Position Statement: Cathartics

References

• Cooney D O, Wijaya J. Effect of magnesium citrate on the adsorptive capacity of activated charcoal for sodium salicylate. Vet Hum Toxicol 1986; 28: 521–523
   PubMedGoogle Scholar
• Czajka P A, Konrad J D. Saline cathartics and the adsorptive capacity of activated charcoal for aspirin. Ann Emerg Med 1986; 15: 548–551
   PubMed Web of Science ®Google Scholar
• Ryan C F, Spigiel R W, Zeldes G. Enhanced adsorptive capacity of activated charcoal in the presence of magnesium citrate, N.F. Clin Toxicol 1980; 17: 457–461
   PubMed Web of Science ®Google Scholar
• Gaudreault P, Friedman P A, Lovejoy F H, Jr. Efficacy of activated charcoal and magnesium citrate in the treatment of oral paraquat intoxication. Ann Emerg Med 1985; 14: 123–125
   PubMed Web of Science ®Google Scholar
• LaPierre G, Algozzine G, Doering P L. Effect of magnesium citrate on the in vitro adsorption of aspirin by activated charcoal. Clin Toxicol 1981; 18: 793–796
   PubMed Web of Science ®Google Scholar
• Al-Shareef A H, Buss D C, Allen E M, Routledge P A. The effects of charcoal and sorbitol (alone and in combination) on plasma theophylline concentrations after a sustained-release formulation. Hum Exp Toxicol 1990; 9: 179–182
   PubMed Web of Science ®Google Scholar
• Van de Graaff W B, Thompson W L, Sunshine I, et al. Adsorbent and cathartic inhibition of enteral drug absorption. J Pharmacol Exp Ther 1982; 221: 656–663
   PubMed Web of Science ®Google Scholar
• Picchioni A L, Chin L, Gillespie T. Evaluation of activated charcoal-sorbitol suspension as an antidote. Clin Toxicol 1982; 19: 433–444
   Web of Science ®Google Scholar
• Chin L, Picchioni A L, Gillespie T. Saline cathartics and saline cathartics plus activated charcoal as antidotal treatments. Clin Toxicol 1981; 18: 865–871
   PubMed Web of Science ®Google Scholar
• Galey F D, Lambert R J, Busse M, Buck W B. Therapeutic efficacy of superactive charcoal in rats exposed to oral lethal doses of T-2 toxin. Toxicon 1987; 25: 493–499
   PubMed Web of Science ®Google Scholar
• Sorensen P N, Lindkaer-Jensen S T. The effect of magnesium sulfate on the absorption of acetylsalicylic acid and lithium carbonate from the human intestine. Arch Toxicol 1975; 34: 121–127
   PubMed Web of Science ®Google Scholar
• Galinsky R E, Levy G. Evaluation of activated charcoal-sodium sulfate combination for inhibition of acetaminophen absorption and repletion of inorganic sulfate. Clin Toxicol 1984; 22: 21–30
   Web of Science ®Google Scholar
• Mayersohn M, Perrier D, Picchioni A L. Evaluation of a charcoal-sorbitol mixture as an antidote for oral aspirin overdose. Clin Toxicol 1977; 11: 561–570
   PubMed Web of Science ®Google Scholar
• Minton N A, Henry J A. Prevention of drug absorption in simulated theophylline overdose. J Toxicol Clin Toxicol 1995; 33: 43–49
   PubMed Web of Science ®Google Scholar
• Goldberg M J, Spector R, Park G D, Johnson G F, Roberts P. The effect of sorbitol and activated charcoal on serum theophylline concentrations after slow-release theophylline. Clin Pharmacol Ther 1987; 41: 108–111
   PubMed Web of Science ®Google Scholar
• Keller R E, Schwab R A, Krenzelok E P. Contribution of sorbitol combined with activated charcoal in prevention of salicylate absorption. Ann Emerg Med 1990; 19: 654–656
   PubMed Web of Science ®Google Scholar
• Scholtz E C, Jaffe J M, Colaizzi J L. Evaluation of five activated charcoal formulations for the inhibition of aspirin absorption and palatability in man. Am J Hosp Pharm 1978; 35: 1355–1359
   PubMedGoogle Scholar
• McNamara R M, Aaron C K, Gemborys M, David-Heiser S. Sorbitol catharsis does not enhance efficacy of charcoal in a simulated acetaminophen overdose. Ann Emerg Med 1988; 17: 243–246
   PubMed Web of Science ®Google Scholar
• Neuvonen P J, Olkkola K T. Effect of purgatives on antidotal efficacy of oral activated charcoal. Hum Toxicol 1986; 5: 255–263
   PubMedGoogle Scholar
• Sketris I S, Mowry J B, Czajka P A, Anderson W H, Stafford D T. Saline catharsis: Effect on aspirin bioavailability in combination with activated charcoal. J Clin Pharmacol 1982; 22: 59–64
   PubMed Web of Science ®Google Scholar
• Krenzelok E P. Gastrointestinal transit times of cathartics used with activated charcoal. Clin Pharm 1985; 4: 446–448
   PubMedGoogle Scholar
• Orisakwe O E, Ogbonna E. Effect of saline cathartics on gastrointestinal transit time of activated charcoal. Hum Exp Toxicol 1993; 12: 403–405
   PubMed Web of Science ®Google Scholar
• Krenzelok E P, Keller R, Stewart R D. Gastrointestinal transit times of cathartics combined with charcoal. Ann Emerg Med 1985; 14: 1152–1155
   PubMed Web of Science ®Google Scholar
• Sue Y J, Woolf A. Efficacy of magnesium citrate cathartic in pediatric toxic ingestions. Ann Emerg Med 1994; 24: 709–712
   PubMed Web of Science ®Google Scholar
• Minocha A, Herold D A, Bruns D E, Spyker D A. Effect of activated charcoal in 70% sorbitol in healthy individuals. J Toxicol Clin Toxicol 1984-5; 22: 529–536
   PubMed Web of Science ®Google Scholar
• James L P, Nichols M H, King W D. A comparison of cathartics in pediatric ingestions. Pediatrics 1995; 96: 235–238
   PubMed Web of Science ®Google Scholar
• Vuignier B I, Oderda G M, Gorman R L, Klein-Schwartz W, Watson W A. Effects of magnesium citrate and clidinium bromide on the excretion of activated charcoal in normal subjects. Ann Pharmacother 1989; 23: 26–29
   Web of Science ®Google Scholar
• Harchelroad F, Cottington E, Krenzelok E P. Gastrointestinal transit times of a charcoal/sorbitol slurry in overdose patients. J Toxicol Clin Toxicol 1989; 27: 91–99
   PubMed Web of Science ®Google Scholar
• Pond S M, Lewis-Driver D J, Williams G M, Green A C, Stevenson N W. Gastric emptying in acute overdose: A prospective randomized controlled trial. Med J Aust 1995; 163: 345–349
   PubMed Web of Science ®Google Scholar
• Morris M E, Le Roy S, Sutton S C. Absorption of magnesium from orally administered magnesium sulfate in man. J Toxicol Clin Toxicol 1987; 25: 371–382
   PubMed Web of Science ®Google Scholar
• Smilkstein M J, Steedle D, Kulig K W, Marx J A, Rumack B H. Magnesium levels after magnesium-containing cathartics. J Toxicol Clin Toxicol 1988; 26: 51–65
   PubMed Web of Science ®Google Scholar
• Weber C A, Santiago R M. Hypermagnesemia: A potential complication during treatment of theophylline intoxication with oral activated charcoal and magnesium-containing cathartics. Chest 1989; 95: 56–59
   PubMed Web of Science ®Google Scholar