574
Views
41
CrossRef citations to date
0
Altmetric
Short Reports

Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose

, , , , , & show all
Pages 945-948 | Received 07 Jun 2010, Accepted 22 Sep 2010, Published online: 20 Dec 2010

References

  • Jumbelic MI, Hanzlick R, Cohle S. Alkylamine antihistamine toxicity and review of Pediatric Toxicology Registry of the National Association of Medical Examiners. Report 4: Alkylamines. Am J Forensic Med Pathol 1997;18:65–69.
  • Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA. 2002;287:337–344.
  • Pragst F, Herre S, Bakdash A. Poisonings with diphenhydramine – a survey of 68 clinical and 55 death cases. Forensic Sci Int 2006;161:189–197.
  • Krenzelok EP, Anderson GM, Mirick M. Massive diphenhydramine overdose resulting in death. Ann Emerg Med 1982;11:212–213.
  • Koppel C, Ibe K, Tenczer J. Clinical symptomatology of diphenhydramine overdose: an evaluation of 136 cases. J Toxicol Clin Toxicol 1987;25:53–70.
  • Alldredge BK, Lowenstein DH, Simon RP. Seizures associated recreational drug abuse. Neurology 1989;39:1037–1039.
  • Kamei C, Ohuchi M, Sugimoto Y, Okuma C. Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats. Brain Res 2000;887:183–186.
  • Radovanovic D, Meier PJ, Guirguis M, Lorent JP, Kupferschmidt H. Dose-dependent toxicity of diphenhydramine overdose. Hum Exp Toxicol 2000;19:489–495.
  • Kuo CC, Huang RC, Lou BS. Inhibition of Na current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Mol Pharmacol 2000;57:135–143.
  • Nuemann JT, Bessen HA, Rothstein RJ, Laks MM. Electrocardiographic criteria for tricyclic antidepressant cardiotoxicity. Am J Cardiol 1986;57:1154–1159.
  • Zareba W, Moss AJ, Rosero SZ, Hajj-Ali R, Konecki J, Andrews M. Electrocardiographic findings in patients with diphenhydramine overdose. Am J Cardiol 1977;80:1168–1173.
  • Sharma AN, Hexdall AH, Chang EK, Nelson LS, Hoffman RS. Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. Am J Emerg Med 2003;21:212–215.
  • Clark RF, Vance MV. Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: successful treatment with sodium bicarbonate. Ann Emerg Med 1992;21:318–321.
  • Thakur AC, Aslam AK, Aslam AF, Vasavada BC, Sacchi TJ, Khan IA. QT interval prolongation in diphenhydramine toxicity. Int J Cardiol 2005;98: 341–343.
  • Joshi AK, Sljpic T, Borghei H, Kowey PR. Case of polymorphic ventricular tachycardia in diphenhydramine poisoning. J Cardiovasc Electrophysiol 2004;15:591–593.
  • Rossetti AO, Santoli F. Drug treatment of refractory status epilepticus. Rev Neurol (Paris) 2009;165:373–379.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.