9
Views
6
CrossRef citations to date
0
Altmetric
Research Article

The Neurotoxic Effects of Ricinus communis Agglutinin-II

, &
Pages 1-46 | Published online: 28 Sep 2008

References

  • Delgado-Garcia J. M., Pozo F., Spencer R. F., Baker R. Behavior of neurons in the abducens nucleus of the alert cat-III. Axotomized motoneurons. Neuroscience 1988; 24: 143
  • Armengol J. A., Sotelo C., Angaut P., Alvarado-Mallart R. M. Organization of host afferents to cerebellar grafts implanted in adult rats. Hodological evidence for the specificity of host-graft interactions. Eur. J. Neurosci. 1990; 1: 75
  • Sofroniew M. W., Galletly N. P., Isacson O., Svendsen C. N. Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science 1990; 247: 338
  • Coyle J. T., Schwarcz R. Handbook of Chemical Neuroanatomy, A. Björklund, T. Hökfelt. Elsevier, Amsterdam 1983; 508
  • Wiley R. G., Blessing W. W., Reis D. J. Suicide transport: destruction of neurons by retrograde transport of ricin, abrin and modeccin. Science 1982; 216: 889
  • Cruz R. R., Pastor A. M., Garcia J. M. Effects of target depletion on adult mammalian central neurons: morphological correlates. Neuroscience 1994; 58: 59
  • Pubols L. M., Foglesong M. E. Acute and chronic effects of the neurolytic agent ricin on dorsal root ganglia, spinal cord, and nerves. J. Comp. Neurol. 1988; 275: 271
  • Fabian R., Coulter J. D. Transneuronal transport of lectins. Brain Res. 1985; 344: 41
  • Yamamoto T., Iwasaki Y., Konno H., Kudo H. Primary degeneration of motor neurons by toxic lectins conveyed from the peripheral nerve. J. Neurol. Sci. 1985; 70: 327
  • Dumas M., Schwab M. E., Thoenen H. Retrograde axonal transport of specific macromolecules as a tool for characterizing nerve terminal membranes. J. Neurobiol. 1979; 10: 179
  • LaVail J. H., La Vail M. M. Retrograde axonal transport in the central nervous system. Science 1972; 176: 1416
  • Johnson L. R., Lesnick E., Westrum M. A. H., Canfield R. C. Toxin ricin demonstrates a dual dental projection. Brain Res. 1985; 345: 379
  • Leong S. K., Tan C. K. Central projection of rat sciatic nerve fibres as revealed by Ricinus communis agglutinin and horseradish peroxidase tracers. J. Anat. 1987; 154: 15
  • Harper C. G., Gonatas J. O., Mizutani T., Gonatas N. K. Retrograde transport and effects of toxic ricin in the autonomic nervous system. Lab. Invest. 1980; 42: 396
  • Yamamoto T., Iwasaki Y., Konno H. Experimental sensory ganglionectomy by way of suicide axoplasmic transport. J. Neurosurg. 1984; 60: 108
  • Yamamoto T., Iwasaki Y., Konno H. Retrograde axoplasmic transport of Adriamycin: an experimental form of motor neuron disease?. Neurology (Cleveland) 1984; 34: 1299
  • de laCruz R. R., Pastor A. M., Delgado-García J. M. Effects of target depletion on adult mammalian central neurons: functional correlates. Neuroscience 1994; 58: 81
  • Sharon N., Lis H. Lectins: cell-agglutinating and sugar-specific proteins. Science 1972; 177: 949
  • Andrews G. A., Chavey P. S., Smith J. E. Reactivity of seed lectins with blood-typed canine erythrocytes. Comp. Haematol. Int. 1992; 2: 68
  • Becht H., Rott R., Klenk H. D. Effect of concanavalin A on cells infected with enveloped RNA viruses. J. Gen. Virol. 1972; 14: 1
  • Lin J., Tserng K., Chen C., Lin K., Tung T. Abrin and ricin: new antitumour substances. Nature, Lond. 1970; 227: 292
  • Stirpe F., Licastro F., Morini M. C., Parente A., Sabino G., Abbondanza A., Bolognesi A., Falasca A. I., Rossi C. A. Purification and partial characterization of a mitogenic lectin from the latex of Euphorbia marginata. Biochim. Biophys. Acta 1993; 1158: 33
  • Olsnes S., Saltvedt E., Phil A. Isolation and comparison of galactose-binding lectins from Abrus precatorius and Ricinus communis. J. Biol. Chem. 1974; 249: 803
  • Saltvedt E. Structure and toxicity of pure ricinus agglutinin. Biochim. Biophys. Acta 1976; 451: 536
  • Morton J. F. Poisonous and Injurious Higher Plants from Forensic Medicine. W. B. Saunders & Co., London 1977; 1456
  • Olsnes S., Pihl A. Abrin and ricin - two toxic lectins. Trends Biochem. Sci. 1978; 3: 7
  • Olsnes S., Refsnes K., Christensen T. B., Phil A. Studies on the structure and properties of the lectins from Abrus precatorius and Ricinus communis. Biochim. Biophys. Acta 1975; 405: 1
  • Endo Y., Tsurugi K. RNA N-glycosidase activity of ricin A-chain. J. Biol. Chem. 8128; 262: 8128
  • Greco M., Montanaro L., Novello F., Saccone C., Sperti S., Stirpe F. Inhibition of protein synthesis by ricin: experiments with rat liver mitochondria and nuclei and with ribosomes from Escherichia coli. Biochem. J. 1974; 142: 695
  • Montfort W., Villafranca J. E., Monzingo A. F., Ernst S. R., Katzin B., Rutember E., Xuong N. H., Hamil R., Robertus J. D. The three dimensional structure of ricin at 2.8 A. J. Biol. Chem. 1987; 262: 5398
  • Rutenber E., Katzin B. J., Collins E. J., Misna D., Ernst S. E., Ready M. P., Robertus J. D. Crystallographic refinement of ricin to 2.5-Å resolution. Proteins-Structure Function and Genetics 1991; 10: 240
  • Katzin B. J., Collins E. J., Robertus J. D. Structure of ricin A-chain at 2.5-Å. Proteins-Structure Function and Genetics 1991; 10: 251
  • Ready M. P., Kim Y., Robertus J. D. Site directed mutagenesis of ricin A-chain and implications for the mechanism of action. Proteins-Structure Function and Genetics 1991; 10: 270
  • Olsnes S., øivind Moskaug J., Stenmark H., Sandvig K. Molecular Mimicry in Health and Disease. Elsevier Science Publishers. 1988; 197
  • Sperti S., Zamboni M., Brigotti M., Rambelli F., Montanaro L. Alpha-sarcin impairs the N-glycosidase activity of ricin on ribosomes. Biochem. Biophys. Res. Commun. 1989; 160: 857
  • Fernández-Puentes C., Benson S., Olsnes S., Pihl A. Protective effect of elongation factor 2 on the inactivation of ribosomes by the toxic lectins Abrin and Ricin. Eur. J. Biochem. 1976; 64: 437
  • Montanaro L., Sperti S., Mattioli A., Testoni G., Stirpe F. Inhibition by ricin of protein synthesis in vitro. Inhibition of the binding of elongation factor 2 and of adenosine diphosphate-ribosylates elongation factor 2 to ribosomes. Biochem. J. 1927; 146: 127
  • Sperti S., Montanaro L. Ricin and modeccin do not inhibit the elongation factor 1-dependent binding of aminoacyl-tRNA to ribosomes. Biochem. J. 1979; 178: 233
  • Brigotti M., Rambelli F., Zamboni M., Montanaro L., Sperti S. Effect of α-sarcin and ribosome-inactivating proteins on the interaction of elongation factors with ribosomes. Biochem. J. 1989; 257: 723
  • Fodstad ø., Olsnes S. Studies on the accessibility of ribosomes to inactivation by the toxic lectins abrin and ricin. Eur. J. Biochem. 1977; 74: 209
  • Osborn R. W., Hartley M. R. Dual effects of the ricin A chain on protein synthesis in rabbit reticulocyte lysate. Inhibition of initiation and translocation. Eur. J. Biochem. 1990; 193: 401
  • Morris K. N., Wool I. G. Determination by systematic deletion of the amino acids essential for catalysis by ricin A chain. Proc. Natl. Acad. Sci. U.S.A. 1992; 89: 4869
  • Olsnes S., Sandvig K. Receptor-mediated Endocytosis, Receptor and Recognition. Chapman and Hall, London 1983; 187
  • Richardson P. T., Roberts L. M., Gould J. H., Lord J. M. The expression of functional ricin B-chain in Saccharomyces cerevisiae (BBA 91846). Biochim. Biophys. Acta 1988; 950: 385
  • Hussain K., Bowler C., Roberts L. M., Lord J. M. Expression of ricin B-chain in Escherichia-coli. FEBS Lett. 1989; 244: 383
  • Swimmer C., Lehar S. M., Mc Cafferty J., Chiswell D. J., Blattler W. A., Guild B. C. Phage display of ricin B chain and its single binding domains: System for screening galactose-binding mutants. Proc. Natl. Acad. Sci. U.S.A. 1992; 89: 3756
  • Wales R., Richardson P. T., Roberts L. M., Woodland H. R., Lord J. M. Mutational analysis of the galactose binding ability of recombinant ricin B-chain. J. Biol. Chem. 1991; 266: 19172
  • Brown J. C., Hunt R. C. Lectins. Int. Rev. Cytol. 1978; 52: 277
  • Nicolson G. L., Blaustein J., Etzler M. E. Characterization of two plant lectins from Ricinus communis and their quantitative interaction with a murine lymphoma. Biochem. 1974; 13: 196
  • Pappenheimer A. M., Jr, Olsnes S., Harper A. A. Lectins from Abrus precatorius and Ricinus communis. I. Immunochemical relationships between Toxins and Agglutinins. J. Immunol. 1974; 113: 835
  • Fodstad ø., Olsnes S, Pihl A. Toxicity distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. Br. J. Cancer 1976; 34: 418
  • Aminoff D., Breugge W. F. V., Bell W. C., Sarpolis K., Williams R. Role of sialic acid in survival of erythrocytes in the circulation: interaction of neuraminidase-treated and untreated erythrocytes with spleen and liver at the cellular level. Proc. Natl. Acad. Sci. U.S.A. 1977; 74: 1521
  • Rosen S. W., Hughes R. C. Effects of neuraminidase on lectin binding by wild-type and ricin-resistant strains of hamster fibroblasts. Biochem. 1977; 16: 4908
  • Wood J. G., Byrd F. I., Gurd J. W. Lectin cytochemistry of carbohydrates on cell membranes of rat cerebellum. J. Neurocytol. 1981; 10: 149
  • Reid D. M., Friedel U., Molday R. S., Cook N. J. Identification of the sodium-calcium exchanger as the major ricin-binding glycoprotein of bovine rod outer segments and its localization to the plasma membrane. Biochem. 1990; 29: 1601
  • Kelly P., Cotman C. W., Gentry C, Nicolson G. L. Distribution and mobility of lectin receptors on synaptic membranes of identified neurons in the central nervous system. J. Cell Biol. 1976; 71: 487
  • Hatten M. E., Schachner M., Sidman R. L. Histochemical characterization of lectin binding in mouse cerebellum. Neuroscience 1979; 4: 921
  • Wiley R. G., Oeltmann T. N. Anatomically selective peripheral nerve ablation using intraneural ricin injection. J. Neurosci. Methods 1986; 17: 43
  • Bouldin T. W., Earnhardt T. S., Goines N. D. Temporal course of blood-nerve barrier alterations in ricin-induced neuronopathy. J. Neuropathol. Exp. Neurol. 1989; 48: 370
  • de laCruz R. R., Baker R., Delgado-García J. M. Behavior of cat abducens motoneurons following the injection of toxic ricin into the lateral rectus muscle. Brain Res. 1991; 544: 260
  • Henry M. A., Westrum L. E., Johnson L R., Canfield R. C. Ultrastructure of degenerative changes following ricin application to feline dental pulps. J. Neurocytol. 1987; 16: 601
  • de laCruz R. R., Baker R., Delgado-García J. M. Response of adult cat abducens internuclear interneurons to selective removal of their target motoneurons. Exp. Brain Res. 1991; 84: 167
  • Ling E. A., Leong S. K. Infiltration of carbon-labelled monocytes into the dorsal motor nucleus following an intraneural injection of ricinus communis agglutinin-60 into the vagus nerve in rats. J. Anat. 1988; 159: 207
  • Ling E. A., Wen C. Y., Shieh J. Y., Yick T. Y., Leong S. K. Neuroglial response to neuron injury. A study using intraneural injection of ricinus communis agglutinin-60. J. Anat. 1989; 164: 210
  • Wiley R. G., Oeltmann T. N. Anti-ricin antibody protects against systemic toxicity without affecting suicide transport. J. Neurosci. Methods 1989; 27: 203
  • Wiley R. G., Talman W. T., Reis D. J. Ricin transport distinguishes between central and peripheral neurons. Brain Res. 1983; 269: 357
  • DeSilva N. S., Gurd J. W., Schwartz C. Developmental alteration of rat brain synaptic membranes. Reaction of glycoproteins with plant lectins. Brain Res. 1979; 165: 283
  • Gurd J. W. Synaptic membrane glycoproteins: molecular identification of lectin receptors. Biochem. 1977; 16: 369
  • Fu S. C., Cruz T. F., Gurd J. W. Development of synaptic glycoproteins: effects of postnatal age on the synthesis and concentration of synaptic membrane and synaptic junctional fucosyl and sialyl glycoproteins. J. Neurochem. 1981; 36: 1338
  • Margolis R. K., Gomes L. Structural changes in brain glycoproteins during development. Brain Res. 1974; 74: 370
  • Margolis R. K., Petri C., Lai D., Margolis R. U. Developmental changes in brain glycoproteins. Brain Res. 1976; 112: 363
  • Wiley R. G., Stirpe F. Neuronotoxicity of axonally transported toxic lectins, abrin, modeccin and volkensin in rat peripheral nervous system. Neuropathol. Appl. Neurobiol. 1987; 13: 39
  • Wiley R. G., Stirpe F. Modeccin and volkensin but not abrin are effective suicide transport agents in rat CNS. Brain Res. 1988; 438: 145
  • Pangalos M. N., Francis P. T., Pearson R. C. A., Middlemiss D. N., Bowen D. M. Destruction of a sub-population of cortical neurons by suicide transport of volkensin, a lectin from Adenia volkensii. J. Neurosci. Methods 1991; 40: 17
  • Hatten M. E., Sidman R. L. Plant lectins detect age and region specific differences in cell surface carbohydrates and cell reassociation behavior of embryonic mouse cerebellar cells. J. Supramol. Struct. 1977; 7: 267
  • Huck S., Hatten M. E. Developmental stage-specific changes in lectin binding to mouse cerebellar cells in vitro. J. Neurosci. 1981; 1: 1075
  • Mc Laughlin B. J., Wood J. G., Gurd J. W. The localization of lectin binding sites during photoreceptor synaptogenesis in the chick retina. Brain Res. 1945; 191: 345
  • Paul I., Devor M. Completeness and selectivity of ricin “suicide transport” lesions in rat dorsal root ganglia. J. Neurosci. Methods 1987; 22: 103
  • Ling E. A., Leong S. K. Effects of intraneural injection of Ricinus communis agglutinin-60 into the rat vagus nerve. J. Neurocytol. 1987; 16: 373
  • Barron K. D. Neural Regeneration and Transplantation, F. J. Scil. Alan R. Liss Inc., New York 1989; 79
  • Leong S. K., Tan C. K. Central projection of rat sciatic nerve fibers as revealed by Ricinus communis agglutinin and horseradish peroxidase tracers. J. Anat. 1987; 154: 15
  • Yamamoto T., Iwasaki Y., Konno H. Retrograde axoplasmic transport of toxic lectins is useful for transganglionic tracings of the peripheral nerve. Brain Res. 1983; 274: 325
  • Streit W. J., Kreutzberg G. W. Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin. J. Comp. Neurol. 1988; 268: 248
  • Lannoo M. J., Maler L., Hawkes R. Collateral sprouting in the electrosensory lateral line lobe of weakly electric teleosts (Gymnotiforms) following ricin ablation. J. Comp. Neurol. 1946; 333: 246
  • Evinger C. Neuroanatomy of the Oculomotor System. Reviews of Oculomotor Research, J. A. Büttner-Ennever. Elsevier, Amsterdam 1988; 81
  • Highstein S. M., Baker R. Excitatory termination of abducens internuclear neurons on medial rectus motoneurons, relationship to syndrome of internuclear ophthalmoplegia. J. Neurophysiol. 1978; 41: 1647
  • Fuchs A. F., Robinson D. A. A method for measuring horizontal and vertical eye movement chronically in the monkey. J. Appl. Physiol. 1966; 21: 1068
  • Delgado-García J. M., Del Pozo F., Baker R. Behavior of neurons in the abducens nucleus of the alert cat. I. Motoneurons. Neuroscience 1986; 17: 929
  • Spencer R. F., Baker R., Mc Crea R. A. Localization and morphology of cat retractor bulbi motoneurons. J. Neurophysiol. 1980; 43: 754
  • Crandall W. F., Goldberg S. J., Wilson J. S., Mc Clung J. R. Muscle units divided among retractor bulbi muscle slips and between the lateral rectus and retractor bulbi muscles in cat. Exp. Neurol. 1981; 71: 251
  • Delgado-García J. M., Evinger C., Escudero M., Baker R. Behavior of accessory abducens and abducens motoneurons during eye retraction and rotation in the alert cat. J. Neurophysiol. 1990; 64: 413
  • de laCruz R. R., Pastor A. M., Aa J. M. Long-term effects of selective target removal on brainstem premotor neurons in the adult cat. Eur. J. Neurosci. 1993; 5: 232
  • Rivero-Melian C., Arvidsson J. Dose- and time-dependent selective and non-selective effects of ricin (RCA 120) on rat primary sensory neurons. Brain Res. 1989; 496: 131
  • Helke C. J., Charlton C. G., Wiley R. G. Suicide transport of ricin demonstrates the presence of substance P receptors on medullary somatic and autonomic motor neurons. Brain Res. 1985; 328: 190
  • Wall J. T., Cusick C. G., Migani-Wall S. A., Wiley R. G. Cortical organization after treatment of a peripheral nerve with ricin: an evaluation of the relationship between sensory neuron death and cortical adjustment after nerve injury. J. Comp. Neurol. 1988; 277: 578
  • Cusick C. G., Wall J. T., Wiley R. G. Temporal progression of cortical reorganization following nerve injury. Brain Res. 1990; 537: 355
  • Fodstad ø., Olsnes S, Pihl A. Inhibitory effect of abrin and ricin on the growth of transplantable murine tumors and of abrin on human cancers in nude mice. Cancer Res. 1977; 37: 4559
  • Pihl A., Fodstad Ø., Olsnes S. Biology of the Cancer Cell, Proceedings of the Fifth Meeting of the European Association for Cancer Research. Kugler Publications, Amsterdam 1980; 261
  • Vallera D. A., Myers D. E. Immunotoxins, A. E. Frankel. Kluwer Academic Publishers. 1988; 141
  • Wiley R. G. Neural lesioning with ribosome-inactivating proteins: suicide transport and immunolesioning. Trends Neurosci. 1992; 15: 285
  • DiStefano P. S., Schweitzer J. B., Taniuchi M., Johnson E. M. Selective destruction of nerve growth factor receptor-bearing cells in vitro using a hybrid toxin composed of ricin A chain and a monoclonal antibody against the nerve growth factor receptor. J. Cell Biol. 1985; 101: 1107
  • Preijers F. W. M., Witte T., Wessels J. M.C., Gast G. C., Leeuwen E., Capel P. J. A., Haanen C. Autologous transplantation of bone marrow purged in vitro with anti-CD7-(WT1-) ricin A immunotoxin in T-cell lymphoblastic leukemia and lymphoma. Blood 1989; 74: 1152
  • Weiner L. M., Dwyer J., Kitson J., Comis R. L., Frankel A. E., Bauer R. J., Konrad M. S., Groves E. S. Phase I evaluation of an anti-breast carcinoma monoclonal antibody 260F9-recombinant ricin A chain immunoconjugate. Cancer Res. 1989; 49: 4062

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.