Should phenytoin or barbiturates be used as second-line anticonvulsant therapy for toxicological seizures?

References

• Thundiyil JG, Kearney TE, Olson KR. Evolving epidemiology of drug-induced seizures reported to a poison control center system. J Med Toxicol 2007; 3:15–19.
   PubMedGoogle Scholar
• Lowenstein DH. Status epilepticus: an overview of the clinical problem. Epilepsia 1999; 40(Suppl. 1):S3–S8.
   PubMed Web of Science ®Google Scholar
• Roberts DM, Dissanayake W, Rezvi Sheriff MH, Eddleston M. Refractory status epilepticus following self-poisoning with the organochlorine pesticide endosulfan. J Clin Neurosci 2004; 11:760–762.
   PubMed Web of Science ®Google Scholar
• Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurology 1975; 25:730–734.
   PubMed Web of Science ®Google Scholar
• Wallace KL. Toxin-induced seizures In: Brent J, Wallace K, Burkhart K, eds. Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient. Philadelphia, Pennsylvania: Elsevier Mosby; 2005:225–239.
   Google Scholar
• McNamara JO. Drugs effective in the therapy of the epilepsies. In: Hardman JG, Limbird LE, Gilman GA, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw Hill; 2001:521–547.
   Google Scholar
• Fisher RS. Animal models of the epilepsies. Brain Res Brain Res Rev 1989; 14:245–278.
   PubMed Web of Science ®Google Scholar
• Victor M, Ropper AH, eds. Epilepsy and other seizure disorders. In: Adams and Victor’s Principles of Neurology. 7th ed. New York: McGraw-Hill; 2001:331–365.
   Google Scholar
• Daly FF, Little M, Murray L. A risk assessment based approach to the management of acute poisoning. Emerg Med J 2006; 23:396–399.
   PubMed Web of Science ®Google Scholar
• Bey AT, Walter FG. Seizures. In: Ford M, Delaney KA, Ling L, Erickson T, eds. Clinical Toxicology. Philadelphia, Pennsylvania: Saunders; 2001:155–167.
   Google Scholar
• Rao RB. Neurologic principles. In: Flobenbaum N, Goldfrank L, Hoffman R, Howland MA, Lewin N, eds. Goldfrank Toxicologic Emergencies, 8th ed. New York: McGraw-Hill Professional; 2006:307–328.
   Google Scholar
• Bronstein AC, Spyker DA, Cantilena LR Jr., Green JL, Rumack BH, Giffin SL. 2008 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 26th annual report. Clin Toxicol (Phila) 2009; 47:911–1084.
   PubMed Web of Science ®Google Scholar
• Bronstein AC, Spyker DA, Cantilena LR Jr., Green JL, Rumack BH, Heard SE. 2007 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 25th annual report. Clin Toxicol (Phila) 2008; 46:927–1057.
   PubMed Web of Science ®Google Scholar
• Bronstein AC, Spyker DA, Cantilena LR Jr., Green J, Rumack BH, Heard SE. 2006 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS). Clin Toxicol (Phila) 2007; 45:815–917.
   PubMed Web of Science ®Google Scholar
• Wood DM, Rajalingam Y, Greene SL, Morgan PE, Gerrie D, Jones AL, Dargan PI. Status epilepticus following intentional overdose of fluvoxamine: a case report with serum fluvoxamine concentration. Clin Toxicol (Phila) 2007; 45:791.
   PubMed Web of Science ®Google Scholar
• Prasad K, Al Roomi K, Krishnan PR, Sequeira R. Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev 2005; CD003723.
   Google Scholar
• Sofia RD, Gordon R, Gels M, Diamantis W. Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat. Res Commun Chem Pathol Pharmacol 1993; 79:335–341.
   PubMedGoogle Scholar
• Turski WA, Cavalheiro EA, Coimbra C, da Penha BM, Ikonomidou-Turski C, Turski L. Only certain antiepileptic drugs prevent seizures induced by pilocarpine. Brain Res 1987; 434:281–305.
   PubMedGoogle Scholar
• Derlet RW, Albertson TE. Anticonvulsant modification of cocaine-induced toxicity in the rat. Neuropharmacology 1990; 29:255–259.
   PubMed Web of Science ®Google Scholar
• Goldberg MJ, Spector R, Miller G. Phenobarbital improves survival in theophylline-intoxicated rabbits. J Toxicol Clin Toxicol 1986; 24:203–211.
   PubMed Web of Science ®Google Scholar
• Weihrauch T, Rieger H, Köhler H. Influence of diazepam and phenytoin on penicillin induced cerebral convulsion. Arzneimittelforschung 1976; 26:104–108.
   Google Scholar
• Amabeoku GJ, Farmer CC. Gamma-aminobutyric acid and mefloquine-induced seizures in mice. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29:917–921.
   PubMedGoogle Scholar
• Hoffman A, Pinto E, Gilhar D. Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. J Crit Care 1993; 8:198–202.
   PubMed Web of Science ®Google Scholar
• Sawaki K, Ohno K, Miyamoto K, Hirai S, Yazaki K, Kawaguchi M. Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats. Pharmacol Toxicol 2000; 86:59–62.
   PubMedGoogle Scholar
• Beaubien AR, Carpenter DC, Mathieu LF, MacConaill M, Hrdina PD. Antagonism of imipramine poisoning by anticonvulsants in the rat. Toxicol Appl Pharmacol 1976; 38:1–6.
   PubMed Web of Science ®Google Scholar
• Blake KV, Massey KL, Hendeles L, Nickerson D, Neims A. Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice. Ann Emerg Med 1988; 17:1024–1028.
   PubMed Web of Science ®Google Scholar
• Shih T, McDonough JH Jr., Koplovitz I. Anticonvulsants for soman-induced seizure activity. J Biomed Sci 1999; 6:86–96.
   PubMed Web of Science ®Google Scholar
• Zivanovic D, Stanojlovic O, Susic V, Stojanovic J. The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. Acta Neurol 2004; 104:20–26.
   Google Scholar
• Grundy HF, Howarth F. Pharmacological studies on hemlock water dropwort. Br J Pharmacol Chemother 1956; 11:225–230.
   PubMed Web of Science ®Google Scholar
• Lowenstein DH, Alldredge BK. Status epilepticus. N Engl J Med 1998; 338:970–976.
   PubMed Web of Science ®Google Scholar
• Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 1998; 339:792–798.
   PubMed Web of Science ®Google Scholar
• Leppik IE, Derivan AT, Homan RW, Walker J, Ramsay RE, Patrick B. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA 1983; 249:1452–1454.
   PubMed Web of Science ®Google Scholar
• Treatment of Convulsive Status Epilepticus. Recommendations of the Epilepsy Foundation of America’s Working Group on Status Epilepticus. JAMA 1993; 270:854–859.
   PubMed Web of Science ®Google Scholar
• Shaner DM, McCurdy SA, Herring MO, Gabor AJ. Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. Neurology 1988; 38:202–207.
   PubMed Web of Science ®Google Scholar
• Guidelines for treating status epilepticus in adults and children. NICE Guidelines 2004.
   Google Scholar
• Mayer SA, Claassen J, Lokin J, Mendelsohn F, Dennis LJ, Fitzsimmons BF. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol 2002; 59:205–210.
   PubMed Web of Science ®Google Scholar
• Williams JD, ed. Chemotherapy. New York: Plenum Press; 1976:339–344.
   Google Scholar
• Lallement G, Dorandeu F, Filliat P, Carpentier P, Baille V, Blanchet G. Medical management of organophosphate-induced seizures. J Physiol Paris 1998; 92:369–373.
   PubMed Web of Science ®Google Scholar
• Boucher BA. Fosphenytoin: a novel phenytoin prodrug. Pharmacotherapy 1996; 16:777–791.
   PubMed Web of Science ®Google Scholar
• Eriksson K, Keranen T, Kalviainen R. Fosphenytoin. Expert Opin Drug Metab Toxicol 2009; 5:695–701.
   PubMed Web of Science ®Google Scholar
• Chua HC, Venketasubramanian N, Tan CB, Tjia H. Paradoxical seizures in phenytoin toxicity. Singapore Med J 1999; 40:276–277.
   PubMedGoogle Scholar
• Osorio I, Burnstine TH, Remler B, Manon-Espaillat R, Reed RC. Phenytoin-induced seizures: a paradoxical effect at toxic concentrations in epileptic patients. Epilepsia 1989; 30:230–234.
   PubMed Web of Science ®Google Scholar
• Trevor AJ, Way WL. Sedative hypnotic drugs. In: Katzung B, ed. Basic & Clinical Pharmacology, 10 ed. New York: McGrawHill; 2007.
   Google Scholar
• Trapani G, Latrofa A, Franco M, Altomare C, Sanna E, Usala M, Biggio G, Liso G. Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors. J Med Chem 1998; 41:1846–1854.
   PubMed Web of Science ®Google Scholar
• Prasad A, Worrall BB, Bertram EH, Bleck TP. Propofol and midazolam in the treatment of refractory status epilepticus. Epilepsia 2001; 42:380–386.
   PubMed Web of Science ®Google Scholar
• Payne TA, Bleck TP. Status epilepticus. Crit Care Clin 1997; 13:17–38.
   PubMed Web of Science ®Google Scholar
• Rossetti AO, Reichhart MD, Schaller MD, Despland PA, Bogousslavsky J. Propofol treatment of refractory status epilepticus: a study of 31 episodes. Epilepsia 2004; 45:757–763.
   PubMed Web of Science ®Google Scholar
• Stecker MM, Kramer TH, Raps EC, O’Meeghan R, Dulaney E, Skaar DJ. Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia 1998; 39:18–26.
   PubMed Web of Science ®Google Scholar
• Knake S, Gruener J, Hattemer K, Klein KM, Bauer S, Oertel WH, Hamer HM, Rosenow F. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry 2008; 79:588–589.
   PubMed Web of Science ®Google Scholar
• Moddel G, Bunten S, Dobis C, Kovac S, Dogan M, Fischera M, Dziewas R, Schabitz WR, Evers S, Happe S. Intravenous levetiracetam: a new treatment alternative for refractory status epilepticus. J Neurol Neurosurg Psychiatry 2009; 80:689–692.
   PubMed Web of Science ®Google Scholar
• Eue S, Grumbt M, Muller M, Schulze A. Two years of experience in the treatment of status epilepticus with intravenous levetiracetam. Epilepsy Behav 2009; 15:467–469.
   PubMed Web of Science ®Google Scholar