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Brief Communications

Severe sodium channel blockade and cardiovascular collapse due to a massive Lamotrigine overdose

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Pages 854-857 | Received 01 May 2011, Accepted 21 Aug 2011, Published online: 05 Oct 2011

References

  • Messenheimer JA. Lamotrigine Epilepsia 1995;36:S87–S94.
  • Buckley NA, Whyte IM, Dawson AH. Self-poisoning with lamotrigine. Lancet 1993; 342:1552–1553.
  • Lofton AL, Klein-Schwartz W. Evaluation of lamotrigine toxicity reported to poison centers. Ann Pharmacother 2004; 38:1811–1815.
  • Seo HJ, Chiesa A, Lee SJ, . Safety and tolerability of lamotrigine: results from 12 placebo-controlled clinical trials and clinical implications. Clin Neuropharmacol 2011; 34:39–47.
  • Bronstein AC, Spyker DA, Cantilena LR, Jr., Green JL, Rumack BH, Giffin SL. 2009 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol (Phila) 2010;48:979–1178.
  • Willis T, Roper H, Rabb L. Lamotrigine poisoning presenting as seizures: a case of deliberate poisoning. Child Abuse Negl 2007; 31: 85–88.
  • O’Donnell J, Bateman DN. Lamotrigine overdose in an adult. J Toxicol Clin Toxicol 2000; 38:659–660.
  • Thundiyil JG, Anderson IB, Stewart PJ, Olson KR. Lamotrigine-induced seizures in a child: case report and literature review. Clin Toxicol (Phila) 2007; 45:169–172.
  • Sukumaran S, Herbert J, Tracey J, Delanty N. Safety of newer generation anti-epileptic drugs in non-accidental overdose: An Irish population study. Seizure 2005; 14:151–156.
  • Schwartz MD, Geller RJ. Seizures and altered mental status after lamotrigine overdose. Ther Drug Monit 2007; 29:843–844.
  • Close BR, Banks CJ. Seizures secondary to lamotrigine toxicity in a two-year-old. Ann Pharmacother 2010; 44:1112–1115.
  • Herold TJ. Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder. CJEM 2006; 8:361–364.
  • Sirianni AJ, Osterhoudt KC, Calello DP, Muller AA, Waterhouse MR, Goodkin MB, Weinberg GL, Henretig FM. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008; 51:412–415, 5 e1.
  • Strimel WJ, Woodruff A, Cheung P, Kirmani BF, Stephen Huang SK. Brugada-like electrocardiographic pattern induced by lamotrigine toxicity. Clin Neuropharmacol 2010; 33:265–267.
  • French LK, McKeown NJ, Hendrickson RG. Complete heart block and death following lamotrigine overdose. Clin Toxicol (Phila) 2011; 49:330–333.
  • Castanares-Zapatero D, Wittebole X, Huberlant V, Morunglav M, Hantson P. Lipid Emulsion as Rescue Therapy in Lamotrigine Overdose. J Emerg Med. (published online ahead of print May 26, 2011). Accessed June 1, 2001.
  • Padwal R, Brocks D, Sharma AM. A systematic review of drug absorption following bariatric surgery and its theoretical implications. Obes Rev 2010; 11:41–50.
  • Kaufman KR. Lamotrigine and hemodialysis in bipolar disorder: case analysis of dosing strategy with literature review. Bipolar Disord 2010; 12:446–449.
  • Benson BE, Farooqi MF, Klein-Schwartz W, Litovitz T, Webb AN, Borys DJ, Lung D, Rose SR, Aleguas A, Sollee DR, Seifert SA. Diphenhydramine dose-response: a novel approach to determine triage thresholds. Clin Toxicol (Phila) 2010; 48:820–831.
  • Radovanovic D, Meier PJ, Guirguis M, Lorent JP, Kupferschmidt H. Dose-dependent toxicity of diphenhydramine overdose. Hum Exp Toxicol 2000; 19:489–495.
  • Jang DH, Manini AF, Trueger NS, . Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. Clin Toxicol (Phila) 2010; 48:945–948.

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