Gulf war syndrome – a syndrome or not?

References

• Ablin JN, Shoenfeld Y, Buskila D. (2006). Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle. J Autoimmun 27:145–52
   PubMed Web of Science ®Google Scholar
• Abu-Qare A, Abou-Donia M. (2002). Sarin: health effects, metabolism, and methods of analysis. Food Chem Toxicol 40:1327–33
   PubMed Web of Science ®Google Scholar
• Alloway JA, Older SA, Battafarano DF, Carpenter MT. (1998). Persian Gulf War myalgia syndrome. J Rheumatol 25:388–9
   PubMedGoogle Scholar
• Alving CR, Grabenstein JD. (2000). Untitled. Exp Mol Pathol 68:196–7
   PubMed Web of Science ®Google Scholar
• Appel S, Chapman J, Shoenfeld Y. (2007). Infection and vaccination in chronic fatigue syndrome: myth or reality? Autoimmunity 40:48–53
   PubMed Web of Science ®Google Scholar
• Asa PB, Cao Y, Garry RF. (2000). Antibodies to squalene in Gulf War Syndrome. Exp Mol Pathol 68:55–64
   PubMedGoogle Scholar
• Asa PB, Wilson RB, Garry RF. (2002). Antibodies to squalene in recipients of anthrax vaccine. Exp Mol Pathol 73:19–27
   PubMed Web of Science ®Google Scholar
• Auxéméry Y. (2013). The Gulf War Syndrome twenty years on. L’Encephale 39:332–8
   PubMedGoogle Scholar
• Baireddy P, Mirajkar N, Nallapaneni A, et al. (2007). Effects of combined, multiple stressors on pyridostigmine-induced acute toxicity in rats. Arch Toxicol 81:283–9
   PubMed Web of Science ®Google Scholar
• Bajgar J. (2004). Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 38:151–216
   PubMed Web of Science ®Google Scholar
• Blick DW, Murphy MR, Brown GC, et al. (1994). Acute behavioral toxicity of pyridostigmine or soman in primates. Toxicol Appl Pharmacol 126:311–18
   PubMed Web of Science ®Google Scholar
• Brown MA, Brix KA. (1998). Review of health consequences from high-, intermediate- and low-level exposure to organophosphorus nerve agents. J Appl Toxicol 18:393–408
   PubMed Web of Science ®Google Scholar
• Buchwald D, Cheney PR, Peterson DL, et al. (1992). A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann Intern Med 116:103–13
   PubMed Web of Science ®Google Scholar
• Buskila D. (1999). Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. Curr Opin Rheumatol 11:119–26
   PubMedGoogle Scholar
• Carlson BC, Jansson AM, Larsson A, et al. (2000). The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats. Am J Pathol 156:2057–65
   PubMed Web of Science ®Google Scholar
• CGRHR. (2000). The anthrax vaccine immunization program – what we have learned. Washington, DC: Commitee on Government Reform House of Representatives (Hearing)
   Google Scholar
• Cook DB, Stegner AJ, Ellingson LD. (2010). Exercise alters pain sensitivity in Gulf War Veterans with chronic musculoskeletal pain. J Pain 11:764–72
   PubMedGoogle Scholar
• Cook JE, Kolka MA, Wenger C. (1992). Chronic pyridostigmine bromide administration: side effects among soldiers working in a desert environment. Mil Med 157:250–4
   PubMed Web of Science ®Google Scholar
• Coughlin SS, Kang HK, Mahan CM. (2011). Alcohol use and selected health conditions of 1991 Gulf War veterans: survey results, 2003–2005. Prev Chronic Dis 8:A52
   PubMedGoogle Scholar
• Craddock TJ, Fritsch P, Rice Jr MA, et al. (2014). A role for homeostatic drive in the perpetuation of complex chronic illness: Gulf War Illness and chronic fatigue syndrome. PLoS One 9:e84839
   PubMed Web of Science ®Google Scholar
• Del Giudice G, Fragapane E, Bugarini R, et al. (2006). Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene. Clin Vaccine Immunol 13:1010–13
   PubMed Web of Science ®Google Scholar
• Durakoviæ A. (2001). On depleted uranium: Gulf War and Balkan syndrome. Croat Med J 42:130–4
   PubMedGoogle Scholar
• Ehrich M, Jortner BS. (2001). Organophospahte-induced delayed neuropathy. In: Massaro EJ, ed. Handbook of neurotoxicology. Totowa, NJ: Humana Press Inc., 17–27
   Google Scholar
• Eisen SA, Kang HK, Murphy FM, et al. (2005). Gulf war veterans’ health: medical evaluation of a US cohort. Ann Intern Med 142:881–90
   PubMed Web of Science ®Google Scholar
• Endresen GK. (2003). Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes. Rheumatol Int 23:211–5
   PubMed Web of Science ®Google Scholar
• Enserink M. (2001). Gulf War illness: the battle continues. Science 291:812–7 [Erratum in Science 291:2317]
   Google Scholar
• Escalante A, Fischbach M. (1998). Musculoskeletal manifestations, pain, and quality of life in Persian Gulf War veterans referred for rheumatologic evaluation. J Rheumatol 25:2228–35
   PubMedGoogle Scholar
• Flicker RD. (2000). Pesticide use during the Gulf War: a survey of Gulf War veterans. Arlington, VA: National Defense Research Institute (RAND)
   Google Scholar
• Fukuda K, Nisenbaum R, Stewart G, et al. (1998). Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA 280:981–8
   PubMed Web of Science ®Google Scholar
• Fulco CE, Liverman CT, Sox HC. (2000). Gulf War and Health: Volume 1. depleted uranium, pyridostigmine bromide, sarin, and vaccines. Washington, DC: The National Academies Press
   Google Scholar
• Fulco CE, Liverman CT, Sox HC. (2005). Gulf War and Health: Volume 3. Fuels, combustion products, and propellants. Washington, DC: The National Academies Press
   Google Scholar
• FYR. (2010). A fifteen year report. London: King’s Center for Military College
   Google Scholar
• Golier JA, Schmeidler J, Legge J, Yehuda R. (2007). Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War veterans: relationships to posttraumatic stress disorder and health symptoms. Biol Psychiatry 62:1175–8
   PubMed Web of Science ®Google Scholar
• Gray GC, Reed RJ, Kaiser KS, et al. (2002). Self-reported symptoms and medical conditions among 11,868 Gulf War-era veterans. Am J Epidemiol 155:1033–44
   PubMed Web of Science ®Google Scholar
• Gray GC, Smith TC, Knoke JD, Heller JM. (1999). The postwar hospitalization experience of Gulf War veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq. Am J Epidemiol 150:532–40
   PubMed Web of Science ®Google Scholar
• Gronseth GS. (2005). Gulf War Syndrome: a toxic exposure? A systematic review. Neurol Clin 23:523–40
   PubMed Web of Science ®Google Scholar
• GWH. (2010). Institute of medicine of the National Academies, USA. Gulf war and health; Update of Health effects of serving in the gulf war. Washington, DC: The National Academies Press
   Google Scholar
• Haley RW. (1997). Is there a Gulf War syndrome? Searching for syndromes by factor analysis of symptoms. JAMA 277:215–22 [Erratum in JAMA 278:388]
   PubMed Web of Science ®Google Scholar
• Heller JM. (2011). Oil well fires of Operation Desert Storm – defining troop exposures and determining health risks. Mil Med 176:46–51
   PubMedGoogle Scholar
• Hyams KC, Bourgeois AL, Merrell BR, et al. (1991). Diarrheal disease during operation desert shield. N Engl J Med 325:1423–8
   PubMed Web of Science ®Google Scholar
• Hyams KC, Hanson K, Wignall FS, et al. (1995). The impact of infectious diseases on the health of US troops deployed to the Persian Gulf during operations Desert Shield and Desert Storm. Clin Infect Dis 20:1497–504
   PubMed Web of Science ®Google Scholar
• Hyams KC, Riddle J, Trump DH, Graham JT. (2001). Endemic infectious diseases and biological warfare during the Gulf War: a decade of analysis and final concerns. Am J Trop Med Hyg 65:664–70
   PubMed Web of Science ®Google Scholar
• Hyams KC, Wignall FS, Roswell R. (1996). War syndromes and their evaluation: from the US Civil War to the Persian Gulf War. Ann Intern Med 125:398–405
   PubMed Web of Science ®Google Scholar
• Cherry N, Creed F, Silman A, et al. (2001). Health and exposures of United Kingdom Gulf war veterans. Part II: the relation of health to exposure. Occup Environ Med 58:299–306
   PubMedGoogle Scholar
• Ismail K, Kent K, Sherwood R, et al. (2008). Chronic fatigue syndrome and related disorders in UK veterans of the Gulf War 1990–1991: results from a two-phase cohort study. Psychol Med 38:953–62
   PubMed Web of Science ®Google Scholar
• Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. (2009). Adjuvants and autoimmunity. Lupus 18:1217–25
   PubMed Web of Science ®Google Scholar
• Iversen A, Chalder T, Wessely S. (2007). Gulf War Illness: lessons from medically unexplained symptoms. Clin Psychol Rev 27:842–54
   PubMed Web of Science ®Google Scholar
• Johnson MK, Glynn P. (1995). Neuropathy target esterase (NTE) and organophosphorus-induced delayed polyneuropathy (OPIDP): recent advances. Toxicol Lett 82–83:459–63
   PubMedGoogle Scholar
• Karasova JZ, Pohanka M, Musilek K, et al. (2010). Passive diffusion of acetylcholinesterase oxime reactivators through the blood–brain barrier: influence of molecular structure. Toxicol In Vitro 24:1838–44
   PubMed Web of Science ®Google Scholar
• Kassa J, Koupilová M, Herink J, Vachek J. (2001a). The long term influence of low-level sarin exposure on behavioral and neurophysiological functions in rats. Acta Medica (Hradec Kralove) 44:21–8
   PubMedGoogle Scholar
• Kassa J, Krejcová G, Skopec F, et al. (2004). The influence of sarin on various physiological functions in rats following single or repeated low-level inhalation exposure. Inhal Toxicol 16:517–30
   PubMed Web of Science ®Google Scholar
• Kassa J, Pecka M, Tichý M, et al. (2001b). Toxic effects of Sarin in rats at three months following single or repeated low-level inhalation exposure. Pharmacol Toxicol 88:209–12
   PubMedGoogle Scholar
• Keeler JR, Hurst CG, Dunn MA. (1991). Pyridostigmine used as a nerve agent pretreatment under wartime conditions. JAMA 266:693–5
   PubMed Web of Science ®Google Scholar
• Kluwe W, Page J, Toft J, et al. (1990). Pharmacological and toxicological evaluation of orally administered pyridostigmine in dogs. Fundam Appl Toxicol 14:40–53
   PubMedGoogle Scholar
• Koplovitz I, Harris L, Anderson D, et al. (1992). Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents. Fundam Appl Toxicol 18:102–6
   PubMedGoogle Scholar
• Kovacic P. (2003). Mechanism of organophosphates (nerve gases and pesticides) and antidotes: electron transfer and oxidative stress. Curr Med Chem 10:2705–9
   PubMed Web of Science ®Google Scholar
• Kroenke K, Koslowe P, Roy M. (1998). Symptoms in 18,495 Persian Gulf War veterans – latency of onset and lack of association with self-reported exposures. J Occup Environ Med 40:520–8
   PubMed Web of Science ®Google Scholar
• Kroenke K, Spitzer RL, Williams J, et al. (1994). Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment. Arch Fam Med 3:774–9
   PubMedGoogle Scholar
• Kuzma JM, Black DW. (2006). Chronic widespread pain and psychiatric disorders in veterans of the first Gulf War. Curr Pain Headache Rep 10:85–9
   PubMedGoogle Scholar
• Landrigan PJ. (1997). Illness in Gulf War veterans – causes and consequences. JAMA 277:259–61
   PubMed Web of Science ®Google Scholar
• Lee H, Gabriel R, Bale A, et al. (2001). Clinical findings of the second 1000 UK Gulf war veterans who attended the Ministry of Defence’s medical assessment programme. J R Army Med Corps 147:153–60
   PubMedGoogle Scholar
• Lippi G, Targher G, Franchini M. (2010). Vaccination, squalene and anti-squalene antibodies: facts or fiction? Eur J Intern Med 21:70–3
   PubMed Web of Science ®Google Scholar
• Lotti M. (1992). The pathogenesis of organophosphate polyneuropathy. Crit Rev Toxicol 21:465–87
   Web of Science ®Google Scholar
• Mahan CM, Kang HK, Dalager NA, Heller JM. (2004). Anthrax vaccination and self-reported symptoms, functional status, and medical conditions in the national health survey of Gulf War era veterans and their families. Ann Epidemiol 14:81–8
   PubMed Web of Science ®Google Scholar
• Martinez-Lavin M, Infante O, Lerma C. (2008). Hypothesis: the chaos and complexity theory may help our understanding of fibromyalgia and similar maladies. Semin Arthritis Rheum (Elsevier) 37:260–4
   PubMed Web of Science ®Google Scholar
• Matyas GR, Rao M, Pittman PR, et al. (2004). Detection of antibodies to squalene III. Naturally occurring antibodies to squalene in humans and mice. J Immunol Methods 286:47–67
   PubMed Web of Science ®Google Scholar
• Mitchell AE, Sivitz LB, Black RE. (2007). Gulf War and health: Vol. 5. Infectious diseases. Washington, DC: The National Academies Press
   Google Scholar
• Murphy FM. (1999). Gulf war syndrome: there may be no specific syndrome, but troops suffer after most wars. BMJ 318:274
   PubMedGoogle Scholar
• Murray VS, Bailey MR, Spratt BG. (2002). Depleted uranium: a new battlefield hazard. Lancet 360:s31–2
   PubMedGoogle Scholar
• Nancy A-L, Shoenfeld Y. (2008). Chronic fatigue syndrome with autoantibodies – the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant. Autoimmun Rev 8:52–5
   PubMedGoogle Scholar
• Nicolson GL, Gan R, Haier J. (2003). Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. Apmis 111:557–66
   PubMed Web of Science ®Google Scholar
• Nisenbaum R, Barrett DH, Reyes M, Reeves WC. (2000). Deployment stressors and a chronic multisymptom illness among Gulf War veterans. J Nerv Ment Dis 188:259–66
   PubMed Web of Science ®Google Scholar
• Patočka J, Kassa J, Štětina R, et al. (2004). Toxicological aspects of depleted uranium. J Appl Biomed 2:37–42
   Google Scholar
• Petrovsky N. (2013). Vaccine adjuvant safety: the elephant in the room. Expert Rev Vaccines 12:715–17
   PubMed Web of Science ®Google Scholar
• Phillips CJ, Matyas GR, Hansen CJ, et al. (2009). Antibodies to squalene in US Navy Persian Gulf War veterans with chronic multisymptom illness. Vaccine 27:3921–6
   PubMed Web of Science ®Google Scholar
• RAC. (2008). Research Advisory Committee on Gulf War Veterans’ Illnesses, Department of Veterans Affairs. Gulf War Illness and the Health of Gulf War Veterans: Scientific Findings and Recommendations. Washington, DC: U.S. Government Printing Office
   Google Scholar
• RAC. (2013). Research Advisory Committee on Gulf War Veterans’ Illnesses, Department of Veterans Affairs. Gulf War Illness and the Health of Gulf War Veterans: Research update and Recommendations, 2009–2013. Washington, DC: U.S. Government Printing Office
   Google Scholar
• Rayhan RU, Ravindran MK, Baraniuk JN. (2012). Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation. Front Physiol 4:181
   Google Scholar
• Richards AL, Hyams KC, Merrell BR, et al. (1991). Medical aspects of operation desert storm. N Engl J Med 325:970
   PubMedGoogle Scholar
• Richards AL, Hyams KC, Watts DM, et al. (1993). Respiratory disease among military personnel in Saudi Arabia during Operation Desert Shield. Am J Public Health 83:1326–9
   PubMed Web of Science ®Google Scholar
• Savage EP, Keefe TJ, Mounce LM, et al. (1988). Chronic neurological sequale of acute organophosphate pesticide poisoning. Arch Environ Health 43:38–45
   PubMed Web of Science ®Google Scholar
• Shaki F, Hosseini M-J, Ghazi-Khansari M, Pourahmad J. (2013). Depleted uranium induces disruption of energy homeostasis and oxidative stress in isolated rat brain mitochondria. Metallomics 5:736–44
   PubMed Web of Science ®Google Scholar
• Shoenfeld Y, Agmon-Levin N. (2011). ‘ASIA’ – Autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun 36:4–8
   PubMed Web of Science ®Google Scholar
• Schwartz DA, Doebbeling BN, Merchant JA, et al. (1997). Self-reported illness and health status among gulf war veterans – a population-based study. JAMA 277:238–45
   PubMed Web of Science ®Google Scholar
• Spanggord RJ, Sun M, Lim P, Ellis WY. (2006). Enhancement of an analytical method for the determination of squalene in anthrax vaccine adsorbed formulations. J Pharm Biomed Anal 42:494–9
   PubMedGoogle Scholar
• Spencer PS, McCauley LA, Lapidus JA, et al. (2001). Self-reported exposures and their association with unexplained illness in a population-based case-control study of Gulf War veterans. J Occup Environ Med 43:1041–56
   PubMedGoogle Scholar
• Steenland K, Jenkins B, Ames RG, et al. (1994). Chronic neurological sequale of acute organophosphate pesticide poisoning. Am J Public Health 84:731–6
   PubMed Web of Science ®Google Scholar
• Straus SE. (1999). Bridging the gulf in war syndromes. Lancet 353:162–3
   PubMedGoogle Scholar
• Straus SE, Cohen JI, Tosato G, Meier J. (1993). Epstein-Barr-virus infections –biology, pathogenesis and managment. Ann Intern Med 118:45–58
   PubMed Web of Science ®Google Scholar
• Suadicani P, Ishøy T, Guldager B, et al. (1999). Determinants of long-term neuropsychological symptoms. The Danish Gulf War Study. Dan Med Bull 46:423–7
   PubMedGoogle Scholar
• Thomas R, Vigerstad T, Meagher J, McMullin C. (2000). Particulate exposure during the Persian Gulf War. Falls Church, VA: Defense Technical Information Center
   Google Scholar
• Tucker JB. (1997). Evidence Iraq used chemical weapons during the 1991 persian gulf war. Nonprolif Rev 4:114–22
   Google Scholar
• Unwin C, Blatchley N, Coker W, et al. (1999). Health of UK servicemen who served in Persian Gulf War. Lancet 353:169–78
   PubMed Web of Science ®Google Scholar
• USGAO. (1999). Gulf War illnesses: questions about the presence of squalene antibodies in veterans can be resolved. Washington, DC: GAO
   Google Scholar
• Windkenwerder W. (2003). Environmental exposure report: pesticides final report. Washington, DC: DOD
   Google Scholar
• Wolfe J, Proctor SP, Erickson DJ, Hu H. (2002). Risk factors for multisymptom illness in US Army veterans of the Gulf War. J Occup Environ Med 44:271–81
   PubMedGoogle Scholar