Emerging POPs with potential immunotoxicity. Toxicol. Lett. 230:263–270
   PubMed Web of Science ®Google Scholar
• Corsini, E., Sangiovanni, E., Avogadro, A., et al. 2012. In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs). Toxicol. Appl. Pharmacol. 258:248–255
   PubMed Web of Science ®Google Scholar
• DeWitt, J. C., Copeland, C. B., Strynar, M. J., and Luebke, R. W. 2008. Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice. Environ. Health Perspect. 116:644–650
   PubMed Web of Science ®Google Scholar
• DeWitt, J. C., Peden-Adams, M. M., Keller, J. M., and Germolec, D. R. 2012. Immunotoxicity of perfluorinated compounds: Recent developments. Toxicol. Pathol. 40:300–311
   PubMed Web of Science ®Google Scholar
• Fei, C., McLaughlin, J. K., Lipworth, L., and Olsen, J. 2010. Prenatal exposure to PFOA and PFOS and risk of hospitalization for infectious diseases in early childhood. Environ. Res. 110:773–777
   PubMed Web of Science ®Google Scholar
• Fleuren, W. W., Verhoeven, S., Frijters, R., et al. 2011. CoPub update: CoPub 5.0 a text mining system to answer biological questions. Nucl. Acids Res. 39:W450–454
   PubMed Web of Science ®Google Scholar
• Frawley, R., White, K. Jr, Brown, R., et al. 2011. Gene expression alterations in immune system pathways in the thymus after exposure to immuno-suppressive chemicals. Environ. Health Perspect. 119:371–376
   PubMed Web of Science ®Google Scholar
• Fromme, H., Tittlemier, S. A., Volkel, W., et al. 2009. Perfluorinated compounds - exposure assessment for the general population in Western countries. Int. J. Hyg. Environ. Health 212:239–270
   PubMed Web of Science ®Google Scholar
• Gluckman, P. D., Hanson, M. A., Cooper, C., and Thornburg, K. L. 2008. Effect of in utero and early-life conditions on adult health and disease. New Engl. J. Med. 359:61–73
   PubMed Web of Science ®Google Scholar
• Grandjean, P., Andersen, E. W., Budtz-Jorgensen, E., et al. 2012. Serum vaccine antibody concentrations in children exposed to perfluori–nated compounds. JAMA 307:391–397
   PubMed Web of Science ®Google Scholar
• Granum, B., Haug, L. S., Namork, E., et al. 2013. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. J. Immunotoxicol. 10:373–379
   PubMed Web of Science ®Google Scholar
• Gutzkow, K. B., Haug, L. S., Thomsen, C., et al. 2012. Placental transfer of perfluorinated compounds is selective - a Norwegian Mother and Child sub–cohort study. Int. J. Hyg Environ. Health 215:216–219
   PubMed Web of Science ®Google Scholar
• Haug, L. S., Salihovic, S., Jogsten, I. E., et al. 2010. Levels in food and beverages and daily intake of perfluorinated compounds in Norway. Chemosphere 80:1137–1143
   PubMed Web of Science ®Google Scholar
• Hochstenbach, K., van Leeuwen, D. M., Gmuender, H., et al. 2012. Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns. Toxicol. Sci. 129:315–324
   PubMed Web of Science ®Google Scholar
• Holsapple, M. P., Paustenbach, D. J., Charnley, G., et al. 2004. Symposium summary: Children's health risk - what's so special about the developing immune system? Toxicol. Appl. Pharmacol. 199:61–70
   PubMed Web of Science ®Google Scholar
• Houde, M., Martin, J. W., Letcher, R. J., et al. 2006. Biological monitoring of polyfluoroalkyl substances: A review. Environ. Sci. Technol. 40:3463–3473
   PubMed Web of Science ®Google Scholar
• Jeon, J., Oh, H., Lee, G., et al. 2011. Cytokine-like 1 knockout mice (Cytl1–/–) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction. J. Biol. Chem. 286:27206–27213
   PubMed Web of Science ®Google Scholar
• Kim, J. S., Ryoo, Z. Y., and Chun, J. S. 2007. Cytokine-like 1 (Cytl1) regulates the chondro-genesis of mesenchymal cells. J. Biol. Chem. 282:29359–29367
   PubMed Web of Science ®Google Scholar
• Lau, C., Anitole, K., Hodes, C., et al. 2007. Perfluoroalkyl acids: A review of monitoring and toxicological findings. Toxicol. Sci. 99:366–394
   PubMed Web of Science ®Google Scholar
• Liu, X., Rapp, N., Deans, R., and Cheng, L. 2000. Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells. Genomics 65:283–292
   PubMed Web of Science ®Google Scholar
• Magnus, P., Irgens, L. M., Haug, K., et al; and the MoBa Study. 2006. Cohort profile: The Norwegian Mother and Child Cohort Study (MoBa). Int. J. Epidemiol. 35:1146–1150
   PubMed Web of Science ®Google Scholar
• Midgett, K., Peden-Adams, M. M., Gilkeson, G. S., and Kamen, D. L. 2014. In vitro evaluation of the effects of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on IL-2 production in human T-cells. J. Appl. Toxicol. (in press)
   PubMed Web of Science ®Google Scholar
• Okada, E., Sasaki, S., Saijo, Y., et al. 2012. Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants. Environ. Res. 112:118–125
   PubMed Web of Science ®Google Scholar
• Peden-Adams, M. M., Keller, J. M., Eudaly, J. G., et al. 2008. Suppression of humoral immunity in mice following exposure to perfluorooctane sulfonate. Toxicol. Sci. 104:144–154
   PubMed Web of Science ®Google Scholar
• Pflanz, S., Timans, J. C., Cheung, J., et al. 2002. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T-cells. Immunity 16:779–790
   PubMed Web of Science ®Google Scholar
• Stenberg, J., Ruetschi, U., Skioldebrand, E., et al. 2013. Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients. Proteome Sci. 11:43
   PubMed Web of Science ®Google Scholar
• Stølevik, S. B., Nygaard, U. C., Namork, E., et al. 2011. Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. Food Chem. Toxicol. 49:1843–1848
   PubMed Web of Science ®Google Scholar
• Stølevik, S. B., Nygaard, U. C., Namork, E., et al. 2013. Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood. Food Chem. Toxicol. 51:165–172
   PubMed Web of Science ®Google Scholar
• Tomczak, A., and Pisabarro, M. T. 2011. Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model. Proteins 79:1277–1292
   PubMed Web of Science ®Google Scholar
• van den Heuvel, J. P., Thompson, J. T., Frame, S. R., and Gillies, P. J. 2006. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: A comparison of human, mouse, and rat peroxisome proliferator-activated receptor-α, -β, and -γ, liver X receptor-β, and retinoid X receptor-α. Toxicol. Sci. 92:476–489
   PubMed Web of Science ®Google Scholar
• Vestergren, R., and Cousins, I. T. 2009. Tracking the pathways of human exposure to perfluoro-carboxylates. Environ. Sci. Technol. 43:5565–5575
   PubMed Web of Science ®Google Scholar
• Wang, I. J., Hsieh, W. S., Chen, C. Y., et al. 2011. The effect of prenatal perfluorinated chemicals exposures on pediatric atopy. Environ. Res. 111:785–791
   PubMed Web of Science ®Google Scholar
• West, L. J. 2002. Defining critical windows in the development of the human immune system. Human Exp. Toxicol. 21:499–505
   PubMed Web of Science ®Google Scholar
• Wick, H. C., Drabkin, H., Ngu, H., et al. 2014. DFLAT: Functional annotation for human development. BMC Bioinformatics 15:45
   PubMed Web of Science ®Google Scholar