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ArticlesResearch

Bioscavenger therapy for organophosphate poisoning – an open-labeled pilot randomized trial comparing fresh frozen plasma or albumin with saline in acute organophosphate poisoning in humans

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Pages 813-819 | Received 13 May 2010, Accepted 24 Aug 2010, Published online: 06 Oct 2010

References

  • Peter JV, John G. Management of acute organophosphate poisoning. Lancet 2008; 371:2170–2171.
  • Roberts DM, Karunarathna A, Buckley NA, Manuweera G, Sheriff MH, Eddleston M. Influence of pesticide regulation on acute poisoning deaths in Sri Lanka. Bull World Health Organ 2003; 81:789–798.
  • Peter JV, Jerobin J, Nair A, Bennett A. Is there a relationship between the WHO hazard classification of organophosphate pesticide and outcomes in suicidal human poisoning with commercial organophosphate formulations? Regul Toxicol Pharmacol 2010; 57:99–102.
  • Konradsen F, van der Hoek W, Cole DC, Hutchinson G, Daisley H, Singh S, Eddleston M. Reducing acute poisoning in developing countries – options for restricting the availability of pesticides. Toxicology 2003; 192:249–261.
  • Peter JV, Moran JL, Pichamuthu K, Chacko B. Adjuncts and alternatives to oxime therapy in organophosphate poisoning – is there evidence of benefit in human poisoning? A review. Anaesth Intensive Care 2008; 36:339–350.
  • Eddleston M, Eyer P, Worek F, Juszczak E, Alder N, Mohamed F, Senarathna L, Hittarage A, Azher S, Jeganathan K, Jayamanne S, von Meyer L, Dawson AH, Sheriff MH, Buckley NA. Pralidoxime in acute organophosphorus insecticide poisoning – a randomised controlled trial. PLoS Med 2009; 6(6):e1000104.
  • Peter JV, Moran JL, Graham PL. Advances in the management of organophosphate poisoning. Expert Opin Pharmacother 2007; 8(10):1451–1464.
  • Rahimi R, Nikfar S, Abdollahi M. Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials. Hum Exp Toxicol 2006; 25:157–162.
  • Buckley NA, Eddleston M, Szinicz L. Oximes for acute organophosphate pesticide poisoning. Cochrane Database Syst Rev 2005; 25(1):CD005085.
  • Doctor BP, Saxena A. Bioscavengers for the protection of humans against organophosphate toxicity. Chem Biol Interact 2005; 157–158:167–171.
  • Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci 2005; 83:303–312.
  • Guven M, Sungur M, Eser B, Sari I, Altuntas F. The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning. J Toxicol Clin Toxicol 2004; 42:617–623.
  • Peter JV, Cherian AM. Organic insecticides. Anaesth Intensive Care 2000; 28(1):11–21.
  • Sudarsanam TD, Pichaimuthu K, Zachariah A, John G. Oximes in acute organophosphate poisoning. Crit Care Med. 2006; 34:2265–2266.
  • Eddleston M, Eyer P, Worek F, Mohamed F, Senarathna L, von Meyer L, Juszczak E, Hittarage A, Azhar S, Dissanayake W, Sheriff MH, Szinicz L, Dawson AH, Buckley NA. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet 2005; 366:1452–1459.
  • Saxena A, Sun W, Luo C, Doctor BP. Human serum butyrylcholinesterase: in vitro and in vivo stability, pharmacokinetics, and safety in mice. Chem Biol Interact 2005; 157–158:199–203.
  • Eddleston M, Buckley NA, Eyer P, Dawson AH. Management of acute organophosphorus pesticide poisoning. Lancet 2008; 371:597–607.
  • Guven M, Sungur M, Eser B. The effect of plasmapheresis on plasma cholinesterase in a patient with organophosphate poisoning. Hum Exp Toxicol 2004; 23:365–368.
  • Fulton JA, Bouchard NC, Becker ML, Gertz S, Hoffman RS. FFP in organophosphate poisoning: what's the secret ingredient? Clin Toxicol (Phila) 2005; 43:215.
  • Wadia RS, Sadagopan C, Amin RB, Sardesai HV. Neurological manifestations of organophosphorus insecticide poisoning. J Neurol Neurosurg Psychiatry 1974; 37:841–847.
  • Senanayake N, Karalliedde L. Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome. N Engl J Med 1987; 316:761–763.
  • Jayawardane P, Dawson AH, Weerasinghe V, Karalliedde L, Buckley NA, Senanayake N. The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka. PLoS Med 2008; 15 5(7):e147.
  • Jayawardane P, Senanayake N, Dawson A. Electrophysiological correlates of intermediate syndrome following acute organophosphate poisoning. Clin Toxicol (Phila) 2009; 47:193–205.

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