511
Views
16
CrossRef citations to date
0
Altmetric
Research Article

The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes

, , , , , , & show all
Pages 242-249 | Received 09 Dec 2011, Accepted 27 Feb 2012, Published online: 28 Mar 2012

References

  • Hunt WA. Role of acetaldehyde in the actions of ethanol on the brain-a review. Alcohol 1996; 13:147–151.
  • Quertemont E, Tambour S. Is ethanol a pro-drug? Role of acetaldehyde in the central effects of ethanol. Trends Pharmacol Sci 2004; 25:130–134.
  • Zakhari S. Overview: How is alcohol metabolized by the body? Alcohol Res Health 2006; 29:245–254.
  • Goedde HW, Agarwal DP, Harada S, Meier-Tackmann D, Ruofu D, Bienzle U, . Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. Am J Hum Genet 1983; 35:769–772.
  • Yoshida A, Huang IY, Ikawa M. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci USA 1984; 81:258–261.
  • Brooks PJ, Enoch MA, Goldman D, Li TK, Yokoyama A. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med 2009; 6:e50.
  • Wolff PH. Ethnic differences in alcohol sensitivity. Science 1972; 175:449–450.
  • Mizoi Y, Ijiri W, Tatsuno Y, Kijima T, Fujiwara S, Adachi J, . Relationship between facial flushing and blood acetaldehyde levels after alcohol intake. Pharmacol Biochem Behav 1979; 10:303–311.
  • Mizoi Y, Tatsuno Y, Adachi J, Kogame M, Fukunaga T, Fujiwara S, . Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese. Pharmacol Biochem Behav 1983; 181(suppl 1):127–133.
  • Pawlak D, Malinowska B, Buczko W. Cardiovascular effects of acetaldehyde in pithed rats. Pharmacology 1992; 45:83–89.
  • Chiba S, Tsukada M. Possible mechanism of acetaldehyde-induced noradrenaline release from sympathetic nerve terminals in isolated blood vessels. Br J Pharmacol 1988; 95:177–182.
  • Kim SW, Bae KY, Shin HY, Kim JM, Shin IS, Youn T, . The role of acetaldehyde in human psychomotor function: a double-blind placebo-controlled crossover study. Biol Psychiatry 2010; 67:840–845.
  • Yoon JS, Shin SM, Kook SH, Lee HY. A preliminary study on the Korean translation of composite scale (KtCS) to measure morningness-eveningness. J Korean Neuropsychiatr Assoc 1997; 36:122–134.
  • Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption II. Addiction 1993; 88:791–804.
  • Han KH, Lim JY, Min BB, Lee JH, Moon KJ, Kim ZS. Korean MMPI-2 standardization study. Korean J Clin Psychol 2006; 25:533–564.
  • Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 1988; 56:893–897.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4:561–571.
  • Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Yokoyama T. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. Int J cancer 2007; 121:1047–1054.
  • Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves JW, Hill MN, . Council on High Blood Pressure Research Professional and Public Education Subcommittee, American Heart Association. Recommendations for blood pressure measurement in humans: an AHA scientific statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee. J Clin Hypertens 2005; 7:102–109.
  • McLaren K. The development of the CIE 1976 (L*a*b*) uniform colour-space and colour-difference formula. J Soc Dyers Colour 1976; 92:338–341.
  • Yoshida A, Ikawa M, Hsu LC, Tani K. Molecular abnormality and cDNA cloning of human aldehyde dehydrogenase. Alcohol 1985; 2:103–106.
  • Yosida A. Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic disease. Alcohol Alcohol 1994; 29:693–696.
  • Rzhetsky A, Ayala FJ, Hsu LC, Chang C, Yoshida A. Exon/intron structure of aldehyde dehydrogenase genes supports the “introns-late” theory. Proc Natl Acad Sci USA 1997; 94:6820–6825.
  • Vasiliou V, Pappa A. Polymorphisms of human aldehyde dehydrogenases. Pharmacology 2000; 61:192–198.
  • Kim JS, Kim YJ, Kim TY, Song JY, Cho YH, Park YC, . Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake. Toxicology 2005; 210:169–174.
  • Thevananther S, Brecher AS. Acetaldehyde inhibits angiotensin-converting enzyme activity of bovine lung. Alcohol 1993; 10:545–548.
  • Gill K, Eagle EM, Liu Y, Deitrich RA. An examination of ALDH2 genotypes, alcohol metabolism and the flushing response in Native Americans. J Stud Alcohol 1999; 60:149–158.
  • Ward RJ, McPherson AJ, Chow C, Ealing J, Sherman DI, Yoshida A, . Identification and characterisation of alcohol-induced flushing in Caucasian subjects. Alcohol Alcohol 1994; 29:433–438.
  • Zeiner AR, Paredes A, Christensen HD. The role of acetaldehyde in mediating reactivity to an acute dose of ethanol among different racial groups. Alcohol Clin Exp Res 1979; 3:11–18.
  • Tardif R. The determination of acetaldehyde in exhaled breath. Novartis Found Symp 2007; 285:125–133.
  • Jung JG, Kim JS, Oh MK. The role of the flushing response in the relationship between alcohol consumption and insulin resistance. Alcohol Clin Exp Res 2010; 34:1699–1704.
  • Eriksson CJ. The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 2001; 25(5 suppl ISBRA):15–32.
  • Minami J, Todoroki M, Ishimitsu T, Yamamoto H, Abe S, Fukunaga T, . Effects of alcohol intake on ambulatory blood pressure, heart rate, and heart rate variability in Japanese men with different ALDH2 genotypes. J Hum Hypertens 2002; 16:345–351.
  • Akamatsu Y, Hayashi T, Sakane N, Moritani T. Effect of aldehyde dehydrogenase-2 genotype on cardiac autonomic nervous responses to moderate alcohol ingestion. Alcohol Clin Exp Res 2008; 32:1422–1428.
  • Selb Semerl J, Selb K. Coffee and alcohol consumption as triggering factors for sudden cardiac death: case-crossover study. Croat Med J 2004; 45:775–780.
  • Pochmalicki G, Genest M, Jibril H. Late ventricular potentials and heavy drinking. Heart 1997; 78:163–165.
  • Guo R, Ren J. Alcohol and acetaldehyde in public health: from marvel to menace. Int J Environ Res Public Health 2010; 7:1285–1301.
  • Potter JF, Beevers DG. Factors determining the acute pressor response to alcohol. Clin Exp Hypertens A 1991; 13:13–34.
  • Chmiel BA, Olszowy ZB, Turczynski BB, Kusmierski SA. Effect of controlled ethanol intake on arterial blood pressure, heart rate and red blood cells deformability. Clin Hemorheol Microcirc 1999; 21:325–328.
  • Kawano Y, Abe H, Imanishi M, Kojima S, Yoshimi H, Takishita S, . Pressor and depressor hormones during alcohol-induced blood pressure reduction in hypertensive patients. J Hum Hypertens 1996; 10:595–599.
  • Nishimura FT, Kimura Y, Abe S, Fukunaga T, Minami J, Tanii H, . Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population. Alcohol Clin Exp Res 2008; 32:1937–1946.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.