Topical absorption and systemic toxicity

References

• Freeman S, Maibach HI. Systemic toxicity caused by absorption of drugs and chemicals through the skin. In: Marzuli FN, Maibach HI, eds. Dermatotoxicology, 4th ed. New York: Hemisphere Publishing Corporation; 1991:851–875.
   Google Scholar
• Sugihara N, Suetsugu T, Furuno K. High susceptibility to paraquat-driven lipid peroxidation of cultured hepatocytes loaded with linolenic acid. J Pharmacol Exp Ther 1995;274:187–193.
   PubMed Web of Science ®Google Scholar
• Sandy MS, Moldeus P, Ross D, Smith MT. Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity. Studies with a compromised isolated hepatocyte model system. Biochem Pharmacol 1986;35:3095–3101.
   PubMed Web of Science ®Google Scholar
• Bataller R, Bragulat E, Nogué S, Görbig MN, Bruguera M, Rodés J. Prolonged cholestasis after acute paraquat poisoning through skin absorption. Am J Gastroenterol 2000;95:1340–1343.
   PubMed Web of Science ®Google Scholar
• Peiró AM, Zapater P, Alenda C, Ramírez A, Gutiérrez A, Pérez-Mateo M et al. Hepatotoxicity related to paraquat and diquat absorption through intact skin. Dig Dis Sci 2007;52:3282–3284.
   PubMed Web of Science ®Google Scholar
• Wester RC, Maibach HI, Bucks DA, Aufrere MB. In vivo percutaneous absorption of paraquat from hand, leg, and forearm of humans. J Toxicol Environ Health 1984;14:759–762.
   PubMed Web of Science ®Google Scholar
• Guardascione V, Mazzella di Bosco M. [On occupational pathology caused by Paraquat, a dipyridyl herbicide]. Folia Med (Napoli) 1969;52:728–738.
   PubMedGoogle Scholar
• Pateiro-Moure M, Arias-Estévez M, Simal-Gándara J. Competitive and non-competitive adsorption/desorption of paraquat, diquat and difenzoquat in vineyard-devoted soils. J Hazard Mater 2010;178:194–201.
   PubMed Web of Science ®Google Scholar
• Baser NT, Yalaz B, Yilmaz AC, Tuncali D, Aslan G. An unusual and serious complication of topical wart treatment with monochloroacetic acid. Int J Dermatol 2008;47:1295–1297.
   PubMed Web of Science ®Google Scholar
• Pirson J, Toussaint P, Segers N. An unusual cause of burn injury: skin exposure to monochloroacetic acid. J Burn Care Rehabil 2003;24:407–409; discussion 402.
   PubMedGoogle Scholar
• Berardi MR, Snyder R, Waritz RS, Cooper KR. Monochloroacetic acid toxicity in the mouse associated with blood–brain barrier damage. Fundam Appl Toxicol 1987;9:469–479.
   PubMedGoogle Scholar
• Kato J, Dote T, Shimizu H, Shimbo Y, Fujihara M, Kono K. Lethal acute lung injury and hypoglycemia after subcutaneous administration of monochloroacetic acid. Toxicol Ind Health 2006;22:203–209.
   PubMed Web of Science ®Google Scholar
• Horowitz BZ, Albertson TE, O’Malley M, Swenson EJ. An unusual exposure to methyl bromide leading to fatality. J Toxicol Clin Toxicol 1998;36:353–357.
   PubMed Web of Science ®Google Scholar
• Hezemans-Boer M, Toonstra J, Meulenbelt J, Zwaveling JH, Sangster B, van Vloten WA. Skin lesions due to exposure to methyl bromide. Arch Dermatol 1988;124:917–921.
   PubMed Web of Science ®Google Scholar
• Zwaveling JH, de Kort WL, Meulenbelt J, Hezemans-Boer M, van Vloten WA, Sangster B. Exposure of the skin to methyl bromide: a study of six cases occupationally exposed to high concentrations during fumigation. Hum Toxicol 1987;6:491–495.
   PubMedGoogle Scholar
• Yang RS, Witt KL, Alden CJ, Cockerham LG. Toxicology of methyl bromide. Rev Environ Contam Toxicol 1995;142:65–85.
   PubMedGoogle Scholar
• O’Neal L. Acute methyl bromide toxicity. J Emerg Nurs 1987;13:96–98.
   PubMedGoogle Scholar
• Davenport CJ, Ali SF, Miller FJ, Lipe GW, Morgan KT, Bonnefoi MS. Effect of methyl bromide on regional brain glutathione, glutathione-S-transferases, monoamines, and amino acids in F344 rats. Toxicol Appl Pharmacol 1992;112:120–127.
   PubMed Web of Science ®Google Scholar
• Granier R, Rambourg-Schepens MO, Muller A, Hallier E. Glutathione transferase activity and formation of macromolecular adducts in two cases of acute methyl bromide poisoning. Occup Environ Med 1996;53:211–215.
   PubMed Web of Science ®Google Scholar
• Lifshitz M, Gavrilov V. Central nervous system toxicity and early peripheral neuropathy following dermal exposure to methyl bromide. J Toxicol Clin Toxicol 2000;38:799–801.
   PubMed Web of Science ®Google Scholar
• Hayes’ Handbook of Pesticide Toxicology, 3rd ed. Amsterdam: Elsevier; 2010.
   Google Scholar
• Makarovsky I, Markel G, Hoffman A, Schein O, Brosh-Nissimov T, Tashma Z et al. Strychnine—a killer from the past. Isr Med Assoc J 2008;10:142–145.
   PubMed Web of Science ®Google Scholar
• Ellenhorn MJ, Barceloux DG. Medical Toxicology: Diagnosis and Treatment of Human Poisoning, 1st ed. New York: Elsevier; 1988:1086–1087.
   Google Scholar
• Greene R, Meatherall R. Dermal exposure to strychnine. J Anal Toxicol 2001;25:344–347.
   PubMed Web of Science ®Google Scholar
• Sgargli GP, Mannaioni PF. Pharmacokinetics observations on a case of massive strychnine poisoning. Clin Toxicol 1973;6:533–540.
   Web of Science ®Google Scholar
• O’Callaghan WG, Joyce N, Counihan HE, Ward M, Lavelle P, O’Brien E. Unusual strychnine poisoning and its treatment: report of eight cases. Br Med J (Clin Res Ed) 1982;285:478.
   PubMed Web of Science ®Google Scholar
• Kalyoncu M, Dilber E, Okten A. Amitraz intoxication in children in the rural Black Sea region: analysis of forty-three patients. Hum Exp Toxicol 2002;21:269–272.
   PubMed Web of Science ®Google Scholar
• Atabek ME, Aydin K, Erkul I. Different clinical features of amitraz poisoning in children. Hum Exp Toxicol 2002;21:13–16.
   PubMed Web of Science ®Google Scholar
• Demirel Y, Yilmaz A, Gursoy S, Kaygusuz K, Mimaroglu C. Acute amitraz intoxication: retrospective analysis of 45 cases. Hum Exp Toxicol 2006;25:613–617.
   PubMed Web of Science ®Google Scholar
• Aydin K, Kurtoglu S, Poyrazoglu MH, Uzüm K, Ustünbas HB, Hallaç IK. Amitraz poisoning in children: clinical and laboratory findings of eight cases. Hum Exp Toxicol 1997;16:680–682.
   PubMed Web of Science ®Google Scholar
• Yaramis A, Soker M, Bilici M. Amitraz poisoning in children. Hum Exp Toxicol 2000;19:431–433.
   PubMed Web of Science ®Google Scholar
• Aziz SA, Knowles CO. Inhibition of monoamine oxidase by the pesticide chlordimeform and related compounds. Nature 1973;242:417–418.
   PubMed Web of Science ®Google Scholar
• Yim GK, Holsapple MP, Pfister WR, Hollingworth RM. Prostaglandin synthesis inhibited by formamidine pesticides. Life Sci 1978;23:2509–2515.
   PubMed Web of Science ®Google Scholar
• Vijverberg HP, van den Bercken J. Neurotoxicological effects and the mode of action of pyrethroid insecticides. Crit Rev Toxicol 1990;21:105–126.
   PubMed Web of Science ®Google Scholar
• Wilks MF. Pyrethroid-induced paresthesia—a central or local toxic effect? J Toxicol Clin Toxicol 2000;38:103–105.
   PubMed Web of Science ®Google Scholar
• Flannigan SA, Tucker SB, Key MM, Ross CE, Fairchild EJ 2nd, Grimes BA et al. Synthetic pyrethroid insecticides: a dermatological evaluation. Br J Ind Med 1985;42:363–372.
   PubMedGoogle Scholar
• Tucker SB, Flannigan SA, Smolensky MH. Comparison of therapeutic agents for synthetic pyrethroid exposure. Contact Derm 1983;9:316.
   PubMed Web of Science ®Google Scholar
• Kaplan JG, Kessler J, Rosenberg N, Pack D, Schaumburg HH. Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. Neurology 1993;43:2193–2196.
   PubMed Web of Science ®Google Scholar
• Meggs WJ. Permanent paralysis at sites of dermal exposure to chlorpyrifos. J Toxicol Clin Toxicol 2003;41:883–886.
   PubMed Web of Science ®Google Scholar
• Keifer M, Mahurin R. Chronic neurological effects of pesticide exposure. Occup Med 1997;12:291–304.
   PubMedGoogle Scholar
• Jamal GA. Long term neurotoxic effects of organophosphate compounds. Adverse Drug React Toxicol Rev 1995;14:85–99.
   PubMedGoogle Scholar
• Dahlgren JG, Takhar HS, Ruffalo CA, Zwass M. Health effects of diazinon on a family. J Toxicol Clin Toxicol 2004;42:579–591.
   PubMed Web of Science ®Google Scholar
• Lur’e AA, Gleiberman SE, Tsizin IuS. [Pharmacokinetics of insect repellent, N,N-diethyltoluamide]. Med Parazitol (Mosk) 1978;47:72–77.
   PubMedGoogle Scholar
• Briassoulis G, Narlioglou M, Hatzis T. Toxic encephalopathy associated with use of DEET insect repellents: a case analysis of its toxicity in children. Hum Exp Toxicol 2001;20:8–14.
   PubMed Web of Science ®Google Scholar
• Miller JD. Anaphylaxis associated with insect repellent. N Engl J Med 1982;307:1341–1342.
   PubMed Web of Science ®Google Scholar
• Clem JR, Havemann DF, Raebel MA. Insect repellent (N,N-diethyl-m-toluamide) cardiovascular toxicity in an adult. Ann Pharmacother 1993;27:289–293.
   PubMed Web of Science ®Google Scholar
• Ma H. Insecticides: chlorinated hydrocarbons, pyrethrinsm and DEET. Toxicol Emergencies 1994;5:1125.
   Google Scholar
• Vashkov VI, Gleiberman SE, Volkova AP. [Remote effects of the use of repellents. 2. Certain problems of regulations concerning the use of diethyltoluamide (DETA)]. Med Parazitol (Mosk) 1976;45:720–725.
   PubMedGoogle Scholar
• Lewis PR, Phillips TG, Sassani JW. Topical therapies for glaucoma: what family physicians need to know. Am Fam Physician 1999;59:1871–1879, 1882.
   PubMed Web of Science ®Google Scholar
• Goldberg I, Moloney G, McCluskey P. Topical ophthalmic medications: what potential for systemic side effects and interactions with other medications? Med J Aust 2008;189:356–357.
   PubMed Web of Science ®Google Scholar
• Han JA, Frishman WH, Wu Sun S, Palmiero PM, Petrillo R. Cardiovascular and respiratory considerations with pharmacotherapy of glaucoma and ocular hypertension. Cardiol Rev 2008;16:95–108.
   PubMed Web of Science ®Google Scholar
• Gottfredsdottir MS, Allingham RR, Shields MB. Physicians’ guide to interactions between glaucoma and systemic medications. J Glaucoma 1997;6:377–383.
   PubMed Web of Science ®Google Scholar
• Mabuchi F, Yoshimura K, Kashiwagi K, Shioe K, Yamagata Z, Kanba S et al. High prevalence of anxiety and depression in patients with primary open-angle glaucoma. J Glaucoma 2008;17:552–557.
   PubMed Web of Science ®Google Scholar
• Schuman JS. Effects of systemic beta-blocker therapy on the efficacy and safety of topical brimonidine and timolol. Brimonidine Study Groups 1 and 2. Ophthalmology 2000;107:1171–1177.
   PubMed Web of Science ®Google Scholar
• Levy Y, Zadok D. Systemic side effects of ophthalmic drops. Clin Pediatr (Phila) 2004;43:99–101.
   PubMed Web of Science ®Google Scholar
• Georgala S, Befon A, Maniatopoulou E, Georgala C. Topical use of minoxidil in children and systemic side effects. Dermatology (Basel) 2007;214:101–102.
   PubMed Web of Science ®Google Scholar
• Ranchoff RE, Bergfeld WF. Topical minoxidil reduces blood pressure. J Am Acad Dermatol 1985;12:586–587.
   PubMed Web of Science ®Google Scholar
• Leenen FH, Smith DL, Unger WP. Topical minoxidil: cardiac effects in bald man. Br J Clin Pharmacol 1988;26:481–485.
   PubMed Web of Science ®Google Scholar
• Satoh H, Morikaw S, Fujiwara C, Terada H, Uehara A, Ohno R. A case of acute myocardial infarction associated with topical use of minoxidil (RiUP) for treatment of baldness. Jpn Heart J 2000;41:519–523.
   PubMedGoogle Scholar
• Kaler SG, Patrinos ME, Lambert GH, Myers TF, Karlman R, Anderson CL. Hypertrichosis and congenital anomalies associated with maternal use of minoxidil. Pediatrics 1987;79:434–436.
   PubMed Web of Science ®Google Scholar
• Smorlesi C, Caldarella A, Caramelli L, Di Lollo S, Moroni F. Topically applied minoxidil may cause fetal malformation: a case report. Birth Defects Res Part A Clin Mol Teratol 2003;67:997–1001.
   PubMed Web of Science ®Google Scholar
• Badii F, Maghelli S, Costa N, Borreggine D, Zoccali G, Durì D. Acute methemoglobinemia after nitroglycerine transcutaneous absorption after bomb explosion: a case report. J Trauma 2009;66:936–937.
   PubMed Web of Science ®Google Scholar
• Clifton J 2nd, Leikin JB. Methylene blue. Am J Ther 2003;10:289–291.
   PubMedGoogle Scholar
• Welsch F. Routes and modes of administration of resorcinol and their relationship to potential manifestations of thyroid gland toxicity in animals and man. Int J Toxicol 2008;27:59–63.
   PubMed Web of Science ®Google Scholar
• Divi RL, Doerge DR. Mechanism-based inactivation of lactoperoxidase and thyroid peroxidase by resorcinol derivatives. Biochemistry 1994;33:9668–9674.
   PubMed Web of Science ®Google Scholar
• Benfeldt E, Serup J. Effect of barrier perturbation on cutaneous penetration of salicylic acid in hairless rats: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Arch Dermatol Res 1999;291:517–526.
   PubMed Web of Science ®Google Scholar
• Maibach H, Patrick E. Dermatotoxicology. In: Hayes AW, ed. Principles and Methods of Toxicology. Philadelphia, PA: Taylor & Francis; 2001:1039–1084.
   Google Scholar
• Pascher F. Systemic reactions to topically applied drugs. Int J Dermatol 1978;17:768–775.
   PubMed Web of Science ®Google Scholar
• Navarre-Belhassen C, Blanchet P, Hillaire-Buys D, Sarda P, Blayac JP. Multiple congenital malformations associated with topical tretinoin. Ann Pharmacother 1998;32:505–506.
   PubMed Web of Science ®Google Scholar
• Camera G, Pregliasco P. Ear malformation in baby born to mother using tretinoin cream. Lancet 1992;339:687.
   PubMed Web of Science ®Google Scholar
• Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT et al. Retinoic acid embryopathy. N Engl J Med 1985;313:837–841.
   PubMed Web of Science ®Google Scholar
• Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol 2003;4:473–492.
   PubMed Web of Science ®Google Scholar
• Piérard GE, Piérard-Franchimont C, Paquet P, Quatresooz P. Spotlight on adapalene. Expert Opin Drug Metab Toxicol 2009;5:1565–1575.
   PubMed Web of Science ®Google Scholar
• Autret E, Berjot M, Jonville-Béra AP, Aubry MC, Moraine C. Anophthalmia and agenesis of optic chiasma associated with adapalene gel in early pregnancy. Lancet 1997;350:339.
   PubMed Web of Science ®Google Scholar
• Raschke R, Arnold-Capell PA, Richeson R, Curry SC. Refractory hypoglycemia secondary to topical salicylate intoxication. Arch Intern Med 1991;151:591–593.
   PubMed Web of Science ®Google Scholar
• Raithel M, Baenkler HW, Naegel A, Buchwald F, Schultis HW, Backhaus B et al. Significance of salicylate intolerance in diseases of the lower gastrointestinal tract. J Physiol Pharmacol 2005;56 (Suppl 5):89–102.
   PubMedGoogle Scholar
• Rubin Z. Ophthalmic sulfonamide-induced Stevens–Johnson syndrome. Arch Dermatol 1977;113:235–236.
   PubMed Web of Science ®Google Scholar
• Davies P, Levy S, Pahari A, Martinez D. Acute nicotine poisoning associated with a traditional remedy for eczema. Arch Dis Child 2001;85:500–502.
   PubMed Web of Science ®Google Scholar
• Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev 2010;12:CD006103.
   PubMed Web of Science ®Google Scholar
• Ozerdem U, Levi L, Cheng L, Song MK, Scher C, Freeman WR. Systemic toxicity of topical and periocular corticosteroid therapy in an 11-year-old male with posterior uveitis. Am J Ophthalmol 2000;130:240–241.
   PubMed Web of Science ®Google Scholar
• Newell-Price J. Diagnosis/differential diagnosis of Cushing’s syndrome: a review of best practice. Best Pract Res Clin Endocrinol Metab 2009;23 (Suppl 1):S5–S14.
   PubMed Web of Science ®Google Scholar
• Halverstam CP, Vachharajani A, Mallory SB. Cushing syndrome from percutaneous absorption of 1% hydrocortisone ointment in Netherton syndrome. Pediatr Dermatol 2007;24:42–45.
   PubMed Web of Science ®Google Scholar
• Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994;331:1272–1285.
   PubMed Web of Science ®Google Scholar
• Bocquet H, Bagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). Semin Cutan Med Surg 1996;15:250–257.
   PubMed Web of Science ®Google Scholar
• Huang H, Kamijima M, Wang H, Li S, Yoshikawa T, Lai G et al. Human herpesvirus 6 reactivation in trichloroethylene-exposed workers suffering from generalized skin disorders accompanied by hepatic dysfunction. J Occup Health 2006;48:417–423.
   PubMed Web of Science ®Google Scholar
• Singal A, Thami GP. Lindane neurotoxicity in childhood. Am J Ther 2006;13:277–280.
   PubMedGoogle Scholar
• Bhalla M, Thami GP. Reversible neurotoxicity after an overdose of topical lindane in an infant. Pediatr Dermatol 2004;21:597–599.
   PubMed Web of Science ®Google Scholar
• Dollery CT. [Testing and control of therapeutic materials and drugs]. Acta Odontol Venez 1973;11:28–38.
   PubMedGoogle Scholar
• Lievremont M, Barnier JV, Potus J. Gamma-hexachlorocyclohexane inhibition of the calcium fluxes at the desensitized mouse neuromuscular junction. Toxicol Appl Pharmacol 1984;76:280–287.
   PubMed Web of Science ®Google Scholar
• Pramanik AK, Hansen RC. Transcutaneous gamma benzene hexachloride absorption and toxicity in infants and children. Arch Dermatol 1979;115:1224–1225.
   PubMed Web of Science ®Google Scholar
• Ginsburg CM, Lowry W, Reisch JS. Absorption of lindane (gamma benzene hexachloride) in infants and children. J Pediatr 1977;91:998–1000.
   PubMed Web of Science ®Google Scholar
• Lin CC, Wu ML, Yang CC, Ger J, Tsai WJ, Deng JF. Acute severe chromium poisoning after dermal exposure to hexavalent chromium. J Chin Med Assoc 2009;72:219–221.
   PubMed Web of Science ®Google Scholar
• Terrill PJ, Gowar JP. Chromic acid burns; beware, be aggressive, be watchful. Br J Plast Surg 1990;43:699–701.
   PubMedGoogle Scholar
• Matey P, Allison KP, Sheehan TM, Gowar JP. Chromic acid burns: early aggressive excision is the best method to prevent systemic toxicity. J Burn Care Rehabil 2000;21:241–245.
   PubMedGoogle Scholar
• Wang XW, Davies JW, Zapata Sirvent RL, Robinson WA. Chromic acid burns and acute chromium poisoning. Burns Incl Therm Inj 1985;11:181–184.
   PubMedGoogle Scholar
• Asatiani N, Kartvelishvili T, Abuladze M, Asanishvili L, Sapojnikova N. Chromium (VI) can activate and impair antioxidant defense system. Biol Trace Elem Res 2010.
   PubMed Web of Science ®Google Scholar
• Pelclová D, Lukás E, Urban P, Preiss J, Rysavá R, Lebenhart P et al. Mercury intoxication from skin ointment containing mercuric ammonium chloride. Int Arch Occup Environ Health 2002;75 (Suppl):S54–S59.
   PubMed Web of Science ®Google Scholar
• Landau M. Cardiac complications in deep chemical peels. Dermatol Surg 2007;33:190–193; discussion 193.
   PubMed Web of Science ®Google Scholar
• Stagnone GJ, Orgel MG, Stagnone JJ. Cardiovascular effects of topical 50% trichloroacetic acid and Baker’s phenol solution. J Dermatol Surg Oncol 1987;13:999–1002.
   PubMedGoogle Scholar
• Botta SA, Straith RE, Goodwin HH. Cardiac arrhythmias in phenol face peeling: a suggested protocol for prevention. Aesthetic Plast Surg 1988;12:115–117.
   PubMed Web of Science ®Google Scholar
• Wexler MR, Halon DA, Teitelbaum A, Tadjer G, Peled IJ. The prevention of cardiac arrhythmias produced in an animal model by the topical application of a phenol preparation in common use for face peeling. Plast Reconstr Surg 1984;73:595–598.
   PubMed Web of Science ®Google Scholar
• Ratnaike RN. Acute and chronic arsenic toxicity. Postgrad Med J 2003;79:391–396.
   PubMed Web of Science ®Google Scholar
• Ghariani M, Adrien ML, Raucoules M, Bayle J, Jacomet Y, Grimaud D. [Subacute arsenic poisoning]. Ann Fr Anesth Reanim 1991;10:304–307.
   PubMedGoogle Scholar
• Campbell JP, Alvarez JA. Acute arsenic intoxication. Am Fam Physician 1989;40:93–97.
   PubMed Web of Science ®Google Scholar
• Majid Cheraghali A, Haghqoo S, Shalviri G, Shariati YR, Ghassemi M, Khosravi S. Fatalities following skin exposure to arsenic. Clin Toxicol (Phila) 2007;45:965–967.
   PubMed Web of Science ®Google Scholar
• Turkall RM, Skowronski GA, Suh DH, Abdel-Rahman MS. Effect of a chemical mixture on dermal penetration of arsenic and nickel in male pig in vitro. J Toxicol Environ Health Part A 2003;66:647–655.
   PubMed Web of Science ®Google Scholar
• Wester RC, Melendres JL, Maibach HI. In vivo percutaneous absorption of acetochlor in the rhesus monkey: dose–response and exposure risk assessment. Food Chem Toxicol 1996;34:979–983.
   PubMed Web of Science ®Google Scholar
• Boonyatumanond R, Murakami M, Wattayakorn G, Togo A, Takada H. Sources of polycyclic aromatic hydrocarbons (PAHs) in street dust in a tropical Asian mega-city, Bangkok, Thailand. Sci Total Environ 2007;384:420–432.
   PubMed Web of Science ®Google Scholar
• Kaerlev L, Hansen J, Hansen HL, Nielsen PS. Cancer incidence among Danish seafarers: a population based cohort study. Occup Environ Med 2005;62:761–765.
   PubMed Web of Science ®Google Scholar
• Virich G, Gudi V, Canal A. Extramammary Paget’s disease—occupational exposure to used engine oil and a new skin grafting technique. J Plast Reconstr Aesthet Surg 2008;61:1528–1529.
   PubMed Web of Science ®Google Scholar
• Burgher F, Mathieu L, Lati E, Gasser P, Peno-Mazzarino L, Blomet J et al. Experimental 70% hydrofluoric acid burns: histological observations in an established human skin explants ex vivo model. Cutan Ocul Toxicol 2010.
   Web of Science ®Google Scholar
• Kono K, Yoshida Y, Watanabe M, Tanioka Y, Dote T, Orita Y et al. An experimental study on the treatment of hydrofluoric acid burns. Arch Environ Contam Toxicol 1992;22:414–418.
   PubMed Web of Science ®Google Scholar
• Bartlett D. Dermal exposure to hydrofluoric acid causing significant systemic toxicity. J Emerg Nurs 2004;30:371–373.
   PubMedGoogle Scholar
• Dibbell DG, Iverson RE, Jones W, Laub DR, Madison MS. Hydrofluoric acid burns of the hand. J Bone Joint Surg Am 1970;52:931–936.
   PubMed Web of Science ®Google Scholar