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Clinical Toxicology Volume 47, 2009 - Issue 9
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ArticlesCritical care

Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs

Geoffrey K. Isbister Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia; Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Faculty of Health, University of Newcastle, Newcastle, NSW, AustraliaCorrespondence[email protected]
,
Leonie Calver Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia
,
Freek Van Gorp Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia; Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
,
Barrie Stokes Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
&
Colin B. Page Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia; Emergency Department, Princess Alexandra Hospital, Brisbane, QLD, Australia
Pages 884-888 | Received 30 Jul 2009, Accepted 14 Sep 2009, Published online: 12 Oct 2009

References

  • Gupta A, Lawrence AT, Krishnan K, Kavinsky CJ, Trohman RG. Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J 2007; 153:891–899.
  • Fermini B, Fossa AA. The impact of drug-induced QT interval prolongation on drug discovery and development. Nat Rev Drug Discov 2003; 2:439–447.
  • Shah RR. Drugs, QTc interval prolongation and final ICH E14 guideline: an important milestone with challenges ahead. Drug Saf 2005; 28:1009–1028.
  • Malik M, Camm AJ. Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug Saf 2001; 24:323–351.
  • Hunt AC. Accuracy of popular automatic QT interval algorithms assessed by a “gold standard” and comparison with a Novel method: computer simulation study. BMC Cardiovasc Disord 2005; 5:29.
  • Malik M, Farbom P, Batchvarov V, Hnatkova K, Camm AJ. Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval. Heart 2002; 87:220–228.
  • Hnatkova K, Gang Y, Batchvarov VN, Malik M. Precision of QT interval measurement by advanced electrocardiographic equipment. Pacing Clin Electrophysiol 2006; 29:1277–1284.
  • Isbister GK, Balit CR, MacLeod D, Joy JP, Duffull SB. Amisulpride overdose causes QT prolongation and Torsades de Pointes – a national study. Clin Toxicol 2009; 47(5):227.
  • van Gorp F, Whyte IM, Isbister GK. Clinical and ECG effects of escitalopram overdose. Ann Emerg Med 2009; 54:404–408.
  • Isbister GK. Electrocardiogram changes and arrhythmias in venlafaxine overdose. Br J Clin Pharmacol 2009; 67:572–576.
  • Isbister GK, Duffull SB. Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. Int Clin Psychopharmacol 2009; 24:174–180.
  • Isbister GK, Murray L, John S, Hackett LP, Haider T, O'Mullane P, Gosselin S, Daly F. Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes. Med J Aust 2006; 184:354–356.
  • Isbister GK, Friberg LE, Stokes B, Buckley NA, Lee C, Gunja N, Brown SG, MacDonald E, Graudins A, Holdgate A, Duffull SB. Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med 2007; 50:593–600.
  • Donner A, Wells G. A comparison of confidence interval methods for the intraclass correlation coefficient. Biometrics 1986; 42:401–412.
  • Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM 2007; 100:609–615.
  • Fossa AA, Wisialowski T, Magnano A, Wolfgang E, Winslow R, Gorczyca W, Crimin K, Raunig DL. Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition. J Pharmacol Exp Ther 2005; 312:1–11.
  • Fleiss JL. Measuring nominal scale agreement among many raters. Psychol Bull 1971; 76:378–382.
  • Fleiss JL, Cohen J. The equivalence of weighted kappa and the intraclass correlation coefficient as measures of reliability. Educ Psychol Meas 1973; 33:613–619.
  • Cohen J. Weighted kappa: Nominal scale agreement with provision for scaled disagreement or partal credit. Psychol Bull 1968; 70:213–220.

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