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Journal of Toxicology: Clinical Toxicology Volume 36, 1998 - Issue 1-2
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Original Article

Variation in Human Plasma Cholinesterase Activity During Low-Dose Cocaine Administration

Robert S. Hoffman New York University School of Medicine and New York City Poison Control Center, New York, New York (RSH, GCH), USA; Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota (TT, DKH, PRP), USACorrespondence[email protected]
,
Tim Thompson New York University School of Medicine and New York City Poison Control Center, New York, New York (RSH, GCH), USA; Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota (TT, DKH, PRP), USA
,
Glendon C. Henry New York University School of Medicine and New York City Poison Control Center, New York, New York (RSH, GCH), USA; Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota (TT, DKH, PRP), USA
,
Dorothy K. Hatsukami New York University School of Medicine and New York City Poison Control Center, New York, New York (RSH, GCH), USA; Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota (TT, DKH, PRP), USA
&
Paul R. Pentel New York University School of Medicine and New York City Poison Control Center, New York, New York (RSH, GCH), USA; Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota (TT, DKH, PRP), USA
Pages 3-9 | Published online: 29 Jul 2009

References

  • Mac Donald D I. Cocaine leads emergency department drug visits. JAMA 1987; 258: 2029
  • Gay G R. Clinical management of acute and chronic cocaine poisoning. Ann Emerg Med 1982; 11: 562–572
  • Om A, Ellahham S, Ornato J P, et al. Medical complications of cocaine: Possible relationship to low plasma cholinesterase enzyme. Am Heart J 1993; 125: 1114–1117
  • Stewart D J, Inaba T, Lucassen M, Kalow W. Cocaine metabolism: Cocaine and norcocaine hydrolysis by liver and serum esterases. Clin Pharmacol Ther 1979; 25: 464–468
  • Stewart D J, Inaba T, Tang B K, Kalow W. Hydrolysis of cocaine in human plasma by cholinesterase. Life Sci 1977; 20: 1557–1563
  • Inaba T, Stewart D J, Kalow W. Metabolism of cocaine in man. Clin Pharmacol Ther 1978; 23: 547–552
  • Leighty E G, Fentiman A F, Jr. Metabolism of cocaine to norcocaine and benzoyl ecgonine by an in vitro microsomal enzyme system. Res Commun Chem Pathol Pharmacol 1974; 8: 65–74
  • Stewart D J, Inaba T, Kalow W. N-demethylation of cocaine in the rat and in isolated rat hepatocytes: Comparison with aminopyrine demethylation. J Pharmacol Exp Ther 1978; 207: 171–177
  • Dean R A, Christian C D, Sample R H, Bosron W F. Human liver cocaine esterases: Ethanol-mediated formation of ethylcocaine. FASEB J 1991; 5: 2735–2739
  • Ambre J J, Fischman M, Ruo T I. Urinary excretion of ecgonine methyl ester, a major metabolite of cocaine in humans. J Anal Toxicol 1984; 8: 23–25
  • Jatlow P, Barash P G, Van Dyke C, Radding J, Byck R. Cocaine and succinylcholine sensitivity: A new caution. Anesth Analg 1979; 58: 235–238
  • Hoffman R S, Henry G C, Howland M A, Weisman R S, Weil L, Goldfrank L R. Association between life-threatening cocaine toxicity and plasma cholinesterase activity. Ann Emerg Med 1992; 21: 247–253
  • Devenyi P. Cocaine complications and pseudocholin-esterase. Ann Intern Med 1989; 110: 167–168
  • Hoffman R S, Henry G C, Wax P M, Weisman R S, Howland M A, Goldfrank L R. Decreased plasma cholinesterase activity enhances cocaine toxicity in mice. J. Pharmacol Exp Ther 1992; 263: 698–702
  • Hoffman R S, Morasco R, Goldfrank L R. Administration of purified human plasma cholinesterase protects against cocaine toxicity in mice. J Toxicol Clin Toxicol 1996; 34: 259–266
  • Hatsukami D K, Keenan R, Carroll M, Colon E, Geiske D, Wilson B, Huber M. A method for delivery of precise doses of smoked cocaine-base to humans. Pharmacol Biochem Behav 1990; 36: 1–7
  • Kalow W, Lindsay H A. A comparison of optical and manometric methods for the assay of human serum cholinesterase. Can J Biochem Physiol 1955; 33: 568–574
  • Lange R A, Cigarroa R G, Flores E D, et al. Potentiation of cocaine-induced coronary vasoconstriction by beta-adrenergic blockade. Ann Intern Med 1990; 112: 897–903
  • Schwartz H J, Johnson D. In vitro competitive inhibition of plasma cholinesterase by cocaine: Normal and variant genotypes. J Toxicol Clin Toxicol 1996; 34: 77–81
  • Herschman Z, Aaron C. Prolongation of cocaine effect. Anesthesiology 1991; 74: 631–632

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