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Letter to Editor

What Target Pralidoxime Concentration?-Author's Reply

, , , &
Pages 229-230 | Published online: 25 Sep 2008

References

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  • Medicis J J, Stock C M, Howland M A, Hoffman R S, Goldfrand LR. Pharmacokinetics following a loading plus a continuous infusion of pralidoxime compared with the traditional short infusion regimen in human volunteers. J Toxicol Clin Toxicol 1996; 34: 289–295
  • Sundwall A. Minimum concentrations of nmethylpyridinium-2-aldoxime methane sulphonate (PS2) which reverse neuromuscular block. Biochem Pharmacol 1961; 8: 413–417
  • Zvirblis P, Kondritzer AA. Prophylaxis against sarin poisoning in the rat by oral administration of pralidoxime chloride. J Pharmacol Exp Ther 1967; 157: 432–434
  • Crook J W, Goodman A L, Colboum J L, Zvirblis P, Oberst F W, Wills JH. Adjunctive value of oral prophylaxis with the oximes 2-PAM lactate and 2-PAM methyl sulfonate to therapeutic administration of atropine in dogs poisoned by inhaled sarin vapor. J Pharmacol Exp Ther 1962; 136: 397–399

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