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Review article

Occupational health of miners at altitude: Adverse health effects, toxic exposures, pre-placement screening, acclimatization, and worker surveillance

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Pages 629-640 | Received 12 Jul 2011, Accepted 18 Jul 2011, Published online: 23 Aug 2011

References

  • West JB. Highest inhabitants in the world. Nature 1986; 324:517.
  • West JB. Highest permanent human habitation. High Alt Med Biol 2002; 3:401–407.
  • Mazzeo RS, Bender PR, Brooks GA, Butterfield GE, Groves BM, Sutton JR, . Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am J Physiol 1991; 261:E419–424.
  • Mazzeo RS, Child A, Butterfield GE, Mawson JT, Zamudio S, Moore LG. Catecholamine response during 12 days of high-altitude exposure (4,300 m) in women. J Appl Physiol 1998; 84:1151–1157.
  • Reeves JT, Welsh CH, Wagner PD. The heart and lungs at extreme altitude. Thorax 1994; 49:631–633.
  • Hansen J, Sander M. Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol (Lond) 2003; 546:921–929.
  • Wu T-Y, Ding SQ, Liu JL, Yu MT, Jia JH, Chai ZC, . Who should not go high: chronic disease and work at altitude during construction of the Qinghai-Tibet railroad. High Alt Med Biol 2007; 8:88–107.
  • Luks AM. Should travelers with hypertension adjust their medications when traveling to high altitude? High Alt Med Biol 2009; 10:11–15.
  • Messerli-Burgy N, Meyer K, Steptoe A, Laederach-Hofmann K. Autonomic and cardiovascular effects of acute high altitude exposure after myocardial infarction and in normal volunteers. Circ J 2009; 73:1485–1491.
  • Levine BD, Zuckerman JH, deFilippi CR. Effect of high-altitude exposure in the elderly: the Tenth Mountain Division study. Circulation 1997; 96:1224–1232.
  • Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, . ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). [Erratum appears in Circulation. 2005 Apr 19;111(15):2013–4]. [Erratum appears in Circulation. 2010 Jun 15;121(23):e441]. [Erratum appears in Circulation. 2007 Apr 17;115(15):e411]. Circulation 2004; 110:e82–292.
  • Kleinman MT, Leaf DA, Kelly E, Caiozzo V, Osann K, O'Niell T. Urban angina in the mountains: effects of carbon monoxide and mild hypoxemia on subjects with chronic stable angina. Arch Environ Health 1998; 53:388–397.
  • West JB. Who should not go high? High Alt Med Biol 2009; 10:1–2.
  • Alexander JK. Coronary heart disease at altitude. Tex Heart Inst J 1994; 21:261–266.
  • de Vries ST, Kleijn SA, van ‘t Hof AW, Snaak H, van Enst GC, Kamp O, Breeman A. Impact of high altitude on echocardiographically determined cardiac morphology and function in patients with coronary artery disease and healthy controls. Eur J Echocardiogr 2010; 11(5):446–450.
  • Kozarsky PE. Prevention of common travel ailments. Infect Dis Clin North Am 1998; 12:305–324.
  • Agostoni P, Cattadori G, Guazzi M, Bussotti M, Conca C, Lomanto M, . Effects of simulated altitude-induced hypoxia on exercise capacity in patients with chronic heart failure. Am J Med 2000; 109:450–455.
  • Abinader EG, Sharif DS, Goldhammer E. Effects of low altitude on exercise performance in patients with congestive heart failure after healing of acute myocardial infarction. Am J Cardiol 1999; 83:383–387.
  • Anand IS, Chandrashekhar Y, Rao SK, Malhotra RM, Ferrari R, Chandana J, . Body fluid compartments, renal blood flow, and hormones at 6,000 m in normal subjects. J Appl Physiol 1993; 74:1234–1239.
  • Koller EA, Buhrer A, Felder L, Schopen M, Vallotton MB. Altitude diuresis: endocrine and renal responses to acute hypoxia of acclimatized and non-acclimatized subjects. Eur J Appl Physiol 1991; 62:228–234.
  • Moldotashev IK. [Characteristics of the pharmacotherapy of chronic heart failure under high-altitude conditions]. Ter Arkh 1988; 60:92–96.
  • Hainsworth R, Drinkhill MJ. Cardiovascular adjustments for life at high altitude. Respir Physiol Neurobiol 2007; 158:204–211.
  • Groves BM, Reeves JT, Sutton JR, . Operation Everest II: elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol 1987; 63:521–530.
  • Boussuges A, Molenat F, Burnet H, Cauchy E, Gardette B, Sainty JM, . Operation Everest III (Comex ’97): modifications of cardiac function secondary to altitude-induced hypoxia. An echocardiographic and Doppler study. Am J Respir Crit Care Med 2000; 161:264–270.
  • Sarybaev AS, Palasiewicz G, Usupbaeva DA, Plywaczewski R, Maripov AM, Sydykov AS, . Effects of intermittent exposure to high altitude on pulmonary hemodynamics: a prospective study. High Alt Med Biol 2003; 4:455–463.
  • Maggiorini M, Leon-Velarde F. High-altitude pulmonary hypertension: a pathophysiological entity to different diseases. Eur Respir J 2003; 22:1019–1025.
  • Urushihata K, Koizumi T, Hanaoka M, Fujimoto K, Kubo K, Kobayashi T, . Reduced lung uptake of iodine-123 metaiodobenzylguanidine in high-altitude pulmonary oedema. Respirology 2008; 13:897–902.
  • Wu T, Ding S, Liu J, Jia J, Dai R, Liang B, . Ataxia: an early indicator in high altitude cerebral edema. High Alt Med Biol 2006; 7:275–280.
  • Carrasco M. [Acute mountain sickness in workers of the Marte mine in the Copiapo mountain range]. Rev Med Chil 1991; 119:941–942.
  • Monge C. High altitude disease. Arch Intern Med 1937; 59:32–40.
  • Monge C, Leon-Velarde F, Arregui A. Increasing prevalence of excessive erythrocytosis with age among healthy high-altitude miners. N Engl J Med 1989; 321:1271.
  • Gong H, Jr, Tashkin DP, Lee EY, Simmons MS. Hypoxia-altitude simulation test. Evaluation of patients with chronic airway obstruction. Am Rev Respir Dis 1984; 130:980–986.
  • Cote TR, Stroup DF, Dwyer DM, Horan JM, Peterson DE. Chronic obstructive pulmonary disease mortality. A role for altitude. Chest 1993; 103:1194–1197.
  • Piacentini GL, Peterson C, Peroni DG, Bodini A, Boner AL. Allergen avoidance at high altitude and urinary eosinophil protein X. J Allergy Clin Immunol 1999; 104:243–244.
  • van Velzen E, van den Bos JW, Benckhuijsen JA, van Essel T, de Bruijn R, Aalbers R. Effect of allergen avoidance at high altitude on direct and indirect bronchial hyperresponsiveness and markers of inflammation in children with allergic asthma. Thorax 1996; 51:582–584.
  • Peroni DG, Boner AL, Vallone G, Antolini I, Warner JO. Effective allergen avoidance at high altitude reduces allergen-induced bronchial hyperresponsiveness. Am J Respir Crit Care Med 1994; 149:1442–1446.
  • Boner AL, Peroni DG, Piacentini GL, Venge P. Influence of allergen avoidance at high altitude on serum markers of eosinophil activation in children with allergic asthma. Clin Exp Allergy 1993; 23:1021–1026.
  • Voznesenskii NK. [Characteristics of the progression of silicosis under alpine conditions]. Gig Sanit 1996:16–18.
  • Odinaev FI. [The mechanisms of the formation of pneumoconiosis under high-altitude conditions]. Gig Tr Prof Zabol 1992:11–13.
  • Odinaev FI. [The characteristics of the development and course of pneumoconiosis under the conditions of a mountain climate]. Gig Tr Prof Zabol 1992:13–14.
  • Welsh CH, Wagner PD, Reeves JT, Lynch D, Cink TM, Armstrong J, . Operation Everest. II: spirometric and radiographic changes in acclimatized humans at simulated high altitudes. Am Rev Respir Dis 1993; 147:1239–1244.
  • Wagner PD, Sutton JR, Reeves JT, Cymerman A, Groves BM, Malconian MK. Operation Everest II: pulmonary gas exchange during a simulated ascent of Mt. Everest. J Appl Physiol 1987; 63:2348–2359.
  • Tolmach DV, Bondarenko GA, Soboleva NP, Denisenko AF, Ignatova OA. [The significance of an alpine climate in the combined treatment of occupational diseases]. Vrach Delo 1989:109–111.
  • Dong F, Langford WF. Models of Cheyne-Stokes respiration with cardiovascular pathologies. J Math Biol 2008; 57:497–519.
  • Ward MP, Milledge JS, West JB. High altitude medicine and physiology. 3rd. New York: Oxford University Press; 2000.
  • Przybylowski T, Ashirbaev A, Le Roux J, Zielinski J. [Sleep and breathing at altitude of 3800 m–-the acclimatization effect]. Pneumonol Alergol Pol 2003; 71:213–220.
  • Valencia-Flores M, Rebollar V, Santiago V, Orea A, Rodriguez C, Resendiz M, . Prevalence of pulmonary hypertension and its association with respiratory disturbances in obese patients living at moderately high altitude. Int J Obes Relat Metab Disord 2004; 28:1174–1180.
  • Ri-Li G, Chase PJ, Witkowski S, Wyrick BL, Stone JA, Levine BD, . Obesity: associations with acute mountain sickness. Ann Intern Med 2003; 139:253–257.
  • Ge R-L, Stone JA, Levine BD, Babb TG. Exaggerated respiratory chemosensitivity and association with SaO2 level at 3568 m in obesity. Respir Physiol Neurobiol 2005; 146:47–54.
  • Gronbeck C, 3rd. Chronic mountain sickness at an elevation of 2,000 meters. Chest 1984; 85:577–578.
  • Toff NJ. Hazards of air travel for the obese: Miss Pickwick and the Boeing 747. J R Coll Physicians Lond 1993; 27:375–376.
  • Basnyat B, Wu T, Gertsch JH. Neurological conditions at altitude that fall outside the usual definition of altitude sickness. High Alt Med Biol 2004; 5:171–179.
  • Winkelmayer WC, Liu J, Brookhart MA. Altitude and all-cause mortality in incident dialysis patients. Jama 2009; 301:508–512.
  • West JB. Tolerance to severe hypoxia: lessons from Mt. Everest. Acta Anaesthesiol Scand Suppl 1990; 94:18–23.
  • Sanner B, Schafer T. [Central sleep apnea syndrome]. Dtsch Med Wochenschr 2008; 133:722–726.
  • Angerer P, Nowak D. Working in permanent hypoxia for fire protection-impact on health. Int Arch Occup Environ Health 2003; 76:87–102.
  • Crowley JS, Wesensten N, Kamimori G, Devine J, Iwanyk E, Balkin T. Effect of high terrestrial altitude and supplemental oxygen on human performance and mood. Aviat Space Environ Med 1992; 63:696–701.
  • Roscoe RJ. An update of mortality from all causes among white uranium miners from the Colorado Plateau Study Group. Am J Ind Med 1997; 31:211–222.
  • Koller EA, Bischoff M, Buhrer A, Felder L, Schopen M. Respiratory, circulatory and neuropsychological responses to acute hypoxia in acclimatized and non-acclimatized subjects. Eur J Appl Physiol 1991; 62:67–72.
  • Usui C, Inoue Y, Kimura M, Kirino E, Nagaoka S, Abe M, . Irreversible subcortical dementia following high altitude illness. High Alt Med Biol 2004; 5:77–81.
  • Garrido E, Segura R, Capdevila A, Aldoma J, Rodriguez FA, Javierra C, . New evidence from magnetic resonance imaging of brain changes after climbs at extreme altitude. Eur J Appl Physiol 1995; 70:477–481.
  • Garrido E, Castello A, Ventura JL, Capdevila A, Rodriguez FA. Cortical atrophy and other brain magnetic resonance imaging (MRI) changes after extremely high-altitude climbs without oxygen. Int J Sports Med 1993; 14:232–234.
  • Rodway GW, Hoffman LA, Sanders MH. High-altitude-related disorders – Part II: prevention, special populations, and chronic medical conditions. Heart Lung 2004; 33:3–12.
  • Poduval RG. Adult subacute mountain sickness – a syndrome at extremes of high altitude. J Assoc Physicians India 2000; 48:511–513.
  • Ellerton JA, Zuljan I, Agazzi G, Boyd JJ. Eye problems in mountain and remote areas: prevention and onsite treatment – official recommendations of the International Commission for Mountain Emergency Medicine ICAR MEDCOM. Wilderness Environ Med 2009; 20:169–175.
  • Zlateva V, Pavlova S. [The impact of trinitrotoluene on eyes in miners] [in Russian]. Med Tr Prom Ekol 1998:26–29.
  • Winkle RK, Mader TH, Parmley VC, White LJ, Polse KA. The etiology of refractive changes at high altitude after radial keratotomy. Hypoxia versus hypobaria. Ophthalmology 1998; 105:282–286.
  • Morris DS, Somner JEA, Scott KM, McCormick IJC, Aspinall P, Dhillon B. Corneal thickness at high altitude. Cornea 2007; 26: 308–311.
  • Butler FK, Jr. The eye at altitude. Int Ophthalmol Clin 1999; 39:59–78.
  • Sun Z, Hong J, Liu Z, Jin X, Gu C. Coal dust contiguity-induced changes in the concentration of TNF-alpha and NF-kappa B p65 on the ocular surface. Ocul Immunol Inflamm 2009; 17:76–82.
  • Wiedman M, Tabin GC. High-altitude retinopathy and altitude illness. Ophthalmology 1999; 106:1924–1926; discussion 1927.
  • Fang IM, Huang J-S. Central retinal artery occlusion caused by expansion of intraocular gas at high altitude. Am J Ophthalmol 2002; 134:603–605.
  • Moore K, Thompson C, Hayes R. Diabetes and extreme altitude mountaineering. Br J Sports Med 2001; 35:83.
  • Pavan P, Sarto P, Merlo L, Casara D, Ponchia A, Biasin R, . Metabolic and cardiovascular parameters in type 1 diabetes at extreme altitude. Med Sci Sports Exerc 2004; 36:1283–1289.
  • Fink KS, Christensen DB, Ellsworth A. Effect of high altitude on blood glucose meter performance. Diabetes Technol Ther 2002; 4:627–635.
  • Giordano BP, Thrash W, Hollenbaugh L, Dube WP, Hodges C, Swain A, . Performance of seven blood glucose testing systems at high altitude. Diabetes Educ 1989; 15:444–448.
  • Fenwick S, Main J. Increased prevalence of renal disease in silica-exposed workers. Lancet 2000; 356:913–914.
  • Calvert GM, Steenland K, Palu S. End-stage renal disease among silica-exposed gold miners. A new method for assessing incidence among epidemiologic cohorts. JAMA 1997; 277:1219–1223.
  • Thun M, Stayner L, Brown D, Waxweiler R. Mining and deaths from chronic renal failure. Lancet 1982; 2:606.
  • Selevan SG, Landrigan PJ, Stern FB, Jones JH. Mortality of lead smelter workers. Am J Epidemiol 1985; 122:673–683.
  • Frisancho AR. Origins of differences in hemoglobin concentration between Himalayan and Andean populations. Respir Physiol 1988; 72:13–18.
  • Meehan R, Duncan U, Neale L, Taylor G, Muchmore H, Scott N, . Operation Everest II: alterations in the immune system at high altitudes. J Clin Immunol 1988; 8:397–406.
  • Andrew M, O'Brodovich H, Sutton J. Operation Everest II: coagulation system during prolonged decompression to 282 Torr. J Appl Physiol 1987; 63:1262–1267.
  • Bradford A. The role of hypoxia and platelets in air travel-related venous thromboembolism. Curr Pharm Des 2007; 13:2668–2672.
  • van't Hof AWJ, de Vries ST, Nadal F, Niella M, Fokkert MJ, Slingerland RJ, . A case of very late stent thrombosis at high altitude. Thromb Haemost 2007; 98:1379–1380.
  • Fagenholz PJ, Gutman JA, Murray AF, Noble VE, Wu A, Zeimer G, . Arterial thrombosis at high altitude resulting in loss of limb. High Alt Med Biol 2007; 8:340–347.
  • Baumgartner RW, Siegel AM, Hackett PH. Going high with preexisting neurological conditions. High Alt Med Biol 2007; 8: 108–116.
  • Skaiaa SC, Stave H. Recurrent sagittal sinus thrombosis occurring at high altitude during expeditions to Cho Oyu. Wilderness Environ Med 2006; 17:132–136.
  • Anand AC, Saha A, Seth AK, Chopra GS, Nair V, Sharma V. Symptomatic portal system thrombosis in soldiers due to extended stay at extreme altitude. J Gastroenterol Hepatol 2005; 20:777–783.
  • Anand AC, Jha SK, Saha A, Sharma V, Adya CM. Thrombosis as a complication of extended stay at high altitude. Natl Med J India 2001; 14:197–201.
  • Anand AC, Sashindran VK, Mohan L. Gastrointestinal problems at high altitude. Trop Gastroenterol 2006; 27:147–153.
  • Wu T-Y, Ding S-Q, Liu J-L, Jia JH, Dai RC, Zhu DC, . High-altitude gastrointestinal bleeding: an observation in Qinghai-Tibetan railroad construction workers on Mountain Tanggula. World J Gastroenterol 2007; 13:774–780.
  • Garner SH, Sutton JR, Burse RL, McComas AJ, Cymerman A, Houston CS. Operation Everest II: neuromuscular performance under conditions of extreme simulated altitude. J Appl Physiol 1990; 68:1167–1172.
  • Liang H, Wu W, Wang S, Yu H, Hou S, He L, . [A monitoring study of electromyography median frequency on fatigue of erector spinalis in drivers working at high altitude] [in Chinese]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2002; 20:461–463.
  • Bilski B, Bednarek A. [Disorders of locomotor system and effectiveness of physiotherapy in coal miners]. Med Pr 2003; 54:503–509.
  • Limburska I, Gazdzik TS, Zejda JE. [Back pain in coal miners of anthracite coal–pilot study results] [in Polish]. Med Pr 1996; 47:339–346.
  • Anholm JD, Powles AC, Downey R, 3rd, Houston CS, Sutton JR, Bonnet MH, . Operation Everest II: arterial oxygen saturation and sleep at extreme simulated altitude. Am Rev Respir Dis 1992; 145:817–826.
  • Plywaczewski R, Palasiewicz G, Sarybaev AS, Le Roux J, Usupbaeva DA, Nowiński A, . [Quality of sleep and periodic breathing in healthy individuals working at an altitude of 3700 meters] [in Polish]. Pol Arch Med Wewn 1999; 101:117–121.
  • Przybylowski T, Ashirbaev A, Le Roux J, Zielinski J. [Sleep and breathing at altitude of 3800 m–the acclimatization effect] [in Polish]. Pneumonol Alergol Pol 2003; 71:213–220.
  • Jobe JB, Shukitt-Hale B, Banderet LE, Rock PB. Effects of dexamethasone and high terrestrial altitude on cognitive performance and affect. Aviat Space Environ Med 1991; 62:727–732.
  • Shukitt-Hale B, Banderet LE, Lieberman HR. Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia. Int J Aviat Psychol 1998; 8:319–334.
  • Kobal Grum D, Kobal AB, Arneric N, Horvat M, Zenko B, Dzeroski S, . Personality traits in miners with past occupational elemental mercury exposure. Environ Health Perspect 2006; 114:290–296.
  • McGrath JJ. Carbon monoxide studies at high altitude. Neurosci Biobehav Rev 1988; 12:311–314.
  • McGrath JJ. Cardiovascular effects of chronic carbon monoxide and high-altitude exposure. Res Rep Health Eff Inst 1989:1–23.
  • Data PG, Cacchio M, Monge C, Di Tano G. [Evaluation of various hematologic parameters in Andean miners (Morococha-Peru 4560 m)] [in Italian]. Boll Soc Ital Biol Sper 1981; 57:1411–1416.
  • Hart JE, Laden F, Eisen EA, Smith TJ, Garshick E. Chronic obstructive pulmonary disease mortality in railroad workers. Occup Environ Med 2009; 66:221–226.
  • Bartsch P, Saltin B. General introduction to altitude adaptation and mountain sickness. Scand J Med Sci Sports 2008; 18 Suppl 1:1–10.
  • Wu TY, Ding SQ, Liu JL, Yu MT, Jia JH, Duan JQ, . Reduced incidence and severity of acute mountain sickness in Qinghai-Tibet railroad construction workers after repeated 7-month exposures despite 5-month low altitude periods. High Alt Med Biol 2009; 10:221–232.
  • Siques P, Brito J, Leon-Velarde F, Barrios L, Cruz JJ, López V, . Time course of cardiovascular and hematological responses in rats exposed to chronic intermittent hypobaric hypoxia (4600 m). High Alt Med Biol 2006; 7:72–80.
  • Richalet J-P, Donoso MV, Jimenez D, Antezana AM, Hudson C, Cortès G, . Chilean miners commuting from sea level to 4500 m: a prospective study. High Alt Med Biol 2002; 3:159–166.
  • Farias JG, Osorio J, Soto G, Brito J, Siques P, Reyes JG. Sustained acclimatization in Chilean mine workers subjected to chronic intermittent hypoxia. High Alt Med Biol 2006; 7:302–306.
  • Purkayastha SS, Ray US, Arora BS, Chhabra PC, Thakur L, Bandopadhyay P, . Acclimatization at high altitude in gradual and acute induction. J Appl Physiol 1995; 79:487–492.
  • Hackett PH, Roach RC. High-altitude illness. N Engl J Med 2001; 345:107–114.
  • West JB. Oxygen enrichment of room air to improve well-being and productivity at high altitude. Int J Occup Environ Health 1999; 5:187–193.
  • Donroe JA, Maurtua-Neumann PJ, Gilman RH, Acosta AT, Cain G, Parker JE, . Surveillance for early silicosis in high altitude miners using pulse oximetry. Int J Occup Environ Health 2008; 14:187–192.

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