Dendritic cells and the assessment in vitro of skin sensitizing potential

References

• Jowsey IR, Basketter DA, Westmoreland C, Kimber I. A future approach to measuring relative skin sensitising potency: A proposal. J Appl Toxicol 2006;26:341–350.
   PubMed Web of Science ®Google Scholar
• Basketter DA, Kimber I. Updating the skin sensitization in vitro data assessment paradigm in 2009. J Appl Toxicol 2009;29:545–550.
   PubMed Web of Science ®Google Scholar
• Casati S, Aeby P, Basketter DA, Cavani A, Gennari A, Gerberick GF et al.; Report and Recommendations of ECVAM Workshop 51. Dendritic cells as a tool for the predictive identification of skin sensitisation hazard. Altern Lab Anim 2005;33:47–62.
   PubMed Web of Science ®Google Scholar
• dos Santos GG, Reinders J, Ouwehand K, Rustemeyer T, Scheper RJ, Gibbs S. Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol Appl Pharmacol 2009;236:372–382.
   PubMed Web of Science ®Google Scholar
• Kimber I, Cumberbatch M, Betts CJ, Dearman RJ. Dendritic cells and skin sensitisation hazard assessment. Toxicol In Vitro 2004;18:195–202.
   PubMed Web of Science ®Google Scholar
• Ryan CA, Hulette BC, Gerberick GF. Approaches for the development of cell-based in vitro methods for contact sensitization. Toxicol In Vitro 2001;15:43–55.
   PubMed Web of Science ®Google Scholar
• Vandebriel RJ, van Loveren H. Non-animal sensitization testing: State-of-the-art. Crit Rev Toxicol 2010;40:389–404.
   PubMed Web of Science ®Google Scholar
• Kimber I, Basketter DA, Gerberick GF, Ryan CA, Dearman RJ. Chemical allergy: Translating biology into hazard characterization. Toxicol Sci 2011;120 Suppl 1:S238–S268.
   PubMed Web of Science ®Google Scholar
• Kaplan DH, Igyártó BZ, Gaspari AA. Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol 2012;12:114–124.
   PubMed Web of Science ®Google Scholar
• Sasaki Y, Aiba S. Dendritic cells and contact dermatitis. Clin Rev Allergy Immunol 2007;33:27–34.
   PubMed Web of Science ®Google Scholar
• Ryan CA, Kimber I, Basketter DA, Pallardy M, Gildea LA, Gerberick GF. Dendritic cells and skin sensitization: Biological roles and uses in hazard identification. Toxicol Appl Pharmacol 2007;221:384–394.
   PubMed Web of Science ®Google Scholar
• Toebak MJ, Gibbs S, Bruynzeel DP, Scheper RJ, Rustemeyer T. Dendritic cells: Biology of the skin. Contact Derm 2009;60:2–20.
   PubMed Web of Science ®Google Scholar
• Breit R. The Langerhans cell: The master key to contact dermatitis: A hypothesis. Arch Dermatol Res 1982;272:401–405.
   PubMed Web of Science ®Google Scholar
• Neves BM, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC, Cruz MT. Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification? Toxicol Appl Pharmacol 2011;250:87–95.
   PubMed Web of Science ®Google Scholar
• Enk AH, Katz SI. Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 1992;89:1398–1402.
   PubMed Web of Science ®Google Scholar
• Enk AH, Angeloni VL, Udey MC, Katz SI. An essential role for Langerhans cell-derived IL-1 β in the initiation of primary immune responses in skin. J Immunol 1993;150:3698–3704.
   PubMed Web of Science ®Google Scholar
• Reutter K, Jäger D, Degwert J, Hoppe U. In vitro model for contact sensitization: II. Induction of IL-1β mRNA in human blood-derived dendritic cells by contact sensitizers. Toxicol In Vitro 1997;11:619–626.
   PubMed Web of Science ®Google Scholar
• Degwert J, Steckel F, Hoppe U, Kligman LH. In vitro model for contact sensitization: I. Stimulatory capacities of human blood-derived dendritic cells and their phenotypical alterations in the presence of contact sensitizers. Toxicol In Vitro 1997;11:613–618.
   PubMed Web of Science ®Google Scholar
• De Smedt AC, Van Den Heuvel RL, Zwi Berneman N, Schoeters GE. Modulation of phenotype, cytokine production and stimulatory function of CD34+-derived DC by NiCl(2) and SDS. Toxicol In Vitro 2001;15:319–325.
   PubMed Web of Science ®Google Scholar
• Pichowski JS, Cumberbatch M, Dearman RJ, Basketter DA, Kimber I. Allergen-induced changes in interleukin 1 β (IL-1 β) mRNA expression by human blood-derived dendritic cells: Inter-individual differences and relevance for sensitization testing. J Appl Toxicol 2001;21:115–121.
   PubMed Web of Science ®Google Scholar
• Gilmour NJ, Basketter DA. Use of dendritic cells for the identification of skin allergens. Int J Cos Sci 2003;6:287–294.
   Google Scholar
• Reuter H, Spieker J, Gerlach S, Engels U, Pape W, Kolbe L et al. In vitro detection of contact allergens: Development of an optimized protocol using human peripheral blood monocyte-derived dendritic cells. Toxicol In Vitro 2011;25:315–323.
   PubMed Web of Science ®Google Scholar
• Ebner S, Lenz A, Reider D, Fritsch P, Schuler G, Romani N. Expression of maturation-/migration-related molecules on human dendritic cells from blood and skin. Immunobiology 1998;198:568–587.
   PubMed Web of Science ®Google Scholar
• Hooyberghs J, Schoeters E, Lambrechts N, Nelissen I, Witters H, Schoeters G et al. A cell-based in vitro alternative to identify skin sensitizers by gene expression. Toxicol Appl Pharmacol 2008;231:103–111.
   PubMed Web of Science ®Google Scholar
• Lambrechts N, Nelissen I, Van Tendeloo V, Witters H, Van Den Heuvel R, Hooyberghs J et al. Functionality and specificity of gene markers for skin sensitization in dendritic cells. Toxicol Lett 2011;203:106–110.
   PubMed Web of Science ®Google Scholar
• Ashikaga T, Hoya M, Itagaki H, Katsumura Y, Aiba S. Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers. Toxicol In Vitro 2002;16:711–716.
   PubMed Web of Science ®Google Scholar
• Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H et al. Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol. Toxicol In Vitro 2006;20:767–773.
   PubMed Web of Science ®Google Scholar
• Sakaguchi H, Ashikaga T, Miyazawa M, Yoshida Y, Ito Y, Yoneyama K et al. Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT. Toxicol In Vitro 2006;20:774–784.
   PubMed Web of Science ®Google Scholar
• Sakaguchi H, Ashikaga T, Miyazawa M, Kosaka N, Ito Y, Yoneyama K et al. The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test–human cell line activation test (h-CLAT). Cell Biol Toxicol 2009;25:109–126.
   PubMed Web of Science ®Google Scholar
• Sakaguchi H, Ryan C, Ovigne JM, Schroeder KR, Ashikaga T. Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials. Toxicol In Vitro 2010;24:1810–1820.
   PubMed Web of Science ®Google Scholar
• Basketter DA, Clewell H, Kimber I, Rossi A, Blaauboer B, Burrier R et al. A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX 2012;29:3–91.
   PubMedGoogle Scholar
• Maxwell G, Aeby P, Ashikaga T, Bessou-Touya S, Diembeck W, Gerberick F et al. Skin sensitisation: The Colipa strategy for developing and evaluating non-animal test methods for risk assessment. ALTEX 2011;28:50–55.
   PubMedGoogle Scholar
• Goebel C, Aeby P, Ade N, Alépée N, Aptula A, Araki D et al. Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: Skin sensitisation. Regul Toxicol Pharmacol 2012;63:40–52.
   PubMed Web of Science ®Google Scholar
• Ashikaga T, Sakaguchi H, Sono S, Kosaka N, Ishikawa M, Nukada Y et al. A comparative evaluation of in vitro skin sensitisation tests: The human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA). Altern Lab Anim 2010;38:275–284.
   PubMed Web of Science ®Google Scholar
• Nukada Y, Ashikaga T, Sakaguchi H, Sono S, Mugita N, Hirota M et al. Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT). Contact Derm 2011;65:343–353.
   PubMed Web of Science ®Google Scholar
• United Nations. (2011). Globally Harmonized System of Classification and Labelling of Chemicals (GHS). Part 3: Health Hazards. Available at: http://www.unece.org/fileadmin/DAM/trans/danger/publi/ghs/ghs_rev04/English/ST-SG-AC10–30-Rev4e.pdf. Accessed on: 23rd March 2012.
   Google Scholar
• Rambukkana A, Pistoor FH, Bos JD, Kapsenberg ML, Das PK. Effects of contact allergens on human Langerhans cells in skin organ culture: Migration, modulation of cell surface molecules, and early expression of interleukin-1 β protein. Lab Invest 1996;74:422–436.
   PubMed Web of Science ®Google Scholar
• Jacobs JJ, Lehé CL, Hasegawa H, Elliott GR, Das PK. Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration. Exp Dermatol 2006;15:432–440.
   PubMed Web of Science ®Google Scholar
• Lehé CL, Jacobs JJ, Hua CM, Courtellemont P, Elliott GR, Das PK. Subtoxic concentrations of allergenic haptens induce LC migration and maturation in a human organotypic skin explant culture model: A novel method for identifying potential contact allergens. Exp Dermatol 2006;15:421–431.
   PubMed Web of Science ®Google Scholar
• Watanabe H, Gaide O, Pétrilli V, Martinon F, Contassot E, Roques S et al. Activation of the IL-1β-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 2007;127:1956–1963.
   PubMed Web of Science ®Google Scholar
• Martin SF, Dudda JC, Bachtanian E, Lembo A, Liller S, Dürr C et al. Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity. J Exp Med 2008;205:2151–2162.
   PubMed Web of Science ®Google Scholar
• Antonopoulos C, Cumberbatch M, Mee JB, Dearman RJ, Wei XQ, Liew FY et al. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J Leukoc Biol 2008;83:361–367.
   PubMed Web of Science ®Google Scholar
• Weber FC, Esser PR, Müller T, Ganesan J, Pellegatti P, Simon MM et al. Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity. J Exp Med 2010;207:2609–2619.
   PubMed Web of Science ®Google Scholar
• Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S et al. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol 2010;11:814–819.
   PubMed Web of Science ®Google Scholar
• Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M et al. Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy 2011;66:1152–1163.
   PubMed Web of Science ®Google Scholar
• Kimber I, Cumberbatch M. Dendritic cells and cutaneous immune responses to chemical allergens. Toxicol Appl Pharmacol 1992;117:137–146.
   PubMed Web of Science ®Google Scholar
• Kimber I, Cumberbatch M, Dearman RJ, Bhushan M, Griffiths CE. Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br J Dermatol 2000;142:401–412.
   PubMed Web of Science ®Google Scholar
• Kimber I, Dearman RJ, Cumberbatch M, Huby RJ. Langerhans cells and chemical allergy. Curr Opin Immunol 1998;10:614–619.
   PubMed Web of Science ®Google Scholar
• Griffiths CE, Dearman RJ, Cumberbatch M, Kimber I. Cytokines and Langerhans cell mobilisation in mouse and man. Cytokine 2005;32:67–70.
   PubMed Web of Science ®Google Scholar
• Guilliams M, Henri S, Tamoutounour S, Ardouin L, Schwartz-Cornil I, Dalod M et al. From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets. Eur J Immunol 2010;40:2089–2094.
   PubMed Web of Science ®Google Scholar
• Bennett CL, Noordegraaf M, Martina CA, Clausen BE. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol 2007;179:6830–6835.
   PubMed Web of Science ®Google Scholar
• Noordegraaf M, Flacher V, Stoitzner P, Clausen BE. Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity. J Invest Dermatol 2010;130:2752–2759.
   PubMedGoogle Scholar
• Edelson BT, KC W, Juang R, Kohyama M, Benoit LA, Klekotka PA et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. J Exp Med 2010;207:823–836.
   PubMed Web of Science ®Google Scholar
• Igyarto BZ, Kaplan DH. The evolving function of Langerhans cells in adaptive skin immunity. Immunol Cell Biol 2010;88:361–365.
   PubMed Web of Science ®Google Scholar
• Kaplan DH. In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol 2010;31:446–451.
   PubMed Web of Science ®Google Scholar
• Klechevsky E, Morita R, Liu M, Cao Y, Coquery S, Thompson-Snipes L et al. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity 2008;29:497–510.
   PubMed Web of Science ®Google Scholar
• Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005;23:611–620.
   PubMed Web of Science ®Google Scholar
• Bobr A, Olvera-Gomez I, Igyarto BZ, Haley KM, Hogquist KA, Kaplan DH. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol 2010;185:4724–4728.
   PubMedGoogle Scholar
• Kautz-Neu K, Noordegraaf M, Dinges S, Bennett CL, John D, Clausen BE et al. Langerhans cells are negative regulators of the anti-Leishmania response. J Exp Med 2011;208:885–891.
   PubMed Web of Science ®Google Scholar
• Shklovskaya E, O’Sullivan BJ, Ng LG, Roediger B, Thomas R, Weninger W et al. Langerhans cells are precommitted to immune tolerance induction. Proc Natl Acad Sci USA 2011;108:18049–18054.
   PubMed Web of Science ®Google Scholar
• Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T, Tokura Y. IL-10-producing Langerhans cells and regulatory T cells are responsible for depressed contact hypersensitivity in grafted skin. J Invest Dermatol 2009;129:705–713.
   PubMed Web of Science ®Google Scholar
• Schwarz A, Noordegraaf M, Maeda A, Torii K, Clausen BE, Schwarz T. Langerhans cells are required for UVR-induced immunosuppression. J Invest Dermatol 2010;130:1419–1427.
   PubMed Web of Science ®Google Scholar
• Cumberbatch M, Clelland K, Dearman RJ, Kimber I. Impact of cutaneous IL-10 on resident epidermal Langerhans’ cells and the development of polarized immune responses. J Immunol 2005;175:43–50.
   PubMed Web of Science ®Google Scholar