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Clinical Toxicology Volume 48, 2010 - Issue 3
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Brief Communications

Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin

Samuel J. Stellpflug Regions Hospital Clinical Toxicology Service and Department of Emergency Medicine, St. Paul, MN, USA; Hennepin Regional Poison Center, Minneapolis, MN, USACorrespondence[email protected]
,
Carson R. Harris Regions Hospital Clinical Toxicology Service and Department of Emergency Medicine, St. Paul, MN, USA
,
Kristin M. Engebretsen Regions Hospital Clinical Toxicology Service and Department of Emergency Medicine, St. Paul, MN, USA
,
Jon B. Cole Regions Hospital Clinical Toxicology Service and Department of Emergency Medicine, St. Paul, MN, USA; Hennepin Regional Poison Center, Minneapolis, MN, USA
&
Joel S. Holger Regions Hospital Clinical Toxicology Service and Department of Emergency Medicine, St. Paul, MN, USA
Pages 227-229 | Received 15 Oct 2009, Accepted 14 Dec 2009, Published online: 08 Feb 2010

References

  • US Food and Drug Administration. 2007. http://www.accessdata.fda.gov/Scripts/cder/DrugsatFDA/index.cfm?fuseaction=Search.Label_ApprovalHistory#apphist. Accessed 1 October 2009.
  • Strain J, Brown L. Nebivolol (Bystolic™): overview of a third generation beta-blocker. S D Med 2008; 61:219–220.
  • Heinroth KM, Kuhn C, Walper R, Busch I, Winkler M, Prondzinsky R. [Acute beta 1-selective beta-receptor blocker nebivolol poisoning in attempted suicide]. Dtsch Med Wochenschr 1999; 124:1230–1234.
  • Lang RM, Borow KM, Neumann A, Feldman T. Adverse cardiac effects of acute alcohol ingestion in young adults. Ann Intern Med 1985; 102:742–747.
  • Cooper DJ, Bergman J. Massive baclofen overdose. Crit Care Resusc 2000; 2:195–197.
  • Delhaas EM, Brauers JR. Intrathecal baclofen overdose: report of 7 events in 5 patients and review of the literature. Int J Clin Pharmacol Ther Toxicol 1991; 29:274–280.
  • Berger R, Green G, Melnik A. Cardiac arrest caused by oral diazepam intoxication. Clin Pediatr 1975; 14:842–844.
  • Perez E, Bania TC. Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model. Acad Emerg Med 2008; 15:1284–1289.
  • Picard J. Lipid emulsion to treat drug overdose: past, present, and future. Anaesthesia 2009; 64:119–121.
  • Wojciechowski D, Papademetriou V. Beta-blockers in the management of hypertension: focus on nebivolol. Expert Rev Cardiovasc Ther 2008; 6:471–479.
  • Brown SA, Lipschitz AH, Kenkel JM, Sorokin E, Sheperd G, Grebe S, Oliver LK, Luby M, Rohrich RJ. Pharmacokinetics and safety of epinephrine use in liposuction. Plast Reconstr Surg 2004; 114:756–763.
  • Cheymol G, Woestenborghs R, Snoeck E, Lanucci R, Le Moing JP, Naditch L, Levron JC, Poirier JM. The pharmacokinetic study and cardiovascular monitoring of nebivolol in normal and obese subjects. Eur J Clin Pharmacol 1997; 51:493–498.
  • Arendt RM, Greenblatt DJ, DeJong RH, Bonin JD, Abernethy DR, Ehrenberg DL, Giles HG, Sellers EM, Shader RI. Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity. Psychopharmacology 1987; 93:72–76.
  • Mandema JW, Heijligers-Feijen CD, Tukker E, De Boer AG, Danhof M. Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures. JPET 1992; 261:88–95.
  • Megarbane B, Karyo S, Baud FJ. The role of insulin and glucose (hyperinsulinaemia/euglycaemia) therapy in acute calcium channel antagonist and beta-blocker poisoning. Toxicol Rev 2004; 23:215–222.
  • Shepard G. Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers. Am J Health Syst Pharm 2006; 63:1828–1835.
  • Holger JS, Engebretsen KM, Fritzlar SJ, Patton LC, Harris CR, Flottermesch TJ. Insulin versus vasopressin and epinephrine to treat beta-blocker toxicity. Clin Toxicol 2007; 45:396–401.
  • Morgan MW, Engebretsen KM, Stellpflug SJ, Vigessa GS, Dillon CC, Holger JS, Anderson C. The addition of an alpha-agonist to high-dose insulin in the rescue of swine poisoned with a dihydropyridine does not improve outcome. Clin Toxicol 2009; 47:760.
  • Holger JS, Engebretsen KM, Marini JJ. High dose insulin in toxic cardiogenic shock. Clin Toxicol 2009; 47:303–307.

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