Biological and Ultrastructural Aspects of Iron Overload: An Overview

References

• Neilands J B. Microbial iron compounds. Annu Rev Biochem 1981; 50: 715–31
   PubMed Web of Science ®Google Scholar
• Addy D P. Happiness is: iron. Br Med J ‘Clin Res’ 1986; 292: 969–70
   PubMed Web of Science ®Google Scholar
• Brock J H. Iron and the outcome of infection. (Editorial). Br Med J ‘Clin Res’ 1986; 293: 518–20
   PubMed Web of Science ®Google Scholar
• Hann H L, Stahlhut M W, Blumberg B S. Iron nutrition and tumor growth: Decreased tumor growth in iron-deficient mice. Cancer Res 1988; 48: 4168–70
   PubMed Web of Science ®Google Scholar
• Harrison P M, Andrews S C, Ford G F, Smith J M A, Treffry A, White J L. Ferritin and bacterioferritin: Iron sequestering molecules from man to microbe. Iron Transport in Microbes, Plants and Animals, G Winkelmann, D Van der Helm, J B Neilands. Weinheim, FDR 1987; 45–75, New York: VCH
   Google Scholar
• Stevens R G, Jones Y D, Micozzi M S, Taylor P R. Body iron stores and the risk of cancer. N Engl J Med 1988; 319: 1047–52
   PubMed Web of Science ®Google Scholar
• Lancu T C, Landing B H, Neustein H B. Pathogenetic mechanisms in hepatic cirrhosis of thalassemia major: Light and electron microscopic studies. Pathot Annu 1977, Pt 1: 171–200
   Google Scholar
• Lancu T C, Neustein H B, Landing B H. The liver in thalassemia major: Ultrastructural observations. Ciba Found Symp 1977; 51: 293–309
   Google Scholar
• Lancu T C. Iron overload. Molec Aspects Med 1983; 6: 1–100
   PubMed Web of Science ®Google Scholar
• Bessis M. Living Blood Cells and their Ultrastructure. Springer Verlag, Berlin 1973
   Google Scholar
• Richter G W. The iron-loaded cell: The cytopathology of iron storage. A review. Am J Pathol 1978; 91: 362–404
   PubMed Web of Science ®Google Scholar
• Richter G W. Studies of iron overload. Rat liver siderosome ferritin. Lab Invest 1984; 50: 26–35
   PubMed Web of Science ®Google Scholar
• Lancu T C, Neustein H B. Ferritin in human liver cells of homozygous β-thalassemia: Ultrastructural observations. Br J Haematol 1977; 37: 527–35
   PubMed Web of Science ®Google Scholar
• Bauminger E R, Iancu T C, Link G, Pinson A, Hershko C. Iron overload in cultured rat myocardial cells. Hyperfine Interactions 1987; 33: 249–62
   Google Scholar
• Cooper P J, Iancu T C, Ward R J, Guttridge K M, Peters T J. Quantitative analysis of immungold labeling for ferritin in liver from control and iron-overloaded rats. Histochem J 1988; 20: 499–509
   PubMedGoogle Scholar
• Cleton M I, de Bruijn W C, van Blokland W T, Marx J J, Roelofs J M, Rademakers L H. Iron content and acid phosphatase activitiy in hepatic parenchymal lysosomes of patients with hemochromatosis before and after phlebotomy treatment. Ultrastruct Pathol 1988; 12: 161–74
   PubMed Web of Science ®Google Scholar
• Vitale L, Opitz J M, Shahidi N T. Congenital and familial iron overload. N Engl J Med 1969; 280: 642–5
   PubMed Web of Science ®Google Scholar
• Goldfischer S, Grotsky H W, Chang C H, et al. Idiopathic neonatal iron storage involving the liver, pancreas, heart and endocrine and exocrine glands. Hepatology 1981; 1: 58–64
   PubMed Web of Science ®Google Scholar
• Blisard K S, Bartow S A. Neonatal hemochromatosis. Hum Pathol 1986; 17: 376–83
   PubMed Web of Science ®Google Scholar
• Colletti R B, Clemmons J J. Familial neonatal hemochromatosis with survival. J Pediatr Gastroenterol Nutr 1988; 7: 39–45
   PubMed Web of Science ®Google Scholar
• Peters T J, Raja K B, Simpson R J, Snape S. Mechanisms and regulation of intestinal iron absorption. Ann NY Acad Sci 1988; 526: 141–7
   PubMed Web of Science ®Google Scholar
• Jacobs A. An intracellular transit iron pool. Ciba Found Symp 1977; 51: 91–106
   Google Scholar
• Crosby W H. The safety of iron-fortified food. JAMA 1978; 239: 2026–7
   PubMed Web of Science ®Google Scholar
• Ley T J, Griffith P, Nienhuis A W. Transfusion haemosiderosis and chelation therapy. Clin Haematol 1982; 11: 437–64
   PubMedGoogle Scholar
• Kothary T, Swamy A P, Lee J C, Mangla J C, Cestero R V. Hepatic hemosiderosis in maintenance hemodialysis (MHD) patients. Dig Dis Sci 1980; 25: 363–8
   PubMed Web of Science ®Google Scholar
• Cleton M I, Sindram J W, Rademakers L H, Zuyderhoudt F M, De Bruijn W C, Marx J J. Ultrastructural evidence for the presence of ferritin iron in the biliary system of patients with iron overload. Hepatology 1986; 6: 30–5
   PubMed Web of Science ®Google Scholar
• Charlton R W, Bothwell T H, Seftel H C. Dietary iron overload. Clin Haematol 1973; 2: 383–403
   Google Scholar
• Iancu T C, Rabinowitz H, Brissot P, Guillouzo A, Deugnier Y, Bourel M. Iron overload of the liver in the baboon: An ultrastructural study. J Hepatol 1985; 1: 261–75
   PubMed Web of Science ®Google Scholar
• Cutz E. Idiopathic pulmonary hemosiderosis and related disorders in infancy and childhood. Perspect Pediatr Pathol 1987; 11: 47–81
   PubMedGoogle Scholar
• Ghadially F N, Ailsby R L, Yong N K. Ultrastructure of the haemophilic synovial membrane and electron probe x-ray analysis of haemosiderin. J Pathol 1976; 120: 201–8
   PubMed Web of Science ®Google Scholar
• Basset M L, Halliday J W, Powell L W. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986; 6: 24–9
   PubMed Web of Science ®Google Scholar
• Iancu T C, Shiloh H, Link G, Bauminger E R, Pinson A, Hershko C. Ultrastructural pathology of ironloaded rat myocardial cells in culture. Br J Exp Path 1987; 68: 53–65
   PubMedGoogle Scholar
• Link G, Pinson A, Hershko C. Heart cells in culture: A model of myocardial overload and chelation. J Lab Clin Med 1985; 106: 147–53
   PubMed Web of Science ®Google Scholar
• Searle J W, Kerr J F R, Halliday J W, Powell L W. Iron storage disease. Pathology of the Liver, R N M MacSween, P P Anthony, P J Scheuer. Churchill Livingstone, Edinburgh 1987; 181–201
   Google Scholar
• Iancu T C, Ward R J, Peters T J. Ultrastructural observations in the carbonyl iron-fed rat: An animal model for hemochromatosis. Virchows Arch ‘B’ 1987; 53: 208–17
   Web of Science ®Google Scholar
• Ward R J, Iancu T C, Henderson G M, Kirkwood J K, Peters T J. Hepatic iron overload in avian species. Avian Pathol 1988; 17: 451–64
   PubMed Web of Science ®Google Scholar
• Bacon B R, Tavill A S, Brittenham G M, Park C H, Recknagel R O. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 1983; 71: 429–39
   PubMed Web of Science ®Google Scholar
• Peters T J, O'Connell M J, Ward R J. Role of free radical mediated lipid peroxidation in the pathogenesis of hepatic damage by lysosomal disruption. Free Radicals in Liver Injury, G Poli, K H Cheeseman, M U Dianzani, T F Slater. IRL Press, Oxford 1986; 107–15
   Google Scholar
• Peters T J, Seldon C, Seymour C A. Lysosomal disruption in the pathogenesis of hepatic damage in primary and secondary haemochromatosis. Ciba Found Symp 1977; 51: 317–29
   Google Scholar
• Hann H L, Levy H M, Evans A E. Serum ferritin as a guide to therapy in neuroblastoma. Cancer Res 1980; 40: 1411–3
   PubMed Web of Science ®Google Scholar
• Iancu T C, Shiloh H, Kedar A. Neuroblastomas contain iron-rich ferritin. Cancer 1988; 61: 2497–502
   PubMed Web of Science ®Google Scholar
• Hill J M. The distribution of iron in the brain. Brain Iron: Neurochemical and Behavioural Aspects, M B Youdim. Taylor and Francis, London 1988; 1–24
   Google Scholar
• Yehuda S, Youdim M, Mostofsky D I. Brain iron deficiency causes reduced learning capacity in rats. Pharmacol Biochem Behav 1986; 25: 141–4
   PubMed Web of Science ®Google Scholar
• Lozoff B, Brittenham G M, Viteri F E, Wolf A W, Urrutis J J. Developmental deficits in iron-deficient infants: Effects of age and severity of iron lack. J Pediatr 1982; 101: 948–52
   PubMed Web of Science ®Google Scholar